Human Phenotype Ontology 
Grandparent Node:
expand
Anemia (HP:0001903)help
Parent Node:
expand
Anemia due to reduced life span of red cells (HP:0011895)help
..Starting node
..expand
Hemolytic anemia (HP:0001878)help
Term ID: 1878
Name: Hemolytic anemia
Synonym: Haemolytic anaemia; Increased hemolysis
Definition: A type of anemia caused by premature destruction of red blood cells (hemolysis).
Comments:
Reference: HP:0001878
Genes and Diseases:
 
       Child Nodes:
........expandAutoimmune hemolytic anemia (HP:0001890) help
........expandNonspherocytic hemolytic anemia (HP:0001930) help
........expandMicroangiopathic hemolytic anemia (HP:0001937) help
........expandEpisodic hemolytic anemia (HP:0004802) help
........expandCongenital hemolytic anemia (HP:0004804) help
........expandFava bean-induced hemolytic anemia (HP:0004814) help
........expandDrug-sensitive hemolytic anemia (HP:0004817) help
........expandCoombs-positive hemolytic anemia (HP:0004844) help
........expandCompensated hemolytic anemia (HP:0004863) help
........expandChronic hemolytic anemia (HP:0004870) help
........expandHeinz body anemia (HP:0005511) help
........expandMacrocytic hemolytic disease (HP:0005524) help
........expandSpontaneous hemolytic crises (HP:0005525) help
........expandExercise-induced hemolysis (HP:0005535) help
........expandIncreased red cell hemolysis by shear stress (HP:0008269) help
........expandCold-induced hemolysis (HP:0031484) help

 Sister Nodes: 
..expandIncreased red cell sickling tendency (HP:0008346) help
InputHPO IDHPO termDistanceGeneGene id entrezDiseaseIdDiseaseNameDiseaseMIMConceptIDSourceTypical associationHGMD variantsClinVar variantsHGNC IDGeneMIM
 
HPO disease - gene - phenotype typical associations:
HP:0001878HP:0001878Hemolytic anemia0AK1 CL E G H203612631Adenylate kinase deficiency, hemolytic anemia due to612631C2675459OMIM11258361103000
HP:0001878HP:0001878Hemolytic anemia0ANK1 CL E G H286251066ORPHA1111388492612641
HP:0001878HP:0001878Hemolytic anemia0ANK1 CL E G H286182900Spherocytosis type 1182900C2674218OMIM1111388492612641
HP:0001878HP:0001878Hemolytic anemia0ATP11C CL E G H286410301015HEMOLYTIC ANEMIA, CONGENITAL, X-LINKED301015CN253426OMIM1320713554300516
HP:0001878HP:0001878Hemolytic anemia0ATP7B CL E G H540277900Wilson disease277900C0019202OMIM1938958870606882
HP:0001878HP:0001878Hemolytic anemia0CD19 CL E G H9301572ORPHA1101961633107265
HP:0001878HP:0001878Hemolytic anemia0CD40LG CL E G H959308230Immunodeficiency with hyper IgM type 1308230C0398689OMIM124127811935300386
HP:0001878HP:0001878Hemolytic anemia0CD59 CL E G H966612300CD59-mediated hemolytic anemia with or without immune-mediated polyneuropathy612300C2676767OMIM18371689107271
HP:0001878HP:0001878Hemolytic anemia0CD81 CL E G H9751572ORPHA12491701186845
HP:0001878HP:0001878Hemolytic anemia0COL4A1 CL E G H1282175780Porencephaly 1175780CN032791OMIM11144982202120130
HP:0001878HP:0001878Hemolytic anemia0CR2 CL E G H13801572ORPHA1192332336120650
HP:0001878HP:0001878Hemolytic anemia0EPB41 CL E G H2035611804Elliptocytosis 1611804C2678497OMIM114323377130500
HP:0001878HP:0001878Hemolytic anemia0EPB42 CL E G H2038612690Spherocytosis type 5612690C2675192OMIM118943381177070
