Human Phenotype Ontology

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Examples Gene: MT-ND1, POLG, Region: M:1-1000 Variant: m.8993T>G, 1:g.10042757T>C rs3888511 MSCV_0000006, ClinVar: RCV000000015, Disease: Leigh syndrome, Phenotype: Retinopathy

Grandparent Node:
Abnormal EKG (HP:0003115)

Parent Node:
Abnormal QT interval (HP:0031547)

..Starting node
..Prolonged QT interval (HP:0001657)

Term ID:

1657

Name:

Prolonged QT interval

Synonym:

Long Q-T syndrome; Long QT syndrome; Prolong qt interval on ekg

Definition:

Increased time between the start of the Q wave and the end of the T wave as measured by the electrocardiogram (EKG).

Comments:

Reference:

HP:0001657

Genes and Diseases:

Child Nodes:

........

Prolonged QTc interval (HP:0005184)

Sister Nodes:

Shortened QT interval (HP:0012232)

Input	HPO ID	HPO term	Distance	Gene	Gene id entrez	HGNC ID	DiseaseId	DiseaseName	Frequency	ClinVar variants
HPO disease - gene - phenotype typical associations:
HPO disease - gene - phenotype less frequent non-typical associations:
HP:0001657	HP:0001657	Prolonged QT interval	0	ACADVL CL E G H	37	92	ORPHA:26793	Very long chain acyl-CoA dehydrogenase deficiency	HP:0040284 - Very rare	200
HP:0001657	HP:0001657	Prolonged QT interval	0	AKAP9 CL E G H	10142	379	OMIM:611820	Long QT syndrome 11	.	289
HP:0001657	HP:0001657	Prolonged QT interval	0	AKAP9 CL E G H	10142	379	ORPHA:101016	Romano-Ward syndrome		289
HP:0001657	HP:0001657	Prolonged QT interval	0	ALG10B CL E G H	144245	31088	OMIM:613688	Long QT syndrome 2	.	3
HP:0001657	HP:0001657	Prolonged QT interval	0	ALPK3 CL E G H	57538	17574	OMIM:618052	Cardiomyopathy, familial hypertrophic 27	.	89
HP:0001657	HP:0001657	Prolonged QT interval	0	ANK2 CL E G H	287	493	OMIM:600919	Cardiac arrhythmia, ankyrin-b-related	.	539
HP:0001657	HP:0001657	Prolonged QT interval	0	ANK2 CL E G H	287	493	ORPHA:101016	Romano-Ward syndrome		539
HP:0001657	HP:0001657	Prolonged QT interval	0	BPTF CL E G H	2186	3581	ORPHA:529962	17q24.2 microdeletion syndrome	HP:0040283 - Occasional	2
HP:0001657	HP:0001657	Prolonged QT interval	0	CACNA1C CL E G H	775	1390	OMIM:620029			572
HP:0001657	HP:0001657	Prolonged QT interval	0	CACNA1C CL E G H	775	1390	OMIM:618447	LONG QT SYNDROME 8; LQT8		572
HP:0001657	HP:0001657	Prolonged QT interval	0	CACNA1C CL E G H	775	1390	ORPHA:101016	Romano-Ward syndrome		572
HP:0001657	HP:0001657	Prolonged QT interval	0	CACNA1C CL E G H	775	1390	OMIM:601005	Timothy syndrome	.	572
HP:0001657	HP:0001657	Prolonged QT interval	0	CACNA1S CL E G H	779	1397	ORPHA:79102	Thyrotoxic periodic paralysis	HP:0040283 - Occasional	247
HP:0001657	HP:0001657	Prolonged QT interval	0	CALM1 CL E G H	801	1442	OMIM:616247	Long QT syndrome 14	.	18
HP:0001657	HP:0001657	Prolonged QT interval	0	CALM1 CL E G H	801	1442	ORPHA:101016	Romano-Ward syndrome		18
HP:0001657	HP:0001657	Prolonged QT interval	0	CALM2 CL E G H	805	1445	OMIM:616249	Long QT syndrome 15	.	13
