Human Phenotype Ontology 
Grandparent Node:
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Morphological central nervous system abnormality (HP:0002011)help
Parent Node:
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Increased inflammatory response (HP:0012649)help
Parent Node:
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Unusual CNS infection (HP:0011450)help
..Starting node
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Meningitis (HP:0001287)help
Term ID: 1287
Name: Meningitis
Synonym:
Definition: Inflammation of the meninges.
Comments:
Reference: HP:0001287
Genes and Diseases:
 
       Child Nodes:
........expandChronic lymphocytic meningitis (HP:0007041) help

 Sister Nodes: 
..expandBrain abscess (HP:0030049) help
..expandInfectious encephalitis (HP:0002383) help
..expandRecurrent meningitis (HP:0006946) help
InputHPO IDHPO termDistanceGeneGene id entrezHGNC IDDiseaseIdDiseaseNameFrequencyOnsetHGMD variantsClinVar variants
 
HPO disease - gene - phenotype typical associations:
 
HPO disease - gene - phenotype less frequent non-typical associations:
HP:0001287HP:0001287Meningitis0ARPC1B CL E G H10095704OMIM:617718Platelet abnormalities with eosinophilia and immune-mediated inflammatory disease
HP:0001287HP:0001287Meningitis0BCL2 CL E G H596990ORPHA:545Follicular lymphomaHP:0040283 - Occasional1
HP:0001287HP:0001287Meningitis0BCL6 CL E G H6041001ORPHA:545Follicular lymphomaHP:0040283 - Occasional1
HP:0001287HP:0001287Meningitis0BLNK CL E G H2976014211ORPHA:33110Autosomal agammaglobulinemiaHP:0040283 - Occasional4
HP:0001287HP:0001287Meningitis0BTK CL E G H6951133OMIM:300755Agammaglobulinemia, X-linked.109
HP:0001287HP:0001287Meningitis0BTK CL E G H6951133OMIM:307200Isolated growth hormone deficiency, type III, with agammaglobulinemia.109
HP:0001287HP:0001287Meningitis0BTK CL E G H6951133ORPHA:47X-linked agammaglobulinemiaHP:0040282 - Frequent109
HP:0001287HP:0001287Meningitis0C4A CL E G H7201323ORPHA:117Behçet diseaseHP:0040281 - Very frequent1
HP:0001287HP:0001287Meningitis0C4B CL E G H7211324OMIM:614379Complement component 4B deficiency.1
HP:0001287HP:0001287Meningitis0C8A CL E G H7311352OMIM:613790Complement component 8 deficiency, type I.9
HP:0001287HP:0001287Meningitis0C8B CL E G H7321353OMIM:613789Complement component 8 deficiency, type II.7
HP:0001287HP:0001287Meningitis0CARD9 CL E G H6417016391OMIM:212050Candidiasis, familial chronic mucocutaneous, autosomal recessiveHP:0040283 - Occasional45
HP:0001287HP:0001287Meningitis0CCR1 CL E G H12301602ORPHA:117Behçet diseaseHP:0040281 - Very frequent
HP:0001287HP:0001287Meningitis0CD19 CL E G H9301633OMIM:240500Immunodeficiency, common variable, 2.38
HP:0001287HP:0001287Meningitis0CD40LG CL E G H95911935OMIM:308230Immunodeficiency, X-linked, with hyper-IgM33
HP:0001287HP:0001287Meningitis0CD79A CL E G H9731698ORPHA:33110Autosomal agammaglobulinemiaHP:0040283 - Occasional9
HP:0001287HP:0001287Meningitis0CD79B CL E G H9741699ORPHA:33110Autosomal agammaglobulinemiaHP:0040283 - Occasional6
HP:0001287HP:0001287Meningitis0CFB CL E G H6291037OMIM:615561COMPLEMENT FACTOR B DEFICIENCY; CFBD30
HP:0001287HP:0001287Meningitis0CIITA CL E G H42617067OMIM:209920Bare lymphocyte syndrome, type II118
HP:0001287HP:0001287Meningitis0CR2 CL E G H13802336OMIM:240500Immunodeficiency, common variable, 2.10
HP:0001287HP:0001287Meningitis0CTLA4 CL E G H14932505ORPHA:900Granulomatosis with polyangiitisHP:0040283 - Occasional10
HP:0001287HP:0001287Meningitis0CXCR4 CL E G H78522561ORPHA:51636WHIM syndromeHP:0040284 - Very rare9
HP:0001287HP:0001287Meningitis0CYBA CL E G H15352577ORPHA:379Chronic granulomatous diseaseHP:0040283 - Occasional27
HP:0001287HP:0001287Meningitis0CYBB CL E G H15362578ORPHA:379Chronic granulomatous diseaseHP:0040283 - Occasional111
HP:0001287HP:0001287Meningitis0CYBC1 CL E G H7941528672ORPHA:379Chronic granulomatous diseaseHP:0040283 - Occasional
HP:0001287HP:0001287Meningitis0DNASE1L3 CL E G H17762959ORPHA:36412Hypocomplementemic urticarial vasculitisHP:0040283 - Occasional3
