Human Phenotype Ontology 
Grandparent Node:
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Abnormality of the cardiovascular system (HP:0001626)help
Parent Node:
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Abnormal cardiovascular system physiology (HP:0011025)help
..Starting node
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Syncope (HP:0001279)help
Term ID: 1279
Name: Syncope
Synonym: Fainting spell
Definition: Syncope refers to a generalized weakness of muscles with loss of postural tone, inability to stand upright, and loss of consciousness. Once the patient is in a horizontal position, blood flow to the brain is no longer hindered by gravitation and consciousness is regained. Unconsciousness usually lasts for seconds to minutes. Headache and drowsiness (which usually follow seizures) do not follow a syncopal attack. Syncope results from a sudden impairment of brain metabolism usually due to a reduction in cerebral blood flow.
Comments:
Reference: HP:0001279
Genes and Diseases:
 
       Child Nodes:
........expandVasovagal syncope (HP:0012668) help
........expandCarotid sinus syncope (HP:0012669) help
........expandOrthostatic syncope (HP:0012670) help

 Sister Nodes: 
..expandAbnormal cardiac atrial physiology (HP:0025443) help
..expandAbnormal cardiac ventricular function (HP:0030872) help
..expandAbnormal echocardiogram (HP:0003116) help
..expandAbnormal heart sound (HP:0031657) help
..expandAbnormal heart valve physiology (HP:0031653) help
..expandAbnormal systemic blood pressure (HP:0030972) help
..expandAbnormal vascular physiology (HP:0030163) help
..expandAbnormality of blood circulation (HP:0011028) help
..expandAbnormality of cardiovascular system electrophysiology (HP:0030956) help
..expandAngina pectoris (HP:0001681) help
..expandCongestive heart failure (HP:0001635) help
..expandMyocardial infarction (HP:0001658) help
..expandShock (HP:0031273) help
InputHPO IDHPO termDistanceGeneGene id entrezHGNC IDDiseaseIdDiseaseNameFrequencyOnsetHGMD variantsClinVar variants
 
HPO disease - gene - phenotype typical associations:
 
HPO disease - gene - phenotype less frequent non-typical associations:
HP:0001279HP:0001279Syncope0ABCC8 CL E G H683359ORPHA:276575Autosomal dominant hyperinsulinism due to SUR1 deficiencyHP:0040283 - Occasional245
HP:0001279HP:0001279Syncope0ABCC9 CL E G H1006060ORPHA:130Brugada syndromeHP:0040282 - Frequent254
HP:0001279HP:0001279Syncope0ACTC1 CL E G H70143ORPHA:99103Atrial septal defect, ostium secundum typeHP:0040284 - Very rare208
HP:0001279HP:0001279Syncope0ACTC1 CL E G H70143OMIM:612098Cardiomyopathy, familial hypertrophic, 11208
HP:0001279HP:0001279Syncope0AKAP9 CL E G H10142379ORPHA:130Brugada syndromeHP:0040282 - Frequent289
HP:0001279HP:0001279Syncope0AKAP9 CL E G H10142379OMIM:611820Long QT syndrome 11.289
HP:0001279HP:0001279Syncope0AKAP9 CL E G H10142379ORPHA:101016Romano-Ward syndromeHP:0040282 - Frequent289
HP:0001279HP:0001279Syncope0AKT1 CL E G H207391ORPHA:2495MeningiomaHP:0040284 - Very rare54
HP:0001279HP:0001279Syncope0ALG10B CL E G H14424531088OMIM:613688Long QT syndrome 2.3
HP:0001279HP:0001279Syncope0ANK2 CL E G H287493OMIM:600919Cardiac arrhythmia, ankyrin-b-related.539
HP:0001279HP:0001279Syncope0ANK2 CL E G H287493ORPHA:101016Romano-Ward syndromeHP:0040282 - Frequent539
HP:0001279HP:0001279Syncope0ASXL1 CL E G H17102318318ORPHA:98849Systemic mastocytosis with associated hematologic neoplasmHP:0040283 - Occasional145
HP:0001279HP:0001279Syncope0ATP13A3 CL E G H7957224113OMIM:265400Pulmonary hypertension, primary, autosomal recessive.
