Human Phenotype Ontology 
Grandparent Node:
expand
Abnormality of skin adnexa morphology (HP:0011138)help
Parent Node:
expand
Abnormality of the nail (HP:0001597)help
..Starting node
..expand
Onychogryposis (HP:0001805)help
Term ID: 1805
Name: Onychogryposis
Synonym: Dystrophic thickened nails; Thick nail; Thickened nails
Definition: Nail that appears thick when viewed on end.
Comments:
Reference: HP:0001805
Genes and Diseases:
 
       Child Nodes:
........expandOnychogryposis of toenails (HP:0008401) help
........expandOnychauxis (HP:0012542) help
........expandOnychogryposis of fingernail (HP:0040036) help

 Sister Nodes: 
..expandAbnormal fingernail morphology (HP:0001231) help
..expandAbnormal nail growth (HP:0030807) help
..expandAbnormal toenail morphology (HP:0008388) help
..expandAbnormality of nail color (HP:0100643) help
..expandAbnormality of the periungual region (HP:0100803) help
..expandAbnormality of the subungual region (HP:0009723) help
..expandAbsent lunula (HP:0030805) help
..expandAplasia/Hypoplasia of the nails (HP:0008386) help
..expandBeaked nails (HP:0030817) help
..expandChronic monilial nail infection (HP:0008396) help
..expandFragile nails (HP:0001808) help
..expandIngrown nail (HP:0012710) help
..expandNail bed hemorrhage (HP:0030254) help
..expandNail bed telangiectasia (HP:0001232) help
..expandNail dysplasia (HP:0002164) help
..expandNail dystrophy (HP:0008404) help
..expandNeoplasm of the nail (HP:0100826) help
..expandOnycholysis (HP:0001806) help
..expandPterygium of nails (HP:0002165) help
..expandPyramidal skinfold extending from the base to the top of the nails (HP:0009758) help
..expandRagged cuticle (HP:0030808) help
..expandRecurrent loss of toenails and fingernails (HP:0008390) help
..expandSki jump nail (HP:0030819) help
..expandThin nail (HP:0001816) help
InputHPO IDHPO termDistanceGeneGene id entrezDiseaseIdDiseaseNameDiseaseMIMConceptIDSourceTypical associationHGMD variantsClinVar variantsHGNC IDGeneMIM
 
HPO disease - gene - phenotype typical associations:
HP:0001805HP:0001805Onychogryposis0ADAM17 CL E G H6868614328Inflammatory skin and bowel disease, neonatal 1614328C3280501OMIM1329195603639
HP:0001805HP:0001805Onychogryposis0ADAM17 CL E G H6868614328Inflammatory skin and bowel disease, neonatal 1614328C3280501OMIM1263195603639
HP:0001805HP:0001805Onychogryposis0CTSC CL E G H1075245010Haim-Munk syndrome245010C1855627OMIM12372528602365
HP:0001805HP:0001805Onychogryposis0CTSC CL E G H1075245010Haim-Munk syndrome245010C1855627OMIM11962528602365
HP:0001805HP:0001805Onychogryposis0GJB6 CL E G H10804189Elliott Ludman Teebi syndromeORPHA12234288604418
HP:0001805HP:0001805Onychogryposis0GJB6 CL E G H10804189Elliott Ludman Teebi syndromeORPHA12144288604418
HP:0001805HP:0001805Onychogryposis0IKBKG CL E G H8517308300Incontinentia pigmenti syndrome308300C0021171OMIM13375961300248
HP:0001805HP:0001805Onychogryposis0IKBKG CL E G H8517308300Incontinentia pigmenti syndrome308300C0021171OMIM13265961300248
HP:0001805HP:0001805Onychogryposis0INSR CL E G H3643769ORPHA15416091147670
HP:0001805HP:0001805Onychogryposis0INSR CL E G H3643769ORPHA15086091147670
HP:0001805HP:0001805Onychogryposis0KRT14 CL E G H3861601001Epidermolysis bullosa simplex, autosomal recessive601001C1832926OMIM11556416148066
