Human Phenotype Ontology 
Grandparent Node:
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Abnormality of movement (HP:0100022)help
Parent Node:
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Gait disturbance (HP:0001288)help
..Starting node
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Broad-based gait (HP:0002136)help
Term ID: 2136
Name: Broad-based gait
Synonym: Broad based gait; Wide based gait; Wide based walk; Wide-based gait
Definition: An abnormal gait pattern in which persons stand and walk with their feet spaced widely apart. This is often a component of cerebellar ataxia.
Comments:
Reference: HP:0002136
Genes and Diseases:
 
       Child Nodes:

 Sister Nodes: 
..expandCerebellar ataxia associated with quadrupedal gait (HP:0009878) help
..expandCock-walk gait (HP:0031848) help
..expandDifficulty walking (HP:0002355) help
..expandDifficulty walking backward (HP:0031847) help
..expandFalls (HP:0002527) help
..expandFreezing of gait (HP:0031825) help
..expandGait apraxia (HP:0010521) help
..expandGait ataxia (HP:0002066) help
..expandGait imbalance (HP:0002141) help
..expandHobby horse gait (HP:0031856) help
..expandImpaired tandem gait (HP:0031629) help
..expandInability to walk (HP:0002540) help
..expandScissor gait (HP:0012407) help
..expandShuffling gait (HP:0002362) help
..expandSteppage gait (HP:0003376) help
..expandTip-toe gait (HP:0030051) help
..expandToe walking (HP:0040083) help
..expandUnsteady gait (HP:0002317) help
..expandWaddling gait (HP:0002515) help
InputHPO IDHPO termDistanceGeneGene id entrezDiseaseIdDiseaseNameDiseaseMIMConceptIDSourceTypical associationHGMD variantsClinVar variantsHGNC IDGeneMIM
 