HP:0001657	HP:0001657	Prolonged QT interval	0	CALM2 CL E G H	805	1445	ORPHA:101016	Romano-Ward syndrome		13
HP:0001657	HP:0001657	Prolonged QT interval	0	CALM3 CL E G H	808	1449	OMIM:618782	LONG QT SYNDROME 16; LQT16		16
HP:0001657	HP:0001657	Prolonged QT interval	0	CALM3 CL E G H	808	1449	ORPHA:101016	Romano-Ward syndrome		16
HP:0001657	HP:0001657	Prolonged QT interval	0	CAV3 CL E G H	859	1529	OMIM:611818	Long QT syndrome 9		148
HP:0001657	HP:0001657	Prolonged QT interval	0	CAV3 CL E G H	859	1529	ORPHA:101016	Romano-Ward syndrome		148
HP:0001657	HP:0001657	Prolonged QT interval	0	CAVIN1 CL E G H	284119	9688	OMIM:613327	Lipodystrophy, congenital generalized, type 4	.	48
HP:0001657	HP:0001657	Prolonged QT interval	0	CLCNKB CL E G H	1188	2027	ORPHA:358	Gitelman syndrome	HP:0040282 - Frequent	27
HP:0001657	HP:0001657	Prolonged QT interval	0	DNAJC19 CL E G H	131118	30528	OMIM:610198	3-@methylglutaconic aciduria, type V	.	25
HP:0001657	HP:0001657	Prolonged QT interval	0	DNAJC19 CL E G H	131118	30528	ORPHA:66634	Dilated cardiomyopathy with ataxia	HP:0040282 - Frequent	25
HP:0001657	HP:0001657	Prolonged QT interval	0	DPAGT1 CL E G H	1798	2995	ORPHA:86309	DPAGT1-CDG	HP:0040283 - Occasional	38
HP:0001657	HP:0001657	Prolonged QT interval	0	FLNC CL E G H	2318	3756	OMIM:617047	Cardiomyopathy, familial hypertrophic, 26		197
HP:0001657	HP:0001657	Prolonged QT interval	0	GABRA3 CL E G H	2556	4077	ORPHA:79102	Thyrotoxic periodic paralysis	HP:0040283 - Occasional
HP:0001657	HP:0001657	Prolonged QT interval	0	GMPPB CL E G H	29925	22932	OMIM:615351	MUSCULAR DYSTROPHY-DYSTROGLYCANOPATHY (CONGENITAL WITH MENTAL RETARDATION), TYPE B, 14	HP:0040283 - Occasional	34
HP:0001657	HP:0001657	Prolonged QT interval	0	GNAS CL E G H	2778	4392	ORPHA:79443	Pseudohypoparathyroidism type 1A	HP:0040283 - Occasional	101
HP:0001657	HP:0001657	Prolonged QT interval	0	GNAS CL E G H	2778	4392	ORPHA:94089	Pseudohypoparathyroidism type 1B	HP:0040283 - Occasional	101
HP:0001657	HP:0001657	Prolonged QT interval	0	GNAS CL E G H	2778	4392	ORPHA:79444	Pseudohypoparathyroidism type 1C	HP:0040283 - Occasional	101
HP:0001657	HP:0001657	Prolonged QT interval	0	GPC3 CL E G H	2719	4451	ORPHA:373	Simpson-Golabi-Behmel syndrome	HP:0040282 - Frequent	73
HP:0001657	HP:0001657	Prolonged QT interval	0	GPC4 CL E G H	2239	4452	ORPHA:373	Simpson-Golabi-Behmel syndrome	HP:0040282 - Frequent
HP:0001657	HP:0001657	Prolonged QT interval	0	HADH CL E G H	3033	4799	ORPHA:71212	Hyperinsulinism due to short chain 3-hydroxylacyl-CoA dehydrogenase deficiency	HP:0040284 - Very rare	41
HP:0001657	HP:0001657	Prolonged QT interval	0	HCN4 CL E G H	10021	16882	OMIM:163800	Sick sinus syndrome 2		185
HP:0001657	HP:0001657	Prolonged QT interval	0	KCNA5 CL E G H	3741	6224	OMIM:612240	Atrial fibrillation, familial, 7		38
HP:0001657	HP:0001657	Prolonged QT interval	0	KCND3 CL E G H	3752	6239	OMIM:616399	Brugada syndrome 9		35
