Human Phenotype Ontology 
Grandparent Node:
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Anemia due to reduced life span of red cells (HP:0011895)help
Parent Node:
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Autoimmunity (HP:0002960)help
Parent Node:
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Hemolytic anemia (HP:0001878)help
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Autoimmune hemolytic anemia (HP:0001890)help
Term ID: 1890
Name: Autoimmune hemolytic anemia
Synonym: Autoimmune haemolytic anaemia; Autoimmune hemolytic anaemia; Hemolytic anemia, autoimmune
Definition: An autoimmune form of hemolytic anemia.
Comments:
Reference: HP:0001890
Genes and Diseases:
 
       Child Nodes:

 Sister Nodes: 
..expandChronic hemolytic anemia (HP:0004870) help
..expandCold-induced hemolysis (HP:0031484) help
..expandCompensated hemolytic anemia (HP:0004863) help
..expandCongenital hemolytic anemia (HP:0004804) help
..expandCoombs-positive hemolytic anemia (HP:0004844) help
..expandDrug-sensitive hemolytic anemia (HP:0004817) help
..expandEpisodic hemolytic anemia (HP:0004802) help
..expandExercise-induced hemolysis (HP:0005535) help
..expandFava bean-induced hemolytic anemia (HP:0004814) help
..expandHeinz body anemia (HP:0005511) help
..expandIncreased red cell hemolysis by shear stress (HP:0008269) help
..expandMacrocytic hemolytic disease (HP:0005524) help
..expandMicroangiopathic hemolytic anemia (HP:0001937) help
..expandNonspherocytic hemolytic anemia (HP:0001930) help
..expandSpontaneous hemolytic crises (HP:0005525) help
InputHPO IDHPO termDistanceGeneGene id entrezHGNC IDDiseaseIdDiseaseNameFrequencyOnsetHGMD variantsClinVar variants
 
HPO disease - gene - phenotype typical associations:
 
