Human Phenotype Ontology

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Hello! Guest! Please Login or Register! Clinician Mode

Examples Gene: MT-ND1, POLG, Region: M:1-1000 Variant: m.8993T>G, 1:g.10042757T>C rs3888511 MSCV_0000006, ClinVar: RCV000000015, Disease: Leigh syndrome, Phenotype: Retinopathy

Grandparent Node:
Abnormal central motor function (HP:0011442)

Parent Node:
Abnormal muscle tone (HP:0003808)

Parent Node:
Upper motor neuron dysfunction (HP:0002493)

..Starting node
..Hypertonia (HP:0001276)

Term ID:

1276

Name:

Hypertonia

Synonym:

Hypertonicity; Increased muscle tone; Muscle hypertonia; Spasticity and rigidity of muscles

Definition:

A condition in which there is increased muscle tone so that arms or legs, for example, are stiff and difficult to move.

Comments:

Reference:

HP:0001276

Genes and Diseases:

Child Nodes:

........

Spasticity (HP:0001257)

................... HP:0001264 Spastic diplegia
................... HP:0001285 Spastic tetraparesis
................... HP:0002061 Lower limb spasticity
................... HP:0002064 Spastic gait
................... HP:0002179 Opisthotonus
................... HP:0002191 Progressive spasticity
................... HP:0002464 Spastic dysarthria
................... HP:0002491 Spasticity of facial muscles
................... HP:0002501 Spasticity of pharyngeal muscles
................... HP:0002510 Spastic tetraplegia
................... HP:0006986 Upper limb spasticity
................... HP:0011099 Spastic hemiparesis
................... HP:0031866 Clasp-knife sign

........

Limb hypertonia (HP:0002509)

................... HP:0006895 Lower limb hypertonia
................... HP:0200049 Upper limb hypertonia

........

Neck hypertonia (HP:0031867)

Sister Nodes:

Abnormal pyramidal sign (HP:0007256)

Dysfunction of lateral corticospinal tracts (HP:0007299)

Weakness due to upper motor neuron dysfunction (HP:0010549)