HP:0001657	HP:0001657	Prolonged QT interval	0	KCNE1 CL E G H	3753	6240	ORPHA:90647	Jervell and Lange-Nielsen syndrome		148
HP:0001657	HP:0001657	Prolonged QT interval	0	KCNE1 CL E G H	3753	6240	OMIM:612347	Jervell and lange-nielsen syndrome 2	.	148
HP:0001657	HP:0001657	Prolonged QT interval	0	KCNE1 CL E G H	3753	6240	OMIM:613695	Long QT syndrome 5	.	148
HP:0001657	HP:0001657	Prolonged QT interval	0	KCNE1 CL E G H	3753	6240	ORPHA:101016	Romano-Ward syndrome		148
HP:0001657	HP:0001657	Prolonged QT interval	0	KCNE2 CL E G H	9992	6242	OMIM:613693	Long QT syndrome 6	.	43
HP:0001657	HP:0001657	Prolonged QT interval	0	KCNE2 CL E G H	9992	6242	ORPHA:101016	Romano-Ward syndrome		43
HP:0001657	HP:0001657	Prolonged QT interval	0	KCNH2 CL E G H	3757	6251	OMIM:613688	Long QT syndrome 2	.	901
HP:0001657	HP:0001657	Prolonged QT interval	0	KCNH2 CL E G H	3757	6251	ORPHA:101016	Romano-Ward syndrome		901
HP:0001657	HP:0001657	Prolonged QT interval	0	KCNJ18 CL E G H	100134444	39080	ORPHA:79102	Thyrotoxic periodic paralysis	HP:0040283 - Occasional	10
HP:0001657	HP:0001657	Prolonged QT interval	0	KCNJ2 CL E G H	3759	6263	OMIM:170390	Andersen cardiodysrhythmic periodic paralysis	.	193
HP:0001657	HP:0001657	Prolonged QT interval	0	KCNJ2 CL E G H	3759	6263	ORPHA:37553	Andersen-Tawil syndrome	HP:0040282 - Frequent	193
HP:0001657	HP:0001657	Prolonged QT interval	0	KCNJ5 CL E G H	3762	6266	ORPHA:37553	Andersen-Tawil syndrome	HP:0040282 - Frequent	128
HP:0001657	HP:0001657	Prolonged QT interval	0	KCNJ5 CL E G H	3762	6266	ORPHA:251274	Familial hyperaldosteronism type III	HP:0040283 - Occasional	128
HP:0001657	HP:0001657	Prolonged QT interval	0	KCNJ5 CL E G H	3762	6266	OMIM:613485	Long QT syndrome 13	.	128
HP:0001657	HP:0001657	Prolonged QT interval	0	KCNJ5 CL E G H	3762	6266	ORPHA:101016	Romano-Ward syndrome		128
HP:0001657	HP:0001657	Prolonged QT interval	0	KCNQ1 CL E G H	3784	6294	OMIM:607554	Atrial fibrillation, familial, 3		730
HP:0001657	HP:0001657	Prolonged QT interval	0	KCNQ1 CL E G H	3784	6294	ORPHA:90647	Jervell and Lange-Nielsen syndrome		730
HP:0001657	HP:0001657	Prolonged QT interval	0	KCNQ1 CL E G H	3784	6294	OMIM:220400	Jervell and lange-nielsen syndrome 1	.	730
HP:0001657	HP:0001657	Prolonged QT interval	0	KCNQ1 CL E G H	3784	6294	OMIM:192500	LONG QT SYNDROME 1; LQT1		730
HP:0001657	HP:0001657	Prolonged QT interval	0	KCNQ1 CL E G H	3784	6294	ORPHA:101016	Romano-Ward syndrome		730
HP:0001657	HP:0001657	Prolonged QT interval	0	MECP2 CL E G H	4204	6990	OMIM:312750	Rett syndrome		950
HP:0001657	HP:0001657	Prolonged QT interval	0	NOS1AP CL E G H	9722	16859	ORPHA:101016	Romano-Ward syndrome		4
HP:0001657	HP:0001657	Prolonged QT interval	0	PHOX2B CL E G H	8929	9143	ORPHA:2151	Hirschsprung disease-ganglioneuroblastoma syndrome	HP:0040281 - Very frequent	86
HP:0001657	HP:0001657	Prolonged QT interval	0	PSMD12 CL E G H	5718	9557	ORPHA:529962	17q24.2 microdeletion syndrome	HP:0040283 - Occasional	4
