Human Phenotype Ontology 
Grandparent Node:
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Abnormality of movement (HP:0100022)help
Parent Node:
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Diminished movement (HP:0002374)help
..Starting node
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Akinesia (HP:0002304)help
Term ID: 2304
Name: Akinesia
Synonym:
Definition: Inability to initiate changes in activity or movement and to perform ordinary volitional movements rapidly and easily.
Comments:
Reference: HP:0002304
Genes and Diseases:
 
       Child Nodes:

 Sister Nodes: 
..expandHypokinesia (HP:0002375) help
InputHPO IDHPO termDistanceGeneGene id entrezDiseaseIdDiseaseNameDiseaseMIMConceptIDSourceTypical associationHGMD variantsClinVar variantsHGNC IDGeneMIM
 
HPO disease - gene - phenotype typical associations:
HP:0002304HP:0002304Akinesia0ATP13A2 CL E G H23400606693Parkinson disease 9606693C1847640OMIM160930213610513
HP:0002304HP:0002304Akinesia0ATP13A2 CL E G H23400606693Parkinson disease 9606693C1847640OMIM148730213610513
HP:0002304HP:0002304Akinesia0CHRNA1 CL E G H1134253290Lethal multiple pterygium syndrome253290C1854678OMIM13571955100690
HP:0002304HP:0002304Akinesia0CHRNA1 CL E G H1134253290Lethal multiple pterygium syndrome253290C1854678OMIM13161955100690
HP:0002304HP:0002304Akinesia0CHRND CL E G H1144253290Lethal multiple pterygium syndrome253290C1854678OMIM13731965100720
HP:0002304HP:0002304Akinesia0CHRND CL E G H1144253290Lethal multiple pterygium syndrome253290C1854678OMIM13311965100720
HP:0002304HP:0002304Akinesia0CHRNG CL E G H1146253290Lethal multiple pterygium syndrome253290C1854678OMIM12121967100730
HP:0002304HP:0002304Akinesia0CHRNG CL E G H1146253290Lethal multiple pterygium syndrome253290C1854678OMIM12061967100730
HP:0002304HP:0002304Akinesia0CNTN1 CL E G H1272612540Myopathy, congenital, compton-north612540C2675527OMIM14262171600016
HP:0002304HP:0002304Akinesia0CNTN1 CL E G H1272612540Myopathy, congenital, compton-north612540C2675527OMIM13692171600016
HP:0002304HP:0002304Akinesia0DNAJC13 CL E G H23317411602ORPHA116330343614334
HP:0002304HP:0002304Akinesia0DNAJC13 CL E G H23317411602ORPHA116130343614334
HP:0002304HP:0002304Akinesia0DNAJC6 CL E G H9829391411ORPHA117315469608375
HP:0002304HP:0002304Akinesia0DNAJC6 CL E G H9829391411ORPHA121515469608375
HP:0002304HP:0002304Akinesia0DOK7 CL E G H285489994ORPHA175026594610285
HP:0002304HP:0002304Akinesia0DOK7 CL E G H285489994ORPHA164526594610285
HP:0002304HP:0002304Akinesia0EIF4G1 CL E G H1981411602ORPHA1913296600495
HP:0002304HP:0002304Akinesia0EIF4G1 CL E G H1981411602ORPHA1923296600495
HP:0002304HP:0002304Akinesia0ERBB3 CL E G H2065607598Lethal congenital contracture syndrome 2607598C1843478OMIM1953431190151
HP:0002304HP:0002304Akinesia0ERBB3 CL E G H2065607598Lethal congenital contracture syndrome 2607598C1843478OMIM1943431190151
HP:0002304HP:0002304Akinesia0FLVCR2 CL E G H55640225790Proliferative vasculopathy and hydranencephaly-hydrocephaly syndrome225790C1856972OMIM114020105610865
HP:0002304HP:0002304Akinesia0FLVCR2 CL E G H55640225790Proliferative vasculopathy and hydranencephaly-hydrocephaly syndrome225790C1856972OMIM113820105610865
