Human Phenotype Ontology 
Grandparent Node:
expand
Abnormality of central motor function (HP:0011442)help
Parent Node:
expand
Abnormality of extrapyramidal motor function (HP:0002071)help
..Starting node
..expand
Bradykinesia (HP:0002067)help
Term ID: 2067
Name: Bradykinesia
Synonym: Slow movements; Slowness of movements
Definition: Bradykinesia literally means slow movement, and is used clinically to denote a slowness in the execution of movement (in contrast to hypokinesia, which is used to refer to slowness in the initiation of movement).
Comments:
Reference: HP:0002067
Genes and Diseases:
 
       Child Nodes:

 Sister Nodes: 
..expandAthetoid cerebral palsy (HP:0011445) help
..expandExaggerated startle response (HP:0002267) help
..expandExtrapyramidal dyskinesia (HP:0007308) help
..expandExtrapyramidal muscular rigidity (HP:0007076) help
..expandParkinsonism (HP:0001300) help
..expandProgressive extrapyramidal movement disorder (HP:0007153) help
InputHPO IDHPO termDistanceGeneGene id entrezDiseaseIdDiseaseNameDiseaseMIMConceptIDSourceTypical associationHGMD variantsClinVar variantsHGNC IDGeneMIM
 
HPO disease - gene - phenotype typical associations:
HP:0002067HP:0002067Bradykinesia0ACTA1 CL E G H58171439ORPHA1217272129102610
HP:0002067HP:0002067Bradykinesia0ATP13A2 CL E G H23400314632ORPHA14436530213610513
HP:0002067HP:0002067Bradykinesia0ATP1A3 CL E G H47871517ORPHA1122407801182350
HP:0002067HP:0002067Bradykinesia0ATP1A3 CL E G H478128235Dystonia 12128235C1868681OMIM1122407801182350
HP:0002067HP:0002067Bradykinesia0ATP6AP2 CL E G H10159363654ORPHA1622618305300556
HP:0002067HP:0002067Bradykinesia0ATP6AP2 CL E G H10159300423Mental retardation, X-linked, syndromic, Hedera type300423C1845543OMIM1622618305300556
HP:0002067HP:0002067Bradykinesia0ATP6AP2 CL E G H10159300911Parkinsonism with spasticity, X-linked300911C3806722OMIM1622618305300556
HP:0002067HP:0002067Bradykinesia0ATXN1 CL E G H631098755ORPHA176910548601556
HP:0002067HP:0002067Bradykinesia0ATXN2 CL E G H6311183090Spinocerebellar ataxia 2183090C0752121OMIM1444910555601517
HP:0002067HP:0002067Bradykinesia0ATXN3 CL E G H4287109150Azorean disease109150C0024408OMIM13347106607047
HP:0002067HP:0002067Bradykinesia0ATXN8 CL E G H72406698760ORPHA12232925613289
HP:0002067HP:0002067Bradykinesia0ATXN8OS CL E G H631598760ORPHA156910561603680
HP:0002067HP:0002067Bradykinesia0C19orf12 CL E G H83636289560ORPHA13820625443614297
HP:0002067HP:0002067Bradykinesia0CHCHD2 CL E G H51142616710Parkinson disease 22, autosomal dominant616710C4225238OMIM1133521645616244
HP:0002067HP:0002067Bradykinesia0COASY CL E G H80347615643Neurodegeneration with brain iron accumulation 6615643C3810230OMIM137629932609855
HP:0002067HP:0002067Bradykinesia0COQ2 CL E G H2723598933ORPHA13310225223609825
HP:0002067HP:0002067Bradykinesia0CSF1R CL E G H1436221820Hereditary diffuse leukoencephalopathy with spheroids221820C3711381OMIM11002582433164770
HP:0002067HP:0002067Bradykinesia0DCTN1 CL E G H1639168605Perry syndrome168605C1868594OMIM1574212711601143
HP:0002067HP:0002067Bradykinesia0DHDDS CL E G H79947617836DEVELOPMENTAL DELAY AND SEIZURES WITH OR WITHOUT MOVEMENT ABNORMALITIES617836CN769090OMIM1812220603608172
HP:0002067HP:0002067Bradykinesia0DNAJC12 CL E G H56521617384Hyperphenylalaninemia, mild, non-bh4-deficient617384C4479270OMIM194128908606060
HP:0002067HP:0002067Bradykinesia0DNAJC6 CL E G H9829391411ORPHA1148315469608375
HP:0002067HP:0002067Bradykinesia0DNAJC6 CL E G H9829615528Parkinson disease 19a, juvenile-onset615528C3809811OMIM1148315469608375
HP:0002067HP:0002067Bradykinesia0EARS2 CL E G H124454614924Combined oxidative phosphorylation deficiency 12614924C3554079OMIM13017929419612799
HP:0002067HP:0002067Bradykinesia0FBXO7 CL E G H25793171695ORPHA11710913586605648
HP:0002067HP:0002067Bradykinesia0FBXO7 CL E G H25793260300Parkinson disease 15260300C1850100OMIM11710913586605648
HP:0002067HP:0002067Bradykinesia0FMR1 CL E G H2332300623Fragile X tremor/ataxia syndrome300623C1839780OMIM1812813775309550
HP:0002067HP:0002067Bradykinesia0FTL CL E G H2512157846ORPHA164913999134790
HP:0002067HP:0002067Bradykinesia0FTL CL E G H2512606159Neuroferritinopathy606159C1853578OMIM164913999134790
HP:0002067HP:0002067Bradykinesia0HTT CL E G H3064248111ORPHA181274851613004
HP:0002067HP:0002067Bradykinesia0HTT CL E G H3064143100Huntington's chorea143100C0020179OMIM181274851613004
HP:0002067HP:0002067Bradykinesia0HTT CL E G H3064617435Lopes-Maciel-Rodan syndrome617435C4479491OMIM181274851613004
HP:0002067HP:0002067Bradykinesia0JPH3 CL E G H57338606438Huntington disease-like 2606438C1847987OMIM1212014203605268
HP:0002067HP:0002067Bradykinesia0KBTBD13 CL E G H390594171439ORPHA11126037227613727
HP:0002067HP:0002067Bradykinesia0KLHL41 CL E G H10324171439ORPHA199816905607701
HP:0002067HP:0002067Bradykinesia0MAPT CL E G H4137601104Progressive supranuclear ophthalmoplegia601104C0038868OMIM11203796893157140
HP:0002067HP:0002067Bradykinesia0MYPN CL E G H84665171439ORPHA14666423246608517
HP:0002067HP:0002067Bradykinesia0NEB CL E G H4703171439ORPHA132130107720161650