HP:0001657	HP:0001657	Prolonged QT interval	0	RYR1 CL E G H	6261	10483	ORPHA:466650	Exercise-induced malignant hyperthermia	HP:0040283 - Occasional	1200
HP:0001657	HP:0001657	Prolonged QT interval	0	SCN10A CL E G H	6336	10582	ORPHA:101016	Romano-Ward syndrome		146
HP:0001657	HP:0001657	Prolonged QT interval	0	SCN4B CL E G H	6330	10592	OMIM:611819	Long QT syndrome 10		110
HP:0001657	HP:0001657	Prolonged QT interval	0	SCN4B CL E G H	6330	10592	ORPHA:101016	Romano-Ward syndrome		110
HP:0001657	HP:0001657	Prolonged QT interval	0	SCN5A CL E G H	6331	10593	OMIM:603830	Long QT syndrome 3	.	1134
HP:0001657	HP:0001657	Prolonged QT interval	0	SCN5A CL E G H	6331	10593	ORPHA:101016	Romano-Ward syndrome		1134
HP:0001657	HP:0001657	Prolonged QT interval	0	SCN5A CL E G H	6331	10593	OMIM:608567	SICK SINUS SYNDROME 1; SSS1		1134
HP:0001657	HP:0001657	Prolonged QT interval	0	SLC12A3 CL E G H	6559	10912	ORPHA:358	Gitelman syndrome	HP:0040282 - Frequent	145
HP:0001657	HP:0001657	Prolonged QT interval	0	SLC12A3 CL E G H	6559	10912	OMIM:263800	Gitelman syndrome		145
HP:0001657	HP:0001657	Prolonged QT interval	0	SLC6A8 CL E G H	6535	11055	OMIM:300352	Creatine deficiency syndrome, X-linked		122
HP:0001657	HP:0001657	Prolonged QT interval	0	SNTA1 CL E G H	6640	11167	OMIM:612955	Long QT syndrome 12		118
HP:0001657	HP:0001657	Prolonged QT interval	0	SNTA1 CL E G H	6640	11167	ORPHA:101016	Romano-Ward syndrome		118
HP:0001657	HP:0001657	Prolonged QT interval	0	SRY CL E G H	6736	11311	ORPHA:1772	45,X/46,XY mixed gonadal dysgenesis	HP:0040283 - Occasional	23
HP:0001657	HP:0001657	Prolonged QT interval	0	STX16 CL E G H	8675	11431	ORPHA:94089	Pseudohypoparathyroidism type 1B	HP:0040283 - Occasional	86
HP:0001657	HP:0001657	Prolonged QT interval	0	SVIL CL E G H	6840	11480	OMIM:619040	MYOFIBRILLAR MYOPATHY 10; MFM10		1
HP:0001657	HP:0001657	Prolonged QT interval	0	TANGO2 CL E G H	128989	25439	OMIM:616878	Metabolic encephalomyopathic crises, recurrent, with rhabdomyolysis, cardiac arrhythmias, and neurodegeneration		12
HP:0001657	HP:0001657	Prolonged QT interval	0	TANGO2 CL E G H	128989	25439	ORPHA:480864	Recurrent metabolic encephalomyopathic crises-rhabdomyolysis-cardiac arrhythmia-intellectual disability syndrome	HP:0040282 - Frequent	12
HP:0001657	HP:0001657	Prolonged QT interval	0	TBX5 CL E G H	6910	11604	ORPHA:101016	Romano-Ward syndrome		123
HP:0001657	HP:0001657	Prolonged QT interval	0	TECRL CL E G H	253017	27365	OMIM:614021	Ventricular tachycardia, catecholaminergic polymorphic, 3	.	4
HP:0001657	HP:0001657	Prolonged QT interval	0	TNNI3K CL E G H	51086	19661	OMIM:616117	Cardiac conduction disease with or without dilated cardiomyopathy		1
HP:0001657	HP:0001657	Prolonged QT interval	0	TNNT2 CL E G H	7139	11949	OMIM:601494	Cardiomyopathy, dilated, 1D		248
HP:0001657	HP:0001657	Prolonged QT interval	0	TRDN CL E G H	10345	12261	ORPHA:101016	Romano-Ward syndrome		145
HP:0001657	HP:0001657	Prolonged QT interval	0	TRPM4 CL E G H	54795	17993	OMIM:604559	Progressive familial heart block, type IB	.	124