HP:0001878HP:0001878Hemolytic anemia0FECH CL E G H2235177000Erythropoietic protoporphyria177000C0162568OMIM11952173647612386
HP:0001878HP:0001878Hemolytic anemia0GALT CL E G H2592230400Deficiency of UDPglucose-hexose-1-phosphate uridylyltransferase230400C0268151OMIM13375554135606999
HP:0001878HP:0001878Hemolytic anemia0GATA1 CL E G H262379277ORPHA1152354170305371
HP:0001878HP:0001878Hemolytic anemia0GATA1 CL E G H2623314050Thrombocytopenia, platelet dysfunction, hemolysis, and imbalanced globin synthesis314050C1839161OMIM1152354170305371
HP:0001878HP:0001878Hemolytic anemia0GCLC CL E G H2729230450Gamma-glutamylcysteine synthetase deficiency, hemolytic anemia due to230450C1856603OMIM111294311606857
HP:0001878HP:0001878Hemolytic anemia0GP1BA CL E G H2811153670Bernard-Soulier syndrome, type A2, autosomal dominant153670C3277076OMIM177734439606672
HP:0001878HP:0001878Hemolytic anemia0GSS CL E G H2937231900Glutathione synthetase deficiency of erythrocytes, hemolytic anemia due to231900C1856399OMIM140884624601002
HP:0001878HP:0001878Hemolytic anemia0GSS CL E G H2937266130Gluthathione synthetase deficiency266130C0398746OMIM140884624601002
HP:0001878HP:0001878Hemolytic anemia0HBA1 CL E G H3039613978Hemoglobin H613978C3161174OMIM12173464823141800
HP:0001878HP:0001878Hemolytic anemia0HBA2 CL E G H3040613978Hemoglobin H613978C3161174OMIM12962744824141850
HP:0001878HP:0001878Hemolytic anemia0HBB CL E G H3043603903Hb SS disease603903C0002895OMIM187110094827141900
HP:0001878HP:0001878Hemolytic anemia0HMOX1 CL E G H3162614034Heme oxygenase 1 deficiency614034C1841651OMIM114325013141250
HP:0001878HP:0001878Hemolytic anemia0ICOS CL E G H298511572ORPHA161085351604558
HP:0001878HP:0001878Hemolytic anemia0KCNN4 CL E G H3783616689Dehydrated hereditary stomatocytosis 2616689C4225242OMIM14186293602754
HP:0001878HP:0001878Hemolytic anemia0KDM6A CL E G H7403147920Kabuki syndrome 1147920CN030661OMIM18131112637300128
HP:0001878HP:0001878Hemolytic anemia0KMT2D CL E G H8085147920Kabuki syndrome 1147920CN030661OMIM171213507133602113
HP:0001878HP:0001878Hemolytic anemia0KRAS CL E G H3845614470RAS-associated autoimmune leukoproliferative disorder614470C2674723OMIM1452746407190070
HP:0001878HP:0001878Hemolytic anemia0LAT CL E G H27040617514Immunodeficiency 52617514C4479588OMIM11812518874602354
HP:0001878HP:0001878Hemolytic anemia0LCAT CL E G H3931245900Norum disease245900C0023195OMIM1109786522606967
HP:0001878HP:0001878Hemolytic anemia0MS4A1 CL E G H9311572ORPHA12147315112210
HP:0001878HP:0001878Hemolytic anemia0NFKB1 CL E G H47901572ORPHA136977794164011
HP:0001878HP:0001878Hemolytic anemia0NFKB2 CL E G H47911572ORPHA1111657795164012
HP:0001878HP:0001878Hemolytic anemia0NRAS CL E G H4893614470RAS-associated autoimmune leukoproliferative disorder614470C2674723OMIM1141817989164790
HP:0001878HP:0001878Hemolytic anemia0NT5C3A CL E G H51251266120Uridine 5-prime monophosphate hydrolase deficiency, hemolytic anemia due to266120C1849507OMIM1304217820606224
HP:0001878HP:0001878Hemolytic anemia0PFKM CL E G H5213232800Glycogen storage disease, type VII232800C0017926OMIM1271768877610681
HP:0001878HP:0001878Hemolytic anemia0PIGA CL E G H5277447ORPHA1293208957311770