HP:0001279HP:0001279Syncope0BAP1 CL E G H8314950ORPHA:2495MeningiomaHP:0040284 - Very rare184
HP:0001279HP:0001279Syncope0BVES CL E G H111491152OMIM:616812Muscular dystrophy, limb-girdle, autosomal recessive 252
HP:0001279HP:0001279Syncope0CACNA1C CL E G H7751390ORPHA:130Brugada syndromeHP:0040282 - Frequent572
HP:0001279HP:0001279Syncope0CACNA1C CL E G H7751390OMIM:611875BRUGADA SYNDROME 3; BRGDA3572
HP:0001279HP:0001279Syncope0CACNA1C CL E G H7751390OMIM:618447LONG QT SYNDROME 8; LQT8572
HP:0001279HP:0001279Syncope0CACNA1C CL E G H7751390ORPHA:101016Romano-Ward syndromeHP:0040282 - Frequent572
HP:0001279HP:0001279Syncope0CACNA1D CL E G H7761391OMIM:614896Sinoatrial node dysfunction and deafness51
HP:0001279HP:0001279Syncope0CACNA2D1 CL E G H7811399ORPHA:130Brugada syndromeHP:0040282 - Frequent59
HP:0001279HP:0001279Syncope0CACNA2D1 CL E G H7811399ORPHA:51083Familial short QT syndromeHP:0040283 - Occasional59
HP:0001279HP:0001279Syncope0CACNB2 CL E G H7831402ORPHA:130Brugada syndromeHP:0040282 - Frequent206
HP:0001279HP:0001279Syncope0CACNB2 CL E G H7831402OMIM:611876BRUGADA SYNDROME 4; BRGDA4206
HP:0001279HP:0001279Syncope0CALM1 CL E G H8011442ORPHA:3286Catecholaminergic polymorphic ventricular tachycardiaHP:0040283 - Occasional18
HP:0001279HP:0001279Syncope0CALM1 CL E G H8011442ORPHA:101016Romano-Ward syndromeHP:0040282 - Frequent18
HP:0001279HP:0001279Syncope0CALM1 CL E G H8011442OMIM:614916Ventricular tachycardia, catecholaminergic polymorphic, 4.18
HP:0001279HP:0001279Syncope0CALM2 CL E G H8051445ORPHA:3286Catecholaminergic polymorphic ventricular tachycardiaHP:0040283 - Occasional13
HP:0001279HP:0001279Syncope0CALM2 CL E G H8051445OMIM:616249Long QT syndrome 1513
HP:0001279HP:0001279Syncope0CALM2 CL E G H8051445ORPHA:101016Romano-Ward syndromeHP:0040282 - Frequent13
HP:0001279HP:0001279Syncope0CALM3 CL E G H8081449ORPHA:3286Catecholaminergic polymorphic ventricular tachycardiaHP:0040283 - Occasional16
HP:0001279HP:0001279Syncope0CALM3 CL E G H8081449ORPHA:101016Romano-Ward syndromeHP:0040282 - Frequent16
HP:0001279HP:0001279Syncope0CASQ2 CL E G H8451513ORPHA:3286Catecholaminergic polymorphic ventricular tachycardiaHP:0040283 - Occasional129
HP:0001279HP:0001279Syncope0CASQ2 CL E G H8451513OMIM:604772VENTRICULAR TACHYCARDIA, CATECHOLAMINERGIC POLYMORPHIC, 1, WITH OR WITHOUT ATRIAL DYSFUNCTION AND/OR DILATED CARDIOMYOPATHY; CPVT1129
HP:0001279HP:0001279Syncope0CASQ2 CL E G H8451513OMIM:611938Ventricular tachycardia, catecholaminergic polymorphic, 2.129
HP:0001279HP:0001279Syncope0CAV3 CL E G H8591529OMIM:611818Long QT syndrome 9148
HP:0001279HP:0001279Syncope0CAV3 CL E G H8591529ORPHA:101016Romano-Ward syndromeHP:0040282 - Frequent148
HP:0001279HP:0001279Syncope0CITED2 CL E G H103701987ORPHA:99103Atrial septal defect, ostium secundum typeHP:0040284 - Very rare5
