Human Phenotype Ontology 
Grandparent Node:
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Abnormal hair morphology (HP:0001595)help
Parent Node:
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Abnormality of hair texture (HP:0010719)help
..Starting node
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Fine hair (HP:0002213)help
Term ID: 2213
Name: Fine hair
Synonym: Fine hair; Fine hair shaft; Fine hair texture; Thin hair; Thin hair shaft; Thin hair texture; Thinned hair
Definition: Hair that is fine or thin to the touch.
Comments:
Reference: HP:0002213
Genes and Diseases:
 
       Child Nodes:

 Sister Nodes: 
..expandBrittle hair (HP:0002299) help
..expandCoarse hair (HP:0002208) help
..expandCurly hair (HP:0002212) help
..expandDry hair (HP:0011359) help
..expandUncombable hair (HP:0030056) help
..expandWoolly hair (HP:0002224) help
InputHPO IDHPO termDistanceGeneGene id entrezHGNC IDDiseaseIdDiseaseNameFrequencyOnsetHGMD variantsClinVar variants
 
HPO disease - gene - phenotype typical associations:
 
HPO disease - gene - phenotype less frequent non-typical associations:
HP:0002213HP:0002213Fine hair0ABCD1 CL E G H21561ORPHA:139399AdrenomyeloneuropathyHP:0040282 - Frequent135
HP:0002213HP:0002213Fine hair0ALMS1 CL E G H7840428ORPHA:64Alström syndromeHP:0040283 - Occasional404
HP:0002213HP:0002213Fine hair0ALX4 CL E G H60529450OMIM:613451Frontonasal dysplasia 2132
HP:0002213HP:0002213Fine hair0ALX4 CL E G H60529450ORPHA:228390Frontonasal dysplasia-alopecia-genital anomalies syndromeHP:0040282 - Frequent132
HP:0002213HP:0002213Fine hair0BRAF CL E G H6731097ORPHA:1340Cardiofaciocutaneous syndromeHP:0040281 - Very frequent276
HP:0002213HP:0002213Fine hair0BRF1 CL E G H297211551ORPHA:444072Cerebellar-facial-dental syndromeHP:0040281 - Very frequent7
HP:0002213HP:0002213Fine hair0BRF1 CL E G H297211551OMIM:616202Cerebellofaciodental syndrome.7
HP:0002213HP:0002213Fine hair0CARS1 CL E G H8331493OMIM:618891MICROCEPHALY, DEVELOPMENTAL DELAY, AND BRITTLE HAIR SYNDROME; MDBH
HP:0002213HP:0002213Fine hair0CBL CL E G H8671541OMIM:613563Noonan syndrome-like disorder with or without juvenile myelomonocytic leukemia.317
HP:0002213HP:0002213Fine hair0CDH3 CL E G H10011762ORPHA:1573Hypotrichosis with juvenile macular degenerationHP:0040282 - Frequent87
HP:0002213HP:0002213Fine hair0CDSN CL E G H10411802ORPHA:90368Hypotrichosis simplex of the scalp7
HP:0002213HP:0002213Fine hair0COL3A1 CL E G H12812201ORPHA:2500AcrogeriaHP:0040281 - Very frequent749
HP:0002213HP:0002213Fine hair0CSTB CL E G H14762482ORPHA:248Autosomal recessive hypohidrotic ectodermal dysplasiaHP:0040281 - Very frequent51
HP:0002213HP:0002213Fine hair0DCAF17 CL E G H8006725784OMIM:241080Woodhouse-Sakati syndrome.87