HP:0001805HP:0001805Onychogryposis0KRT14 CL E G H3861601001Epidermolysis bullosa simplex, autosomal recessive601001C1832926OMIM11486416148066
HP:0001805HP:0001805Onychogryposis0KRT16 CL E G H38682309Fetal parainfluenza virus type 3 syndromeORPHA1686423148067
HP:0001805HP:0001805Onychogryposis0KRT16 CL E G H38682309Fetal parainfluenza virus type 3 syndromeORPHA1656423148067
HP:0001805HP:0001805Onychogryposis0KRT16 CL E G H3868167200Pachyonychia congenita 1167200C1706595OMIM1686423148067
HP:0001805HP:0001805Onychogryposis0KRT16 CL E G H3868167200Pachyonychia congenita 1167200C1706595OMIM1656423148067
HP:0001805HP:0001805Onychogryposis0KRT17 CL E G H38722309Fetal parainfluenza virus type 3 syndromeORPHA1596427148069
HP:0001805HP:0001805Onychogryposis0KRT17 CL E G H38722309Fetal parainfluenza virus type 3 syndromeORPHA1546427148069
HP:0001805HP:0001805Onychogryposis0KRT5 CL E G H3852131960Epidermolysis bullosa simplex with mottled pigmentation131960C0432316OMIM12526442148040
HP:0001805HP:0001805Onychogryposis0KRT5 CL E G H3852131960Epidermolysis bullosa simplex with mottled pigmentation131960C0432316OMIM12416442148040
HP:0001805HP:0001805Onychogryposis0KRT5 CL E G H3852601001Epidermolysis bullosa simplex, autosomal recessive601001C1832926OMIM12526442148040
HP:0001805HP:0001805Onychogryposis0KRT5 CL E G H3852601001Epidermolysis bullosa simplex, autosomal recessive601001C1832926OMIM12416442148040
HP:0001805HP:0001805Onychogryposis0KRT6A CL E G H38532309Fetal parainfluenza virus type 3 syndromeORPHA1786443148041
HP:0001805HP:0001805Onychogryposis0KRT6A CL E G H38532309Fetal parainfluenza virus type 3 syndromeORPHA1776443148041
HP:0001805HP:0001805Onychogryposis0KRT6B CL E G H38542309Fetal parainfluenza virus type 3 syndromeORPHA1396444148042
HP:0001805HP:0001805Onychogryposis0KRT6B CL E G H38542309Fetal parainfluenza virus type 3 syndromeORPHA1386444148042
HP:0001805HP:0001805Onychogryposis0PLEC CL E G H533979401ORPHA138429069601282
HP:0001805HP:0001805Onychogryposis0PLEC CL E G H533979401ORPHA133559069601282
HP:0001805HP:0001805Onychogryposis0SLURP1 CL E G H5715287503ORPHA18118746606119
HP:0001805HP:0001805Onychogryposis0SLURP1 CL E G H5715287503ORPHA18018746606119
HP:0001805HP:0001805Onychogryposis0TP63 CL E G H8626129400Rapp-Hodgkin ectodermal dysplasia syndrome129400C1785148OMIM144415979603273
HP:0001805HP:0001805Onychogryposis0TP63 CL E G H8626129400Rapp-Hodgkin ectodermal dysplasia syndrome129400C1785148OMIM137615979603273
HP:0001805HP:0001805Onychogryposis0ZSWIM6 CL E G H57688603671Acromelic frontonasal dysostosis603671C1863616OMIM125829316615951
HP:0001805HP:0001805Onychogryposis0ZSWIM6 CL E G H57688603671Acromelic frontonasal dysostosis603671C1863616OMIM111629316615951
HP:0001805HP:0012542Onychauxis1ADAM17 CL E G H6868614328Inflammatory skin and bowel disease, neonatal 1614328C3280501OMIM1263195603639
HP:0001805HP:0008401Onychogryposis of toenails1ADAM17 CL E G H6868614328Inflammatory skin and bowel disease, neonatal 1614328C3280501OMIM1263195603639
HP:0001805HP:0040036Onychogryposis of fingernail1ADAM17 CL E G H6868614328Inflammatory skin and bowel disease, neonatal 1614328C3280501OMIM1329195603639