HP:0001287HP:0001287Meningitis0ERAP1 CL E G H5175218173ORPHA:117Behçet diseaseHP:0040281 - Very frequent1
HP:0001287HP:0001287Meningitis0FAS CL E G H35511920ORPHA:117Behçet diseaseHP:0040281 - Very frequent59
HP:0001287HP:0001287Meningitis0FCGR3B CL E G H22153620ORPHA:464370Neonatal alloimmune neutropeniaHP:0040283 - Occasional5
HP:0001287HP:0001287Meningitis0FOXP3 CL E G H509436106ORPHA:37042Immune dysregulation-polyendocrinopathy-enteropathy-X-linked syndromeHP:0040284 - Very rare32
HP:0001287HP:0001287Meningitis0HLA-B CL E G H31064932ORPHA:117Behçet diseaseHP:0040281 - Very frequent4
HP:0001287HP:0001287Meningitis0HLA-B CL E G H31064932ORPHA:397Giant cell arteritisHP:0040283 - Occasional4
HP:0001287HP:0001287Meningitis0HLA-DPA1 CL E G H31134938ORPHA:900Granulomatosis with polyangiitisHP:0040283 - Occasional
HP:0001287HP:0001287Meningitis0HLA-DPB1 CL E G H31154940ORPHA:900Granulomatosis with polyangiitisHP:0040283 - Occasional1
HP:0001287HP:0001287Meningitis0HLA-DRB1 CL E G H31234948ORPHA:545Follicular lymphomaHP:0040283 - Occasional2
HP:0001287HP:0001287Meningitis0HLA-DRB1 CL E G H31234948ORPHA:397Giant cell arteritisHP:0040283 - Occasional2
HP:0001287HP:0001287Meningitis0ICOS CL E G H298515351OMIM:240500Immunodeficiency, common variable, 2.32
HP:0001287HP:0001287Meningitis0IFNGR1 CL E G H34595439ORPHA:117Behçet diseaseHP:0040281 - Very frequent60
HP:0001287HP:0001287Meningitis0IGH CL E G H34925477ORPHA:545Follicular lymphomaHP:0040283 - Occasional7
HP:0001287HP:0001287Meningitis0IGHM CL E G H35075541ORPHA:33110Autosomal agammaglobulinemiaHP:0040283 - Occasional7
HP:0001287HP:0001287Meningitis0IGLL1 CL E G H35435870OMIM:613500Agammaglobulinemia 2, autosomal recessive.3
HP:0001287HP:0001287Meningitis0IGLL1 CL E G H35435870ORPHA:33110Autosomal agammaglobulinemiaHP:0040283 - Occasional3
HP:0001287HP:0001287Meningitis0IL10 CL E G H35865962ORPHA:117Behçet diseaseHP:0040281 - Very frequent2
HP:0001287HP:0001287Meningitis0IL12A CL E G H35925969ORPHA:117Behçet diseaseHP:0040281 - Very frequent
HP:0001287HP:0001287Meningitis0IL12A-AS1 CL E G H10192837649094ORPHA:117Behçet diseaseHP:0040281 - Very frequent
HP:0001287HP:0001287Meningitis0IL23R CL E G H14923319100ORPHA:117Behçet diseaseHP:0040281 - Very frequent1
HP:0001287HP:0001287Meningitis0IL7 CL E G H35746023OMIM:618309EPIDERMODYSPLASIA VERRUCIFORMIS, SUSCEPTIBILITY TO, 5; EV5
HP:0001287HP:0001287Meningitis0JAK3 CL E G H37186193OMIM:600802Scid, autosomal recessive, T-Negative/b-Positive type.140
HP:0001287HP:0001287Meningitis0KLRC4 CL E G H83026377ORPHA:117Behçet diseaseHP:0040281 - Very frequent
HP:0001287HP:0001287Meningitis0LRRC8A CL E G H5626219027ORPHA:33110Autosomal agammaglobulinemiaHP:0040283 - Occasional3
HP:0001287HP:0001287Meningitis0MEFV CL E G H42106998ORPHA:117Behçet diseaseHP:0040281 - Very frequent281
HP:0001287HP:0001287Meningitis0MEFV CL E G H42106998ORPHA:342Familial Mediterranean feverHP:0040283 - Occasional281
HP:0001287HP:0001287Meningitis0MEFV CL E G H42106998OMIM:249100Familial Mediterranean fever, AR.281
HP:0001287HP:0001287Meningitis0MRTFA CL E G H5759114334OMIM:618847IMMUNODEFICIENCY 66; IMD66
HP:0001287HP:0001287Meningitis0NCF1 CL E G H6533617660ORPHA:379Chronic granulomatous diseaseHP:0040283 - Occasional13
HP:0001287HP:0001287Meningitis0NCF2 CL E G H46887661ORPHA:379Chronic granulomatous diseaseHP:0040283 - Occasional67
HP:0001287HP:0001287Meningitis0NCF4 CL E G H46897662ORPHA:379Chronic granulomatous diseaseHP:0040283 - Occasional37
HP:0001287HP:0001287Meningitis0NDE1 CL E G H5482017619ORPHA:2177HydranencephalyHP:0040282 - Frequent96
HP:0001287HP:0001287Meningitis0NLRC4 CL E G H5848416412OMIM:616050AUTOINFLAMMATION WITH INFANTILE ENTEROCOLITIS; AIFEC30
HP:0001287HP:0001287Meningitis0NLRP3 CL E G H11454816400ORPHA:1451CINCA syndromeHP:0040281 - Very frequent217
HP:0001287HP:0001287Meningitis0NLRP3 CL E G H11454816400OMIM:607115CINCA SYNDROME; CINCA217
HP:0001287HP:0001287Meningitis0P4HA2 CL E G H89748547ORPHA:397Giant cell arteritisHP:0040283 - Occasional3