HPO disease - gene - phenotype less frequent non-typical associations:
HP:0001890HP:0001890Autoimmune hemolytic anemia0ACP5 CL E G H54124ORPHA:1855SpondyloenchondrodysplasiaHP:0040283 - Occasional16
HP:0001890HP:0001890Autoimmune hemolytic anemia0ADA CL E G H100186OMIM:102700Severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-negative, NK cell-negative, due to adenosine deaminase deficiency.75
HP:0001890HP:0001890Autoimmune hemolytic anemia0CASP10 CL E G H8431500ORPHA:3261Autoimmune lymphoproliferative syndromeHP:0040282 - Frequent87
HP:0001890HP:0001890Autoimmune hemolytic anemia0CASP10 CL E G H8431500OMIM:603909Autoimmune lymphoproliferative syndrome, type IIA87
HP:0001890HP:0001890Autoimmune hemolytic anemia0CD247 CL E G H9191677OMIM:610163IMMUNODEFICIENCY 25; IMD258
HP:0001890HP:0001890Autoimmune hemolytic anemia0CD3G CL E G H9171675OMIM:615607Immunodeficiency 17HP:0040283 - Occasional19
HP:0001890HP:0001890Autoimmune hemolytic anemia0CIITA CL E G H42617067ORPHA:572Immunodeficiency by defective expression of MHC class IIHP:0040283 - Occasional118
HP:0001890HP:0001890Autoimmune hemolytic anemia0CTLA4 CL E G H14932505OMIM:616100AUTOIMMUNE LYMPHOPROLIFERATIVE SYNDROME, TYPE V; ALPS510
HP:0001890HP:0001890Autoimmune hemolytic anemia0DEF6 CL E G H506192760OMIM:619573IMMUNODEFICIENCY 87 AND AUTOIMMUNITY; IMD87
HP:0001890HP:0001890Autoimmune hemolytic anemia0FAS CL E G H35511920ORPHA:3261Autoimmune lymphoproliferative syndromeHP:0040282 - Frequent59
HP:0001890HP:0001890Autoimmune hemolytic anemia0FAS CL E G H35511920OMIM:601859Autoimmune lymphoproliferative syndrome.59
HP:0001890HP:0001890Autoimmune hemolytic anemia0FASLG CL E G H35611936ORPHA:3261Autoimmune lymphoproliferative syndromeHP:0040282 - Frequent37
HP:0001890HP:0001890Autoimmune hemolytic anemia0FASLG CL E G H35611936OMIM:601859Autoimmune lymphoproliferative syndrome.37
HP:0001890HP:0001890Autoimmune hemolytic anemia0FOXP3 CL E G H509436106ORPHA:37042Immune dysregulation-polyendocrinopathy-enteropathy-X-linked syndromeHP:0040283 - Occasional32
HP:0001890HP:0001890Autoimmune hemolytic anemia0IL2RB CL E G H35606009OMIM:618495Immunodeficiency 63 with lymphoproliferation and autoimmunity.
HP:0001890HP:0001890Autoimmune hemolytic anemia0ITK CL E G H37026171OMIM:613011LYMPHOPROLIFERATIVE SYNDROME 1; LPFS151
HP:0001890HP:0001890Autoimmune hemolytic anemia0LCP2 CL E G H39376529OMIM:619374IMMUNODEFICIENCY 81; IMD81
HP:0001890HP:0001890Autoimmune hemolytic anemia0LRBA CL E G H9871742OMIM:614700IMMUNODEFICIENCY, COMMON VARIABLE, 8, WITH AUTOIMMUNITY; CVID845
HP:0001890HP:0001890Autoimmune hemolytic anemia0NBN CL E G H46837652ORPHA:647Nijmegen breakage syndromeHP:0040281 - Very frequent706
HP:0001890HP:0001890Autoimmune hemolytic anemia0NBN CL E G H46837652OMIM:251260Nijmegen breakage syndrome.706
HP:0001890HP:0001890Autoimmune hemolytic anemia0NFKB1 CL E G H47907794OMIM:616576IMMUNODEFICIENCY, COMMON VARIABLE, 12; CVID127
HP:0001890HP:0001890Autoimmune hemolytic anemia0NLRP1 CL E G H2286114374OMIM:617388AUTOINFLAMMATION WITH ARTHRITIS AND DYSKERATOSIS; AIADK37
HP:0001890HP:0001890Autoimmune hemolytic anemia0PI4KA CL E G H52978983ORPHA:436252Combined immunodeficiency-enteropathy spectrumHP:0040284 - Very rare11
HP:0001890HP:0001890Autoimmune hemolytic anemia0PIK3CG CL E G H52948978OMIM:619802IMMUNODEFICIENCY 97 WITH AUTOINFLAMMATION; IMD972
HP:0001890HP:0001890Autoimmune hemolytic anemia0PNP CL E G H48607892OMIM:613179Immunodeficiency due to purine nucleoside phosphorylase deficiency.52
HP:0001890HP:0001890Autoimmune hemolytic anemia0PNP CL E G H48607892ORPHA:760Purine nucleoside phosphorylase deficiencyHP:0040282 - Frequent52
HP:0001890HP:0001890Autoimmune hemolytic anemia0PRKCD CL E G H55809399ORPHA:3261Autoimmune lymphoproliferative syndromeHP:0040282 - Frequent10
HP:0001890HP:0001890Autoimmune hemolytic anemia0PRKCD CL E G H55809399OMIM:615559AUTOIMMUNE LYMPHOPROLIFERATIVE SYNDROME, TYPE III; ALPS310
HP:0001890HP:0001890Autoimmune hemolytic anemia0PSMG2 CL E G H5698424929OMIM:619183PROTEASOME-ASSOCIATED AUTOINFLAMMATORY SYNDROME 4; PRAAS4
HP:0001890HP:0001890Autoimmune hemolytic anemia0RAG1 CL E G H58969831ORPHA:231154Combined immunodeficiency due to partial RAG1 deficiencyHP:0040282 - Frequent127
HP:0001890HP:0001890Autoimmune hemolytic anemia0RAG1 CL E G H58969831ORPHA:331206Severe combined immunodeficiency due to complete RAG1/2 deficiencyHP:0040283 - Occasional127
HP:0001890HP:0001890Autoimmune hemolytic anemia0RAG2 CL E G H58979832ORPHA:331206Severe combined immunodeficiency due to complete RAG1/2 deficiencyHP:0040283 - Occasional50
HP:0001890HP:0001890Autoimmune hemolytic anemia0RASGRP1 CL E G H101259878ORPHA:3261Autoimmune lymphoproliferative syndromeHP:0040282 - Frequent
HP:0001890HP:0001890Autoimmune hemolytic anemia0RASGRP1 CL E G H101259878OMIM:618534IMMUNODEFICIENCY 64; IMD64
HP:0001890HP:0001890Autoimmune hemolytic anemia0RFX5 CL E G H59939986ORPHA:572Immunodeficiency by defective expression of MHC class IIHP:0040283 - Occasional38
HP:0001890HP:0001890Autoimmune hemolytic anemia0RFXANK CL E G H86259987ORPHA:572Immunodeficiency by defective expression of MHC class IIHP:0040283 - Occasional26
HP:0001890HP:0001890Autoimmune hemolytic anemia0RFXAP CL E G H59949988ORPHA:572Immunodeficiency by defective expression of MHC class IIHP:0040283 - Occasional34
HP:0001890HP:0001890Autoimmune hemolytic anemia0STAT1 CL E G H677211362ORPHA:391487Autoimmune enteropathy and endocrinopathy-susceptibility to chronic infections syndromeHP:0040282 - Frequent89
HP:0001890HP:0001890Autoimmune hemolytic anemia0STAT1 CL E G H677211362OMIM:614162Immunodeficiency 31CHP:0040283 - Occasional89
HP:0001890HP:0001890Autoimmune hemolytic anemia0STAT3 CL E G H677411364OMIM:615952AUTOIMMUNE DISEASE, MULTISYSTEM, INFANTILE-ONSET, 1; ADMIO1110
HP:0001890HP:0001890Autoimmune hemolytic anemia0STIM1 CL E G H678611386OMIM:612783Immunodeficiency 10.31
HP:0001890HP:0001890Autoimmune hemolytic anemia0TLR8 CL E G H5131115632OMIM:301078IMMUNODEFICIENCY 98 WITH AUTOINFLAMMATION, X-LINKED; IMD98
HP:0001890HP:0001890Autoimmune hemolytic anemia0TOM1 CL E G H1004311982ORPHA:391487Autoimmune enteropathy and endocrinopathy-susceptibility to chronic infections syndromeHP:0040282 - Frequent
HP:0001890HP:0001890Autoimmune hemolytic anemia0TPP2 CL E G H717412016ORPHA:444463Autoimmune hemolytic anemia-autoimmune thrombocytopenia-primary immunodeficiency syndromeHP:0040281 - Very frequent
HP:0001890HP:0001890Autoimmune hemolytic anemia0TPP2 CL E G H717412016OMIM:619220IMMUNODEFICIENCY 78 WITH AUTOIMMUNITY AND DEVELOPMENTAL DELAY; IMD78
HP:0001890HP:0001890Autoimmune hemolytic anemia0TTC7A CL E G H5721719750ORPHA:436252Combined immunodeficiency-enteropathy spectrumHP:0040284 - Very rare26
HP:0001890HP:0001890Autoimmune hemolytic anemia0TTC7A CL E G H5721719750OMIM:243150Gastrointestinal defects and immunodeficiency syndromeHP:0040283 - Occasional26
HP:0001890HP:0001890Autoimmune hemolytic anemia0WAS CL E G H745412731OMIM:301000Wiskott-Aldrich syndrome65
HP:0001890HP:0001890Autoimmune hemolytic anemia0ZAP70 CL E G H753512858ORPHA:911Combined immunodeficiency due to ZAP70 deficiencyHP:0040284 - Very rare46