HP:0001878HP:0001878Hemolytic anemia0PIGT CL E G H51604615399Paroxysmal nocturnal hemoglobinuria 2615399C3809369OMIM1127214938610272
HP:0001878HP:0001878Hemolytic anemia0PRKCD CL E G H55801572ORPHA161449399176977
HP:0001878HP:0001878Hemolytic anemia0PRKCD CL E G H5580615559Autoimmune lymphoproliferative syndrome, type III615559C3809928OMIM161449399176977
HP:0001878HP:0001878Hemolytic anemia0RHAG CL E G H6005268150Rh-null, regulator type268150C1849387OMIM1283110006180297
HP:0001878HP:0001878Hemolytic anemia0RHAG CL E G H6005185000Stomatocytosis I185000C1861455OMIM1283110006180297
HP:0001878HP:0001878Hemolytic anemia0SLC2A1 CL E G H6513608885Stomatin-deficient cryohydrocytosis with neurologic defects608885C1837206OMIM128151611005138140
HP:0001878HP:0001878Hemolytic anemia0SLC4A1 CL E G H6521166900Ovalocytosis, southeast asian166900C1833690OMIM115022711027109270
HP:0001878HP:0001878Hemolytic anemia0SLC4A1 CL E G H6521185020Pseudohyperkalemia Cardiff185020C1861453OMIM115022711027109270
HP:0001878HP:0001878Hemolytic anemia0SLC4A1 CL E G H6521612653Spherocytosis type 4612653C2675212OMIM115022711027109270
HP:0001878HP:0001878Hemolytic anemia0SPTA1 CL E G H6708266140Hereditary pyropoikilocytosis266140C0520739OMIM15935711272182860
HP:0001878HP:0001878Hemolytic anemia0SPTA1 CL E G H6708270970Spherocytosis type 3270970C2678338OMIM15935711272182860
HP:0001878HP:0001878Hemolytic anemia0SPTB CL E G H6710616649Spherocytosis type 2616649C2674219OMIM110321911274182870
HP:0001878HP:0001878Hemolytic anemia0TNFRSF13B CL E G H234951572ORPHA15022818153604907
HP:0001878HP:0001878Hemolytic anemia0TNFRSF13C CL E G H1156501572ORPHA138217755606269
HP:0001878HP:0001878Hemolytic anemia0TNFSF12 CL E G H87421572ORPHA116711927602695
HP:0001878HP:0001878Hemolytic anemia0UROD CL E G H738995159ORPHA11236512591613521
HP:0001878HP:0001878Hemolytic anemia0UROS CL E G H739079277ORPHA15111512592606938
HP:0001878HP:0001878Hemolytic anemia0UROS CL E G H7390263700Congenital erythropoietic porphyria263700C0162530OMIM15111512592606938
HP:0001878HP:0001878Hemolytic anemia0WAS CL E G H7454906ORPHA144134512731300392
HP:0001878HP:0001878Hemolytic anemia0WAS CL E G H7454301000Wiskott-Aldrich syndrome301000C0043194OMIM144134512731300392
HP:0001878HP:0001878Hemolytic anemia0WIPF1 CL E G H7456906ORPHA1310512736602357
HP:0001878HP:0001878Hemolytic anemia1AK1 CL E G H203612631Adenylate kinase deficiency, hemolytic anemia due to612631C2675459OMIM11258361103000
HP:0001878HP:0001878Hemolytic anemia1ANK1 CL E G H286251066ORPHA1111388492612641
HP:0001878HP:0001878Hemolytic anemia1ANK1 CL E G H286182900Spherocytosis type 1182900C2674218OMIM1111388492612641
HP:0001878HP:0001878Hemolytic anemia1ATP11C CL E G H286410301015HEMOLYTIC ANEMIA, CONGENITAL, X-LINKED301015CN253426OMIM1320713554300516
HP:0001878HP:0001878Hemolytic anemia1ATP7B CL E G H540277900Wilson disease277900C0019202OMIM1938958870606882
HP:0001878HP:0001878Hemolytic anemia1CD19 CL E G H9301572ORPHA1101961633107265
HP:0001878HP:0001878Hemolytic anemia1CD40LG CL E G H959308230Immunodeficiency with hyper IgM type 1308230C0398689OMIM124127811935300386
HP:0001878HP:0001878Hemolytic anemia1CD59 CL E G H966612300CD59-mediated hemolytic anemia with or without immune-mediated polyneuropathy612300C2676767OMIM18371689107271