HP:0001657	HP:0005184	Prolonged QTc interval	1	AKAP9 CL E G H	10142	379	OMIM:611820	Long QT syndrome 11		289
HP:0001657	HP:0005184	Prolonged QTc interval	1	AKAP9 CL E G H	10142	379	ORPHA:101016	Romano-Ward syndrome	HP:0040280 - Obligate	289
HP:0001657	HP:0005184	Prolonged QTc interval	1	ALG10B CL E G H	144245	31088	OMIM:613688	Long QT syndrome 2		3
HP:0001657	HP:0005184	Prolonged QTc interval	1	ANK2 CL E G H	287	493	ORPHA:101016	Romano-Ward syndrome	HP:0040280 - Obligate	539
HP:0001657	HP:0005184	Prolonged QTc interval	1	CACNA1C CL E G H	775	1390	OMIM:618447	LONG QT SYNDROME 8; LQT8		572
HP:0001657	HP:0005184	Prolonged QTc interval	1	CACNA1C CL E G H	775	1390	ORPHA:101016	Romano-Ward syndrome	HP:0040280 - Obligate	572
HP:0001657	HP:0005184	Prolonged QTc interval	1	CALM1 CL E G H	801	1442	OMIM:616247	Long QT syndrome 14		18
HP:0001657	HP:0005184	Prolonged QTc interval	1	CALM1 CL E G H	801	1442	ORPHA:101016	Romano-Ward syndrome	HP:0040280 - Obligate	18
HP:0001657	HP:0005184	Prolonged QTc interval	1	CALM2 CL E G H	805	1445	OMIM:616249	Long QT syndrome 15	.	13
HP:0001657	HP:0005184	Prolonged QTc interval	1	CALM2 CL E G H	805	1445	ORPHA:101016	Romano-Ward syndrome	HP:0040280 - Obligate	13
HP:0001657	HP:0005184	Prolonged QTc interval	1	CALM3 CL E G H	808	1449	OMIM:618782	LONG QT SYNDROME 16; LQT16		16
HP:0001657	HP:0005184	Prolonged QTc interval	1	CALM3 CL E G H	808	1449	ORPHA:101016	Romano-Ward syndrome	HP:0040280 - Obligate	16
HP:0001657	HP:0005184	Prolonged QTc interval	1	CAV3 CL E G H	859	1529	ORPHA:101016	Romano-Ward syndrome	HP:0040280 - Obligate	148
HP:0001657	HP:0005184	Prolonged QTc interval	1	FLNC CL E G H	2318	3756	OMIM:617047	Cardiomyopathy, familial hypertrophic, 26		197
HP:0001657	HP:0005184	Prolonged QTc interval	1	HCN4 CL E G H	10021	16882	OMIM:163800	Sick sinus syndrome 2		185
HP:0001657	HP:0005184	Prolonged QTc interval	1	KCNA5 CL E G H	3741	6224	OMIM:612240	Atrial fibrillation, familial, 7	HP:0040283 - Occasional	38
HP:0001657	HP:0005184	Prolonged QTc interval	1	KCNE1 CL E G H	3753	6240	ORPHA:90647	Jervell and Lange-Nielsen syndrome	HP:0040281 - Very frequent	148
HP:0001657	HP:0005184	Prolonged QTc interval	1	KCNE1 CL E G H	3753	6240	OMIM:613695	Long QT syndrome 5		148
HP:0001657	HP:0005184	Prolonged QTc interval	1	KCNE1 CL E G H	3753	6240	ORPHA:101016	Romano-Ward syndrome	HP:0040280 - Obligate	148
HP:0001657	HP:0005184	Prolonged QTc interval	1	KCNE2 CL E G H	9992	6242	OMIM:613693	Long QT syndrome 6		43
HP:0001657	HP:0005184	Prolonged QTc interval	1	KCNE2 CL E G H	9992	6242	ORPHA:101016	Romano-Ward syndrome	HP:0040280 - Obligate	43
HP:0001657	HP:0005184	Prolonged QTc interval	1	KCNH2 CL E G H	3757	6251	OMIM:613688	Long QT syndrome 2		901
HP:0001657	HP:0005184	Prolonged QTc interval	1	KCNH2 CL E G H	3757	6251	ORPHA:101016	Romano-Ward syndrome	HP:0040280 - Obligate	901
HP:0001657	HP:0005184	Prolonged QTc interval	1	KCNJ2 CL E G H	3759	6263	OMIM:170390	Andersen cardiodysrhythmic periodic paralysis		193