HP:0002213HP:0002213Fine hair0DSG4 CL E G H14740921307ORPHA:573MonilethrixHP:0040281 - Very frequent63
HP:0002213HP:0002213Fine hair0EDA CL E G H18963157OMIM:305100Ectodermal dysplasia 1, hypohidrotic, X-linked115
HP:0002213HP:0002213Fine hair0EDAR CL E G H109132895ORPHA:248Autosomal recessive hypohidrotic ectodermal dysplasiaHP:0040281 - Very frequent86
HP:0002213HP:0002213Fine hair0EDAR CL E G H109132895OMIM:129490Ectodermal dysplasia 10A, hypohidrotic/hair/nail type, autosomal dominant.86
HP:0002213HP:0002213Fine hair0EDARADD CL E G H12817814341ORPHA:248Autosomal recessive hypohidrotic ectodermal dysplasiaHP:0040281 - Very frequent56
HP:0002213HP:0002213Fine hair0EDARADD CL E G H12817814341OMIM:129490Ectodermal dysplasia 10A, hypohidrotic/hair/nail type, autosomal dominant.56
HP:0002213HP:0002213Fine hair0EED CL E G H87263188ORPHA:3447Weaver syndromeHP:0040282 - Frequent4
HP:0002213HP:0002213Fine hair0ERCC2 CL E G H20683434OMIM:601675Trichothiodystrophy 1, photosensitive.106
HP:0002213HP:0002213Fine hair0EZH2 CL E G H21463527ORPHA:3447Weaver syndromeHP:0040282 - Frequent81
HP:0002213HP:0002213Fine hair0EZH2 CL E G H21463527OMIM:277590Weaver syndrome.81
HP:0002213HP:0002213Fine hair0GATAD2B CL E G H5745930778ORPHA:363686Severe intellectual disability-poor language-strabismus-grimacing face-long fingers syndromeHP:0040282 - Frequent33
HP:0002213HP:0002213Fine hair0GJA1 CL E G H26974274ORPHA:2710Oculodentodigital dysplasiaHP:0040283 - Occasional68
HP:0002213HP:0002213Fine hair0GJA1 CL E G H26974274OMIM:164200Oculodentodigital dysplasia.68
HP:0002213HP:0002213Fine hair0GJA1 CL E G H26974274OMIM:257850Oculodentodigital dysplasia, autosomal recessive.68
HP:0002213HP:0002213Fine hair0GJB6 CL E G H108044288OMIM:129500Clouston syndrome.56
HP:0002213HP:0002213Fine hair0GJB6 CL E G H108044288ORPHA:189Hidrotic ectodermal dysplasiaHP:0040282 - Frequent56
HP:0002213HP:0002213Fine hair0GNPTAB CL E G H7915829670ORPHA:576Mucolipidosis type IIHP:0040283 - Occasional240
HP:0002213HP:0002213Fine hair0GTPBP2 CL E G H546764670OMIM:617988Jaberi-Elahi syndrome
HP:0002213HP:0002213Fine hair0HPD CL E G H32425147ORPHA:2118HawkinsinuriaHP:0040281 - Very frequent23
HP:0002213HP:0002213Fine hair0HRAS CL E G H32655173ORPHA:79414Woolly hair nevus113
HP:0002213HP:0002213Fine hair0IFT122 CL E G H5576413556OMIM:218330Cranioectodermal dysplasia.93
HP:0002213HP:0002213Fine hair0IFT43 CL E G H11275229669OMIM:614099Cranioectodermal dysplasia 3.11
HP:0002213HP:0002213Fine hair0IKBKG CL E G H85175961OMIM:308300Incontinentia pigmenti.52
HP:0002213HP:0002213Fine hair0ITGA3 CL E G H36756139OMIM:614748Interstitial lung disease, nephrotic syndrome, and epidermolysis bullosa, congenital.6