HP:0001878HP:0001878Hemolytic anemia1CD81 CL E G H9751572ORPHA12491701186845
HP:0001878HP:0001878Hemolytic anemia1COL4A1 CL E G H1282175780Porencephaly 1175780CN032791OMIM11144982202120130
HP:0001878HP:0001878Hemolytic anemia1CR2 CL E G H13801572ORPHA1192332336120650
HP:0001878HP:0001878Hemolytic anemia1EPB41 CL E G H2035611804Elliptocytosis 1611804C2678497OMIM114323377130500
HP:0001878HP:0001878Hemolytic anemia1EPB42 CL E G H2038612690Spherocytosis type 5612690C2675192OMIM118943381177070
HP:0001878HP:0001878Hemolytic anemia1FECH CL E G H2235177000Erythropoietic protoporphyria177000C0162568OMIM11952173647612386
HP:0001878HP:0001878Hemolytic anemia1GALT CL E G H2592230400Deficiency of UDPglucose-hexose-1-phosphate uridylyltransferase230400C0268151OMIM13375554135606999
HP:0001878HP:0001878Hemolytic anemia1GATA1 CL E G H262379277ORPHA1152354170305371
HP:0001878HP:0001878Hemolytic anemia1GATA1 CL E G H2623314050Thrombocytopenia, platelet dysfunction, hemolysis, and imbalanced globin synthesis314050C1839161OMIM1152354170305371
HP:0001878HP:0001878Hemolytic anemia1GCLC CL E G H2729230450Gamma-glutamylcysteine synthetase deficiency, hemolytic anemia due to230450C1856603OMIM111294311606857
HP:0001878HP:0001878Hemolytic anemia1GP1BA CL E G H2811153670Bernard-Soulier syndrome, type A2, autosomal dominant153670C3277076OMIM177734439606672
HP:0001878HP:0001878Hemolytic anemia1GSS CL E G H2937231900Glutathione synthetase deficiency of erythrocytes, hemolytic anemia due to231900C1856399OMIM140884624601002
HP:0001878HP:0001878Hemolytic anemia1GSS CL E G H2937266130Gluthathione synthetase deficiency266130C0398746OMIM140884624601002
HP:0001878HP:0001878Hemolytic anemia1HBA1 CL E G H3039613978Hemoglobin H613978C3161174OMIM12173464823141800
HP:0001878HP:0001878Hemolytic anemia1HBA2 CL E G H3040613978Hemoglobin H613978C3161174OMIM12962744824141850
HP:0001878HP:0001878Hemolytic anemia1HBB CL E G H3043603903Hb SS disease603903C0002895OMIM187110094827141900
HP:0001878HP:0001878Hemolytic anemia1HMOX1 CL E G H3162614034Heme oxygenase 1 deficiency614034C1841651OMIM114325013141250
HP:0001878HP:0001878Hemolytic anemia1ICOS CL E G H298511572ORPHA161085351604558
HP:0001878HP:0001878Hemolytic anemia1KCNN4 CL E G H3783616689Dehydrated hereditary stomatocytosis 2616689C4225242OMIM14186293602754
HP:0001878HP:0001878Hemolytic anemia1KDM6A CL E G H7403147920Kabuki syndrome 1147920CN030661OMIM18131112637300128
HP:0001878HP:0001878Hemolytic anemia1KMT2D CL E G H8085147920Kabuki syndrome 1147920CN030661OMIM171213507133602113
HP:0001878HP:0001878Hemolytic anemia1KRAS CL E G H3845614470RAS-associated autoimmune leukoproliferative disorder614470C2674723OMIM1452746407190070
HP:0001878HP:0001878Hemolytic anemia1LAT CL E G H27040617514Immunodeficiency 52617514C4479588OMIM11812518874602354
HP:0001878HP:0001878Hemolytic anemia1LCAT CL E G H3931245900Norum disease245900C0023195OMIM1109786522606967
HP:0001878HP:0001878Hemolytic anemia1MS4A1 CL E G H9311572ORPHA12147315112210
HP:0001878HP:0001878Hemolytic anemia1NFKB1 CL E G H47901572ORPHA136977794164011
HP:0001878HP:0001878Hemolytic anemia1NFKB2 CL E G H47911572ORPHA1111657795164012