HP:0001279HP:0001279Syncope0CLCNKB CL E G H11882027ORPHA:358Gitelman syndromeHP:0040284 - Very rare27
HP:0001279HP:0001279Syncope0COQ2 CL E G H2723525223ORPHA:227510Multiple system atrophy, cerebellar type54
HP:0001279HP:0001279Syncope0COQ2 CL E G H2723525223ORPHA:98933Multiple system atrophy, parkinsonian type54
HP:0001279HP:0001279Syncope0CTSH CL E G H15122535ORPHA:2073Narcolepsy type 1HP:0040283 - Occasional1
HP:0001279HP:0001279Syncope0DBH CL E G H16212689ORPHA:230Dopamine beta-hydroxylase deficiencyHP:0040282 - Frequent80
HP:0001279HP:0001279Syncope0DSC2 CL E G H18243036OMIM:610476Arrhythmogenic right ventricular dysplasia, familial, 11.268
HP:0001279HP:0001279Syncope0DSP CL E G H18323052OMIM:615821Cardiomyopathy, dilated, with woolly hair, keratoderma, and tooth agenesisHP:0040283 - Occasional747
HP:0001279HP:0001279Syncope0FLNC CL E G H23183756ORPHA:75249Familial isolated restrictive cardiomyopathyHP:0040284 - Very rare197
HP:0001279HP:0001279Syncope0GATA4 CL E G H26264173ORPHA:99103Atrial septal defect, ostium secundum typeHP:0040284 - Very rare87
HP:0001279HP:0001279Syncope0GATA6 CL E G H26274174ORPHA:99103Atrial septal defect, ostium secundum typeHP:0040284 - Very rare37
HP:0001279HP:0001279Syncope0GNB2 CL E G H27834398OMIM:619464SICK SINUS SYNDROME 4; SSS4
HP:0001279HP:0001279Syncope0GPD1L CL E G H2317128956ORPHA:130Brugada syndromeHP:0040282 - Frequent97
HP:0001279HP:0001279Syncope0GPD1L CL E G H2317128956OMIM:611777BRUGADA SYNDROME 2; BRGDA297
HP:0001279HP:0001279Syncope0HCN4 CL E G H1002116882ORPHA:130Brugada syndromeHP:0040282 - Frequent185
HP:0001279HP:0001279Syncope0HCN4 CL E G H1002116882OMIM:163800Sick sinus syndrome 2185
HP:0001279HP:0001279Syncope0HCRT CL E G H30604847ORPHA:2073Narcolepsy type 1HP:0040283 - Occasional1
HP:0001279HP:0001279Syncope0HLA-DQB1 CL E G H31194944ORPHA:2073Narcolepsy type 1HP:0040283 - Occasional
HP:0001279HP:0001279Syncope0HLA-DRB1 CL E G H31234948ORPHA:2073Narcolepsy type 1HP:0040283 - Occasional2
HP:0001279HP:0001279Syncope0HNF1A CL E G H692711621ORPHA:324575Hyperinsulinism due to HNF1A deficiencyHP:0040283 - Occasional161
HP:0001279HP:0001279Syncope0JAK2 CL E G H37176192ORPHA:71493Familial thrombocytosisHP:0040283 - Occasional57
HP:0001279HP:0001279Syncope0JUP CL E G H37286207OMIM:611528ARRHYTHMOGENIC RIGHT VENTRICULAR DYSPLASIA, FAMILIAL, 12; ARVD12222
HP:0001279HP:0001279Syncope0JUP CL E G H37286207OMIM:601214Naxos disease222
HP:0001279HP:0001279Syncope0KCND3 CL E G H37526239ORPHA:130Brugada syndromeHP:0040282 - Frequent35
HP:0001279HP:0001279Syncope0KCNE1 CL E G H37536240ORPHA:90647Jervell and Lange-Nielsen syndromeHP:0040282 - Frequent148
HP:0001279HP:0001279Syncope0KCNE1 CL E G H37536240OMIM:612347Jervell and lange-nielsen syndrome 2.148
HP:0001279HP:0001279Syncope0KCNE1 CL E G H37536240OMIM:613695Long QT syndrome 5.148
HP:0001279HP:0001279Syncope0KCNE1 CL E G H37536240ORPHA:101016Romano-Ward syndromeHP:0040282 - Frequent148