HP:0001287HP:0001287Meningitis0PIK3R1 CL E G H52958979ORPHA:33110Autosomal agammaglobulinemiaHP:0040283 - Occasional43
HP:0001287HP:0001287Meningitis0PRF1 CL E G H55519360OMIM:603553Hemophagocytic lymphohistiocytosis, familial, 2.58
HP:0001287HP:0001287Meningitis0PRTN3 CL E G H56579495ORPHA:900Granulomatosis with polyangiitisHP:0040283 - Occasional
HP:0001287HP:0001287Meningitis0PTPN22 CL E G H261919652ORPHA:397Giant cell arteritisHP:0040283 - Occasional3
HP:0001287HP:0001287Meningitis0PTPN22 CL E G H261919652ORPHA:900Granulomatosis with polyangiitisHP:0040283 - Occasional3
HP:0001287HP:0001287Meningitis0RAG1 CL E G H58969831OMIM:601457Severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-negative, NK cell-positive.127
HP:0001287HP:0001287Meningitis0RAG2 CL E G H58979832OMIM:601457Severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-negative, NK cell-positive.50
HP:0001287HP:0001287Meningitis0RFX5 CL E G H59939986OMIM:209920Bare lymphocyte syndrome, type II38
HP:0001287HP:0001287Meningitis0RFXANK CL E G H86259987OMIM:209920Bare lymphocyte syndrome, type II26
HP:0001287HP:0001287Meningitis0RFXAP CL E G H59949988OMIM:209920Bare lymphocyte syndrome, type II34
HP:0001287HP:0001287Meningitis0SH2D1A CL E G H406810820OMIM:308240Lymphoproliferative syndrome, X-linked, 137
HP:0001287HP:0001287Meningitis0SLC35C1 CL E G H5534320197ORPHA:99843Leukocyte adhesion deficiency type II71
HP:0001287HP:0001287Meningitis0SPI1 CL E G H668811241OMIM:619707AGAMMAGLOBULINEMIA 10, AUTOSOMAL DOMINANT; AGM10
HP:0001287HP:0001287Meningitis0STAT4 CL E G H677511365ORPHA:117Behçet diseaseHP:0040281 - Very frequent2
HP:0001287HP:0001287Meningitis0TBK1 CL E G H2911011584OMIM:617900Encephalopathy, acute, infection-induced (herpes-specific), susceptibility to, 8.20
HP:0001287HP:0001287Meningitis0TCF3 CL E G H692911633ORPHA:33110Autosomal agammaglobulinemiaHP:0040283 - Occasional2
HP:0001287HP:0001287Meningitis0TFRC CL E G H703711763OMIM:616740Immunodeficiency 461
HP:0001287HP:0001287Meningitis0TLR3 CL E G H709811849OMIM:613002Encephalopathy, acute, infection-induced (herpes-specific), susceptibility to, 2.3
HP:0001287HP:0001287Meningitis0TLR4 CL E G H709911850ORPHA:117Behçet diseaseHP:0040281 - Very frequent3
HP:0001287HP:0001287Meningitis0TNFRSF13B CL E G H2349518153OMIM:240500Immunodeficiency, common variable, 2.32
HP:0001287HP:0001287Meningitis0TNFRSF13C CL E G H11565017755OMIM:240500Immunodeficiency, common variable, 2.12
HP:0001287HP:0001287Meningitis0UBAC2 CL E G H33786720486ORPHA:117Behçet diseaseHP:0040281 - Very frequent
HP:0001287HP:0001287Meningitis0VANGL1 CL E G H8183915512OMIM:600145Sacral defect with anterior meningocele.111
HP:0001287HP:0001287Meningitis0WAS CL E G H745412731ORPHA:906Wiskott-Aldrich syndromeHP:0040283 - Occasional65
HP:0001287HP:0001287Meningitis0WIPF1 CL E G H745612736ORPHA:906Wiskott-Aldrich syndromeHP:0040283 - Occasional6
HP:0001287HP:0001287Meningitis0XIAP CL E G H331592OMIM:308240Lymphoproliferative syndrome, X-linked, 181
HP:0001287HP:0007041Chronic lymphocytic meningitis1CIITA CL E G H42617067OMIM:209920Bare lymphocyte syndrome, type II.118
HP:0001287HP:0032159Fungal meningitis1IL7 CL E G H35746023OMIM:618309EPIDERMODYSPLASIA VERRUCIFORMIS, SUSCEPTIBILITY TO, 5; EV5
HP:0001287HP:0007041Chronic lymphocytic meningitis1RFX5 CL E G H59939986OMIM:209920Bare lymphocyte syndrome, type II.38
HP:0001287HP:0007041Chronic lymphocytic meningitis1RFXANK CL E G H86259987OMIM:209920Bare lymphocyte syndrome, type II.26
HP:0001287HP:0007041Chronic lymphocytic meningitis1RFXAP CL E G H59949988OMIM:209920Bare lymphocyte syndrome, type II.34
HP:0001287HP:0007041Chronic lymphocytic meningitis1SLC35C1 CL E G H5534320197ORPHA:99843Leukocyte adhesion deficiency type IIHP:0040283 - Occasional71
HP:0001287HP:0032161Coccidioidal meningitis2 CL E G H
HP:0001287HP:0032160Cryptococcal meningitis2IL7 CL E G H35746023OMIM:618309EPIDERMODYSPLASIA VERRUCIFORMIS, SUSCEPTIBILITY TO, 5; EV5


