Human Phenotype Ontology 
Grandparent Node:
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Abnormal oral mucosa morphology (HP:0011830)help
Parent Node:
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Abnormal bleeding (HP:0001892)help
Parent Node:
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Abnormality of the gingiva (HP:0000168)help
..Starting node
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Gingival bleeding (HP:0000225)help
Term ID: 225
Name: Gingival bleeding
Synonym: Bleeding gums; Gingival haemorrhage; Gingival hemorrhage; Gingivorrhagia
Definition: Hemorrhage affecting the gingiva.
Comments:
Reference: HP:0000225
Genes and Diseases:
 
       Child Nodes:

 Sister Nodes: 
..expandFusion of gums (HP:0012292) help
..expandGingival calcification (HP:0025141) help
..expandGingival cleft (HP:0030690) help
..expandGingival fibromatosis (HP:0000169) help
..expandGingival hyperkeratosis (HP:0000222) help
..expandGingival overgrowth (HP:0000212) help
..expandGingival recession (HP:0030816) help
..expandGingivitis (HP:0000230) help
..expandPeriodontitis (HP:0000704) help
InputHPO IDHPO termDistanceGeneGene id entrezHGNC IDDiseaseIdDiseaseNameFrequencyOnsetHGMD variantsClinVar variants
 
HPO disease - gene - phenotype typical associations:
 