HP:0001279HP:0001279Syncope0KCNE2 CL E G H99926242OMIM:613693Long QT syndrome 6.43
HP:0001279HP:0001279Syncope0KCNE2 CL E G H99926242ORPHA:101016Romano-Ward syndromeHP:0040282 - Frequent43
HP:0001279HP:0001279Syncope0KCNE3 CL E G H100086243ORPHA:130Brugada syndromeHP:0040282 - Frequent73
HP:0001279HP:0001279Syncope0KCNE5 CL E G H236306241ORPHA:130Brugada syndromeHP:0040282 - Frequent5
HP:0001279HP:0001279Syncope0KCNH2 CL E G H37576251ORPHA:51083Familial short QT syndromeHP:0040283 - Occasional901
HP:0001279HP:0001279Syncope0KCNH2 CL E G H37576251OMIM:613688Long QT syndrome 2.901
HP:0001279HP:0001279Syncope0KCNH2 CL E G H37576251ORPHA:101016Romano-Ward syndromeHP:0040282 - Frequent901
HP:0001279HP:0001279Syncope0KCNH2 CL E G H37576251OMIM:609620SHORT QT SYNDROME 1; SQT1901
HP:0001279HP:0001279Syncope0KCNJ11 CL E G H37676257ORPHA:276580Autosomal dominant hyperinsulinism due to Kir6.2 deficiencyHP:0040283 - Occasional127
HP:0001279HP:0001279Syncope0KCNJ2 CL E G H37596263OMIM:170390Andersen cardiodysrhythmic periodic paralysis.193
HP:0001279HP:0001279Syncope0KCNJ2 CL E G H37596263ORPHA:37553Andersen-Tawil syndromeHP:0040284 - Very rare193
HP:0001279HP:0001279Syncope0KCNJ2 CL E G H37596263ORPHA:51083Familial short QT syndromeHP:0040283 - Occasional193
HP:0001279HP:0001279Syncope0KCNJ5 CL E G H37626266ORPHA:37553Andersen-Tawil syndromeHP:0040284 - Very rare128
HP:0001279HP:0001279Syncope0KCNJ5 CL E G H37626266OMIM:613485Long QT syndrome 13.128
HP:0001279HP:0001279Syncope0KCNJ5 CL E G H37626266ORPHA:101016Romano-Ward syndromeHP:0040282 - Frequent128
HP:0001279HP:0001279Syncope0KCNJ8 CL E G H37646269ORPHA:130Brugada syndromeHP:0040282 - Frequent23
HP:0001279HP:0001279Syncope0KCNQ1 CL E G H37846294OMIM:607554Atrial fibrillation, familial, 3730
HP:0001279HP:0001279Syncope0KCNQ1 CL E G H37846294ORPHA:51083Familial short QT syndromeHP:0040283 - Occasional730
HP:0001279HP:0001279Syncope0KCNQ1 CL E G H37846294ORPHA:90647Jervell and Lange-Nielsen syndromeHP:0040282 - Frequent730
HP:0001279HP:0001279Syncope0KCNQ1 CL E G H37846294OMIM:220400Jervell and lange-nielsen syndrome 1.730
HP:0001279HP:0001279Syncope0KCNQ1 CL E G H37846294OMIM:192500LONG QT SYNDROME 1; LQT1730
HP:0001279HP:0001279Syncope0KCNQ1 CL E G H37846294ORPHA:101016Romano-Ward syndromeHP:0040282 - Frequent730
HP:0001279HP:0001279Syncope0KCNQ1 CL E G H37846294OMIM:609621Short QT syndrome 2730
HP:0001279HP:0001279Syncope0KIF20A CL E G H101129787ORPHA:75249Familial isolated restrictive cardiomyopathyHP:0040284 - Very rare
HP:0001279HP:0001279Syncope0KIT CL E G H38156342ORPHA:98849Systemic mastocytosis with associated hematologic neoplasmHP:0040283 - Occasional327
HP:0001279HP:0001279Syncope0LMNA CL E G H40006636OMIM:181350Emery-Dreifuss muscular dystrophy 2, autosomal dominant645
