Human Phenotype Ontology 
Grandparent Node:
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Abnormality of higher mental function (HP:0011446)help
Parent Node:
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Cognitive impairment (HP:0100543)help
..Starting node
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Memory impairment (HP:0002354)help
Term ID: 2354
Name: Memory impairment
Synonym: Forgetfulness; Memory impairment; Memory loss; Memory problems; Poor memory
Definition: An impairment of memory as manifested by a reduced ability to remember things such as dates and names, and increased forgetfulness.
Comments:
Reference: HP:0002354
Genes and Diseases:
 
       Child Nodes:
........expandDeficit in phonologic short-term memory (HP:0002549) help
........expandProgressive forgetfulness (HP:0007017) help
........expandTransient global amnesia (HP:0010534) help

 Sister Nodes: 
..expandBradyphrenia (HP:0031843) help
..expandMental deterioration (HP:0001268) help
InputHPO IDHPO termDistanceGeneGene id entrezHGNC IDDiseaseIdDiseaseNameFrequencyOnsetHGMD variantsClinVar variants
 
HPO disease - gene - phenotype typical associations:
 
HPO disease - gene - phenotype less frequent non-typical associations:
HP:0002354HP:0002354Memory impairment0ABCA7 CL E G H1034737OMIM:608907Alzheimer disease 9, susceptibility to.3
HP:0002354HP:0002354Memory impairment0ABCA7 CL E G H1034737ORPHA:1020Early-onset autosomal dominant Alzheimer diseaseHP:0040281 - Very frequent3
HP:0002354HP:0002354Memory impairment0ABCD1 CL E G H21561ORPHA:139399AdrenomyeloneuropathyHP:0040283 - Occasional135
HP:0002354HP:0002354Memory impairment0ABCD1 CL E G H21561ORPHA:139396X-linked cerebral adrenoleukodystrophyHP:0040283 - Occasional135
HP:0002354HP:0002354Memory impairment0ACSF3 CL E G H19732227288ORPHA:289504Combined malonic and methylmalonic acidemiaHP:0040283 - Occasional68
HP:0002354HP:0002354Memory impairment0ADA2 CL E G H518161839ORPHA:820Sneddon syndromeHP:0040281 - Very frequent22
HP:0002354HP:0002354Memory impairment0AFG3L2 CL E G H10939315ORPHA:101109Spinocerebellar ataxia type 28HP:0040284 - Very rare86
HP:0002354HP:0002354Memory impairment0AKT1 CL E G H207391ORPHA:2495MeningiomaHP:0040283 - Occasional54
HP:0002354HP:0002354Memory impairment0ALDH18A1 CL E G H58329722ORPHA:447753Autosomal dominant spastic paraplegia type 9AHP:0040283 - Occasional89
HP:0002354HP:0002354Memory impairment0AMACR CL E G H23600451ORPHA:79095Congenital bile acid synthesis defect type 444
HP:0002354HP:0002354Memory impairment0APOE CL E G H348613OMIM:607822Alzheimer disease 3.39
HP:0002354HP:0002354Memory impairment0APOE CL E G H348613OMIM:606889Alzheimer disease 439
HP:0002354HP:0002354Memory impairment0APP CL E G H351620ORPHA:324708ABeta amyloidosis, Iowa typeHP:0040281 - Very frequent74
HP:0002354HP:0002354Memory impairment0APP CL E G H351620ORPHA:1020Early-onset autosomal dominant Alzheimer diseaseHP:0040281 - Very frequent74
HP:0002354HP:0002354Memory impairment0ARMC5 CL E G H7979825781ORPHA:189427Cushing syndrome due to macronodular adrenal hyperplasia7
HP:0002354HP:0002354Memory impairment0ARSA CL E G H410713ORPHA:309271Metachromatic leukodystrophy, adult formHP:0040282 - Frequent253
HP:0002354HP:0002354Memory impairment0ATN1 CL E G H18223033ORPHA:101Dentatorubral pallidoluysian atrophyHP:0040283 - Occasional16
HP:0002354HP:0002354Memory impairment0ATRX CL E G H546886ORPHA:96253Cushing disease169
HP:0002354HP:0002354Memory impairment0ATXN1 CL E G H631010548ORPHA:98755Spinocerebellar ataxia type 1HP:0040282 - Frequent19
HP:0002354HP:0002354Memory impairment0ATXN3 CL E G H42877106ORPHA:276238Machado-Joseph disease type 1HP:0040283 - Occasional14
HP:0002354HP:0002354Memory impairment0ATXN3 CL E G H42877106ORPHA:276241Machado-Joseph disease type 2HP:0040283 - Occasional14
HP:0002354HP:0002354Memory impairment0ATXN3 CL E G H42877106ORPHA:276244Machado-Joseph disease type 3HP:0040283 - Occasional14
HP:0002354HP:0002354Memory impairment0BAP1 CL E G H8314950ORPHA:2495MeningiomaHP:0040283 - Occasional184
HP:0002354HP:0002354Memory impairment0BMPR1A CL E G H6571076ORPHA:440437Familial colorectal cancer Type XHP:0040283 - Occasional385
HP:0002354HP:0002354Memory impairment0BRAF CL E G H6731097ORPHA:96253Cushing disease276
HP:0002354HP:0002354Memory impairment0C4A CL E G H7201323ORPHA:117Behçet diseaseHP:0040283 - Occasional1
HP:0002354HP:0002354Memory impairment0C9ORF72 CL E G H20322828337ORPHA:275864Behavioral variant of frontotemporal dementiaHP:0040281 - Very frequent56
HP:0002354HP:0002354Memory impairment0C9ORF72 CL E G H20322828337ORPHA:401901Huntington disease-like syndrome due to C9ORF72 expansionsHP:0040282 - Frequent56
HP:0002354HP:0002354Memory impairment0C9ORF72 CL E G H20322828337ORPHA:100070Progressive non-fluent aphasiaHP:0040281 - Very frequent56