HPO disease - gene - phenotype less frequent non-typical associations:
HP:0000225HP:0000225Gingival bleeding0ADAMTS2 CL E G H9509218OMIM:225410Ehlers-Danlos syndrome, type VII, autosomal recessive.165
HP:0000225HP:0000225Gingival bleeding0BCOR CL E G H5488020893ORPHA:520Acute promyelocytic leukemiaHP:0040282 - Frequent101
HP:0000225HP:0000225Gingival bleeding0BLOC1S3 CL E G H38855220914OMIM:614077Hermansky-Pudlak syndrome 8.42
HP:0000225HP:0000225Gingival bleeding0BLOC1S5 CL E G H6391518561OMIM:619172HERMANSKY-PUDLAK SYNDROME 11; HPS11
HP:0000225HP:0000225Gingival bleeding0C1R CL E G H7151246OMIM:130080Ehlers-Danlos syndrome, periodontal type, 1.15
HP:0000225HP:0000225Gingival bleeding0C1S CL E G H7161247OMIM:617174Ehlers-Danlos syndrome, periodontal type, 2HP:0040283 - Occasional7
HP:0000225HP:0000225Gingival bleeding0CAT CL E G H8471516ORPHA:926AcatalasemiaHP:0040283 - Occasional5
HP:0000225HP:0000225Gingival bleeding0ELMO2 CL E G H6391617233OMIM:606893Vascular malformation, primary intraosseous.3
HP:0000225HP:0000225Gingival bleeding0F10 CL E G H21593528ORPHA:328Congenital factor X deficiencyHP:0040282 - Frequent33
HP:0000225HP:0000225Gingival bleeding0F10 CL E G H21593528OMIM:227600Factor X deficiency.33
HP:0000225HP:0000225Gingival bleeding0F13A1 CL E G H21623531ORPHA:331Congenital factor XIII deficiencyHP:0040283 - Occasional60
HP:0000225HP:0000225Gingival bleeding0F13A1 CL E G H21623531OMIM:613225Factor XIII, A subunit, deficiency of60
HP:0000225HP:0000225Gingival bleeding0F13B CL E G H21653534ORPHA:331Congenital factor XIII deficiencyHP:0040283 - Occasional32
HP:0000225HP:0000225Gingival bleeding0F2 CL E G H21473535OMIM:613679Congenital prothrombin deficiency.44
HP:0000225HP:0000225Gingival bleeding0F5 CL E G H21533542ORPHA:326Congenital factor V deficiencyHP:0040283 - Occasional159
HP:0000225HP:0000225Gingival bleeding0F7 CL E G H21553544ORPHA:327Congenital factor VII deficiencyHP:0040282 - Frequent70
HP:0000225HP:0000225Gingival bleeding0F8 CL E G H21573546ORPHA:169805Moderate hemophilia AHP:0040282 - Frequent303
HP:0000225HP:0000225Gingival bleeding0FCGR2C CL E G H910315626ORPHA:3002Immune thrombocytopeniaHP:0040283 - Occasional
HP:0000225HP:0000225Gingival bleeding0FGA CL E G H22433661OMIM:202400Afibrinogenemia, congenitalhypofibrinogenemia, congenital, included47
HP:0000225HP:0000225Gingival bleeding0FGA CL E G H22433661ORPHA:98880Familial afibrinogenemiaHP:0040281 - Very frequent47
HP:0000225HP:0000225Gingival bleeding0FGA CL E G H22433661ORPHA:98881Familial dysfibrinogenemiaHP:0040281 - Very frequent47
HP:0000225HP:0000225Gingival bleeding0FGA CL E G H22433661ORPHA:101041Familial hypofibrinogenemiaHP:0040281 - Very frequent47
HP:0000225HP:0000225Gingival bleeding0FGB CL E G H22443662OMIM:202400Afibrinogenemia, congenitalhypofibrinogenemia, congenital, included62
HP:0000225HP:0000225Gingival bleeding0FGB CL E G H22443662ORPHA:98880Familial afibrinogenemiaHP:0040281 - Very frequent62
HP:0000225HP:0000225Gingival bleeding0FGB CL E G H22443662ORPHA:98881Familial dysfibrinogenemiaHP:0040281 - Very frequent62
HP:0000225HP:0000225Gingival bleeding0FGB CL E G H22443662ORPHA:101041Familial hypofibrinogenemiaHP:0040281 - Very frequent62
HP:0000225HP:0000225Gingival bleeding0FGG CL E G H22663694OMIM:202400Afibrinogenemia, congenitalhypofibrinogenemia, congenital, included34
HP:0000225HP:0000225Gingival bleeding0FGG CL E G H22663694ORPHA:98880Familial afibrinogenemiaHP:0040281 - Very frequent34
HP:0000225HP:0000225Gingival bleeding0FGG CL E G H22663694ORPHA:98881Familial dysfibrinogenemiaHP:0040281 - Very frequent34
HP:0000225HP:0000225Gingival bleeding0FGG CL E G H22663694ORPHA:101041Familial hypofibrinogenemiaHP:0040281 - Very frequent34
HP:0000225HP:0000225Gingival bleeding0FIP1L1 CL E G H8160819124ORPHA:520Acute promyelocytic leukemiaHP:0040282 - Frequent4
HP:0000225HP:0000225Gingival bleeding0GBA1 CL E G H26294177ORPHA:77259Gaucher disease type 1HP:0040282 - Frequent
HP:0000225HP:0000225Gingival bleeding0GP1BA CL E G H28114439ORPHA:274Bernard-Soulier syndromeHP:0040283 - Occasional23
HP:0000225HP:0000225Gingival bleeding0GP1BA CL E G H28114439OMIM:153670Bernard-Soulier syndrome, type A2, autosomal dominant.23
HP:0000225HP:0000225Gingival bleeding0GP1BA CL E G H28114439OMIM:231200BERNARD-SOULIER SYNDROME; BSS23
HP:0000225HP:0000225Gingival bleeding0GP1BB CL E G H28124440ORPHA:274Bernard-Soulier syndromeHP:0040283 - Occasional8
HP:0000225HP:0000225Gingival bleeding0GP1BB CL E G H28124440OMIM:231200BERNARD-SOULIER SYNDROME; BSS8
HP:0000225HP:0000225Gingival bleeding0GP9 CL E G H28154444ORPHA:274Bernard-Soulier syndromeHP:0040283 - Occasional21