Genes (79) :ARPC1B BCL2 BCL6 BLNK BTK C4A C4B C8A C8B CARD9 CCR1 CD19 CD40LG CD79A CD79B CFB CIITA CR2 CTLA4 CXCR4 CYBA CYBB CYBC1 DNASE1L3 ERAP1 FAS FCGR3B FOXP3 HLA-B HLA-DPA1 HLA-DPB1 HLA-DRB1 ICOS IFNGR1 IGH IGHM IGLL1 IL10 IL12A IL12A-AS1 IL23R IL7 JAK3 KLRC4 LRRC8A MEFV MRTFA NCF1 NCF2 NCF4 NDE1 NLRC4 NLRP3 P4HA2 PIK3R1 PRF1 PRTN3 PTPN22 RAG1 RAG2 RFX5 RFXANK RFXAP SH2D1A SLC35C1 SPI1 STAT4 TBK1 TCF3 TFRC TLR3 TLR4 TNFRSF13B TNFRSF13C UBAC2 VANGL1 WAS WIPF1 XIAP

Diseases (42) :OMIM:617718 ORPHA:545 ORPHA:33110 OMIM:300755 OMIM:307200 ORPHA:47 ORPHA:117 OMIM:614379 OMIM:613790 OMIM:613789 OMIM:212050 OMIM:240500 OMIM:308230 OMIM:615561 OMIM:209920 ORPHA:900 ORPHA:51636 ORPHA:379 ORPHA:36412 ORPHA:464370 ORPHA:37042 ORPHA:397 OMIM:613500 OMIM:618309 OMIM:600802 ORPHA:342 OMIM:249100 OMIM:618847 ORPHA:2177 OMIM:616050 ORPHA:1451 OMIM:607115 OMIM:603553 OMIM:601457 OMIM:308240 ORPHA:99843 OMIM:619707 OMIM:617900 OMIM:616740 OMIM:613002 OMIM:600145 ORPHA:906
 

Human Phenotype Ontology(HPO) is developed by the Human Phenotype Ontology Consortium. The version used here is December 15 2022 release.