Input	HPO ID	HPO term	Distance	Gene	Gene id entrez	DiseaseId	DiseaseName	DiseaseMIM	ConceptID	Source	Typical association	ClinVar variants	HGNC ID	GeneMIM
HPO disease - gene - phenotype typical associations:
HP:0001276	HP:0001276	Hypertonia	0	ABCA7 CL E G H	10347	1020				ORPHA	1	148	37	605414
HP:0001276	HP:0001276	Hypertonia	0	ACD CL E G H	65057	3322				ORPHA	1	834	25070	609377
HP:0001276	HP:0001276	Hypertonia	0	ACOX1 CL E G H	51	264470	Pseudoneonatal adrenoleukodystrophy	264470	C1849678	OMIM	1	517	119	609751
HP:0001276	HP:0001276	Hypertonia	0	AFG3L2 CL E G H	10939	610246	Spinocerebellar ataxia 28	610246	C1853249	OMIM	1	385	315	604581
HP:0001276	HP:0001276	Hypertonia	0	ALG3 CL E G H	10195	601110	Congenital disorder of glycosylation type 1D	601110	C1832736	OMIM	1	179	23056	608750
HP:0001276	HP:0001276	Hypertonia	0	APP CL E G H	351	1020				ORPHA	1	404	620	104760
HP:0001276	HP:0001276	Hypertonia	0	ARHGEF9 CL E G H	23229	300607	Early infantile epileptic encephalopathy 8	300607	C1845102	OMIM	1	439	14561	300429
HP:0001276	HP:0001276	Hypertonia	0	ARV1 CL E G H	64801	617020	Epileptic encephalopathy, early infantile, 38	617020	C4310762	OMIM	1	71	29561	611647
HP:0001276	HP:0001276	Hypertonia	0	ARX CL E G H	170302	308350	Epileptic encephalopathy, early infantile, 1	308350	C3463992	OMIM	1	679	18060	300382
HP:0001276	HP:0001276	Hypertonia	0	ATAD1 CL E G H	84896	618011	HYPEREKPLEXIA 4	618011	CN248518	OMIM	1	116	25903	614452
HP:0001276	HP:0001276	Hypertonia	0	ATP7A CL E G H	538	309400	Menkes kinky-hair syndrome	309400	C0022716	OMIM	1	1283	869	300011
HP:0001276	HP:0001276	Hypertonia	0	B3GALNT2 CL E G H	148789	588				ORPHA	1	462	28596	610194
HP:0001276	HP:0001276	Hypertonia	0	BCKDHA CL E G H	593	248600	Maple syrup urine disease	248600	C0024776	OMIM	1	495	986	608348
HP:0001276	HP:0001276	Hypertonia	0	BCKDHB CL E G H	594	248600	Maple syrup urine disease	248600	C0024776	OMIM	1	547	987	248611
HP:0001276	HP:0001276	Hypertonia	0	BRAF CL E G H	673	115150	Cardiofaciocutaneous syndrome 1	115150	CN029449	OMIM	1	948	1097	164757
HP:0001276	HP:0001276	Hypertonia	0	BRAT1 CL E G H	221927	618056	NEURODEVELOPMENTAL DISORDER WITH CEREBELLAR ATROPHY AND WITH OR WITHOUT SEIZURES	618056	CN252657	OMIM	1	960	21701	614506
HP:0001276	HP:0001276	Hypertonia	0	BRAT1 CL E G H	221927	614498	Rigidity and multifocal seizure syndrome, lethal neonatal	614498	C3281029	OMIM	1	960	21701	614506
HP:0001276	HP:0001276	Hypertonia	0	CACNA1A CL E G H	773	617106	Epileptic encephalopathy, early infantile, 42	617106	C4310716	OMIM	1	2689	1388	601011
HP:0001276	HP:0001276	Hypertonia	0	CLCF1 CL E G H	23529	1545	Corsello Opitz syndrome			ORPHA	1	33	17412	607672
HP:0001276	HP:0001276	Hypertonia	0	COG4 CL E G H	25839	613489	Congenital disorder of glycosylation type 2J	613489	C3150736	OMIM	1	262	18620	606976
HP:0001276	HP:0001276	Hypertonia	0	COQ9 CL E G H	57017	614654	Coenzyme Q10 deficiency, primary, 5	614654	C3553374	OMIM	1	183	25302	612837
HP:0001276	HP:0001276	Hypertonia	0	CP CL E G H	1356	48818				ORPHA	1	655	2295	117700