HP:0001805HP:0040036Onychogryposis of fingernail1ADAM17 CL E G H6868614328Inflammatory skin and bowel disease, neonatal 1614328C3280501OMIM1263195603639
HP:0001805HP:0012542Onychauxis1ADAM17 CL E G H6868614328Inflammatory skin and bowel disease, neonatal 1614328C3280501OMIM1329195603639
HP:0001805HP:0008401Onychogryposis of toenails1ADAM17 CL E G H6868614328Inflammatory skin and bowel disease, neonatal 1614328C3280501OMIM1329195603639
HP:0001805HP:0008401Onychogryposis of toenails1CTSC CL E G H1075245010Haim-Munk syndrome245010C1855627OMIM11962528602365
HP:0001805HP:0012542Onychauxis1CTSC CL E G H1075245010Haim-Munk syndrome245010C1855627OMIM11962528602365
HP:0001805HP:0040036Onychogryposis of fingernail1CTSC CL E G H1075245010Haim-Munk syndrome245010C1855627OMIM12372528602365
HP:0001805HP:0040036Onychogryposis of fingernail1CTSC CL E G H1075245010Haim-Munk syndrome245010C1855627OMIM11962528602365
HP:0001805HP:0008401Onychogryposis of toenails1CTSC CL E G H1075245010Haim-Munk syndrome245010C1855627OMIM12372528602365
HP:0001805HP:0012542Onychauxis1CTSC CL E G H1075245010Haim-Munk syndrome245010C1855627OMIM12372528602365
HP:0001805HP:0012542Onychauxis1GJB6 CL E G H10804189Elliott Ludman Teebi syndromeORPHA12144288604418
HP:0001805HP:0008401Onychogryposis of toenails1GJB6 CL E G H10804189Elliott Ludman Teebi syndromeORPHA12144288604418
HP:0001805HP:0040036Onychogryposis of fingernail1GJB6 CL E G H10804189Elliott Ludman Teebi syndromeORPHA12234288604418
HP:0001805HP:0040036Onychogryposis of fingernail1GJB6 CL E G H10804189Elliott Ludman Teebi syndromeORPHA12144288604418
HP:0001805HP:0012542Onychauxis1GJB6 CL E G H10804189Elliott Ludman Teebi syndromeORPHA12234288604418
HP:0001805HP:0008401Onychogryposis of toenails1GJB6 CL E G H10804189Elliott Ludman Teebi syndromeORPHA12234288604418
HP:0001805HP:0012542Onychauxis1IKBKG CL E G H8517308300Incontinentia pigmenti syndrome308300C0021171OMIM13265961300248
HP:0001805HP:0008401Onychogryposis of toenails1IKBKG CL E G H8517308300Incontinentia pigmenti syndrome308300C0021171OMIM13265961300248
HP:0001805HP:0040036Onychogryposis of fingernail1IKBKG CL E G H8517308300Incontinentia pigmenti syndrome308300C0021171OMIM13375961300248
HP:0001805HP:0040036Onychogryposis of fingernail1IKBKG CL E G H8517308300Incontinentia pigmenti syndrome308300C0021171OMIM13265961300248
HP:0001805HP:0012542Onychauxis1IKBKG CL E G H8517308300Incontinentia pigmenti syndrome308300C0021171OMIM13375961300248
HP:0001805HP:0008401Onychogryposis of toenails1IKBKG CL E G H8517308300Incontinentia pigmenti syndrome308300C0021171OMIM13375961300248
HP:0001805HP:0008401Onychogryposis of toenails1INSR CL E G H3643769ORPHA15086091147670
HP:0001805HP:0012542Onychauxis1INSR CL E G H3643769ORPHA15086091147670
HP:0001805HP:0040036Onychogryposis of fingernail1INSR CL E G H3643769ORPHA15416091147670
HP:0001805HP:0040036Onychogryposis of fingernail1INSR CL E G H3643769ORPHA15086091147670
HP:0001805HP:0008401Onychogryposis of toenails1INSR CL E G H3643769ORPHA15416091147670
HP:0001805HP:0012542Onychauxis1INSR CL E G H3643769ORPHA15416091147670
HP:0001805HP:0012542Onychauxis1KRT14 CL E G H3861601001Epidermolysis bullosa simplex, autosomal recessive601001C1832926OMIM11486416148066