HP:0002067HP:0002067Bradykinesia0NR4A2 CL E G H4929168600Parkinson disease, late-onset168600C3160718OMIM123797981601828
HP:0002067HP:0002067Bradykinesia0PANK2 CL E G H80025234200Pigmentary pallidal degeneration234200C0018523OMIM118219215894606157
HP:0002067HP:0002067Bradykinesia0PARK7 CL E G H11315606324Parkinson disease 7606324C1853445OMIM1369116369602533
HP:0002067HP:0002067Bradykinesia0PDE8B CL E G H8622228169Autosomal dominant striatal neurodegenerationC1836694ORPHA1111348794603390
HP:0002067HP:0002067Bradykinesia0PDE8B CL E G H8622609161Striatal degeneration, autosomal dominant 1609161C4310808OMIM1111348794603390
HP:0002067HP:0002067Bradykinesia0PDGFB CL E G H5155213600Idiopathic basal ganglia calcification 1213600C0393590OMIM123448800190040
HP:0002067HP:0002067Bradykinesia0PDGFRB CL E G H5159213600Idiopathic basal ganglia calcification 1213600C0393590OMIM1241508804173410
HP:0002067HP:0002067Bradykinesia0PINK1 CL E G H65018605909Parkinson disease 6, autosomal recessive early-onset605909C1853833OMIM113817214581608309
HP:0002067HP:0002067Bradykinesia0PLA2G6 CL E G H8398199351ORPHA11792899039603604
HP:0002067HP:0002067Bradykinesia0PLA2G6 CL E G H8398610217Neurodegeneration with brain iron accumulation 2b610217C1857747OMIM11792899039603604
HP:0002067HP:0002067Bradykinesia0PLA2G6 CL E G H8398612953Parkinson disease 14612953C2751842OMIM11792899039603604
HP:0002067HP:0002067Bradykinesia0PODXL CL E G H5420391411ORPHA112599171602632
HP:0002067HP:0002067Bradykinesia0POLG CL E G H5428254892ORPHA130011969179174763
HP:0002067HP:0002067Bradykinesia0POLG CL E G H5428157640Autosomal dominant progressive external ophthalmoplegia with mitochondrial DNA deletions 1157640C1834846OMIM130011969179174763
HP:0002067HP:0002067Bradykinesia0POLG CL E G H5428258450Cerebellar ataxia infantile with progressive external ophthalmoplegia258450C1850303OMIM130011969179174763
HP:0002067HP:0002067Bradykinesia0POLG2 CL E G H11232254892ORPHA1141019180604983
HP:0002067HP:0002067Bradykinesia0PRKAR1B CL E G H5575412066ORPHA161219390176911
HP:0002067HP:0002067Bradykinesia0PRKN CL E G H5071600116Parkinson disease 2600116C1868675OMIM14414688607602544
HP:0002067HP:0002067Bradykinesia0PRKRA CL E G H8575210571ORPHA1111029438603424
HP:0002067HP:0002067Bradykinesia0PRKRA CL E G H8575612067Dystonia 16612067C2677567OMIM1111029438603424
HP:0002067HP:0002067Bradykinesia0PRNP CL E G H5621282166ORPHA11091269449176640
HP:0002067HP:0002067Bradykinesia0PRNP CL E G H5621137440Gerstmann-Straussler-Scheinker syndrome137440C0017495OMIM11091269449176640
HP:0002067HP:0002067Bradykinesia0PTS CL E G H58052616406-pyruvoyl-tetrahydropterin synthase deficiency261640C0878676OMIM1112989689612719
HP:0002067HP:0002067Bradykinesia0RAB39B CL E G H116442311510Parkinsonism, early onset with mental retardation311510C0796195OMIM11728016499300774
HP:0002067HP:0002067Bradykinesia0RRM2B CL E G H50484254892ORPHA14321617296604712
HP:0002067HP:0002067Bradykinesia0SLC20A2 CL E G H6575213600Idiopathic basal ganglia calcification 1213600C0393590OMIM18918210947158378
HP:0002067HP:0002067Bradykinesia0SLC25A4 CL E G H291254892ORPHA11723410990103220
HP:0002067HP:0002067Bradykinesia0SLC30A10 CL E G H55532309854ORPHA1229225355611146
HP:0002067HP:0002067Bradykinesia0SLC30A10 CL E G H55532613280Hypermanganesemia with dystonia 1613280OMIM1229225355611146
HP:0002067HP:0002067Bradykinesia0SLC39A14 CL E G H23516617013Hypermanganesemia with dystonia 2617013C4310765OMIM1910320858608736
HP:0002067HP:0002067Bradykinesia0SLC6A3 CL E G H6531238455ORPHA14625911049126455
HP:0002067HP:0002067Bradykinesia0SLC6A3 CL E G H6531613135Infantile Parkinsonism-dystonia613135C2751067OMIM14625911049126455
HP:0002067HP:0002067Bradykinesia0SNCA CL E G H6622171695ORPHA13713011138163890
HP:0002067HP:0002067Bradykinesia0SNCA CL E G H6622168601Parkinson disease 1168601C1868595OMIM13713011138163890
HP:0002067HP:0002067Bradykinesia0SNCAIP CL E G H9627168600Parkinson disease, late-onset168600C3160718OMIM1611511139603779
HP:0002067HP:0002067Bradykinesia0SPR CL E G H669770594ORPHA12510011257182125
HP:0002067HP:0002067Bradykinesia0SYNJ1 CL E G H8867391411ORPHA12745211503604297
HP:0002067HP:0002067Bradykinesia0SYNJ1 CL E G H8867615530Parkinson disease 20, early-onset615530C3809824OMIM12745211503604297
HP:0002067HP:0002067Bradykinesia0TAF1 CL E G H687253351ORPHA11724011535313650
HP:0002067HP:0002067Bradykinesia0TBP CL E G H6908607136Spinocerebellar ataxia 17607136C1846707OMIM1189111588600075
HP:0002067HP:0002067Bradykinesia0TH CL E G H7054101150ORPHA17734511782191290
HP:0002067HP:0002067Bradykinesia0TPM2 CL E G H7169171439ORPHA14019912011190990
HP:0002067HP:0002067Bradykinesia0TPM3 CL E G H7170171439ORPHA12822512012191030
HP:0002067HP:0002067Bradykinesia0TTC19 CL E G H54902615157Mitochondrial complex III deficiency, nuclear type 2615157C3554605OMIM11020426006613814
HP:0002067HP:0002067Bradykinesia0TWNK CL E G H56652254892ORPHA1831941160606075
HP:0002067HP:0002067Bradykinesia0WDR45 CL E G H11152329284ORPHA17834928912300526
HP:0002067HP:0002067Bradykinesia0WDR45 CL E G H11152300894Neurodegeneration with brain iron accumulation 5300894C3550973OMIM17834928912300526
 