HPO disease - gene - phenotype typical associations:
HP:0002136HP:0002136Broad-based gait0ADGRG1 CL E G H9289606854Polymicrogyria, bilateral frontoparietal606854C1847352OMIM1362774512604110
HP:0002136HP:0002136Broad-based gait0AP5Z1 CL E G H9907613647Spastic paraplegia 48, autosomal recessive613647C3150901OMIM11653622197613653
HP:0002136HP:0002136Broad-based gait0ATCAY CL E G H8530094122ORPHA13172779608179
HP:0002136HP:0002136Broad-based gait0ATCAY CL E G H85300601238Cerebellar ataxia, Cayman type601238C1832585OMIM13172779608179
HP:0002136HP:0002136Broad-based gait0CAD CL E G H790616457Epileptic encephalopathy, early infantile, 50616457C4225320OMIM1121461424114010
HP:0002136HP:0002136Broad-based gait0CCDC88C CL E G H440193423275ORPHA11119219967611204
HP:0002136HP:0002136Broad-based gait0CCDC88C CL E G H440193616053Spinocerebellar ataxia 40616053CN252333OMIM11119219967611204
HP:0002136HP:0002136Broad-based gait0CDK10 CL E G H8558617694AL KAISSI SYNDROME617694C4540156OMIM17691770603464
HP:0002136HP:0002136Broad-based gait0CHD3 CL E G H1107618205SNIJDERS BLOK-CAMPEAU SYNDROME618205OMIM110771918602120
HP:0002136HP:0002136Broad-based gait0COL4A3BP CL E G H10087616351Mental retardation, autosomal dominant 34616351C4225156OMIM182205604677
HP:0002136HP:0002136Broad-based gait0COQ2 CL E G H27235227510ORPHA13310225223609825
HP:0002136HP:0002136Broad-based gait0CUL4B CL E G H845085293ORPHA1402472555300304
HP:0002136HP:0002136Broad-based gait0DDX3X CL E G H1654457260ORPHA1783372745300160
HP:0002136HP:0002136Broad-based gait0DNAJC12 CL E G H56521617384Hyperphenylalaninemia, mild, non-bh4-deficient617384C4479270OMIM194128908606060
HP:0002136HP:0002136Broad-based gait0FLVCR1 CL E G H28982609033Posterior column ataxia with retinitis pigmentosa609033C1836916OMIM11725524682609144
HP:0002136HP:0002136Broad-based gait0GPT2 CL E G H84706477673ANO5-Related DisordersCN239193ORPHA1105818062138210
HP:0002136HP:0002136Broad-based gait0HACE1 CL E G H57531616756Spastic paraplegia and psychomotor retardation with or without seizures616756C4225215OMIM1136321033610876
HP:0002136HP:0002136Broad-based gait0HTT CL E G H3064248111ORPHA181274851613004
HP:0002136HP:0002136Broad-based gait0ITPR1 CL E G H3708117360Spinocerebellar ataxia 29117360C1861732OMIM1955016180147265
HP:0002136HP:0002136Broad-based gait0KMT2A CL E G H4297605130Wiedemann-Steiner syndrome605130C1854630OMIM11273797132159555
HP:0002136HP:0002136Broad-based gait0LMNA CL E G H4000740Aortic arch interruptionORPHA157411526636150330
HP:0002136HP:0002136Broad-based gait0MYOT CL E G H9499182920Spheroid body myopathy182920C1866785OMIM11618812399604103
HP:0002136HP:0002136Broad-based gait0PACS2 CL E G H23241618067EPILEPTIC ENCEPHALOPATHY, EARLY INFANTILE, 66618067CN252658OMIM129223794610423
HP:0002136HP:0002136Broad-based gait0PEX5 CL E G H5830616716Rhizomelic chondrodysplasia punctata type 5616716C4225237OMIM1142809719600414
HP:0002136HP:0002136Broad-based gait0PIEZO2 CL E G H63895617146Arthrogryposis, distal, with impaired proprioception and touch617146C4310692OMIM13232926270613629
HP:0002136HP:0002136Broad-based gait0PIGL CL E G H9487280000Zunich neuroectodermal syndrome280000C1848392OMIM111988966605947
HP:0002136HP:0002136Broad-based gait0PPM1D CL E G H8493617450Intellectual developmental disorder with gastrointestinal difficulties and high pain threshold617450C4479517OMIM163849277605100
HP:0002136HP:0002136Broad-based gait0RLIM CL E G H51132300978Mental retardation, X-linked 61300978C4283894OMIM1516113429300379
HP:0002136HP:0002136Broad-based gait0RNF113A CL E G H7737300953Trichothiodystrophy 5, nonphotosensitive300953C4225420OMIM1117412974300951
HP:0002136HP:0002136Broad-based gait0RNU12 CL E G H267010512260ORPHA1112193800
HP:0002136HP:0002136Broad-based gait0SATB2 CL E G H23314612313Chromosome 2q32-q33 deletion syndrome612313C2676739OMIM110627421637608148
HP:0002136HP:0002136Broad-based gait0SGCB CL E G H6443119ORPHA16426510806600900
HP:0002136HP:0002136Broad-based gait0SGCG CL E G H6445353Kozlowski Warren Fisher syndromeORPHA16930510809608896
HP:0002136HP:0002136Broad-based gait0SHANK3 CL E G H8535860623222q13.3 deletion syndrome606232C1853490OMIM119436614294606230
HP:0002136HP:0002136Broad-based gait0SMS CL E G H6611309583Snyder Robinson syndrome309583C0796160OMIM11520611123300105
HP:0002136HP:0002136Broad-based gait0TBC1D23 CL E G H55773617695PONTOCEREBELLAR HYPOPLASIA, TYPE 11617695C4540164OMIM192525622617687
HP:0002136HP:0002136Broad-based gait0TBP CL E G H6908607136Spinocerebellar ataxia 17607136C1846707OMIM1189111588600075
HP:0002136HP:0002136Broad-based gait0THRA CL E G H7067614450Hypothyroidism, congenital, nongoitrous, 6614450C3280817OMIM1143411796190120
HP:0002136HP:0002136Broad-based gait0TMEM106B CL E G H54664617964LEUKODYSTROPHY, HYPOMYELINATING, 16617964CN244907OMIM135222407613413
HP:0002136HP:0002136Broad-based gait0TOP3A CL E G H7156618098PROGRESSIVE EXTERNAL OPHTHALMOPLEGIA WITH MITOCHONDRIAL DNA DELETIONS, AUTOSOMAL RECESSIVE 5618098CN253818OMIM1713311992601243
HP:0002136HP:0002136Broad-based gait0TPP1 CL E G H1200284324ORPHA11154812073607998
HP:0002136HP:0002136Broad-based gait0TRIM2 CL E G H23321615490Charcot-Marie-Tooth disease, axonal, type 2R615490C3809655OMIM1816915974614141
HP:0002136HP:0002136Broad-based gait0TRPV4 CL E G H59341181405Scapuloperoneal spinal muscular atrophy181405C0751335OMIM18253918083605427
HP:0002136HP:0002136Broad-based gait0UBE3A CL E G H7337105830Angelman syndrome105830C0162635OMIM120275912496601623
HP:0002136HP:0002136Broad-based gait0UROC1 CL E G H131669210128ORPHA136826444613012
HP:0002136HP:0002136Broad-based gait0VLDLR CL E G H7436224050Cerebellar ataxia, mental retardation, and dysequilibrium syndrome 1224050CN074243OMIM12837412698192977
HP:0002136HP:0002136Broad-based gait0WDR26 CL E G H80232617616SKRABAN-DEARDORFF SYNDROME617616C4539927OMIM1346921208617424
HP:0002136HP:0002136Broad-based gait0XRCC4 CL E G H7518616541Short stature, microcephaly, and endocrine dysfunction616541C4225288OMIM1153712831194363
HP:0002136HP:0002136Broad-based gait0YWHAG CL E G H7532617665EPILEPTIC ENCEPHALOPATHY, EARLY INFANTILE, 56617665C4540034OMIM155112852605356
HP:0002136HP:0002136Broad-based gait0ZMPSTE24 CL E G H10269740Aortic arch interruptionORPHA13413612877606480
HP:0002136HP:0002136Broad-based gait0ZSWIM6 CL E G H57688617865NEURODEVELOPMENTAL DISORDER WITH MOVEMENT ABNORMALITIES, ABNORMAL GAIT, AND AUTISTIC FEATURES617865CN800196OMIM126229316615951
 