HP:0001805HP:0008401Onychogryposis of toenails1KRT14 CL E G H3861601001Epidermolysis bullosa simplex, autosomal recessive601001C1832926OMIM11486416148066
HP:0001805HP:0040036Onychogryposis of fingernail1KRT14 CL E G H3861601001Epidermolysis bullosa simplex, autosomal recessive601001C1832926OMIM11556416148066
HP:0001805HP:0040036Onychogryposis of fingernail1KRT14 CL E G H3861601001Epidermolysis bullosa simplex, autosomal recessive601001C1832926OMIM11486416148066
HP:0001805HP:0012542Onychauxis1KRT14 CL E G H3861601001Epidermolysis bullosa simplex, autosomal recessive601001C1832926OMIM11556416148066
HP:0001805HP:0008401Onychogryposis of toenails1KRT14 CL E G H3861601001Epidermolysis bullosa simplex, autosomal recessive601001C1832926OMIM11556416148066
HP:0001805HP:0012542Onychauxis1KRT16 CL E G H38682309Fetal parainfluenza virus type 3 syndromeORPHA1656423148067
HP:0001805HP:0008401Onychogryposis of toenails1KRT16 CL E G H38682309Fetal parainfluenza virus type 3 syndromeORPHA1656423148067
HP:0001805HP:0040036Onychogryposis of fingernail1KRT16 CL E G H38682309Fetal parainfluenza virus type 3 syndromeORPHA1686423148067
HP:0001805HP:0040036Onychogryposis of fingernail1KRT16 CL E G H38682309Fetal parainfluenza virus type 3 syndromeORPHA1656423148067
HP:0001805HP:0012542Onychauxis1KRT16 CL E G H38682309Fetal parainfluenza virus type 3 syndromeORPHA1686423148067
HP:0001805HP:0008401Onychogryposis of toenails1KRT16 CL E G H38682309Fetal parainfluenza virus type 3 syndromeORPHA1686423148067
HP:0001805HP:0012542Onychauxis1KRT16 CL E G H3868167200Pachyonychia congenita 1167200C1706595OMIM1656423148067
HP:0001805HP:0008401Onychogryposis of toenails1KRT16 CL E G H3868167200Pachyonychia congenita 1167200C1706595OMIM1656423148067
HP:0001805HP:0040036Onychogryposis of fingernail1KRT16 CL E G H3868167200Pachyonychia congenita 1167200C1706595OMIM1686423148067
HP:0001805HP:0040036Onychogryposis of fingernail1KRT16 CL E G H3868167200Pachyonychia congenita 1167200C1706595OMIM1656423148067
HP:0001805HP:0012542Onychauxis1KRT16 CL E G H3868167200Pachyonychia congenita 1167200C1706595OMIM1686423148067
HP:0001805HP:0008401Onychogryposis of toenails1KRT16 CL E G H3868167200Pachyonychia congenita 1167200C1706595OMIM1686423148067
HP:0001805HP:0012542Onychauxis1KRT17 CL E G H38722309Fetal parainfluenza virus type 3 syndromeORPHA1546427148069
HP:0001805HP:0008401Onychogryposis of toenails1KRT17 CL E G H38722309Fetal parainfluenza virus type 3 syndromeORPHA1546427148069
HP:0001805HP:0040036Onychogryposis of fingernail1KRT17 CL E G H38722309Fetal parainfluenza virus type 3 syndromeORPHA1596427148069
HP:0001805HP:0040036Onychogryposis of fingernail1KRT17 CL E G H38722309Fetal parainfluenza virus type 3 syndromeORPHA1546427148069
HP:0001805HP:0012542Onychauxis1KRT17 CL E G H38722309Fetal parainfluenza virus type 3 syndromeORPHA1596427148069
HP:0001805HP:0008401Onychogryposis of toenails1KRT17 CL E G H38722309Fetal parainfluenza virus type 3 syndromeORPHA1596427148069
HP:0001805HP:0008401Onychogryposis of toenails1KRT5 CL E G H3852131960Epidermolysis bullosa simplex with mottled pigmentation131960C0432316OMIM12416442148040
HP:0001805HP:0012542Onychauxis1KRT5 CL E G H3852131960Epidermolysis bullosa simplex with mottled pigmentation131960C0432316OMIM12416442148040