HP:0001276	HP:0001276	Hypertonia	0	CRLF1 CL E G H	9244	1545	Corsello Opitz syndrome			ORPHA	1	80	2364	604237
HP:0001276	HP:0001276	Hypertonia	0	CYB5R3 CL E G H	1727	250800	Deficiency of cytochrome-b5 reductase	250800	C0268193	OMIM	1	151	2873	613213
HP:0001276	HP:0001276	Hypertonia	0	DBT CL E G H	1629	248600	Maple syrup urine disease	248600	C0024776	OMIM	1	582	2698	248610
HP:0001276	HP:0001276	Hypertonia	0	DCX CL E G H	1641	2148				ORPHA	1	388	2714	300121
HP:0001276	HP:0001276	Hypertonia	0	DHCR7 CL E G H	1717	270400	Smith-Lemli-Opitz syndrome	270400	C0175694	OMIM	1	648	2860	602858
HP:0001276	HP:0001276	Hypertonia	0	DKC1 CL E G H	1736	3322				ORPHA	1	477	2890	300126
HP:0001276	HP:0001276	Hypertonia	0	DMPK CL E G H	1760	273				ORPHA	1	235	2933	605377
HP:0001276	HP:0001276	Hypertonia	0	DNAJC12 CL E G H	56521	617384	Hyperphenylalaninemia, mild, non-bh4-deficient	617384	C4479270	OMIM	1	93	28908	606060
HP:0001276	HP:0001276	Hypertonia	0	DPAGT1 CL E G H	1798	608093	Congenital disorder of glycosylation type 1J	608093	C2931004	OMIM	1	258	2995	191350
HP:0001276	HP:0001276	Hypertonia	0	DPYD CL E G H	1806	274270	Dihydropyrimidine dehydrogenase deficiency	274270	C2720286	OMIM	1	379	3012	612779
HP:0001276	HP:0001276	Hypertonia	0	EBP CL E G H	10682	300960	MEND syndrome	300960	C4085243	OMIM	1	291	3133	300205
HP:0001276	HP:0001276	Hypertonia	0	EIF2AK3 CL E G H	9451	226980	Wolcott-Rallison dysplasia	226980	C0432217	OMIM	1	359	3255	604032
HP:0001276	HP:0001276	Hypertonia	0	EIF2S3 CL E G H	1968	85282				ORPHA	1	190	3267	300161
HP:0001276	HP:0001276	Hypertonia	0	EPCAM CL E G H	4072	144				ORPHA	1	613	11529	185535
HP:0001276	HP:0001276	Hypertonia	0	ERCC1 CL E G H	2067	1466				ORPHA	1	113	3433	126380
HP:0001276	HP:0001276	Hypertonia	0	ERCC1 CL E G H	2067	610758	Cerebrooculofacioskeletal syndrome 4	610758	C1853100	OMIM	1	113	3433	126380
HP:0001276	HP:0001276	Hypertonia	0	ERCC2 CL E G H	2068	1466				ORPHA	1	1196	3434	126340
HP:0001276	HP:0001276	Hypertonia	0	ERCC5 CL E G H	2073	1466				ORPHA	1	425	3437	133530
HP:0001276	HP:0001276	Hypertonia	0	ERCC6 CL E G H	2074	1466				ORPHA	1	1170	3438	609413
HP:0001276	HP:0001276	Hypertonia	0	EYA1 CL E G H	2138	2792	Hyperbilirubinemia type 1			ORPHA	1	434	3519	601653
HP:0001276	HP:0001276	Hypertonia	0	EZH2 CL E G H	2146	277590	Weaver syndrome	277590	C0265210	OMIM	1	416	3527	601573
HP:0001276	HP:0001276	Hypertonia	0	FAN1 CL E G H	22909	144				ORPHA	1	360	29170	613534
HP:0001276	HP:0001276	Hypertonia	0	FKRP CL E G H	79147	588				ORPHA	1	787	17997	606596
HP:0001276	HP:0001276	Hypertonia	0	FKTN CL E G H	2218	588				ORPHA	1	783	3622	607440
HP:0001276	HP:0001276	Hypertonia	0	FTO CL E G H	79068	612938	Growth retardation, developmental delay, coarse facies, and early death	612938	C2752001	OMIM	1	199	24678	610966
HP:0001276	HP:0001276	Hypertonia	0	GALC CL E G H	2581	245200	Galactosylceramide beta-galactosidase deficiency	245200	C0023521	OMIM	1	962	4115	606890
HP:0001276	HP:0001276	Hypertonia	0	GAMT CL E G H	2593	612736	Deficiency of guanidinoacetate methyltransferase	612736	C0574080	OMIM	1	487	4136	601240