HP:0001279HP:0001279Syncope0LMNA CL E G H40006636ORPHA:300751Familial dilated cardiomyopathy with conduction defect due to LMNA mutationHP:0040282 - Frequent645
HP:0001279HP:0001279Syncope0MGAT2 CL E G H42477045ORPHA:79329MGAT2-CDG39
HP:0001279HP:0001279Syncope0MOG CL E G H43407197ORPHA:2073Narcolepsy type 1HP:0040283 - Occasional1
HP:0001279HP:0001279Syncope0MPL CL E G H43527217ORPHA:71493Familial thrombocytosisHP:0040283 - Occasional97
HP:0001279HP:0001279Syncope0MYBPC3 CL E G H46077551OMIM:115197Cardiomyopathy, familial hypertrophic, 4.1143
HP:0001279HP:0001279Syncope0MYBPC3 CL E G H46077551OMIM:615396Left ventricular noncompaction 101143
HP:0001279HP:0001279Syncope0MYH6 CL E G H46247576ORPHA:99103Atrial septal defect, ostium secundum typeHP:0040284 - Very rare452
HP:0001279HP:0001279Syncope0MYOZ2 CL E G H517781330OMIM:613838Cardiomyopathy, familial hypertrophic, 1681
HP:0001279HP:0001279Syncope0MYPN CL E G H8466523246ORPHA:75249Familial isolated restrictive cardiomyopathyHP:0040284 - Very rare217
HP:0001279HP:0001279Syncope0NF2 CL E G H47717773ORPHA:2495MeningiomaHP:0040284 - Very rare220
HP:0001279HP:0001279Syncope0NKX2-5 CL E G H14822488ORPHA:99103Atrial septal defect, ostium secundum typeHP:0040284 - Very rare90
HP:0001279HP:0001279Syncope0NKX2-5 CL E G H14822488ORPHA:871Familial progressive cardiac conduction defectHP:0040282 - Frequent90
HP:0001279HP:0001279Syncope0NOS1AP CL E G H972216859ORPHA:101016Romano-Ward syndromeHP:0040282 - Frequent4
HP:0001279HP:0001279Syncope0NOTCH2NLC CL E G H10099671753924OMIM:603472NEURONAL INTRANUCLEAR INCLUSION DISEASE
HP:0001279HP:0001279Syncope0NPPA CL E G H48787939ORPHA:1344Atrial standstillHP:0040283 - Occasional13
HP:0001279HP:0001279Syncope0NTRK1 CL E G H49148031ORPHA:642Hereditary sensory and autonomic neuropathy type 4HP:0040283 - Occasional97
HP:0001279HP:0001279Syncope0P2RY11 CL E G H50328540ORPHA:2073Narcolepsy type 1HP:0040283 - Occasional2
HP:0001279HP:0001279Syncope0PDGFB CL E G H51558800ORPHA:2495MeningiomaHP:0040284 - Very rare9
HP:0001279HP:0001279Syncope0PIK3CA CL E G H52908975ORPHA:2495MeningiomaHP:0040284 - Very rare162
HP:0001279HP:0001279Syncope0PKP2 CL E G H53189024OMIM:609040Arrhythmogenic right ventricular dysplasia, familial, 9.406
HP:0001279HP:0001279Syncope0PKP2 CL E G H53189024ORPHA:130Brugada syndromeHP:0040282 - Frequent406
HP:0001279HP:0001279Syncope0PRKAG2 CL E G H514229386OMIM:600858Cardiomyopathy, familial hypertrophic, 6235
HP:0001279HP:0001279Syncope0PRKAG2 CL E G H514229386OMIM:194200WOLFF-PARKINSON-WHITE SYNDROME235
HP:0001279HP:0001279Syncope0PSEN1 CL E G H56639508OMIM:613694Cardiomyopathy, dilated, 1U.241
HP:0001279HP:0001279Syncope0PSEN2 CL E G H56649509OMIM:613697Cardiomyopathy, dilated, 1V.59
HP:0001279HP:0001279Syncope0RANGRF CL E G H2909817679ORPHA:130Brugada syndromeHP:0040282 - Frequent22
HP:0001279HP:0001279Syncope0RNF125 CL E G H5494121150OMIM:616260Tenorio syndrome.5