HP:0002213HP:0002213Fine hair0KAT6B CL E G H2352217582ORPHA:85201Genitopatellar syndromeHP:0040282 - Frequent141
HP:0002213HP:0002213Fine hair0KCTD1 CL E G H28425218249OMIM:181270Scalp-Ear-Nipple syndromeHP:0040283 - Occasional11
HP:0002213HP:0002213Fine hair0KRAS CL E G H38456407ORPHA:1340Cardiofaciocutaneous syndromeHP:0040281 - Very frequent196
HP:0002213HP:0002213Fine hair0KRAS CL E G H38456407OMIM:615278Cardiofaciocutaneous syndrome 2.196
HP:0002213HP:0002213Fine hair0KRT25 CL E G H14718330839ORPHA:170Woolly hairHP:0040281 - Very frequent2
HP:0002213HP:0002213Fine hair0KRT25 CL E G H14718330839OMIM:616760Woolly hair, autosomal recessive 3.2
HP:0002213HP:0002213Fine hair0KRT71 CL E G H11280228927ORPHA:170Woolly hairHP:0040281 - Very frequent1
HP:0002213HP:0002213Fine hair0KRT74 CL E G H12139128929ORPHA:90368Hypotrichosis simplex of the scalp5
HP:0002213HP:0002213Fine hair0KRT74 CL E G H12139128929ORPHA:170Woolly hairHP:0040281 - Very frequent5
HP:0002213HP:0002213Fine hair0KRT81 CL E G H38876458ORPHA:573MonilethrixHP:0040281 - Very frequent3
HP:0002213HP:0002213Fine hair0KRT83 CL E G H38896460ORPHA:573MonilethrixHP:0040281 - Very frequent65
HP:0002213HP:0002213Fine hair0KRT86 CL E G H38926463ORPHA:573MonilethrixHP:0040281 - Very frequent10
HP:0002213HP:0002213Fine hair0LIG4 CL E G H39816601ORPHA:235Dubowitz syndromeHP:0040282 - Frequent88
HP:0002213HP:0002213Fine hair0LIPH CL E G H20087918483ORPHA:170Woolly hairHP:0040281 - Very frequent12
HP:0002213HP:0002213Fine hair0LPAR6 CL E G H1016115520ORPHA:170Woolly hairHP:0040281 - Very frequent8
HP:0002213HP:0002213Fine hair0MAP2K1 CL E G H56046840ORPHA:1340Cardiofaciocutaneous syndromeHP:0040281 - Very frequent134
HP:0002213HP:0002213Fine hair0MAP2K2 CL E G H56056842ORPHA:1340Cardiofaciocutaneous syndromeHP:0040281 - Very frequent178
HP:0002213HP:0002213Fine hair0MED12 CL E G H996811957OMIM:305450Opitz-Kaveggia syndrome.228
HP:0002213HP:0002213Fine hair0MSX1 CL E G H44877391ORPHA:2228Hypodontia-dysplasia of nails syndromeHP:0040282 - Frequent12
HP:0002213HP:0002213Fine hair0MSX1 CL E G H44877391OMIM:189500Witkop syndrome.12
HP:0002213HP:0002213Fine hair0NAA10 CL E G H826018704ORPHA:276432Ogden syndromeHP:0040282 - Frequent23
HP:0002213HP:0002213Fine hair0NAA10 CL E G H826018704OMIM:300855Ogden syndromeHP:0040283 - Occasional23
HP:0002213HP:0002213Fine hair0NBAS CL E G H5159415625OMIM:614800Short stature, optic nerve atrophy, and pelger-huet anomaly.25
HP:0002213HP:0002213Fine hair0NSD1 CL E G H6432414234ORPHA:3447Weaver syndromeHP:0040282 - Frequent544
HP:0002213HP:0002213Fine hair0NSUN2 CL E G H5488825994ORPHA:235Dubowitz syndromeHP:0040282 - Frequent84
HP:0002213HP:0002213Fine hair0OCRL CL E G H49528108ORPHA:534Oculocerebrorenal syndrome of LoweHP:0040282 - Frequent88