HP:0001276	HP:0001276	Hypertonia	0	GBA CL E G H	2629	2072				ORPHA	1		4177	606463
HP:0001276	HP:0001276	Hypertonia	0	GBA CL E G H	2629	85212				ORPHA	1		4177	606463
HP:0001276	HP:0001276	Hypertonia	0	GLRA1 CL E G H	2741	149400	Hyperekplexia hereditary	149400	C1835614	OMIM	1	381	4326	138491
HP:0001276	HP:0001276	Hypertonia	0	GLRB CL E G H	2743	614619	Hyperekplexia 2	614619	C3553291	OMIM	1	287	4329	138492
HP:0001276	HP:0001276	Hypertonia	0	GM2A CL E G H	2760	272750	Tay-Sachs disease, variant AB	272750	C0268275	OMIM	1	166	4367	613109
HP:0001276	HP:0001276	Hypertonia	0	GMPPB CL E G H	29925	588				ORPHA	1	273	22932	615320
HP:0001276	HP:0001276	Hypertonia	0	GMPPB CL E G H	29925	615351	Muscular dystrophy-dystroglycanopathy (congenital with mental retardation), type b, 14	615351	C3809221	OMIM	1	273	22932	615320
HP:0001276	HP:0001276	Hypertonia	0	GPHN CL E G H	10243	149400	Hyperekplexia hereditary	149400	C1835614	OMIM	1	982	15465	603930
HP:0001276	HP:0001276	Hypertonia	0	GRIN2D CL E G H	2906	617162	Epileptic encephalopathy, early infantile, 46	617162	C4310687	OMIM	1	519	4588	602717
HP:0001276	HP:0001276	Hypertonia	0	HDAC8 CL E G H	55869	199	Cardiac hydatid cysts with intracavitary expansion			ORPHA	1	322	13315	300269
HP:0001276	HP:0001276	Hypertonia	0	HEXA CL E G H	3073	272800	Tay-Sachs disease	272800	C0039373	OMIM	1	770	4878	606869
HP:0001276	HP:0001276	Hypertonia	0	HIST1H1E CL E G H	3008	617537	RAHMAN SYNDROME	617537	C4479637	OMIM	1		4718	142220
HP:0001276	HP:0001276	Hypertonia	0	HLCS CL E G H	3141	253270	Holocarboxylase synthetase deficiency	253270	C0268581	OMIM	1	722	4976	609018
HP:0001276	HP:0001276	Hypertonia	0	HNRNPH2 CL E G H	3188	300986	Mental retardation, X-linked, syndromic, Bain type	300986	C4310814	OMIM	1	186	5042	300610
HP:0001276	HP:0001276	Hypertonia	0	HSPG2 CL E G H	3339	800				ORPHA	1	1830	5273	142461
HP:0001276	HP:0001276	Hypertonia	0	HTRA2 CL E G H	27429	617248	3-methylglutaconic aciduria, type VIII	617248	C4310650	OMIM	1	162	14348	606441
HP:0001276	HP:0001276	Hypertonia	0	ITM2B CL E G H	9445	176500	Dementia familial British	176500	C1867773	OMIM	1	114	6174	603904
HP:0001276	HP:0001276	Hypertonia	0	KCNQ2 CL E G H	3785	306				ORPHA	1	1689	6296	602235
HP:0001276	HP:0001276	Hypertonia	0	KCNQ2 CL E G H	3785	1949	Benign familial neonatal seizures		CN200689	ORPHA	1	1689	6296	602235
HP:0001276	HP:0001276	Hypertonia	0	KCNQ3 CL E G H	3786	306				ORPHA	1	1082	6297	602232
HP:0001276	HP:0001276	Hypertonia	0	KCNQ3 CL E G H	3786	1949	Benign familial neonatal seizures		CN200689	ORPHA	1	1082	6297	602232
HP:0001276	HP:0001276	Hypertonia	0	KMT2A CL E G H	4297	199	Cardiac hydatid cysts with intracavitary expansion			ORPHA	1	1317	7132	159555
HP:0001276	HP:0001276	Hypertonia	0	KRAS CL E G H	3845	144				ORPHA	1	440	6407	190070
HP:0001276	HP:0001276	Hypertonia	0	KYNU CL E G H	8942	79155				ORPHA	1	62	6469	605197
HP:0001276	HP:0001276	Hypertonia	0	KYNU CL E G H	8942	236800	Hydroxykynureninuria	236800	C0268474	OMIM	1	62	6469	605197
HP:0001276	HP:0001276	Hypertonia	0	LARGE1 CL E G H	9215	588				ORPHA	1	658	6511	603590