HP:0001279HP:0001279Syncope0RYR2 CL E G H626210484ORPHA:3286Catecholaminergic polymorphic ventricular tachycardiaHP:0040283 - Occasional1103
HP:0001279HP:0001279Syncope0RYR2 CL E G H626210484OMIM:604772VENTRICULAR TACHYCARDIA, CATECHOLAMINERGIC POLYMORPHIC, 1, WITH OR WITHOUT ATRIAL DYSFUNCTION AND/OR DILATED CARDIOMYOPATHY; CPVT11103
HP:0001279HP:0001279Syncope0SCN10A CL E G H633610582ORPHA:130Brugada syndromeHP:0040282 - Frequent146
HP:0001279HP:0001279Syncope0SCN10A CL E G H633610582ORPHA:101016Romano-Ward syndromeHP:0040282 - Frequent146
HP:0001279HP:0001279Syncope0SCN1B CL E G H632410586ORPHA:130Brugada syndromeHP:0040282 - Frequent126
HP:0001279HP:0001279Syncope0SCN1B CL E G H632410586ORPHA:871Familial progressive cardiac conduction defectHP:0040282 - Frequent126
HP:0001279HP:0001279Syncope0SCN2B CL E G H632710589ORPHA:130Brugada syndromeHP:0040282 - Frequent21
HP:0001279HP:0001279Syncope0SCN3B CL E G H5580020665ORPHA:130Brugada syndromeHP:0040282 - Frequent122
HP:0001279HP:0001279Syncope0SCN4B CL E G H633010592ORPHA:101016Romano-Ward syndromeHP:0040282 - Frequent110
HP:0001279HP:0001279Syncope0SCN5A CL E G H633110593ORPHA:1344Atrial standstillHP:0040283 - Occasional1134
HP:0001279HP:0001279Syncope0SCN5A CL E G H633110593ORPHA:130Brugada syndromeHP:0040282 - Frequent1134
HP:0001279HP:0001279Syncope0SCN5A CL E G H633110593OMIM:601144BRUGADA SYNDROME 1; BRGDA11134
HP:0001279HP:0001279Syncope0SCN5A CL E G H633110593OMIM:601154Cardiomyopathy, dilated, 1E.1134
HP:0001279HP:0001279Syncope0SCN5A CL E G H633110593ORPHA:871Familial progressive cardiac conduction defectHP:0040282 - Frequent1134
HP:0001279HP:0001279Syncope0SCN5A CL E G H633110593OMIM:603830Long QT syndrome 3.1134
HP:0001279HP:0001279Syncope0SCN5A CL E G H633110593OMIM:113900Progressive familial heart block, type IA.1134
HP:0001279HP:0001279Syncope0SCN5A CL E G H633110593ORPHA:101016Romano-Ward syndromeHP:0040282 - Frequent1134
HP:0001279HP:0001279Syncope0SCN5A CL E G H633110593OMIM:603829Ventricular fibrillation, familial, 11134
HP:0001279HP:0001279Syncope0SCNN1A CL E G H633710599ORPHA:130Brugada syndromeHP:0040282 - Frequent67
HP:0001279HP:0001279Syncope0SEMA3A CL E G H1037110723ORPHA:130Brugada syndromeHP:0040282 - Frequent14
HP:0001279HP:0001279Syncope0SLC12A3 CL E G H655910912ORPHA:358Gitelman syndromeHP:0040284 - Very rare145
HP:0001279HP:0001279Syncope0SLC4A3 CL E G H650811029ORPHA:51083Familial short QT syndromeHP:0040283 - Occasional7
HP:0001279HP:0001279Syncope0SLC6A5 CL E G H915211051OMIM:614618Hyperekplexia 381
HP:0001279HP:0001279Syncope0SLMAP CL E G H787116643ORPHA:130Brugada syndromeHP:0040282 - Frequent18
HP:0001279HP:0001279Syncope0SMARCB1 CL E G H659811103ORPHA:2495MeningiomaHP:0040284 - Very rare87
HP:0001279HP:0001279Syncope0SMARCE1 CL E G H660511109ORPHA:2495MeningiomaHP:0040284 - Very rare47
HP:0001279HP:0001279Syncope0SMO CL E G H660811119ORPHA:2495MeningiomaHP:0040284 - Very rare22