HP:0002354HP:0002354Memory impairment0CAMTA1 CL E G H2326118806ORPHA:314647Non-progressive cerebellar ataxia with intellectual disabilityHP:0040282 - Frequent34
HP:0002354HP:0002354Memory impairment0CCR1 CL E G H12301602ORPHA:117Behçet diseaseHP:0040283 - Occasional
HP:0002354HP:0002354Memory impairment0CDH23 CL E G H6407213733ORPHA:96253Cushing disease636
HP:0002354HP:0002354Memory impairment0CHMP2B CL E G H2597824537ORPHA:275864Behavioral variant of frontotemporal dementiaHP:0040281 - Very frequent42
HP:0002354HP:0002354Memory impairment0CHMP2B CL E G H2597824537OMIM:600795Frontotemporal dementia and/or amytrophic lateral sclerosis 7.42
HP:0002354HP:0002354Memory impairment0CHMP2B CL E G H2597824537ORPHA:100070Progressive non-fluent aphasiaHP:0040281 - Very frequent42
HP:0002354HP:0002354Memory impairment0CLN3 CL E G H12012074ORPHA:228346CLN3 disease216
HP:0002354HP:0002354Memory impairment0COX1 CL E G H45127419ORPHA:550MELASHP:0040282 - Frequent
HP:0002354HP:0002354Memory impairment0COX2 CL E G H45137421ORPHA:550MELASHP:0040282 - Frequent
HP:0002354HP:0002354Memory impairment0COX3 CL E G H45147422ORPHA:550MELASHP:0040282 - Frequent
HP:0002354HP:0002354Memory impairment0CP CL E G H13562295ORPHA:48818AceruloplasminemiaHP:0040283 - Occasional115
HP:0002354HP:0002354Memory impairment0CSF1R CL E G H14362433OMIM:221820Leukoencephalopathy, diffuse hereditary, with spheroids.149
HP:0002354HP:0002354Memory impairment0CTSH CL E G H15122535ORPHA:2073Narcolepsy type 11
HP:0002354HP:0002354Memory impairment0CYLD CL E G H15402584OMIM:619132FRONTOTEMPORAL DEMENTIA AND/OR AMYOTROPHIC LATERAL SCLEROSIS 8; FTDALS8126
HP:0002354HP:0002354Memory impairment0DNMT1 CL E G H17862976ORPHA:314404Autosomal dominant cerebellar ataxia-deafness-narcolepsy syndromeHP:0040283 - Occasional145
HP:0002354HP:0002354Memory impairment0DNMT1 CL E G H17862976OMIM:604121Cerebellar ataxia, deafness, and narcolepsy, autosomal dominant.145
HP:0002354HP:0002354Memory impairment0DNMT1 CL E G H17862976OMIM:614116Neuropathy, hereditary sensory, type IE.145
HP:0002354HP:0002354Memory impairment0ECM1 CL E G H18933153OMIM:247100Urbach-Wiethe disease.14
HP:0002354HP:0002354Memory impairment0EIF2B1 CL E G H19673257OMIM:603896Leukoencephalopathy with vanishing white matter.42
HP:0002354HP:0002354Memory impairment0EIF2B2 CL E G H88923258OMIM:603896Leukoencephalopathy with vanishing white matter.24
HP:0002354HP:0002354Memory impairment0EIF2B3 CL E G H88913259OMIM:603896Leukoencephalopathy with vanishing white matter.32
HP:0002354HP:0002354Memory impairment0EIF2B4 CL E G H88903260OMIM:603896Leukoencephalopathy with vanishing white matter.38
HP:0002354HP:0002354Memory impairment0EIF2B5 CL E G H88933261OMIM:603896Leukoencephalopathy with vanishing white matter.48
HP:0002354HP:0002354Memory impairment0EPCAM CL E G H407211529ORPHA:144Lynch syndromeHP:0040283 - Occasional170
HP:0002354HP:0002354Memory impairment0ERAP1 CL E G H5175218173ORPHA:117Behçet diseaseHP:0040283 - Occasional1
HP:0002354HP:0002354Memory impairment0FAN1 CL E G H2290929170ORPHA:144Lynch syndromeHP:0040283 - Occasional15
HP:0002354HP:0002354Memory impairment0FAR1 CL E G H8418826222ORPHA:447753Autosomal dominant spastic paraplegia type 9AHP:0040283 - Occasional7
HP:0002354HP:0002354Memory impairment0FAS CL E G H35511920ORPHA:117Behçet diseaseHP:0040283 - Occasional59
HP:0002354HP:0002354Memory impairment0FGF14 CL E G H22593671ORPHA:98764Spinocerebellar ataxia type 27HP:0040282 - Frequent47
HP:0002354HP:0002354Memory impairment0FMR1 CL E G H23323775OMIM:300623Fragile X tremor/ataxia syndrome30
HP:0002354HP:0002354Memory impairment0FMR1 CL E G H23323775ORPHA:93256Fragile X-associated tremor/ataxia syndromeHP:0040281 - Very frequent30
HP:0002354HP:0002354Memory impairment0GNAS CL E G H27784392ORPHA:189427Cushing syndrome due to macronodular adrenal hyperplasia101
HP:0002354HP:0002354Memory impairment0GNE CL E G H1002023657ORPHA:3166SialuriaHP:0040281 - Very frequent173
HP:0002354HP:0002354Memory impairment0GOSR2 CL E G H95704431OMIM:614018Epilepsy, progressive myoclonic, 688
HP:0002354HP:0002354Memory impairment0GRIN2A CL E G H29034585ORPHA:98818Landau-Kleffner syndromeHP:0040283 - Occasional434
HP:0002354HP:0002354Memory impairment0GRN CL E G H28964601ORPHA:275864Behavioral variant of frontotemporal dementiaHP:0040281 - Very frequent126
HP:0002354HP:0002354Memory impairment0GRN CL E G H28964601OMIM:607485Frontotemporal lobar degeneration with TDP43 inclusions.126
HP:0002354HP:0002354Memory impairment0GRN CL E G H28964601ORPHA:100070Progressive non-fluent aphasiaHP:0040281 - Very frequent126
HP:0002354HP:0002354Memory impairment0GSN CL E G H29344620ORPHA:85448AGel amyloidosis53
HP:0002354HP:0002354Memory impairment0HCRT CL E G H30604847ORPHA:2073Narcolepsy type 11
HP:0002354HP:0002354Memory impairment0HLA-B CL E G H31064932ORPHA:117Behçet diseaseHP:0040283 - Occasional4
HP:0002354HP:0002354Memory impairment0HLA-DQB1 CL E G H31194944OMIM:123400Creutzfeldt-Jakob disease.