HP:0001276	HP:0001276	Hypertonia	0	MBOAT7 CL E G H	79143	617188	Mental retardation, autosomal recessive 57	617188	C4310673	OMIM	1	71	15505	606048
HP:0001276	HP:0001276	Hypertonia	0	MFN2 CL E G H	9927	609260	Charcot-Marie-Tooth disease, type 2A2A	609260	C1836485	OMIM	1	1063	16877	608507
HP:0001276	HP:0001276	Hypertonia	0	MGAT2 CL E G H	4247	212066	Carbohydrate-deficient glycoprotein syndrome type II	212066	C2931008	OMIM	1	123	7045	602616
HP:0001276	HP:0001276	Hypertonia	0	MIPEP CL E G H	4285	617228	Combined oxidative phosphorylation deficiency 31	617228	C4310661	OMIM	1	185	7104	602241
HP:0001276	HP:0001276	Hypertonia	0	MLH1 CL E G H	4292	144				ORPHA	1	4826	7127	120436
HP:0001276	HP:0001276	Hypertonia	0	MLH3 CL E G H	27030	144				ORPHA	1	1824	7128	604395
HP:0001276	HP:0001276	Hypertonia	0	MSH2 CL E G H	4436	144				ORPHA	1	6374	7325	609309
HP:0001276	HP:0001276	Hypertonia	0	MSH6 CL E G H	2956	144				ORPHA	1	7706	7329	600678
HP:0001276	HP:0001276	Hypertonia	0	MYO5A CL E G H	4644	79476				ORPHA	1	249	7602	160777
HP:0001276	HP:0001276	Hypertonia	0	NAA10 CL E G H	8260	300855	N-terminal acetyltransferase deficiency	300855	C3275447	OMIM	1	361	18704	300013
HP:0001276	HP:0001276	Hypertonia	0	NECAP1 CL E G H	25977	615833	Early infantile epileptic encephalopathy 21	615833	C4014430	OMIM	1	167	24539	611623
HP:0001276	HP:0001276	Hypertonia	0	NIPBL CL E G H	25836	199	Cardiac hydatid cysts with intracavitary expansion			ORPHA	1	1201	28862	608667
HP:0001276	HP:0001276	Hypertonia	0	NIPBL CL E G H	25836	122470	Cornelia de Lange syndrome 1	122470	CN029798	OMIM	1	1201	28862	608667
HP:0001276	HP:0001276	Hypertonia	0	OGDH CL E G H	4967	31	Serpiginous choroiditis			ORPHA	1	105	8124	613022
HP:0001276	HP:0001276	Hypertonia	0	PAH CL E G H	5053	79254				ORPHA	1	1316	8582	612349
HP:0001276	HP:0001276	Hypertonia	0	PARN CL E G H	5073	3322				ORPHA	1	443	8609	604212
HP:0001276	HP:0001276	Hypertonia	0	PAX1 CL E G H	5075	2792	Hyperbilirubinemia type 1			ORPHA	1	208	8615	167411
HP:0001276	HP:0001276	Hypertonia	0	PCBD1 CL E G H	5092	264070	Hyperphenylalaninemia, BH4-deficient, D	264070	C1849700	OMIM	1	67	8646	126090
HP:0001276	HP:0001276	Hypertonia	0	PIK3CA CL E G H	5290	144				ORPHA	1	975	8975	171834
HP:0001276	HP:0001276	Hypertonia	0	PITX3 CL E G H	5309	610623	Cataract 11	610623	C1864567	OMIM	1	39	9006	602669
HP:0001276	HP:0001276	Hypertonia	0	PLA2G6 CL E G H	8398	610217	Neurodegeneration with brain iron accumulation 2b	610217	C1857747	OMIM	1	598	9039	603604
HP:0001276	HP:0001276	Hypertonia	0	PLAA CL E G H	9373	617527	NEURODEVELOPMENTAL DISORDER WITH PROGRESSIVE MICROCEPHALY, SPASTICITY, AND BRAIN ANOMALIES	617527	C4479631	OMIM	1	338	9043	603873
HP:0001276	HP:0001276	Hypertonia	0	PLK4 CL E G H	10733	2518				ORPHA	1	407	11397	605031
HP:0001276	HP:0001276	Hypertonia	0	PLPBP CL E G H	11212	617290	Epilepsy, early-onset, vitamin b6-dependent	617290	C4310632	OMIM	1	90	9457	604436
HP:0001276	HP:0001276	Hypertonia	0	PMS1 CL E G H	5378	144				ORPHA	1	96	9121	600258
HP:0001276	HP:0001276	Hypertonia	0	PMS2 CL E G H	5395	144				ORPHA	1	4346	9122	600259