HP:0001805HP:0040036Onychogryposis of fingernail1KRT5 CL E G H3852131960Epidermolysis bullosa simplex with mottled pigmentation131960C0432316OMIM12526442148040
HP:0001805HP:0040036Onychogryposis of fingernail1KRT5 CL E G H3852131960Epidermolysis bullosa simplex with mottled pigmentation131960C0432316OMIM12416442148040
HP:0001805HP:0012542Onychauxis1KRT5 CL E G H3852131960Epidermolysis bullosa simplex with mottled pigmentation131960C0432316OMIM12526442148040
HP:0001805HP:0008401Onychogryposis of toenails1KRT5 CL E G H3852131960Epidermolysis bullosa simplex with mottled pigmentation131960C0432316OMIM12526442148040
HP:0001805HP:0012542Onychauxis1KRT5 CL E G H3852601001Epidermolysis bullosa simplex, autosomal recessive601001C1832926OMIM12416442148040
HP:0001805HP:0008401Onychogryposis of toenails1KRT5 CL E G H3852601001Epidermolysis bullosa simplex, autosomal recessive601001C1832926OMIM12416442148040
HP:0001805HP:0040036Onychogryposis of fingernail1KRT5 CL E G H3852601001Epidermolysis bullosa simplex, autosomal recessive601001C1832926OMIM12526442148040
HP:0001805HP:0040036Onychogryposis of fingernail1KRT5 CL E G H3852601001Epidermolysis bullosa simplex, autosomal recessive601001C1832926OMIM12416442148040
HP:0001805HP:0012542Onychauxis1KRT5 CL E G H3852601001Epidermolysis bullosa simplex, autosomal recessive601001C1832926OMIM12526442148040
HP:0001805HP:0008401Onychogryposis of toenails1KRT5 CL E G H3852601001Epidermolysis bullosa simplex, autosomal recessive601001C1832926OMIM12526442148040
HP:0001805HP:0012542Onychauxis1KRT6A CL E G H38532309Fetal parainfluenza virus type 3 syndromeORPHA1776443148041
HP:0001805HP:0008401Onychogryposis of toenails1KRT6A CL E G H38532309Fetal parainfluenza virus type 3 syndromeORPHA1776443148041
HP:0001805HP:0040036Onychogryposis of fingernail1KRT6A CL E G H38532309Fetal parainfluenza virus type 3 syndromeORPHA1786443148041
HP:0001805HP:0040036Onychogryposis of fingernail1KRT6A CL E G H38532309Fetal parainfluenza virus type 3 syndromeORPHA1776443148041
HP:0001805HP:0012542Onychauxis1KRT6A CL E G H38532309Fetal parainfluenza virus type 3 syndromeORPHA1786443148041
HP:0001805HP:0008401Onychogryposis of toenails1KRT6A CL E G H38532309Fetal parainfluenza virus type 3 syndromeORPHA1786443148041
HP:0001805HP:0012542Onychauxis1KRT6B CL E G H38542309Fetal parainfluenza virus type 3 syndromeORPHA1386444148042
HP:0001805HP:0008401Onychogryposis of toenails1KRT6B CL E G H38542309Fetal parainfluenza virus type 3 syndromeORPHA1386444148042
HP:0001805HP:0040036Onychogryposis of fingernail1KRT6B CL E G H38542309Fetal parainfluenza virus type 3 syndromeORPHA1396444148042
HP:0001805HP:0040036Onychogryposis of fingernail1KRT6B CL E G H38542309Fetal parainfluenza virus type 3 syndromeORPHA1386444148042
HP:0001805HP:0012542Onychauxis1KRT6B CL E G H38542309Fetal parainfluenza virus type 3 syndromeORPHA1396444148042
HP:0001805HP:0008401Onychogryposis of toenails1KRT6B CL E G H38542309Fetal parainfluenza virus type 3 syndromeORPHA1396444148042
HP:0001805HP:0012542Onychauxis1PLEC CL E G H533979401ORPHA133559069601282
HP:0001805HP:0008401Onychogryposis of toenails1PLEC CL E G H533979401ORPHA133559069601282
HP:0001805HP:0040036Onychogryposis of fingernail1PLEC CL E G H533979401ORPHA138429069601282