HP:0002304HP:0002304Akinesia0GBA CL E G H2629411602ORPHA12694177606463
HP:0002304HP:0002304Akinesia0GBA CL E G H2629411602ORPHA12614177606463
HP:0002304HP:0002304Akinesia0GBA CL E G H2629608013Gaucher disease, perinatal lethal608013C1842704OMIM12694177606463
HP:0002304HP:0002304Akinesia0GBA CL E G H2629608013Gaucher disease, perinatal lethal608013C1842704OMIM12614177606463
HP:0002304HP:0002304Akinesia0GIGYF2 CL E G H26058411602ORPHA120011960612003
HP:0002304HP:0002304Akinesia0GIGYF2 CL E G H26058411602ORPHA122911960612003
HP:0002304HP:0002304Akinesia0LRRK2 CL E G H120892411602ORPHA169718618609007
HP:0002304HP:0002304Akinesia0LRRK2 CL E G H120892411602ORPHA160718618609007
HP:0002304HP:0002304Akinesia0MAPT CL E G H4137601104Progressive supranuclear ophthalmoplegia601104C0038868OMIM14886893157140
HP:0002304HP:0002304Akinesia0MAPT CL E G H4137601104Progressive supranuclear ophthalmoplegia601104C0038868OMIM14656893157140
HP:0002304HP:0002304Akinesia0MUSK CL E G H4593994ORPHA14507525601296
HP:0002304HP:0002304Akinesia0MUSK CL E G H4593994ORPHA13837525601296
HP:0002304HP:0002304Akinesia0MYOD1 CL E G H4654994ORPHA1347611159970
HP:0002304HP:0002304Akinesia0PANK2 CL E G H80025234200Pigmentary pallidal degeneration234200C0018523OMIM133115894606157
HP:0002304HP:0002304Akinesia0PANK2 CL E G H80025234200Pigmentary pallidal degeneration234200C0018523OMIM126315894606157
HP:0002304HP:0002304Akinesia0PODXL CL E G H5420391411ORPHA11049171602632
HP:0002304HP:0002304Akinesia0PODXL CL E G H5420391411ORPHA1889171602632
HP:0002304HP:0002304Akinesia0RAPSN CL E G H5913994ORPHA13789863601592
HP:0002304HP:0002304Akinesia0RAPSN CL E G H5913994ORPHA13229863601592
HP:0002304HP:0002304Akinesia0SNCA CL E G H6622411602ORPHA115411138163890
HP:0002304HP:0002304Akinesia0SNCA CL E G H6622411602ORPHA116611138163890
HP:0002304HP:0002304Akinesia0SYNJ1 CL E G H8867391411ORPHA173011503604297
HP:0002304HP:0002304Akinesia0SYNJ1 CL E G H8867391411ORPHA190911503604297
HP:0002304HP:0002304Akinesia0TMEM240 CL E G H33945398773ORPHA118625186616101
HP:0002304HP:0002304Akinesia0TMEM240 CL E G H33945398773ORPHA117625186616101
HP:0002304HP:0002304Akinesia0TMEM240 CL E G H339453607454Spinocerebellar ataxia 21607454C1843891OMIM118625186616101
HP:0002304HP:0002304Akinesia0TMEM240 CL E G H339453607454Spinocerebellar ataxia 21607454C1843891OMIM117625186616101
HP:0002304HP:0002304Akinesia0VPS13C CL E G H54832616840Parkinson disease 23, autosomal recessive early-onset616840C4225186OMIM140223594608879
HP:0002304HP:0002304Akinesia0VPS13C CL E G H54832616840Parkinson disease 23, autosomal recessive early-onset616840C4225186OMIM128123594608879
HP:0002304HP:0002304Akinesia0VPS35 CL E G H55737411602ORPHA116713487601501
HP:0002304HP:0002304Akinesia0VPS35 CL E G H55737411602ORPHA115413487601501
HP:0002304HP:0033411Lower extremity akinesia1ATP13A2 CL E G H23400606693Parkinson disease 9606693C1847640OMIM160930213610513
HP:0002304HP:0033411Lower extremity akinesia1ATP13A2 CL E G H23400606693Parkinson disease 9606693C1847640OMIM148730213610513
HP:0002304HP:0033412Upper extremity akinesia1ATP13A2 CL E G H23400606693Parkinson disease 9606693C1847640OMIM160930213610513