HP:0001657	HP:0005184	Prolonged QTc interval	1	KCNJ2 CL E G H	3759	6263	ORPHA:37553	Andersen-Tawil syndrome	HP:0040283 - Occasional	193
HP:0001657	HP:0005184	Prolonged QTc interval	1	KCNJ5 CL E G H	3762	6266	ORPHA:37553	Andersen-Tawil syndrome	HP:0040283 - Occasional	128
HP:0001657	HP:0005184	Prolonged QTc interval	1	KCNJ5 CL E G H	3762	6266	OMIM:613485	Long QT syndrome 13		128
HP:0001657	HP:0005184	Prolonged QTc interval	1	KCNJ5 CL E G H	3762	6266	ORPHA:101016	Romano-Ward syndrome	HP:0040280 - Obligate	128
HP:0001657	HP:0005184	Prolonged QTc interval	1	KCNQ1 CL E G H	3784	6294	OMIM:607554	Atrial fibrillation, familial, 3		730
HP:0001657	HP:0005184	Prolonged QTc interval	1	KCNQ1 CL E G H	3784	6294	ORPHA:90647	Jervell and Lange-Nielsen syndrome	HP:0040281 - Very frequent	730
HP:0001657	HP:0005184	Prolonged QTc interval	1	KCNQ1 CL E G H	3784	6294	OMIM:220400	Jervell and lange-nielsen syndrome 1		730
HP:0001657	HP:0005184	Prolonged QTc interval	1	KCNQ1 CL E G H	3784	6294	OMIM:192500	LONG QT SYNDROME 1; LQT1		730
HP:0001657	HP:0005184	Prolonged QTc interval	1	KCNQ1 CL E G H	3784	6294	ORPHA:101016	Romano-Ward syndrome	HP:0040280 - Obligate	730
HP:0001657	HP:0005184	Prolonged QTc interval	1	MECP2 CL E G H	4204	6990	OMIM:312750	Rett syndrome	.	950
HP:0001657	HP:0005184	Prolonged QTc interval	1	NOS1AP CL E G H	9722	16859	ORPHA:101016	Romano-Ward syndrome	HP:0040280 - Obligate	4
HP:0001657	HP:0005184	Prolonged QTc interval	1	SCN10A CL E G H	6336	10582	ORPHA:101016	Romano-Ward syndrome	HP:0040280 - Obligate	146
HP:0001657	HP:0005184	Prolonged QTc interval	1	SCN4B CL E G H	6330	10592	ORPHA:101016	Romano-Ward syndrome	HP:0040280 - Obligate	110
HP:0001657	HP:0005184	Prolonged QTc interval	1	SCN5A CL E G H	6331	10593	OMIM:603830	Long QT syndrome 3		1134
HP:0001657	HP:0005184	Prolonged QTc interval	1	SCN5A CL E G H	6331	10593	ORPHA:101016	Romano-Ward syndrome	HP:0040280 - Obligate	1134
HP:0001657	HP:0005184	Prolonged QTc interval	1	SNTA1 CL E G H	6640	11167	OMIM:612955	Long QT syndrome 12		118
HP:0001657	HP:0005184	Prolonged QTc interval	1	SNTA1 CL E G H	6640	11167	ORPHA:101016	Romano-Ward syndrome	HP:0040280 - Obligate	118
HP:0001657	HP:0005184	Prolonged QTc interval	1	SVIL CL E G H	6840	11480	OMIM:619040	MYOFIBRILLAR MYOPATHY 10; MFM10		1
HP:0001657	HP:0005184	Prolonged QTc interval	1	TANGO2 CL E G H	128989	25439	OMIM:616878	Metabolic encephalomyopathic crises, recurrent, with rhabdomyolysis, cardiac arrhythmias, and neurodegeneration		12
HP:0001657	HP:0005184	Prolonged QTc interval	1	TBX5 CL E G H	6910	11604	ORPHA:101016	Romano-Ward syndrome	HP:0040280 - Obligate	123
HP:0001657	HP:0005184	Prolonged QTc interval	1	TNNI3K CL E G H	51086	19661	OMIM:616117	Cardiac conduction disease with or without dilated cardiomyopathy	.	1
HP:0001657	HP:0005184	Prolonged QTc interval	1	TRDN CL E G H	10345	12261	ORPHA:101016	Romano-Ward syndrome	HP:0040280 - Obligate	145