HP:0002354HP:0002354Memory impairment0HLA-DQB1 CL E G H31194944ORPHA:2073Narcolepsy type 1
HP:0002354HP:0002354Memory impairment0HLA-DRB1 CL E G H31234948ORPHA:2073Narcolepsy type 12
HP:0002354HP:0002354Memory impairment0HMBS CL E G H31454982ORPHA:79276Acute intermittent porphyriaHP:0040283 - Occasional81
HP:0002354HP:0002354Memory impairment0HTT CL E G H30644851ORPHA:399Huntington diseaseHP:0040282 - Frequent12
HP:0002354HP:0002354Memory impairment0IFNGR1 CL E G H34595439ORPHA:117Behçet diseaseHP:0040283 - Occasional60
HP:0002354HP:0002354Memory impairment0IL10 CL E G H35865962ORPHA:117Behçet diseaseHP:0040283 - Occasional2
HP:0002354HP:0002354Memory impairment0IL12A CL E G H35925969ORPHA:117Behçet diseaseHP:0040283 - Occasional
HP:0002354HP:0002354Memory impairment0IL12A-AS1 CL E G H10192837649094ORPHA:117Behçet diseaseHP:0040283 - Occasional
HP:0002354HP:0002354Memory impairment0IL23R CL E G H14923319100ORPHA:117Behçet diseaseHP:0040283 - Occasional1
HP:0002354HP:0002354Memory impairment0JPH3 CL E G H5733814203ORPHA:98934Huntington disease-like 2HP:0040283 - Occasional2
HP:0002354HP:0002354Memory impairment0KLRC4 CL E G H83026377ORPHA:117Behçet diseaseHP:0040283 - Occasional
HP:0002354HP:0002354Memory impairment0KRAS CL E G H38456407ORPHA:144Lynch syndromeHP:0040283 - Occasional196
HP:0002354HP:0002354Memory impairment0MAPT CL E G H41376893ORPHA:275864Behavioral variant of frontotemporal dementiaHP:0040281 - Very frequent140
HP:0002354HP:0002354Memory impairment0MAPT CL E G H41376893ORPHA:100070Progressive non-fluent aphasiaHP:0040281 - Very frequent140
HP:0002354HP:0002354Memory impairment0MAPT CL E G H41376893ORPHA:240103Progressive supranuclear palsy-corticobasal syndromeHP:0040282 - Frequent140
HP:0002354HP:0002354Memory impairment0MAPT CL E G H41376893ORPHA:240085Progressive supranuclear palsy-parkinsonism syndromeHP:0040283 - Occasional140
HP:0002354HP:0002354Memory impairment0MAPT CL E G H41376893ORPHA:240112Progressive supranuclear palsy-progressive non-fluent aphasia syndrome140
HP:0002354HP:0002354Memory impairment0MAPT CL E G H41376893OMIM:601104Supranuclear palsy, progressive, 1.140
HP:0002354HP:0002354Memory impairment0MEFV CL E G H42106998ORPHA:117Behçet diseaseHP:0040283 - Occasional281
HP:0002354HP:0002354Memory impairment0MEN1 CL E G H42217010ORPHA:97279Insulinoma462
HP:0002354HP:0002354Memory impairment0MLH1 CL E G H42927127ORPHA:144Lynch syndromeHP:0040283 - Occasional1819
HP:0002354HP:0002354Memory impairment0MLH3 CL E G H270307128ORPHA:144Lynch syndromeHP:0040283 - Occasional131
HP:0002354HP:0002354Memory impairment0MMACHC CL E G H2597424525ORPHA:79282Methylmalonic acidemia with homocystinuria, type cblCHP:0040283 - Occasional101
HP:0002354HP:0002354Memory impairment0MOG CL E G H43407197ORPHA:2073Narcolepsy type 11
HP:0002354HP:0002354Memory impairment0MSH2 CL E G H44367325ORPHA:144Lynch syndromeHP:0040283 - Occasional2162
HP:0002354HP:0002354Memory impairment0MSH6 CL E G H29567329ORPHA:144Lynch syndromeHP:0040283 - Occasional2232
HP:0002354HP:0002354Memory impairment0MYD88 CL E G H46157562ORPHA:33226Waldenström macroglobulinemiaHP:0040283 - Occasional9
HP:0002354HP:0002354Memory impairment0MYORG CL E G H5746219918OMIM:618317Basal ganglia calcification, idiopathic, 7, autosomal recessive.