HP:0002304HP:0033412Upper extremity akinesia1ATP13A2 CL E G H23400606693Parkinson disease 9606693C1847640OMIM148730213610513
HP:0002304HP:0033411Lower extremity akinesia1CHRNA1 CL E G H1134253290Lethal multiple pterygium syndrome253290C1854678OMIM13571955100690
HP:0002304HP:0033411Lower extremity akinesia1CHRNA1 CL E G H1134253290Lethal multiple pterygium syndrome253290C1854678OMIM13161955100690
HP:0002304HP:0033412Upper extremity akinesia1CHRNA1 CL E G H1134253290Lethal multiple pterygium syndrome253290C1854678OMIM13571955100690
HP:0002304HP:0033412Upper extremity akinesia1CHRNA1 CL E G H1134253290Lethal multiple pterygium syndrome253290C1854678OMIM13161955100690
HP:0002304HP:0033412Upper extremity akinesia1CHRND CL E G H1144253290Lethal multiple pterygium syndrome253290C1854678OMIM13731965100720
HP:0002304HP:0033412Upper extremity akinesia1CHRND CL E G H1144253290Lethal multiple pterygium syndrome253290C1854678OMIM13311965100720
HP:0002304HP:0033411Lower extremity akinesia1CHRND CL E G H1144253290Lethal multiple pterygium syndrome253290C1854678OMIM13731965100720
HP:0002304HP:0033411Lower extremity akinesia1CHRND CL E G H1144253290Lethal multiple pterygium syndrome253290C1854678OMIM13311965100720
HP:0002304HP:0033411Lower extremity akinesia1CHRNG CL E G H1146253290Lethal multiple pterygium syndrome253290C1854678OMIM12121967100730
HP:0002304HP:0033411Lower extremity akinesia1CHRNG CL E G H1146253290Lethal multiple pterygium syndrome253290C1854678OMIM12061967100730
HP:0002304HP:0033412Upper extremity akinesia1CHRNG CL E G H1146253290Lethal multiple pterygium syndrome253290C1854678OMIM12121967100730
HP:0002304HP:0033412Upper extremity akinesia1CHRNG CL E G H1146253290Lethal multiple pterygium syndrome253290C1854678OMIM12061967100730
HP:0002304HP:0033411Lower extremity akinesia1CNTN1 CL E G H1272612540Myopathy, congenital, compton-north612540C2675527OMIM14262171600016
HP:0002304HP:0033411Lower extremity akinesia1CNTN1 CL E G H1272612540Myopathy, congenital, compton-north612540C2675527OMIM13692171600016
HP:0002304HP:0033412Upper extremity akinesia1CNTN1 CL E G H1272612540Myopathy, congenital, compton-north612540C2675527OMIM14262171600016
HP:0002304HP:0033412Upper extremity akinesia1CNTN1 CL E G H1272612540Myopathy, congenital, compton-north612540C2675527OMIM13692171600016
HP:0002304HP:0033412Upper extremity akinesia1DNAJC13 CL E G H23317411602ORPHA116130343614334
HP:0002304HP:0033411Lower extremity akinesia1DNAJC13 CL E G H23317411602ORPHA116330343614334
HP:0002304HP:0033411Lower extremity akinesia1DNAJC13 CL E G H23317411602ORPHA116130343614334
HP:0002304HP:0033412Upper extremity akinesia1DNAJC13 CL E G H23317411602ORPHA116330343614334
HP:0002304HP:0033411Lower extremity akinesia1DNAJC6 CL E G H9829391411ORPHA117315469608375
HP:0002304HP:0033412Upper extremity akinesia1DNAJC6 CL E G H9829391411ORPHA121515469608375
HP:0002304HP:0033412Upper extremity akinesia1DNAJC6 CL E G H9829391411ORPHA117315469608375
HP:0002304HP:0033411Lower extremity akinesia1DNAJC6 CL E G H9829391411ORPHA121515469608375
HP:0002304HP:0033411Lower extremity akinesia1DOK7 CL E G H285489994ORPHA175026594610285