HPO disease - gene - phenotype less frequent non-typical associations:
HP:0002136HP:0002136Broad-based gait0AP5Z1 CL E G H9907306511ORPHA01653622197613653
HP:0002136HP:0002136Broad-based gait0DDX3X CL E G H1654300958Mental retardation, X-linked 102300958C4085582OMIM0783372745300160
HP:0002136HP:0002136Broad-based gait0GBA2 CL E G H57704320391ORPHA02319418986609471
HP:0002136HP:0002136Broad-based gait0GTF2E2 CL E G H2961616943Trichothiodystrophy 6, nonphotosensitive616943C4310785OMIM02694651189964
HP:0002136HP:0002136Broad-based gait0KCND3 CL E G H375298772ORPHA0291686239605411
HP:0002136HP:0002136Broad-based gait0NRXN1 CL E G H9378614325Pitt-Hopkins-like syndrome 2614325C3280479OMIM034510778008600565
HP:0002136HP:0002136Broad-based gait0PURA CL E G H5813616158Mental retardation, autosomal dominant 31616158C4015357OMIM0482289701600473


Genes (54) :ADGRG1 AP5Z1 ATCAY CAD CCDC88C CDK10 CHD3 COL4A3BP COQ2 CUL4B DDX3X DNAJC12 FLVCR1 GBA2 GPT2 GTF2E2 HACE1 HTT ITPR1 KCND3 KMT2A LMNA MYOT NRXN1 PACS2 PEX5 PIEZO2 PIGL PPM1D PURA RLIM RNF113A RNU12 SATB2 SGCB SGCG SHANK3 SMS TBC1D23 TBP THRA TMEM106B TOP3A TPP1 TRIM2 TRPV4 UBE3A UROC1 VLDLR WDR26 XRCC4 YWHAG ZMPSTE24 ZSWIM6

Diseases (57) :606854 306511 613647 94122 601238 616457 423275 616053 617694 618205 616351 227510 85293 457260 300958 617384 609033 320391 477673 616943 616756 248111 117360 98772 605130 740 182920 614325 618067 616716 617146 280000 617450 616158 300978 300953 512260 612313 119 353 606232 309583 617695 607136 614450 617964 618098 284324 615490 181405 105830 210128 224050 617616 616541 617665 617865
 

Human Phenotype Ontology(HPO) is developed by the Human Phenotype Ontology Consortium. The version used here is June 2019 release.