HP:0002354HP:0002354Memory impairment0ND1 CL E G H45357455ORPHA:550MELASHP:0040282 - Frequent
HP:0002354HP:0002354Memory impairment0ND4 CL E G H45387459ORPHA:550MELASHP:0040282 - Frequent
HP:0002354HP:0002354Memory impairment0ND5 CL E G H45407461ORPHA:550MELASHP:0040282 - Frequent
HP:0002354HP:0002354Memory impairment0ND6 CL E G H45417462ORPHA:550MELASHP:0040282 - Frequent
HP:0002354HP:0002354Memory impairment0NF1 CL E G H47637765ORPHA:9768517q11 microdeletion syndromeHP:0040282 - Frequent1952
HP:0002354HP:0002354Memory impairment0NF2 CL E G H47717773ORPHA:2495MeningiomaHP:0040283 - Occasional220
HP:0002354HP:0002354Memory impairment0NF2 CL E G H47717773ORPHA:637Neurofibromatosis type 2HP:0040283 - Occasional220
HP:0002354HP:0002354Memory impairment0NIPA1 CL E G H12360617043ORPHA:26118315q11.2 microdeletion syndromeHP:0040282 - Frequent117
HP:0002354HP:0002354Memory impairment0NIPA2 CL E G H8161417044ORPHA:26118315q11.2 microdeletion syndromeHP:0040282 - Frequent1
HP:0002354HP:0002354Memory impairment0NOTCH3 CL E G H48547883OMIM:125310Cerebral arteriopathy, autosomal dominant, with subcortical infarctsand leukoencephalopathy144
HP:0002354HP:0002354Memory impairment0NOTCH3 CL E G H48547883ORPHA:136Cerebral autosomal dominant arteriopathy-subcortical infarcts-leukoencephalopathyHP:0040283 - Occasional144
HP:0002354HP:0002354Memory impairment0NR3C1 CL E G H29087978ORPHA:96253Cushing disease79
HP:0002354HP:0002354Memory impairment0P2RY11 CL E G H50328540ORPHA:2073Narcolepsy type 12
HP:0002354HP:0002354Memory impairment0PAH CL E G H50538582ORPHA:79254Classic phenylketonuriaHP:0040282 - Frequent641
HP:0002354HP:0002354Memory impairment0PDE11A CL E G H509408773ORPHA:189439Primary pigmented nodular adrenocortical disease13
HP:0002354HP:0002354Memory impairment0PDE8B CL E G H86228794ORPHA:189439Primary pigmented nodular adrenocortical disease75
HP:0002354HP:0002354Memory impairment0PDGFB CL E G H51558800OMIM:213600Basal ganglia calcification, idiopathic, 1.9
HP:0002354HP:0002354Memory impairment0PDGFB CL E G H51558800ORPHA:2495MeningiomaHP:0040283 - Occasional9
HP:0002354HP:0002354Memory impairment0PDGFRB CL E G H51598804OMIM:213600Basal ganglia calcification, idiopathic, 1.28
HP:0002354HP:0002354Memory impairment0PIDD1 CL E G H5536716491OMIM:619827INTELLECTUAL DEVELOPMENTAL DISORDER, AUTOSOMAL RECESSIVE 75, WITH NEUROPSYCHIATRIC FEATURES AND VARIANT LISSENCEPHALY; MRT75
HP:0002354HP:0002354Memory impairment0PIK3CA CL E G H52908975ORPHA:144Lynch syndromeHP:0040283 - Occasional162
HP:0002354HP:0002354Memory impairment0PIK3CA CL E G H52908975ORPHA:2495MeningiomaHP:0040283 - Occasional162
HP:0002354HP:0002354Memory impairment0PMS1 CL E G H53789121ORPHA:144Lynch syndromeHP:0040283 - Occasional56
HP:0002354HP:0002354Memory impairment0PMS2 CL E G H53959122ORPHA:144Lynch syndromeHP:0040283 - Occasional1121
HP:0002354HP:0002354Memory impairment0POLG CL E G H54289179ORPHA:70595Sensory ataxic neuropathy-dysarthria-ophthalmoparesis syndromeHP:0040283 - Occasional464
HP:0002354HP:0002354Memory impairment0POU4F1 CL E G H54579218ORPHA:314647Non-progressive cerebellar ataxia with intellectual disabilityHP:0040282 - Frequent
HP:0002354HP:0002354Memory impairment0PRKACA CL E G H55669380ORPHA:189439Primary pigmented nodular adrenocortical disease2
HP:0002354HP:0002354Memory impairment0PRKAR1A CL E G H55739388ORPHA:189439Primary pigmented nodular adrenocortical disease134
HP:0002354HP:0002354Memory impairment0PRKAR1B CL E G H55759390ORPHA:412066PRKAR1B-related neurodegenerative dementia with intermediate filamentsHP:0040281 - Very frequent2
HP:0002354HP:0002354Memory impairment0PRKCG CL E G H55829402OMIM:605361Spinocerebellar ataxia 14.83
HP:0002354HP:0002354Memory impairment0PRNP CL E G H56219449OMIM:123400Creutzfeldt-Jakob disease.69
HP:0002354HP:0002354Memory impairment0PRNP CL E G H56219449ORPHA:280397Familial Alzheimer-like prion disease69
HP:0002354HP:0002354Memory impairment0PRNP CL E G H56219449OMIM:137440Gerstmann-Straussler disease.69