HP:0001805HP:0040036Onychogryposis of fingernail1PLEC CL E G H533979401ORPHA133559069601282
HP:0001805HP:0012542Onychauxis1PLEC CL E G H533979401ORPHA138429069601282
HP:0001805HP:0008401Onychogryposis of toenails1PLEC CL E G H533979401ORPHA138429069601282
HP:0001805HP:0012542Onychauxis1SLURP1 CL E G H5715287503ORPHA18018746606119
HP:0001805HP:0008401Onychogryposis of toenails1SLURP1 CL E G H5715287503ORPHA18018746606119
HP:0001805HP:0040036Onychogryposis of fingernail1SLURP1 CL E G H5715287503ORPHA18118746606119
HP:0001805HP:0040036Onychogryposis of fingernail1SLURP1 CL E G H5715287503ORPHA18018746606119
HP:0001805HP:0012542Onychauxis1SLURP1 CL E G H5715287503ORPHA18118746606119
HP:0001805HP:0008401Onychogryposis of toenails1SLURP1 CL E G H5715287503ORPHA18118746606119
HP:0001805HP:0012542Onychauxis1TP63 CL E G H8626129400Rapp-Hodgkin ectodermal dysplasia syndrome129400C1785148OMIM137615979603273
HP:0001805HP:0008401Onychogryposis of toenails1TP63 CL E G H8626129400Rapp-Hodgkin ectodermal dysplasia syndrome129400C1785148OMIM137615979603273
HP:0001805HP:0040036Onychogryposis of fingernail1TP63 CL E G H8626129400Rapp-Hodgkin ectodermal dysplasia syndrome129400C1785148OMIM144415979603273
HP:0001805HP:0040036Onychogryposis of fingernail1TP63 CL E G H8626129400Rapp-Hodgkin ectodermal dysplasia syndrome129400C1785148OMIM137615979603273
HP:0001805HP:0012542Onychauxis1TP63 CL E G H8626129400Rapp-Hodgkin ectodermal dysplasia syndrome129400C1785148OMIM144415979603273
HP:0001805HP:0008401Onychogryposis of toenails1TP63 CL E G H8626129400Rapp-Hodgkin ectodermal dysplasia syndrome129400C1785148OMIM144415979603273
HP:0001805HP:0012542Onychauxis1ZSWIM6 CL E G H57688603671Acromelic frontonasal dysostosis603671C1863616OMIM111629316615951
HP:0001805HP:0008401Onychogryposis of toenails1ZSWIM6 CL E G H57688603671Acromelic frontonasal dysostosis603671C1863616OMIM111629316615951
HP:0001805HP:0040036Onychogryposis of fingernail1ZSWIM6 CL E G H57688603671Acromelic frontonasal dysostosis603671C1863616OMIM125829316615951
HP:0001805HP:0040036Onychogryposis of fingernail1ZSWIM6 CL E G H57688603671Acromelic frontonasal dysostosis603671C1863616OMIM111629316615951
HP:0001805HP:0012542Onychauxis1ZSWIM6 CL E G H57688603671Acromelic frontonasal dysostosis603671C1863616OMIM125829316615951
HP:0001805HP:0008401Onychogryposis of toenails1ZSWIM6 CL E G H57688603671Acromelic frontonasal dysostosis603671C1863616OMIM125829316615951
 
HPO disease - gene - phenotype less frequent non-typical associations:
HP:0001805HP:0001805Onychogryposis0LOR CL E G H401479395ORPHA06663152445
HP:0001805HP:0012542Onychauxis1LOR CL E G H401479395ORPHA06663152445
HP:0001805HP:0008401Onychogryposis of toenails1LOR CL E G H401479395ORPHA06663152445
HP:0001805HP:0040036Onychogryposis of fingernail1LOR CL E G H401479395ORPHA06663152445


Genes (21) :ADAM17 CTSC DVL1 DVL3 FZD2 FZD6 GJB6 IKBKG INSR KRT14 KRT16 KRT17 KRT5 KRT6A KRT6B LOR PLEC SLURP1 TP63 WNT5A ZSWIM6

Diseases (19) :614328 245010 189 308300 769 601001 2309 167200 131960 79395 79401 87503 129400 603671 3107 614157 262190 615726 131950
 

Human Phenotype Ontology(HPO) is developed by the Human Phenotype Ontology Consortium. The version used here is August 2021 release.