HP:0000225HP:0000225Gingival bleeding0GP9 CL E G H28154444OMIM:231200BERNARD-SOULIER SYNDROME; BSS21
HP:0000225HP:0000225Gingival bleeding0HPS1 CL E G H32575163OMIM:203300Hermansky-Pudlak syndrome 1.121
HP:0000225HP:0000225Gingival bleeding0HPS3 CL E G H8434315597OMIM:614072Hermansky-Pudlak syndrome 367
HP:0000225HP:0000225Gingival bleeding0IFNG CL E G H34585438ORPHA:88Idiopathic aplastic anemiaHP:0040283 - Occasional23
HP:0000225HP:0000225Gingival bleeding0IL18BP CL E G H100685987OMIM:618549HEPATITIS, FULMINANT VIRAL, SUSCEPTIBILITY TO; FVH
HP:0000225HP:0000225Gingival bleeding0IRF2BP2 CL E G H35994821729ORPHA:520Acute promyelocytic leukemiaHP:0040282 - Frequent4
HP:0000225HP:0000225Gingival bleeding0ITGA2B CL E G H36746138OMIM:273800Glanzmann thrombasthenia.69
HP:0000225HP:0000225Gingival bleeding0ITGA2B CL E G H36746138ORPHA:849Glanzmann thrombastheniaHP:0040282 - Frequent69
HP:0000225HP:0000225Gingival bleeding0ITGB3 CL E G H36906156ORPHA:849Glanzmann thrombastheniaHP:0040282 - Frequent80
HP:0000225HP:0000225Gingival bleeding0JAK2 CL E G H37176192ORPHA:729Polycythemia veraHP:0040281 - Very frequent57
HP:0000225HP:0000225Gingival bleeding0KIF23 CL E G H94936392ORPHA:98870Congenital dyserythropoietic anemia type IIIHP:0040283 - Occasional1
HP:0000225HP:0000225Gingival bleeding0LMAN1 CL E G H39986631ORPHA:35909Combined deficiency of factor V and factor VIIIHP:0040282 - Frequent56
HP:0000225HP:0000225Gingival bleeding0LYST CL E G H11301968ORPHA:352723Attenuated Chédiak-Higashi syndromeHP:0040281 - Very frequent239
HP:0000225HP:0000225Gingival bleeding0LYST CL E G H11301968ORPHA:167Chédiak-Higashi syndromeHP:0040283 - Occasional239
HP:0000225HP:0000225Gingival bleeding0MCFD2 CL E G H9041118451ORPHA:35909Combined deficiency of factor V and factor VIIIHP:0040282 - Frequent77
HP:0000225HP:0000225Gingival bleeding0MPL CL E G H43527217ORPHA:729Polycythemia veraHP:0040281 - Very frequent97
HP:0000225HP:0000225Gingival bleeding0MYD88 CL E G H46157562ORPHA:33226Waldenström macroglobulinemiaHP:0040282 - Frequent9
HP:0000225HP:0000225Gingival bleeding0NABP1 CL E G H6485926232ORPHA:520Acute promyelocytic leukemiaHP:0040282 - Frequent
HP:0000225HP:0000225Gingival bleeding0NPM1 CL E G H48697910ORPHA:520Acute promyelocytic leukemiaHP:0040282 - Frequent12
HP:0000225HP:0000225Gingival bleeding0NUMA1 CL E G H49268059ORPHA:520Acute promyelocytic leukemiaHP:0040282 - Frequent
HP:0000225HP:0000225Gingival bleeding0PML CL E G H53719113ORPHA:520Acute promyelocytic leukemiaHP:0040282 - Frequent3
HP:0000225HP:0000225Gingival bleeding0PRF1 CL E G H55519360ORPHA:88Idiopathic aplastic anemiaHP:0040283 - Occasional58
HP:0000225HP:0000225Gingival bleeding0PRKAR1A CL E G H55739388ORPHA:520Acute promyelocytic leukemiaHP:0040282 - Frequent134
HP:0000225HP:0000225Gingival bleeding0RACGAP1 CL E G H291279804ORPHA:98870Congenital dyserythropoietic anemia type IIIHP:0040283 - Occasional
HP:0000225HP:0000225Gingival bleeding0RARA CL E G H59149864ORPHA:520Acute promyelocytic leukemiaHP:0040282 - Frequent2
HP:0000225HP:0000225Gingival bleeding0SBDS CL E G H5111919440ORPHA:88Idiopathic aplastic anemiaHP:0040283 - Occasional26
HP:0000225HP:0000225Gingival bleeding0SCARB2 CL E G H9501665ORPHA:77259Gaucher disease type 1HP:0040282 - Frequent77
HP:0000225HP:0000225Gingival bleeding0SERPINF2 CL E G H53459075ORPHA:79Congenital alpha2-antiplasmin deficiencyHP:0040283 - Occasional8
HP:0000225HP:0000225Gingival bleeding0STAT3 CL E G H677411364ORPHA:520Acute promyelocytic leukemiaHP:0040282 - Frequent110
HP:0000225HP:0000225Gingival bleeding0STAT5B CL E G H677711367ORPHA:520Acute promyelocytic leukemiaHP:0040282 - Frequent12
HP:0000225HP:0000225Gingival bleeding0TBL1XR1 CL E G H7971829529ORPHA:520Acute promyelocytic leukemiaHP:0040282 - Frequent22
HP:0000225HP:0000225Gingival bleeding0TERC CL E G H701211727ORPHA:88Idiopathic aplastic anemiaHP:0040283 - Occasional48
HP:0000225HP:0000225Gingival bleeding0TERT CL E G H701511730ORPHA:88Idiopathic aplastic anemiaHP:0040283 - Occasional238
HP:0000225HP:0000225Gingival bleeding0TET2 CL E G H5479025941ORPHA:729Polycythemia veraHP:0040281 - Very frequent3
HP:0000225HP:0000225Gingival bleeding0WAS CL E G H745412731OMIM:301000Wiskott-Aldrich syndrome.65
HP:0000225HP:0000225Gingival bleeding0WAS CL E G H745412731ORPHA:906Wiskott-Aldrich syndromeHP:0040283 - Occasional65
HP:0000225HP:0000225Gingival bleeding0WIPF1 CL E G H745612736ORPHA:906Wiskott-Aldrich syndromeHP:0040283 - Occasional6
HP:0000225HP:0000225Gingival bleeding0ZBTB16 CL E G H770412930ORPHA:520Acute promyelocytic leukemiaHP:0040282 - Frequent1