HP:0001279HP:0001279Syncope0SNTA1 CL E G H664011167OMIM:612955Long QT syndrome 12118
HP:0001279HP:0001279Syncope0SNTA1 CL E G H664011167ORPHA:101016Romano-Ward syndromeHP:0040282 - Frequent118
HP:0001279HP:0001279Syncope0SRSF2 CL E G H642710783ORPHA:98849Systemic mastocytosis with associated hematologic neoplasmHP:0040283 - Occasional1
HP:0001279HP:0001279Syncope0SUFU CL E G H5168416466ORPHA:2495MeningiomaHP:0040284 - Very rare124
HP:0001279HP:0001279Syncope0TBX20 CL E G H5705711598ORPHA:99103Atrial septal defect, ostium secundum typeHP:0040284 - Very rare20
HP:0001279HP:0001279Syncope0TBX5 CL E G H691011604ORPHA:101016Romano-Ward syndromeHP:0040282 - Frequent123
HP:0001279HP:0001279Syncope0TECRL CL E G H25301727365ORPHA:3286Catecholaminergic polymorphic ventricular tachycardiaHP:0040283 - Occasional4
HP:0001279HP:0001279Syncope0TECRL CL E G H25301727365OMIM:614021Ventricular tachycardia, catecholaminergic polymorphic, 3.4
HP:0001279HP:0001279Syncope0TERT CL E G H701511730ORPHA:2495MeningiomaHP:0040284 - Very rare238
HP:0001279HP:0001279Syncope0TET2 CL E G H5479025941ORPHA:98849Systemic mastocytosis with associated hematologic neoplasmHP:0040283 - Occasional3
HP:0001279HP:0001279Syncope0THPO CL E G H706611795ORPHA:71493Familial thrombocytosisHP:0040283 - Occasional23
HP:0001279HP:0001279Syncope0TLL1 CL E G H709211843ORPHA:99106Atrial septal defect, ostium primum typeHP:0040283 - Occasional6
HP:0001279HP:0001279Syncope0TLL1 CL E G H709211843ORPHA:99103Atrial septal defect, ostium secundum typeHP:0040284 - Very rare6
HP:0001279HP:0001279Syncope0TNFSF4 CL E G H729211934ORPHA:2073Narcolepsy type 1HP:0040283 - Occasional
HP:0001279HP:0001279Syncope0TNNC1 CL E G H713411943OMIM:613243Cardiomyopathy, familial hypertrophic, 13.73
HP:0001279HP:0001279Syncope0TNNI3 CL E G H713711947ORPHA:75249Familial isolated restrictive cardiomyopathyHP:0040284 - Very rare180
HP:0001279HP:0001279Syncope0TNNT2 CL E G H713911949ORPHA:75249Familial isolated restrictive cardiomyopathyHP:0040284 - Very rare248
HP:0001279HP:0001279Syncope0TRAF7 CL E G H8423120456ORPHA:2495MeningiomaHP:0040284 - Very rare
HP:0001279HP:0001279Syncope0TRDN CL E G H1034512261ORPHA:3286Catecholaminergic polymorphic ventricular tachycardiaHP:0040283 - Occasional145
HP:0001279HP:0001279Syncope0TRDN CL E G H1034512261ORPHA:101016Romano-Ward syndromeHP:0040282 - Frequent145
HP:0001279HP:0001279Syncope0TRDN CL E G H1034512261OMIM:604772VENTRICULAR TACHYCARDIA, CATECHOLAMINERGIC POLYMORPHIC, 1, WITH OR WITHOUT ATRIAL DYSFUNCTION AND/OR DILATED CARDIOMYOPATHY; CPVT1145
HP:0001279HP:0001279Syncope0TRDN CL E G H1034512261OMIM:615441VENTRICULAR TACHYCARDIA, CATECHOLAMINERGIC POLYMORPHIC, 5, WITH OR WITHOUT MUSCLE WEAKNESS; CPVT5145
HP:0001279HP:0001279Syncope0TRPM4 CL E G H5479517993ORPHA:130Brugada syndromeHP:0040282 - Frequent124