HP:0001878HP:0001878Hemolytic anemia1NRAS CL E G H4893614470RAS-associated autoimmune leukoproliferative disorder614470C2674723OMIM1141817989164790
HP:0001878HP:0001878Hemolytic anemia1NT5C3A CL E G H51251266120Uridine 5-prime monophosphate hydrolase deficiency, hemolytic anemia due to266120C1849507OMIM1304217820606224
HP:0001878HP:0001878Hemolytic anemia1PFKM CL E G H5213232800Glycogen storage disease, type VII232800C0017926OMIM1271768877610681
HP:0001878HP:0001878Hemolytic anemia1PIGA CL E G H5277447ORPHA1293208957311770
HP:0001878HP:0001878Hemolytic anemia1PIGT CL E G H51604615399Paroxysmal nocturnal hemoglobinuria 2615399C3809369OMIM1127214938610272
HP:0001878HP:0001878Hemolytic anemia1PRKCD CL E G H55801572ORPHA161449399176977
HP:0001878HP:0001878Hemolytic anemia1PRKCD CL E G H5580615559Autoimmune lymphoproliferative syndrome, type III615559C3809928OMIM161449399176977
HP:0001878HP:0001878Hemolytic anemia1RHAG CL E G H6005268150Rh-null, regulator type268150C1849387OMIM1283110006180297
HP:0001878HP:0001878Hemolytic anemia1RHAG CL E G H6005185000Stomatocytosis I185000C1861455OMIM1283110006180297
HP:0001878HP:0001878Hemolytic anemia1SLC2A1 CL E G H6513608885Stomatin-deficient cryohydrocytosis with neurologic defects608885C1837206OMIM128151611005138140
HP:0001878HP:0001878Hemolytic anemia1SLC4A1 CL E G H6521166900Ovalocytosis, southeast asian166900C1833690OMIM115022711027109270
HP:0001878HP:0001878Hemolytic anemia1SLC4A1 CL E G H6521185020Pseudohyperkalemia Cardiff185020C1861453OMIM115022711027109270
HP:0001878HP:0001878Hemolytic anemia1SLC4A1 CL E G H6521612653Spherocytosis type 4612653C2675212OMIM115022711027109270
HP:0001878HP:0001878Hemolytic anemia1SPTA1 CL E G H6708266140Hereditary pyropoikilocytosis266140C0520739OMIM15935711272182860
HP:0001878HP:0001878Hemolytic anemia1SPTA1 CL E G H6708270970Spherocytosis type 3270970C2678338OMIM15935711272182860
HP:0001878HP:0001878Hemolytic anemia1SPTB CL E G H6710616649Spherocytosis type 2616649C2674219OMIM110321911274182870
HP:0001878HP:0001878Hemolytic anemia1TNFRSF13B CL E G H234951572ORPHA15022818153604907
HP:0001878HP:0001878Hemolytic anemia1TNFRSF13C CL E G H1156501572ORPHA138217755606269
HP:0001878HP:0001878Hemolytic anemia1TNFSF12 CL E G H87421572ORPHA116711927602695
HP:0001878HP:0001878Hemolytic anemia1UROD CL E G H738995159ORPHA11236512591613521
HP:0001878HP:0001878Hemolytic anemia1UROS CL E G H739079277ORPHA15111512592606938
HP:0001878HP:0001878Hemolytic anemia1UROS CL E G H7390263700Congenital erythropoietic porphyria263700C0162530OMIM15111512592606938
HP:0001878HP:0001878Hemolytic anemia1WAS CL E G H7454906ORPHA144134512731300392
HP:0001878HP:0001878Hemolytic anemia1WAS CL E G H7454301000Wiskott-Aldrich syndrome301000C0043194OMIM144134512731300392
HP:0001878HP:0001878Hemolytic anemia1WIPF1 CL E G H7456906ORPHA1310512736602357
 
HPO disease - gene - phenotype less frequent non-typical associations:
HP:0001878HP:0001878Hemolytic anemia0ADAR CL E G H103615010Aicardi-Goutieres syndrome 6615010C3539013OMIM0229316225146920
HP:0001878HP:0001878Hemolytic anemia0BTNL2 CL E G H56244797ORPHA011181142606000
HP:0001878HP:0001878Hemolytic anemia0DGKE CL E G H8526615008Nephrotic syndrome, type 7615008C3554330OMIM040462852601440