HP:0002354HP:0002354Memory impairment0PRNP CL E G H56219449ORPHA:157941Huntington disease-like 1HP:0040283 - Occasional69
HP:0002354HP:0002354Memory impairment0PRNP CL E G H56219449ORPHA:282166Inherited Creutzfeldt-Jakob disease69
HP:0002354HP:0002354Memory impairment0PRORP CL E G H969219958OMIM:619737COMBINED OXIDATIVE PHOSPHORYLATION DEFICIENCY 54; COXPD54
HP:0002354HP:0002354Memory impairment0PSAP CL E G H56609498ORPHA:309271Metachromatic leukodystrophy, adult formHP:0040282 - Frequent81
HP:0002354HP:0002354Memory impairment0PSEN1 CL E G H56639508OMIM:607822Alzheimer disease 3.241
HP:0002354HP:0002354Memory impairment0PSEN1 CL E G H56639508ORPHA:275864Behavioral variant of frontotemporal dementiaHP:0040281 - Very frequent241
HP:0002354HP:0002354Memory impairment0PSEN1 CL E G H56639508ORPHA:1020Early-onset autosomal dominant Alzheimer diseaseHP:0040281 - Very frequent241
HP:0002354HP:0002354Memory impairment0PSEN1 CL E G H56639508ORPHA:100070Progressive non-fluent aphasiaHP:0040281 - Very frequent241
HP:0002354HP:0002354Memory impairment0PSEN2 CL E G H56649509OMIM:606889Alzheimer disease 459
HP:0002354HP:0002354Memory impairment0PSEN2 CL E G H56649509ORPHA:1020Early-onset autosomal dominant Alzheimer diseaseHP:0040281 - Very frequent59
HP:0002354HP:0002354Memory impairment0REEP2 CL E G H5130817975ORPHA:401849Autosomal spastic paraplegia type 72HP:0040283 - Occasional3
HP:0002354HP:0002354Memory impairment0RNASEH1 CL E G H24624318466ORPHA:329336Adult-onset chronic progressive external ophthalmoplegia with mitochondrial myopathy3
HP:0002354HP:0002354Memory impairment0RPS20 CL E G H622410405ORPHA:440437Familial colorectal cancer Type XHP:0040283 - Occasional1
HP:0002354HP:0002354Memory impairment0RRM2B CL E G H5048417296ORPHA:329336Adult-onset chronic progressive external ophthalmoplegia with mitochondrial myopathy125
HP:0002354HP:0002354Memory impairment0SEMA4A CL E G H6421810729ORPHA:440437Familial colorectal cancer Type XHP:0040283 - Occasional48
HP:0002354HP:0002354Memory impairment0SIM1 CL E G H649210882ORPHA:369873Obesity due to SIM1 deficiencyHP:0040282 - Frequent40
HP:0002354HP:0002354Memory impairment0SLC20A2 CL E G H657510947OMIM:213600Basal ganglia calcification, idiopathic, 1.70
HP:0002354HP:0002354Memory impairment0SLC25A13 CL E G H1016510983ORPHA:247585Citrullinemia type IIHP:0040282 - Frequent82
HP:0002354HP:0002354Memory impairment0SLC2A3 CL E G H651511007ORPHA:399Huntington diseaseHP:0040282 - Frequent1
HP:0002354HP:0002354Memory impairment0SMARCB1 CL E G H659811103ORPHA:2495MeningiomaHP:0040283 - Occasional87
HP:0002354HP:0002354Memory impairment0SMARCE1 CL E G H660511109ORPHA:2495MeningiomaHP:0040283 - Occasional47
HP:0002354HP:0002354Memory impairment0SMO CL E G H660811119ORPHA:2495MeningiomaHP:0040283 - Occasional22
HP:0002354HP:0002354Memory impairment0SORL1 CL E G H665311185ORPHA:1020Early-onset autosomal dominant Alzheimer diseaseHP:0040281 - Very frequent3
HP:0002354HP:0002354Memory impairment0SPAST CL E G H668311233OMIM:182601Spastic paraplegia 4, autosomal dominant.208
HP:0002354HP:0002354Memory impairment0SPG11 CL E G H8020811226ORPHA:2822Autosomal recessive spastic paraplegia type 11HP:0040282 - Frequent287
HP:0002354HP:0002354Memory impairment0SPG7 CL E G H668711237OMIM:607259Spastic paraplegia 7, autosomal recessive.171
HP:0002354HP:0002354Memory impairment0SPG7 CL E G H668711237ORPHA:99013Spastic paraplegia type 7HP:0040284 - Very rare171
HP:0002354HP:0002354Memory impairment0SQSTM1 CL E G H887811280ORPHA:275864Behavioral variant of frontotemporal dementiaHP:0040281 - Very frequent62
HP:0002354HP:0002354Memory impairment0STAT4 CL E G H677511365ORPHA:117Behçet diseaseHP:0040283 - Occasional2
HP:0002354HP:0002354Memory impairment0STUB1 CL E G H1027311427ORPHA:412057Autosomal recessive cerebellar ataxia due to STUB1 deficiencyHP:0040283 - Occasional14
HP:0002354HP:0002354Memory impairment0SUFU CL E G H5168416466ORPHA:2495MeningiomaHP:0040283 - Occasional124