HP:0002304HP:0033411Lower extremity akinesia1DOK7 CL E G H285489994ORPHA164526594610285
HP:0002304HP:0033412Upper extremity akinesia1DOK7 CL E G H285489994ORPHA175026594610285
HP:0002304HP:0033412Upper extremity akinesia1DOK7 CL E G H285489994ORPHA164526594610285
HP:0002304HP:0033411Lower extremity akinesia1EIF4G1 CL E G H1981411602ORPHA1913296600495
HP:0002304HP:0033412Upper extremity akinesia1EIF4G1 CL E G H1981411602ORPHA1923296600495
HP:0002304HP:0033412Upper extremity akinesia1EIF4G1 CL E G H1981411602ORPHA1913296600495
HP:0002304HP:0033411Lower extremity akinesia1EIF4G1 CL E G H1981411602ORPHA1923296600495
HP:0002304HP:0033411Lower extremity akinesia1ERBB3 CL E G H2065607598Lethal congenital contracture syndrome 2607598C1843478OMIM1953431190151
HP:0002304HP:0033411Lower extremity akinesia1ERBB3 CL E G H2065607598Lethal congenital contracture syndrome 2607598C1843478OMIM1943431190151
HP:0002304HP:0033412Upper extremity akinesia1ERBB3 CL E G H2065607598Lethal congenital contracture syndrome 2607598C1843478OMIM1953431190151
HP:0002304HP:0033412Upper extremity akinesia1ERBB3 CL E G H2065607598Lethal congenital contracture syndrome 2607598C1843478OMIM1943431190151
HP:0002304HP:0033411Lower extremity akinesia1FLVCR2 CL E G H55640225790Proliferative vasculopathy and hydranencephaly-hydrocephaly syndrome225790C1856972OMIM114020105610865
HP:0002304HP:0033411Lower extremity akinesia1FLVCR2 CL E G H55640225790Proliferative vasculopathy and hydranencephaly-hydrocephaly syndrome225790C1856972OMIM113820105610865
HP:0002304HP:0033412Upper extremity akinesia1FLVCR2 CL E G H55640225790Proliferative vasculopathy and hydranencephaly-hydrocephaly syndrome225790C1856972OMIM114020105610865
HP:0002304HP:0033412Upper extremity akinesia1FLVCR2 CL E G H55640225790Proliferative vasculopathy and hydranencephaly-hydrocephaly syndrome225790C1856972OMIM113820105610865
HP:0002304HP:0033412Upper extremity akinesia1GBA CL E G H2629411602ORPHA12614177606463
HP:0002304HP:0033411Lower extremity akinesia1GBA CL E G H2629411602ORPHA12694177606463
HP:0002304HP:0033411Lower extremity akinesia1GBA CL E G H2629411602ORPHA12614177606463
HP:0002304HP:0033412Upper extremity akinesia1GBA CL E G H2629411602ORPHA12694177606463
HP:0002304HP:0033412Upper extremity akinesia1GBA CL E G H2629608013Gaucher disease, perinatal lethal608013C1842704OMIM12694177606463
HP:0002304HP:0033412Upper extremity akinesia1GBA CL E G H2629608013Gaucher disease, perinatal lethal608013C1842704OMIM12614177606463
HP:0002304HP:0033411Lower extremity akinesia1GBA CL E G H2629608013Gaucher disease, perinatal lethal608013C1842704OMIM12694177606463
HP:0002304HP:0033411Lower extremity akinesia1GBA CL E G H2629608013Gaucher disease, perinatal lethal608013C1842704OMIM12614177606463
HP:0002304HP:0033411Lower extremity akinesia1GIGYF2 CL E G H26058411602ORPHA120011960612003
HP:0002304HP:0033412Upper extremity akinesia1GIGYF2 CL E G H26058411602ORPHA122911960612003
HP:0002304HP:0033412Upper extremity akinesia1GIGYF2 CL E G H26058411602ORPHA120011960612003
HP:0002304HP:0033411Lower extremity akinesia1GIGYF2 CL E G H26058411602ORPHA122911960612003