Genes (38) :ACP5 ADA CASP10 CD247 CD3G CIITA CTLA4 DEF6 FAS FASLG FOXP3 IL2RB ITK LCP2 LRBA NBN NFKB1 NLRP1 PI4KA PIK3CG PNP PRKCD PSMG2 RAG1 RAG2 RASGRP1 RFX5 RFXANK RFXAP STAT1 STAT3 STIM1 TLR8 TOM1 TPP2 TTC7A WAS ZAP70

Diseases (38) :ORPHA:1855 OMIM:102700 ORPHA:3261 OMIM:603909 OMIM:610163 OMIM:615607 ORPHA:572 OMIM:616100 OMIM:619573 OMIM:601859 ORPHA:37042 OMIM:618495 OMIM:613011 OMIM:619374 OMIM:614700 ORPHA:647 OMIM:251260 OMIM:616576 OMIM:617388 ORPHA:436252 OMIM:619802 OMIM:613179 ORPHA:760 OMIM:615559 OMIM:619183 ORPHA:231154 ORPHA:331206 OMIM:618534 ORPHA:391487 OMIM:614162 OMIM:615952 OMIM:612783 OMIM:301078 ORPHA:444463 OMIM:619220 OMIM:243150 OMIM:301000 ORPHA:911
 

Human Phenotype Ontology(HPO) is developed by the Human Phenotype Ontology Consortium. The version used here is December 15 2022 release.