HP:0002354HP:0002354Memory impairment0TERT CL E G H701511730ORPHA:2495MeningiomaHP:0040283 - Occasional238
HP:0002354HP:0002354Memory impairment0TGFBR2 CL E G H704811773ORPHA:144Lynch syndromeHP:0040283 - Occasional253
HP:0002354HP:0002354Memory impairment0TIA1 CL E G H707211802OMIM:619133AMYOTROPHIC LATERAL SCLEROSIS 26 WITH OR WITHOUT FRONTOTEMPORAL DEMENTIA; ALS265
HP:0002354HP:0002354Memory impairment0TLR4 CL E G H709911850ORPHA:117Behçet diseaseHP:0040283 - Occasional3
HP:0002354HP:0002354Memory impairment0TMEM106B CL E G H5466422407ORPHA:275864Behavioral variant of frontotemporal dementiaHP:0040281 - Very frequent
HP:0002354HP:0002354Memory impairment0TMEM106B CL E G H5466422407ORPHA:100070Progressive non-fluent aphasiaHP:0040281 - Very frequent
HP:0002354HP:0002354Memory impairment0TNFSF4 CL E G H729211934ORPHA:2073Narcolepsy type 1
HP:0002354HP:0002354Memory impairment0TOMM40 CL E G H1045218001ORPHA:1020Early-onset autosomal dominant Alzheimer diseaseHP:0040281 - Very frequent
HP:0002354HP:0002354Memory impairment0TP53 CL E G H715711998ORPHA:96253Cushing disease911
HP:0002354HP:0002354Memory impairment0TRAF7 CL E G H8423120456ORPHA:2495MeningiomaHP:0040283 - Occasional
HP:0002354HP:0002354Memory impairment0TREM2 CL E G H5420917761ORPHA:275864Behavioral variant of frontotemporal dementiaHP:0040281 - Very frequent31
HP:0002354HP:0002354Memory impairment0TREM2 CL E G H5420917761ORPHA:1020Early-onset autosomal dominant Alzheimer diseaseHP:0040281 - Very frequent31
HP:0002354HP:0002354Memory impairment0TREM2 CL E G H5420917761ORPHA:2770Nasu-Hakola diseaseHP:0040281 - Very frequent31
HP:0002354HP:0002354Memory impairment0TREM2 CL E G H5420917761OMIM:618193POLYCYSTIC LIPOMEMBRANOUS OSTEODYSPLASIA WITH SCLEROSING LEUKOENCEPHALOPATHY 2; PLOSL231
HP:0002354HP:0002354Memory impairment0TREM2 CL E G H5420917761ORPHA:100070Progressive non-fluent aphasiaHP:0040281 - Very frequent31
HP:0002354HP:0002354Memory impairment0TREX1 CL E G H1127712269ORPHA:247691Retinal vasculopathy with cerebral leukoencephalopathy and systemic manifestationsHP:0040283 - Occasional56
HP:0002354HP:0002354Memory impairment0TREX1 CL E G H1127712269OMIM:192315Vasculopathy, retinal, with cerebral leukodystrophy56
HP:0002354HP:0002354Memory impairment0TRNF CL E G H45587481ORPHA:550MELASHP:0040282 - Frequent
HP:0002354HP:0002354Memory impairment0TRNH CL E G H45647487ORPHA:550MELASHP:0040282 - Frequent
HP:0002354HP:0002354Memory impairment0TRNL1 CL E G H45677490ORPHA:550MELASHP:0040282 - Frequent
HP:0002354HP:0002354Memory impairment0TRNQ CL E G H45727495ORPHA:550MELASHP:0040282 - Frequent
HP:0002354HP:0002354Memory impairment0TRNS1 CL E G H45747497ORPHA:550MELASHP:0040282 - Frequent
HP:0002354HP:0002354Memory impairment0TRNS2 CL E G H45757498ORPHA:550MELASHP:0040282 - Frequent
HP:0002354HP:0002354Memory impairment0TRNW CL E G H45787501ORPHA:550MELASHP:0040282 - Frequent
HP:0002354HP:0002354Memory impairment0TTPA CL E G H727412404OMIM:277460VITAMIN E, FAMILIAL ISOLATED DEFICIENCY OF62
HP:0002354HP:0002354Memory impairment0TUBG1 CL E G H728312417ORPHA:26118315q11.2 microdeletion syndromeHP:0040282 - Frequent14
HP:0002354HP:0002354Memory impairment0TWNK CL E G H566521160ORPHA:70595Sensory ataxic neuropathy-dysarthria-ophthalmoparesis syndromeHP:0040283 - Occasional113
HP:0002354HP:0002354Memory impairment0TYROBP CL E G H730512449ORPHA:2770Nasu-Hakola diseaseHP:0040281 - Very frequent22
HP:0002354HP:0002354Memory impairment0TYROBP CL E G H730512449OMIM:221770Polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy.22
HP:0002354HP:0002354Memory impairment0UBAC2 CL E G H33786720486ORPHA:117Behçet diseaseHP:0040283 - Occasional
HP:0002354HP:0002354Memory impairment0UGT1A1 CL E G H5465812530ORPHA:79234Crigler-Najjar syndrome type 1HP:0040283 - Occasional73
HP:0002354HP:0002354Memory impairment0USP48 CL E G H8419618533ORPHA:96253Cushing disease1
HP:0002354HP:0002354Memory impairment0USP8 CL E G H910112631ORPHA:96253Cushing disease7