Genes (58) :ADAMTS2 BCOR BLOC1S3 BLOC1S5 C1R C1S CAT ELMO2 F10 F13A1 F13B F2 F5 F7 F8 FCGR2C FGA FGB FGG FIP1L1 GBA1 GP1BA GP1BB GP9 HPS1 HPS3 IFNG IL18BP IRF2BP2 ITGA2B ITGB3 JAK2 KIF23 LMAN1 LYST MCFD2 MPL MYD88 NABP1 NPM1 NUMA1 PML PRF1 PRKAR1A RACGAP1 RARA SBDS SCARB2 SERPINF2 STAT3 STAT5B TBL1XR1 TERC TERT TET2 WAS WIPF1 ZBTB16

Diseases (40) :OMIM:225410 ORPHA:520 OMIM:614077 OMIM:619172 OMIM:130080 OMIM:617174 ORPHA:926 OMIM:606893 ORPHA:328 OMIM:227600 ORPHA:331 OMIM:613225 OMIM:613679 ORPHA:326 ORPHA:327 ORPHA:169805 ORPHA:3002 OMIM:202400 ORPHA:98880 ORPHA:98881 ORPHA:101041 ORPHA:77259 ORPHA:274 OMIM:153670 OMIM:231200 OMIM:203300 OMIM:614072 ORPHA:88 OMIM:618549 OMIM:273800 ORPHA:849 ORPHA:729 ORPHA:98870 ORPHA:35909 ORPHA:352723 ORPHA:167 ORPHA:33226 ORPHA:79 OMIM:301000 ORPHA:906
 

Human Phenotype Ontology(HPO) is developed by the Human Phenotype Ontology Consortium. The version used here is December 15 2022 release.