Human Phenotype Ontology 
Grandparent Node:
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Phenotypic abnormality (HP:0000118)help
Parent Node:
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Abnormality of the voice (HP:0001608)help
..Starting node
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Weak voice (HP:0001621)help
Term ID: 1621
Name: Weak voice
Synonym: Hypophonia; Quiet voice; Soft voice; Weak voice
Definition: Reduced intensity (volume) of speech.
Comments:
Reference: HP:0001621
Genes and Diseases:
 
       Child Nodes:

 Sister Nodes: 
..expandAbnormal cry (HP:0025429) help
..expandAbnormal speech prosody (HP:0031434) help
..expandAbnormally low-pitched voice (HP:0010300) help
..expandDysphonia (HP:0001618) help
..expandHigh pitched voice (HP:0001620) help
..expandHoarse voice (HP:0001609) help
..expandHyponasal speech (HP:0100271) help
..expandLoss of voice (HP:0001686) help
..expandNasal speech (HP:0001611) help
..expandSpeech articulation difficulties (HP:0009088) help
..expandVocal cord dysfunction (HP:0031801) help
InputHPO IDHPO termDistanceGeneGene id entrezHGNC IDDiseaseIdDiseaseNameFrequencyOnsetHGMD variantsClinVar variants
 
HPO disease - gene - phenotype typical associations:
 
HPO disease - gene - phenotype less frequent non-typical associations:
HP:0001621HP:0001621Weak voice0ADH1C CL E G H126251OMIM:168600Parkinson disease, late-onset.4
HP:0001621HP:0001621Weak voice0AOPEP CL E G H849091361OMIM:619565DYSTONIA 31; DYT31
HP:0001621HP:0001621Weak voice0ATP6AP2 CL E G H1015918305ORPHA:93952X-linked intellectual disability, Hedera typeHP:0040283 - Occasional36
HP:0001621HP:0001621Weak voice0ATXN2 CL E G H631110555OMIM:168600Parkinson disease, late-onset.11
HP:0001621HP:0001621Weak voice0ATXN8OS CL E G H631510561OMIM:168600Parkinson disease, late-onset.1
HP:0001621HP:0001621Weak voice0DCTN1 CL E G H16392711OMIM:168605Perry syndrome.86
HP:0001621HP:0001621Weak voice0DNAJC6 CL E G H982915469ORPHA:391411Atypical juvenile parkinsonismHP:0040282 - Frequent6
HP:0001621HP:0001621Weak voice0FTL CL E G H25123999ORPHA:157846NeuroferritinopathyHP:0040283 - Occasional33
HP:0001621HP:0001621Weak voice0GARS1 CL E G H26174162OMIM:619042SPINAL MUSCULAR ATROPHY, INFANTILE, JAMES TYPE; SMAJI
HP:0001621HP:0001621Weak voice0GBA1 CL E G H26294177OMIM:168600Parkinson disease, late-onset.
HP:0001621HP:0001621Weak voice0GLUD2 CL E G H27474336OMIM:168600Parkinson disease, late-onset.1
HP:0001621HP:0001621Weak voice0HSPG2 CL E G H33395273ORPHA:800Schwartz-Jampel syndromeHP:0040282 - Frequent345
HP:0001621HP:0001621Weak voice0HSPG2 CL E G H33395273OMIM:255800Schwartz-jampel syndrome, type 1.345
HP:0001621HP:0001621Weak voice0MAPT CL E G H41376893OMIM:168600Parkinson disease, late-onset.140
HP:0001621HP:0001621Weak voice0MAPT CL E G H41376893ORPHA:240094Progressive supranuclear palsy-pure akinesia with gait freezing syndromeHP:0040282 - Frequent140
HP:0001621HP:0001621Weak voice0MATR3 CL E G H97826912ORPHA:600Vocal cord and pharyngeal distal myopathyHP:0040282 - Frequent80
HP:0001621HP:0001621Weak voice0NR4A2 CL E G H49297981OMIM:168600Parkinson disease, late-onset.27
HP:0001621HP:0001621Weak voice0PODXL CL E G H54209171ORPHA:391411Atypical juvenile parkinsonismHP:0040282 - Frequent6
HP:0001621HP:0001621Weak voice0POLG CL E G H54289179ORPHA:254886Autosomal recessive progressive external ophthalmoplegiaHP:0040283 - Occasional464
HP:0001621HP:0001621Weak voice0SLC52A3 CL E G H11327816187OMIM:211530Brown-Vialetto-Van laere syndrome 1.51
HP:0001621HP:0001621Weak voice0SNCAIP CL E G H962711139OMIM:168600Parkinson disease, late-onset.35
HP:0001621HP:0001621Weak voice0SYNJ1 CL E G H886711503ORPHA:391411Atypical juvenile parkinsonismHP:0040282 - Frequent9
HP:0001621HP:0001621Weak voice0SYNJ1 CL E G H886711503OMIM:615530Parkinson disease 20, early-onset.9
HP:0001621HP:0001621Weak voice0SYT2 CL E G H12783311510OMIM:619461MYASTHENIC SYNDROME, CONGENITAL, 7B, PRESYNAPTIC, AUTOSOMAL RECESSIVE; CMS7B4
HP:0001621HP:0001621Weak voice0TBP CL E G H690811588OMIM:168600Parkinson disease, late-onset.7
HP:0001621HP:0001621Weak voice0TK2 CL E G H708411831ORPHA:254886Autosomal recessive progressive external ophthalmoplegiaHP:0040283 - Occasional103
HP:0001621HP:0001621Weak voice0TONSL CL E G H47967801ORPHA:93357SPONASTRIME dysplasiaHP:0040283 - Occasional
HP:0001621HP:0001621Weak voice0TRIM37 CL E G H45917523OMIM:253250Mulibrey nanism78
HP:0001621HP:0001621Weak voice0TRNT CL E G H45767499OMIM:168600Parkinson disease, late-onset.


Genes (26) :ADH1C AOPEP ATP6AP2 ATXN2 ATXN8OS DCTN1 DNAJC6 FTL GARS1 GBA1 GLUD2 HSPG2 MAPT MATR3 NR4A2 PODXL POLG SLC52A3 SNCAIP SYNJ1 SYT2 TBP TK2 TONSL TRIM37 TRNT

Diseases (17) :OMIM:168600 OMIM:619565 ORPHA:93952 OMIM:168605 ORPHA:391411 ORPHA:157846 OMIM:619042 ORPHA:800 OMIM:255800 ORPHA:240094 ORPHA:600 ORPHA:254886 OMIM:211530 OMIM:615530 OMIM:619461 ORPHA:93357 OMIM:253250
 

Human Phenotype Ontology(HPO) is developed by the Human Phenotype Ontology Consortium. The version used here is December 15 2022 release.