HPO disease - gene - phenotype less frequent non-typical associations:
HP:0002067HP:0002067Bradykinesia0ATL1 CL E G H51062100984ORPHA08522011231606439
HP:0002067HP:0002067Bradykinesia0ATP13A2 CL E G H23400306674ORPHA04436530213610513
HP:0002067HP:0002067Bradykinesia0COQ2 CL E G H27235227510ORPHA03310225223609825
HP:0002067HP:0002067Bradykinesia0DNAJC13 CL E G H23317411602ORPHA0165130343614334
HP:0002067HP:0002067Bradykinesia0EIF4G1 CL E G H1981411602ORPHA020523296600495
HP:0002067HP:0002067Bradykinesia0FMR1 CL E G H233293256ORPHA0812813775309550
HP:0002067HP:0002067Bradykinesia0GBA CL E G H2629411602ORPHA04942064177606463
HP:0002067HP:0002067Bradykinesia0GCH1 CL E G H264398808ORPHA02522084193600225
HP:0002067HP:0002067Bradykinesia0GIGYF2 CL E G H26058411602ORPHA03612611960612003
HP:0002067HP:0002067Bradykinesia0KCNC3 CL E G H374898768ORPHA012946235176264
HP:0002067HP:0002067Bradykinesia0LRRK2 CL E G H120892411602ORPHA013838818618609007
HP:0002067HP:0002067Bradykinesia0LYST CL E G H1130167ORPHA01028071968606897
HP:0002067HP:0002067Bradykinesia0POLG CL E G H5428254886ORPHA030011969179174763
HP:0002067HP:0002067Bradykinesia0PPP2R2B CL E G H552198762ORPHA06329305604325
HP:0002067HP:0002067Bradykinesia0PRNP CL E G H5621157941ORPHA01091269449176640
HP:0002067HP:0002067Bradykinesia0PTS CL E G H580513Brain malformationC0266449ORPHA0112989689612719
HP:0002067HP:0002067Bradykinesia0SNCA CL E G H6622411602ORPHA03713011138163890
HP:0002067HP:0002067Bradykinesia0TK2 CL E G H7084254886ORPHA06020611831188250
HP:0002067HP:0002067Bradykinesia0VPS35 CL E G H55737411602ORPHA02311713487601501