HP:0001878HP:0001878Hemolytic anemia0HLA-DRB1 CL E G H3123797ORPHA026194948142857
HP:0001878HP:0001878Hemolytic anemia0NFKB1 CL E G H4790616576Immunodeficiency, common variable, 12616576C4225277OMIM036977794164011
HP:0001878HP:0001878Hemolytic anemia0PGK1 CL E G H5230300653Phosphoglycerate kinase 1 deficiency300653C1970848OMIM0281968896311800
HP:0001878HP:0001878Hemolytic anemia0PGM3 CL E G H5238615816Immunodeficiency 23615816C4014371OMIM0161088907172100
HP:0001878HP:0001878Hemolytic anemia0SLC4A1 CL E G H6521611590Renal tubular acidosis, distal, with hemolytic anemia611590C1969038OMIM015022711027109270
HP:0001878HP:0001878Hemolytic anemia0TNFAIP3 CL E G H7128616744Autoinflammatory syndrome, familial, Behcet-like616744C4225218OMIM0315511896191163
HP:0001878HP:0001878Hemolytic anemia1ADAR CL E G H103615010Aicardi-Goutieres syndrome 6615010C3539013OMIM0229316225146920
HP:0001878HP:0001878Hemolytic anemia1BTNL2 CL E G H56244797ORPHA011181142606000
HP:0001878HP:0001878Hemolytic anemia1DGKE CL E G H8526615008Nephrotic syndrome, type 7615008C3554330OMIM040462852601440
HP:0001878HP:0001878Hemolytic anemia1HLA-DRB1 CL E G H3123797ORPHA026194948142857
HP:0001878HP:0001878Hemolytic anemia1NFKB1 CL E G H4790616576Immunodeficiency, common variable, 12616576C4225277OMIM036977794164011
HP:0001878HP:0001878Hemolytic anemia1PGK1 CL E G H5230300653Phosphoglycerate kinase 1 deficiency300653C1970848OMIM0281968896311800
HP:0001878HP:0001878Hemolytic anemia1PGM3 CL E G H5238615816Immunodeficiency 23615816C4014371OMIM0161088907172100
HP:0001878HP:0001878Hemolytic anemia1SLC4A1 CL E G H6521611590Renal tubular acidosis, distal, with hemolytic anemia611590C1969038OMIM015022711027109270
HP:0001878HP:0001878Hemolytic anemia1TNFAIP3 CL E G H7128616744Autoinflammatory syndrome, familial, Behcet-like616744C4225218OMIM0315511896191163


Genes (92) :ABCB6 ABCG5 ABCG8 ADA ADAMTS13 ADAR AK1 ALDOA ANK1 ATP11C ATP7B BPGM BTNL2 CASK CASP10 CD19 CD3G CD40LG CD59 CD81 COL4A1 CPOX CR2 CTLA4 DGKE EPB41 EPB42 FAS FASLG FECH FOXP3 G6PD GALT GATA1 GCLC GP1BA GPI GPX1 GSS HBA1 HBA2 HBB HK1 HLA-DRB1 HMOX1 ICOS IL2RA KCNN4 KDM6A KMT2D KRAS LAT LCAT LRBA MS4A1 NBN NFKB1 NFKB2 NHLRC2 NLRP1 NRAS NT5C3A PFKM PGK1 PGM3 PIEZO1 PIGA PIGT PKLR PNP PRKCD RAG1 RHAG SLC2A1 SLC4A1 SPTA1 SPTB STAT1 STAT3 STIM1 TNFAIP3 TNFRSF13B TNFRSF13C TNFRSF4 TNFSF12 TPI1 TPP2 TTC7A UROD UROS WAS WIPF1

Diseases (91) :615010 612631 251066 182900 301015 277900 797 1572 308230 612300 175780 615008 611804 612690 177000 230400 79277 314050 230450 153670 231900 266130 613978 603903 614034 616689 147920 614470 617514 245900 616576 266120 232800 300653 615816 447 615399 615559 268150 185000 608885 166900 185020 611590 612653 266140 270970 616649 616744 95159 263700 906 301000 90044 210250 102700 274150 611881 222800 300908 603909 615607 121300 616100 601859 304790 613470 614164 140700 232 235700 606367 614700 647 251260 618278 617388 194380 766 266200 613179 231154 391487 614162 615952 612783 615593 615512 444463 436252 243150
 

Human Phenotype Ontology(HPO) is developed by the Human Phenotype Ontology Consortium. The version used here is June 2019 release.