HP:0001279HP:0001279Syncope0TRPM4 CL E G H5479517993ORPHA:871Familial progressive cardiac conduction defectHP:0040282 - Frequent124
HP:0001279HP:0001279Syncope0TRPM4 CL E G H5479517993OMIM:604559Progressive familial heart block, type IB.124
HP:0001279HP:0001279Syncope0UCP2 CL E G H735112518ORPHA:276556Hyperinsulinism due to UCP2 deficiencyHP:0040283 - Occasional15
HP:0001279HP:0001279Syncope0ZNF365 CL E G H2289118194ORPHA:2073Narcolepsy type 1HP:0040283 - Occasional3
HP:0001279HP:0012669Carotid sinus syncope1 CL E G H
HP:0001279HP:0012668Vasovagal syncope1 CL E G H
HP:0001279HP:0012670Orthostatic syncope1COQ2 CL E G H2723525223ORPHA:227510Multiple system atrophy, cerebellar typeHP:0040282 - Frequent54
HP:0001279HP:0012670Orthostatic syncope1COQ2 CL E G H2723525223ORPHA:98933Multiple system atrophy, parkinsonian typeHP:0040282 - Frequent54
HP:0001279HP:0012670Orthostatic syncope1DBH CL E G H16212689ORPHA:230Dopamine beta-hydroxylase deficiencyHP:0040283 - Occasional80
HP:0001279HP:0500173Reflex asystolic syncope1MGAT2 CL E G H42477045ORPHA:79329MGAT2-CDGHP:0040283 - Occasional39


Genes (110) :ABCC8 ABCC9 ACTC1 AKAP9 AKT1 ALG10B ANK2 ASXL1 ATP13A3 BAP1 BVES CACNA1C CACNA1D CACNA2D1 CACNB2 CALM1 CALM2 CALM3 CASQ2 CAV3 CITED2 CLCNKB COQ2 CTSH DBH DSC2 DSP FLNC GATA4 GATA6 GNB2 GPD1L HCN4 HCRT HLA-DQB1 HLA-DRB1 HNF1A JAK2 JUP KCND3 KCNE1 KCNE2 KCNE3 KCNE5 KCNH2 KCNJ11 KCNJ2 KCNJ5 KCNJ8 KCNQ1 KIF20A KIT LMNA MGAT2 MOG MPL MYBPC3 MYH6 MYOZ2 MYPN NF2 NKX2-5 NOS1AP NOTCH2NLC NPPA NTRK1 P2RY11 PDGFB PIK3CA PKP2 PRKAG2 PSEN1 PSEN2 RANGRF RNF125 RYR2 SCN10A SCN1B SCN2B SCN3B SCN4B SCN5A SCNN1A SEMA3A SLC12A3 SLC4A3 SLC6A5 SLMAP SMARCB1 SMARCE1 SMO SNTA1 SRSF2 SUFU TBX20 TBX5 TECRL TERT TET2 THPO TLL1 TNFSF4 TNNC1 TNNI3 TNNT2 TRAF7 TRDN TRPM4 UCP2 ZNF365

Diseases (80) :ORPHA:276575 ORPHA:130 ORPHA:99103 OMIM:612098 OMIM:611820 ORPHA:101016 ORPHA:2495 OMIM:613688 OMIM:600919 ORPHA:98849 OMIM:265400 OMIM:616812 OMIM:611875 OMIM:618447 OMIM:614896 ORPHA:51083 OMIM:611876 ORPHA:3286 OMIM:614916 OMIM:616249 OMIM:604772 OMIM:611938 OMIM:611818 ORPHA:358 ORPHA:227510 ORPHA:98933 ORPHA:2073 ORPHA:230 OMIM:610476 OMIM:615821 ORPHA:75249 OMIM:619464 OMIM:611777 OMIM:163800 ORPHA:324575 ORPHA:71493 OMIM:611528 OMIM:601214 ORPHA:90647 OMIM:612347 OMIM:613695 OMIM:613693 OMIM:609620 ORPHA:276580 OMIM:170390 ORPHA:37553 OMIM:613485 OMIM:607554 OMIM:220400 OMIM:192500 OMIM:609621 OMIM:181350 ORPHA:300751 ORPHA:79329 OMIM:115197 OMIM:615396 OMIM:613838 ORPHA:871 OMIM:603472 ORPHA:1344 ORPHA:642 OMIM:609040 OMIM:600858 OMIM:194200 OMIM:613694 OMIM:613697 OMIM:616260 OMIM:601144 OMIM:601154 OMIM:603830 OMIM:113900 OMIM:603829 OMIM:614618 OMIM:612955 OMIM:614021 ORPHA:99106 OMIM:613243 OMIM:615441 OMIM:604559 ORPHA:276556
 

Human Phenotype Ontology(HPO) is developed by the Human Phenotype Ontology Consortium. The version used here is December 15 2022 release.