HP:0002354HP:0002354Memory impairment0VAMP1 CL E G H684312642ORPHA:251282Autosomal dominant spastic ataxia type 1HP:0040282 - Frequent2
HP:0002354HP:0002354Memory impairment0VAMP1 CL E G H684312642OMIM:108600Spastic ataxia 1, autosomal dominant.2
HP:0002354HP:0002354Memory impairment0VCP CL E G H741512666ORPHA:435387Autosomal dominant Charcot-Marie-Tooth disease type 2YHP:0040283 - Occasional63
HP:0002354HP:0002354Memory impairment0VCP CL E G H741512666ORPHA:275864Behavioral variant of frontotemporal dementiaHP:0040281 - Very frequent63
HP:0002354HP:0002354Memory impairment0VCP CL E G H741512666ORPHA:100070Progressive non-fluent aphasiaHP:0040281 - Very frequent63
HP:0002354HP:0002354Memory impairment0XPR1 CL E G H921312827OMIM:616413Basal ganglia calcification, idiopathic, 6.4
HP:0002354HP:0002354Memory impairment0YY1 CL E G H752812856ORPHA:97279Insulinoma7
HP:0002354HP:0002354Memory impairment0ZNF365 CL E G H2289118194ORPHA:2073Narcolepsy type 13
HP:0002354HP:0033688Long term memory impairment1 CL E G H
HP:0002354HP:0010534Transient global amnesia1AKT1 CL E G H207391ORPHA:2495MeningiomaHP:0040284 - Very rare54
HP:0002354HP:0010534Transient global amnesia1BAP1 CL E G H8314950ORPHA:2495MeningiomaHP:0040284 - Very rare184
HP:0002354HP:0010534Transient global amnesia1CTSH CL E G H15122535ORPHA:2073Narcolepsy type 1HP:0040281 - Very frequent1
HP:0002354HP:0033687Short term memory impairment1GSN CL E G H29344620ORPHA:85448AGel amyloidosis53
HP:0002354HP:0010534Transient global amnesia1HCRT CL E G H30604847ORPHA:2073Narcolepsy type 1HP:0040281 - Very frequent1
HP:0002354HP:0010534Transient global amnesia1HLA-DQB1 CL E G H31194944ORPHA:2073Narcolepsy type 1HP:0040281 - Very frequent
HP:0002354HP:0010534Transient global amnesia1HLA-DRB1 CL E G H31234948ORPHA:2073Narcolepsy type 1HP:0040281 - Very frequent2
HP:0002354HP:0033687Short term memory impairment1MAPT CL E G H41376893ORPHA:240112Progressive supranuclear palsy-progressive non-fluent aphasia syndrome140
HP:0002354HP:0010534Transient global amnesia1MEN1 CL E G H42217010ORPHA:97279InsulinomaHP:0040281 - Very frequent462
HP:0002354HP:0010534Transient global amnesia1MOG CL E G H43407197ORPHA:2073Narcolepsy type 1HP:0040281 - Very frequent1
HP:0002354HP:0010534Transient global amnesia1NF2 CL E G H47717773ORPHA:2495MeningiomaHP:0040284 - Very rare220
HP:0002354HP:0010534Transient global amnesia1P2RY11 CL E G H50328540ORPHA:2073Narcolepsy type 1HP:0040281 - Very frequent2
HP:0002354HP:0010534Transient global amnesia1PDGFB CL E G H51558800ORPHA:2495MeningiomaHP:0040284 - Very rare9
HP:0002354HP:0010534Transient global amnesia1PIK3CA CL E G H52908975ORPHA:2495MeningiomaHP:0040284 - Very rare162
HP:0002354HP:0033687Short term memory impairment1PRNP CL E G H56219449ORPHA:280397Familial Alzheimer-like prion disease69
HP:0002354HP:0007017Progressive forgetfulness1PRNP CL E G H56219449ORPHA:282166Inherited Creutzfeldt-Jakob diseaseHP:0040282 - Frequent69
HP:0002354HP:0033687Short term memory impairment1RNASEH1 CL E G H24624318466ORPHA:329336Adult-onset chronic progressive external ophthalmoplegia with mitochondrial myopathy3
HP:0002354HP:0033687Short term memory impairment1RRM2B CL E G H5048417296ORPHA:329336Adult-onset chronic progressive external ophthalmoplegia with mitochondrial myopathy125
HP:0002354HP:0010534Transient global amnesia1SMARCB1 CL E G H659811103ORPHA:2495MeningiomaHP:0040284 - Very rare87
HP:0002354HP:0010534Transient global amnesia1SMARCE1 CL E G H660511109ORPHA:2495MeningiomaHP:0040284 - Very rare47
HP:0002354HP:0010534Transient global amnesia1SMO CL E G H660811119ORPHA:2495MeningiomaHP:0040284 - Very rare22
HP:0002354HP:0010534Transient global amnesia1SUFU CL E G H5168416466ORPHA:2495MeningiomaHP:0040284 - Very rare124
HP:0002354HP:0010534Transient global amnesia1TERT CL E G H701511730ORPHA:2495MeningiomaHP:0040284 - Very rare238
HP:0002354HP:0010534Transient global amnesia1TNFSF4 CL E G H729211934ORPHA:2073Narcolepsy type 1HP:0040281 - Very frequent