Genes (54) :ACADVL AKAP9 ALG10B ALPK3 ANK2 BPTF CACNA1C CACNA1S CALM1 CALM2 CALM3 CAV3 CAVIN1 CLCNKB DNAJC19 DPAGT1 FLNC GABRA3 GMPPB GNAS GPC3 GPC4 HADH HCN4 KCNA5 KCND3 KCNE1 KCNE2 KCNH2 KCNJ18 KCNJ2 KCNJ5 KCNQ1 MECP2 NOS1AP PHOX2B PSMD12 RYR1 SCN10A SCN4B SCN5A SLC12A3 SLC6A8 SNTA1 SRY STX16 SVIL TANGO2 TBX5 TECRL TNNI3K TNNT2 TRDN TRPM4

Diseases (58) :ORPHA:26793 OMIM:611820 ORPHA:101016 OMIM:613688 OMIM:618052 OMIM:600919 ORPHA:529962 OMIM:620029 OMIM:618447 OMIM:601005 ORPHA:79102 OMIM:616247 OMIM:616249 OMIM:618782 OMIM:611818 OMIM:613327 ORPHA:358 OMIM:610198 ORPHA:66634 ORPHA:86309 OMIM:617047 OMIM:615351 ORPHA:79443 ORPHA:94089 ORPHA:79444 ORPHA:373 ORPHA:71212 OMIM:163800 OMIM:612240 OMIM:616399 ORPHA:90647 OMIM:612347 OMIM:613695 OMIM:613693 OMIM:170390 ORPHA:37553 ORPHA:251274 OMIM:613485 OMIM:607554 OMIM:220400 OMIM:192500 OMIM:312750 ORPHA:2151 ORPHA:466650 OMIM:611819 OMIM:603830 OMIM:608567 OMIM:263800 OMIM:300352 OMIM:612955 ORPHA:1772 OMIM:619040 OMIM:616878 ORPHA:480864 OMIM:614021 OMIM:616117 OMIM:601494 OMIM:604559

Human Phenotype Ontology(HPO) is developed by the Human Phenotype Ontology Consortium. The version used here is December 15 2022 release.

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