HP:0002304HP:0033412Upper extremity akinesia1LRRK2 CL E G H120892411602ORPHA160718618609007
HP:0002304HP:0033411Lower extremity akinesia1LRRK2 CL E G H120892411602ORPHA169718618609007
HP:0002304HP:0033411Lower extremity akinesia1LRRK2 CL E G H120892411602ORPHA160718618609007
HP:0002304HP:0033412Upper extremity akinesia1LRRK2 CL E G H120892411602ORPHA169718618609007
HP:0002304HP:0033412Upper extremity akinesia1MAPT CL E G H4137601104Progressive supranuclear ophthalmoplegia601104C0038868OMIM14886893157140
HP:0002304HP:0033412Upper extremity akinesia1MAPT CL E G H4137601104Progressive supranuclear ophthalmoplegia601104C0038868OMIM14656893157140
HP:0002304HP:0033411Lower extremity akinesia1MAPT CL E G H4137601104Progressive supranuclear ophthalmoplegia601104C0038868OMIM14886893157140
HP:0002304HP:0033411Lower extremity akinesia1MAPT CL E G H4137601104Progressive supranuclear ophthalmoplegia601104C0038868OMIM14656893157140
HP:0002304HP:0033412Upper extremity akinesia1MUSK CL E G H4593994ORPHA14507525601296
HP:0002304HP:0033412Upper extremity akinesia1MUSK CL E G H4593994ORPHA13837525601296
HP:0002304HP:0033411Lower extremity akinesia1MUSK CL E G H4593994ORPHA14507525601296
HP:0002304HP:0033411Lower extremity akinesia1MUSK CL E G H4593994ORPHA13837525601296
HP:0002304HP:0033412Upper extremity akinesia1MYOD1 CL E G H4654994ORPHA1347611159970
HP:0002304HP:0033411Lower extremity akinesia1MYOD1 CL E G H4654994ORPHA1347611159970
HP:0002304HP:0033412Upper extremity akinesia1PANK2 CL E G H80025234200Pigmentary pallidal degeneration234200C0018523OMIM133115894606157
HP:0002304HP:0033412Upper extremity akinesia1PANK2 CL E G H80025234200Pigmentary pallidal degeneration234200C0018523OMIM126315894606157
HP:0002304HP:0033411Lower extremity akinesia1PANK2 CL E G H80025234200Pigmentary pallidal degeneration234200C0018523OMIM133115894606157
HP:0002304HP:0033411Lower extremity akinesia1PANK2 CL E G H80025234200Pigmentary pallidal degeneration234200C0018523OMIM126315894606157
HP:0002304HP:0033412Upper extremity akinesia1PODXL CL E G H5420391411ORPHA1889171602632
HP:0002304HP:0033411Lower extremity akinesia1PODXL CL E G H5420391411ORPHA11049171602632
HP:0002304HP:0033411Lower extremity akinesia1PODXL CL E G H5420391411ORPHA1889171602632
HP:0002304HP:0033412Upper extremity akinesia1PODXL CL E G H5420391411ORPHA11049171602632
HP:0002304HP:0033412Upper extremity akinesia1RAPSN CL E G H5913994ORPHA13229863601592
HP:0002304HP:0033411Lower extremity akinesia1RAPSN CL E G H5913994ORPHA13789863601592
HP:0002304HP:0033411Lower extremity akinesia1RAPSN CL E G H5913994ORPHA13229863601592
HP:0002304HP:0033412Upper extremity akinesia1RAPSN CL E G H5913994ORPHA13789863601592
HP:0002304HP:0033411Lower extremity akinesia1SNCA CL E G H6622411602ORPHA115411138163890
HP:0002304HP:0033412Upper extremity akinesia1SNCA CL E G H6622411602ORPHA116611138163890
HP:0002304HP:0033412Upper extremity akinesia1SNCA CL E G H6622411602ORPHA115411138163890
HP:0002304HP:0033411Lower extremity akinesia1SNCA CL E G H6622411602ORPHA116611138163890
HP:0002304HP:0033411Lower extremity akinesia1SYNJ1 CL E G H8867391411ORPHA173011503604297