HP:0002213HP:0002213Fine hair0PCNT CL E G H511616068ORPHA:2637Microcephalic osteodysplastic primordial dwarfism type IIHP:0040281 - Very frequent531
HP:0002213HP:0002213Fine hair0PIGL CL E G H94878966ORPHA:3474CHIME syndromeHP:0040283 - Occasional36
HP:0002213HP:0002213Fine hair0PIGL CL E G H94878966OMIM:280000Zunich neuroectodermal syndrome.36
HP:0002213HP:0002213Fine hair0PPP1R15B CL E G H8491914951OMIM:616817Microcephaly, short stature, and impaired glucose metabolism 2.2
HP:0002213HP:0002213Fine hair0PPP1R15B CL E G H8491914951ORPHA:391408Primary microcephaly-mild intellectual disability-young-onset diabetes syndromeHP:0040283 - Occasional2
HP:0002213HP:0002213Fine hair0PYCR1 CL E G H58319721OMIM:614438Cutis laxa, autosomal recessive, type IIIB.53
HP:0002213HP:0002213Fine hair0RAF1 CL E G H58949829OMIM:611553Noonan syndrome 5212
HP:0002213HP:0002213Fine hair0RLIM CL E G H5113213429OMIM:300978Tonne-Kalscheuer syndrome.7
HP:0002213HP:0002213Fine hair0RMRP CL E G H602310031OMIM:250250Cartilage-Hair hypoplasia.37
HP:0002213HP:0002213Fine hair0RNU4ATAC CL E G H10015168334016OMIM:210710Microcephalic osteodysplastic primordial dwarfism, type I15
HP:0002213HP:0002213Fine hair0SATB2 CL E G H2331421637ORPHA:2510192q32q33 microdeletion syndromeHP:0040282 - Frequent34
HP:0002213HP:0002213Fine hair0SATB2 CL E G H2331421637ORPHA:251028SATB2-associated syndrome due to a chromosomal rearrangementHP:0040283 - Occasional34
HP:0002213HP:0002213Fine hair0SIN3A CL E G H2594219353ORPHA:500166SIN3A-related intellectual disability syndrome due to a point mutationHP:0040283 - Occasional9
HP:0002213HP:0002213Fine hair0SIN3A CL E G H2594219353OMIM:613406Witteveen-Kolk syndrome.9
HP:0002213HP:0002213Fine hair0SIN3B CL E G H2330919354ORPHA:500166SIN3A-related intellectual disability syndrome due to a point mutationHP:0040283 - Occasional
HP:0002213HP:0002213Fine hair0SKIC3 CL E G H965223639OMIM:222470Trichohepatoenteric syndrome 1.
HP:0002213HP:0002213Fine hair0SLC7A7 CL E G H905611065OMIM:222700Lysinuric protein intolerance.104
HP:0002213HP:0002213Fine hair0SMAD4 CL E G H40896770OMIM:139210Myhre syndrome.HP:0003577 - Congenital onset504
HP:0002213HP:0002213Fine hair0SMARCAL1 CL E G H5048511102OMIM:242900Immunoosseous dysplasia, Schimke type.74
HP:0002213HP:0002213Fine hair0SPINK5 CL E G H1100515464ORPHA:634Netherton syndromeHP:0040281 - Very frequent100
HP:0002213HP:0002213Fine hair0SUOX CL E G H682111460OMIM:272300SULFOCYSTEINURIA.40
HP:0002213HP:0002213Fine hair0SUZ12 CL E G H2351217101ORPHA:3447Weaver syndromeHP:0040282 - Frequent1
HP:0002213HP:0002213Fine hair0TINF2 CL E G H2627711824OMIM:613990Dyskeratosis congenita, autosomal dominant 3.60
HP:0002213HP:0002213Fine hair0TINF2 CL E G H2627711824OMIM:268130Revesz syndrome.60