Genes (77) :ACTA1 ATL1 ATP13A2 ATP1A3 ATP6AP2 ATXN1 ATXN2 ATXN3 ATXN8 ATXN8OS C19ORF12 C19orf12 CHCHD2 COASY COQ2 CSF1R DCTN1 DHDDS DNAJC12 DNAJC13 DNAJC6 EARS2 EIF4G1 FBXO7 FMR1 FTL GBA GCH1 GIGYF2 HTT JPH3 KBTBD13 KCNC3 KLHL41 LRRK2 LYST MAPT MYPN NEB NR4A2 PANK2 PARK7 PDE8B PDGFB PDGFRB PINK1 PLA2G6 PODXL POLG POLG2 PPP2R2B PRKAR1B PRKN PRKRA PRNP PTS RAB39B RRM2B SLC20A2 SLC25A4 SLC30A10 SLC39A14 SLC6A3 SNCA SNCAIP SPR SYNJ1 TAF1 TBP TH TK2 TPM2 TPM3 TTC19 TWNK VPS35 WDR45

Diseases (79) :171439 100984 306674 314632 71517 128235 363654 300423 300911 98755 183090 109150 98760 289560 616710 615643 227510 98933 221820 168605 617836 617384 411602 391411 615528 614924 171695 260300 93256 300623 157846 606159 98808 248111 143100 617435 606438 98768 167 601104 168600 234200 606324 228169 609161 213600 605909 199351 610217 612953 254886 254892 157640 258450 98762 412066 600116 210571 612067 282166 157941 137440 261640 13 311510 309854 613280 617013 238455 613135 168601 70594 615530 53351 607136 101150 615157 329284 300894
 

Human Phenotype Ontology(HPO) is developed by the Human Phenotype Ontology Consortium. The version used here is June 2019 release.