HP:0002304HP:0033412Upper extremity akinesia1SYNJ1 CL E G H8867391411ORPHA190911503604297
HP:0002304HP:0033412Upper extremity akinesia1SYNJ1 CL E G H8867391411ORPHA173011503604297
HP:0002304HP:0033411Lower extremity akinesia1SYNJ1 CL E G H8867391411ORPHA190911503604297
HP:0002304HP:0033412Upper extremity akinesia1TMEM240 CL E G H33945398773ORPHA117625186616101
HP:0002304HP:0033411Lower extremity akinesia1TMEM240 CL E G H33945398773ORPHA118625186616101
HP:0002304HP:0033411Lower extremity akinesia1TMEM240 CL E G H33945398773ORPHA117625186616101
HP:0002304HP:0033412Upper extremity akinesia1TMEM240 CL E G H33945398773ORPHA118625186616101
HP:0002304HP:0033412Upper extremity akinesia1TMEM240 CL E G H339453607454Spinocerebellar ataxia 21607454C1843891OMIM118625186616101
HP:0002304HP:0033412Upper extremity akinesia1TMEM240 CL E G H339453607454Spinocerebellar ataxia 21607454C1843891OMIM117625186616101
HP:0002304HP:0033411Lower extremity akinesia1TMEM240 CL E G H339453607454Spinocerebellar ataxia 21607454C1843891OMIM118625186616101
HP:0002304HP:0033411Lower extremity akinesia1TMEM240 CL E G H339453607454Spinocerebellar ataxia 21607454C1843891OMIM117625186616101
HP:0002304HP:0033412Upper extremity akinesia1VPS13C CL E G H54832616840Parkinson disease 23, autosomal recessive early-onset616840C4225186OMIM140223594608879
HP:0002304HP:0033412Upper extremity akinesia1VPS13C CL E G H54832616840Parkinson disease 23, autosomal recessive early-onset616840C4225186OMIM128123594608879
HP:0002304HP:0033411Lower extremity akinesia1VPS13C CL E G H54832616840Parkinson disease 23, autosomal recessive early-onset616840C4225186OMIM140223594608879
HP:0002304HP:0033411Lower extremity akinesia1VPS13C CL E G H54832616840Parkinson disease 23, autosomal recessive early-onset616840C4225186OMIM128123594608879
HP:0002304HP:0033412Upper extremity akinesia1VPS35 CL E G H55737411602ORPHA115413487601501
HP:0002304HP:0033411Lower extremity akinesia1VPS35 CL E G H55737411602ORPHA116713487601501
HP:0002304HP:0033411Lower extremity akinesia1VPS35 CL E G H55737411602ORPHA115413487601501
HP:0002304HP:0033412Upper extremity akinesia1VPS35 CL E G H55737411602ORPHA116713487601501
 
HPO disease - gene - phenotype less frequent non-typical associations:
HP:0002304HP:0002304Akinesia0FGF14 CL E G H225998764ORPHA01873671601515
HP:0002304HP:0002304Akinesia0FGF14 CL E G H225998764ORPHA01903671601515
HP:0002304HP:0033411Lower extremity akinesia1FGF14 CL E G H225998764ORPHA01873671601515
HP:0002304HP:0033412Upper extremity akinesia1FGF14 CL E G H225998764ORPHA01903671601515
HP:0002304HP:0033412Upper extremity akinesia1FGF14 CL E G H225998764ORPHA01873671601515
HP:0002304HP:0033411Lower extremity akinesia1FGF14 CL E G H225998764ORPHA01903671601515


Genes (26) :ATP13A2 CHRNA1 CHRND CHRNG CNTN1 DNAJC13 DNAJC6 DOK7 EIF4G1 ERBB3 FGF14 FLVCR2 GBA GIGYF2 LRRK2 MAPT MUSK MYOD1 PANK2 PODXL RAPSN SNCA SYNJ1 TMEM240 VPS13C VPS35

Diseases (15) :606693 253290 612540 411602 391411 994 607598 98764 225790 608013 601104 234200 98773 607454 616840
 

Human Phenotype Ontology(HPO) is developed by the Human Phenotype Ontology Consortium. The version used here is August 2021 release.