HP:0002213HP:0002213Fine hair0TP63 CL E G H862615979ORPHA:978ADULT syndromeHP:0040281 - Very frequent140
HP:0002213HP:0002213Fine hair0TP63 CL E G H862615979ORPHA:1896EEC syndromeHP:0040283 - Occasional140
HP:0002213HP:0002213Fine hair0TP63 CL E G H862615979OMIM:129400Rapp-Hodgkin syndrome.140
HP:0002213HP:0002213Fine hair0TRIM8 CL E G H8160315579OMIM:619428FOCAL SEGMENTAL GLOMERULOSCLEROSIS AND NEURODEVELOPMENTAL SYNDROME; FSGSNEDS1
HP:0002213HP:0002213Fine hair0TRMT10A CL E G H9358728403ORPHA:391408Primary microcephaly-mild intellectual disability-young-onset diabetes syndromeHP:0040283 - Occasional7
HP:0002213HP:0002213Fine hair0TRPS1 CL E G H722712340OMIM:190350Trichorhinophalangeal syndrome, type I.171
HP:0002213HP:0002213Fine hair0TWIST2 CL E G H11758120670ORPHA:920Ablepharon macrostomia syndromeHP:0040281 - Very frequent7
HP:0002213HP:0002213Fine hair0WDR35 CL E G H5753929250OMIM:614091Short-Rib thoracic dysplasia 7 with or without polydactyly.136
HP:0002213HP:0002213Fine hair0WNT10A CL E G H8032613829ORPHA:248Autosomal recessive hypohidrotic ectodermal dysplasiaHP:0040281 - Very frequent71
HP:0002213HP:0002213Fine hair0WNT10A CL E G H8032613829OMIM:257980Odontoonychodermal dysplasia.71


Genes (77) :ABCD1 ALMS1 ALX4 BRAF BRF1 CARS1 CBL CDH3 CDSN COL3A1 CSTB DCAF17 DSG4 EDA EDAR EDARADD EED ERCC2 EZH2 GATAD2B GJA1 GJB6 GNPTAB GTPBP2 HPD HRAS IFT122 IFT43 IKBKG ITGA3 KAT6B KCTD1 KRAS KRT25 KRT71 KRT74 KRT81 KRT83 KRT86 LIG4 LIPH LPAR6 MAP2K1 MAP2K2 MED12 MSX1 NAA10 NBAS NSD1 NSUN2 OCRL PCNT PIGL PPP1R15B PYCR1 RAF1 RLIM RMRP RNU4ATAC SATB2 SIN3A SIN3B SKIC3 SLC7A7 SMAD4 SMARCAL1 SPINK5 SUOX SUZ12 TINF2 TP63 TRIM8 TRMT10A TRPS1 TWIST2 WDR35 WNT10A

Diseases (77) :ORPHA:139399 ORPHA:64 OMIM:613451 ORPHA:228390 ORPHA:1340 ORPHA:444072 OMIM:616202 OMIM:618891 OMIM:613563 ORPHA:1573 ORPHA:90368 ORPHA:2500 ORPHA:248 OMIM:241080 ORPHA:573 OMIM:305100 OMIM:129490 ORPHA:3447 OMIM:601675 OMIM:277590 ORPHA:363686 ORPHA:2710 OMIM:164200 OMIM:257850 OMIM:129500 ORPHA:189 ORPHA:576 OMIM:617988 ORPHA:2118 ORPHA:79414 OMIM:218330 OMIM:614099 OMIM:308300 OMIM:614748 ORPHA:85201 OMIM:181270 OMIM:615278 ORPHA:170 OMIM:616760 ORPHA:235 OMIM:305450 ORPHA:2228 OMIM:189500 ORPHA:276432 OMIM:300855 OMIM:614800 ORPHA:534 ORPHA:2637 ORPHA:3474 OMIM:280000 OMIM:616817 ORPHA:391408 OMIM:614438 OMIM:611553 OMIM:300978 OMIM:250250 OMIM:210710 ORPHA:251019 ORPHA:251028 ORPHA:500166 OMIM:613406 OMIM:222470 OMIM:222700 OMIM:139210 OMIM:242900 ORPHA:634 OMIM:272300 OMIM:613990 OMIM:268130 ORPHA:978 ORPHA:1896 OMIM:129400 OMIM:619428 OMIM:190350 ORPHA:920 OMIM:614091 OMIM:257980
 

Human Phenotype Ontology(HPO) is developed by the Human Phenotype Ontology Consortium. The version used here is December 15 2022 release.