HP:0002354HP:0010534Transient global amnesia1TRAF7 CL E G H8423120456ORPHA:2495MeningiomaHP:0040284 - Very rare
HP:0002354HP:0007017Progressive forgetfulness1TREX1 CL E G H1127712269OMIM:192315Vasculopathy, retinal, with cerebral leukodystrophy.56
HP:0002354HP:0033687Short term memory impairment1TTPA CL E G H727412404OMIM:277460VITAMIN E, FAMILIAL ISOLATED DEFICIENCY OF62
HP:0002354HP:0010534Transient global amnesia1YY1 CL E G H752812856ORPHA:97279InsulinomaHP:0040281 - Very frequent7
HP:0002354HP:0010534Transient global amnesia1ZNF365 CL E G H2289118194ORPHA:2073Narcolepsy type 1HP:0040281 - Very frequent3
HP:0002354HP:0033690Retrograde memory impairment2 CL E G H
HP:0002354HP:0033689Anterograde memory impairment2 CL E G H
HP:0002354HP:0002549Deficit in phonologic short-term memory2GSN CL E G H29344620ORPHA:85448AGel amyloidosisHP:0040284 - Very rare53
HP:0002354HP:0002549Deficit in phonologic short-term memory2MAPT CL E G H41376893ORPHA:240112Progressive supranuclear palsy-progressive non-fluent aphasia syndromeHP:0040281 - Very frequent140
HP:0002354HP:0002549Deficit in phonologic short-term memory2PRNP CL E G H56219449ORPHA:280397Familial Alzheimer-like prion diseaseHP:0040281 - Very frequent69
HP:0002354HP:0002549Deficit in phonologic short-term memory2RNASEH1 CL E G H24624318466ORPHA:329336Adult-onset chronic progressive external ophthalmoplegia with mitochondrial myopathyHP:0040283 - Occasional3
HP:0002354HP:0002549Deficit in phonologic short-term memory2RRM2B CL E G H5048417296ORPHA:329336Adult-onset chronic progressive external ophthalmoplegia with mitochondrial myopathyHP:0040283 - Occasional125
HP:0002354HP:0033692Declarative memory loss3 CL E G H
HP:0002354HP:0033691Procedural memory loss3 CL E G H


Genes (160) :ABCA7 ABCD1 ACSF3 ADA2 AFG3L2 AKT1 ALDH18A1 AMACR APOE APP ARMC5 ARSA ATN1 ATRX ATXN1 ATXN3 BAP1 BMPR1A BRAF C4A C9ORF72 CAMTA1 CCR1 CDH23 CHMP2B CLN3 COX1 COX2 COX3 CP CSF1R CTSH CYLD DNMT1 ECM1 EIF2B1 EIF2B2 EIF2B3 EIF2B4 EIF2B5 EPCAM ERAP1 FAN1 FAR1 FAS FGF14 FMR1 GNAS GNE GOSR2 GRIN2A GRN GSN HCRT HLA-B HLA-DQB1 HLA-DRB1 HMBS HTT IFNGR1 IL10 IL12A IL12A-AS1 IL23R JPH3 KLRC4 KRAS MAPT MEFV MEN1 MLH1 MLH3 MMACHC MOG MSH2 MSH6 MYD88 MYORG ND1 ND4 ND5 ND6 NF1 NF2 NIPA1 NIPA2 NOTCH3 NR3C1 P2RY11 PAH PDE11A PDE8B PDGFB PDGFRB PIDD1 PIK3CA PMS1 PMS2 POLG POU4F1 PRKACA PRKAR1A PRKAR1B PRKCG PRNP PRORP PSAP PSEN1 PSEN2 REEP2 RNASEH1 RPS20 RRM2B SEMA4A SIM1 SLC20A2 SLC25A13 SLC2A3 SMARCB1 SMARCE1 SMO SORL1 SPAST SPG11 SPG7 SQSTM1 STAT4 STUB1 SUFU TERT TGFBR2 TIA1 TLR4 TMEM106B TNFSF4 TOMM40 TP53 TRAF7 TREM2 TREX1 TRNF TRNH TRNL1 TRNQ TRNS1 TRNS2 TRNW TTPA TUBG1 TWNK TYROBP UBAC2 UGT1A1 USP48 USP8 VAMP1 VCP XPR1 YY1 ZNF365

Diseases (98) :OMIM:608907 ORPHA:1020 ORPHA:139399 ORPHA:139396 ORPHA:289504 ORPHA:820 ORPHA:101109 ORPHA:2495 ORPHA:447753 ORPHA:79095 OMIM:607822 OMIM:606889 ORPHA:324708 ORPHA:189427 ORPHA:309271 ORPHA:101 ORPHA:96253 ORPHA:98755 ORPHA:276238 ORPHA:276241 ORPHA:276244 ORPHA:440437 ORPHA:117 ORPHA:275864 ORPHA:401901 ORPHA:100070 ORPHA:314647 OMIM:600795 ORPHA:228346 ORPHA:550 ORPHA:48818 OMIM:221820 ORPHA:2073 OMIM:619132 ORPHA:314404 OMIM:604121 OMIM:614116 OMIM:247100 OMIM:603896 ORPHA:144 ORPHA:98764 OMIM:300623 ORPHA:93256 ORPHA:3166 OMIM:614018 ORPHA:98818 OMIM:607485 ORPHA:85448 OMIM:123400 ORPHA:79276 ORPHA:399 ORPHA:98934 ORPHA:240103 ORPHA:240085 ORPHA:240112 OMIM:601104 ORPHA:97279 ORPHA:79282 ORPHA:33226 OMIM:618317 ORPHA:97685 ORPHA:637 ORPHA:261183 OMIM:125310 ORPHA:136 ORPHA:79254 ORPHA:189439 OMIM:213600 OMIM:619827 ORPHA:70595 ORPHA:412066 OMIM:605361 ORPHA:280397 OMIM:137440 ORPHA:157941 ORPHA:282166 OMIM:619737 ORPHA:401849 ORPHA:329336 ORPHA:369873 ORPHA:247585 OMIM:182601 ORPHA:2822 OMIM:607259 ORPHA:99013 ORPHA:412057 OMIM:619133 ORPHA:2770 OMIM:618193 ORPHA:247691 OMIM:192315 OMIM:277460 OMIM:221770 ORPHA:79234 ORPHA:251282 OMIM:108600 ORPHA:435387 OMIM:616413
 

Human Phenotype Ontology(HPO) is developed by the Human Phenotype Ontology Consortium. The version used here is December 15 2022 release.