HP:0001276	HP:0001276	Hypertonia	0	PNPO CL E G H	55163	79096				ORPHA	1	281	30260	603287
HP:0001276	HP:0001276	Hypertonia	0	PNPO CL E G H	55163	610090	Pyridoxal 5'-phosphate-dependent epilepsy	610090	C1864723	OMIM	1	281	30260	603287
HP:0001276	HP:0001276	Hypertonia	0	POLG CL E G H	5428	203700	Progressive sclerosing poliodystrophy	203700	C0205710	OMIM	1	1917	9179	174763
HP:0001276	HP:0001276	Hypertonia	0	POMGNT1 CL E G H	55624	588				ORPHA	1	943	19139	606822
HP:0001276	HP:0001276	Hypertonia	0	POMT1 CL E G H	10585	588				ORPHA	1	737	9202	607423
HP:0001276	HP:0001276	Hypertonia	0	POMT2 CL E G H	29954	588				ORPHA	1	766	19743	607439
HP:0001276	HP:0001276	Hypertonia	0	PRF1 CL E G H	5551	603553	Hemophagocytic lymphohistiocytosis, familial, 2	603553	C1863727	OMIM	1	404	9360	170280
HP:0001276	HP:0001276	Hypertonia	0	PRRT2 CL E G H	112476	306				ORPHA	1	702	30500	614386
HP:0001276	HP:0001276	Hypertonia	0	PSAP CL E G H	5660	611722	Krabbe disease atypical due to Saposin A deficiency	611722	C2673266	OMIM	1	598	9498	176801
HP:0001276	HP:0001276	Hypertonia	0	PSAT1 CL E G H	29968	610992	Phosphoserine aminotransferase deficiency	610992	C1970253	OMIM	1	443	19129	610936
HP:0001276	HP:0001276	Hypertonia	0	PSEN1 CL E G H	5663	1020				ORPHA	1	452	9508	104311
HP:0001276	HP:0001276	Hypertonia	0	PSEN2 CL E G H	5664	1020				ORPHA	1	237	9509	600759
HP:0001276	HP:0001276	Hypertonia	0	PSPH CL E G H	5723	614023	Deficiency of phosphoserine phosphatase	614023	C1291463	OMIM	1	160	9577	172480
HP:0001276	HP:0001276	Hypertonia	0	PTS CL E G H	5805	261640	6-pyruvoyl-tetrahydropterin synthase deficiency	261640	C0878676	OMIM	1	214	9689	612719
HP:0001276	HP:0001276	Hypertonia	0	QDPR CL E G H	5860	261630	Dihydropteridine reductase deficiency	261630	C0268465	OMIM	1	259	9752	612676
HP:0001276	HP:0001276	Hypertonia	0	RAD21 CL E G H	5885	199	Cardiac hydatid cysts with intracavitary expansion			ORPHA	1	293	9811	606462
HP:0001276	HP:0001276	Hypertonia	0	RTEL1 CL E G H	51750	3322				ORPHA	1	2005	15888	608833
HP:0001276	HP:0001276	Hypertonia	0	SCN2A CL E G H	6326	306				ORPHA	1	1914	10588	182390
HP:0001276	HP:0001276	Hypertonia	0	SCN4A CL E G H	6329	99734				ORPHA	1	1391	10591	603967
HP:0001276	HP:0001276	Hypertonia	0	SCN4A CL E G H	6329	99735				ORPHA	1	1391	10591	603967
HP:0001276	HP:0001276	Hypertonia	0	SCN4A CL E G H	6329	99736				ORPHA	1	1391	10591	603967
HP:0001276	HP:0001276	Hypertonia	0	SCN8A CL E G H	6334	306				ORPHA	1	1494	10596	600702
HP:0001276	HP:0001276	Hypertonia	0	SETD5 CL E G H	55209	199	Cardiac hydatid cysts with intracavitary expansion			ORPHA	1	617	25566	615743
HP:0001276	HP:0001276	Hypertonia	0	SLC19A3 CL E G H	80704	607483	Basal ganglia disease, biotin-responsive	607483	C1843807	OMIM	1	482	16266	606152
HP:0001276	HP:0001276	Hypertonia	0	SLC6A19 CL E G H	340024	234500	Neutral 1 amino acid transport defect	234500	C0018609	OMIM	1	371	27960	608893
HP:0001276	HP:0001276	Hypertonia	0	SLC6A3 CL E G H	6531	613135	Infantile Parkinsonism-dystonia	613135	C2751067	OMIM	1	479	11049	126455
HP:0001276	HP:0001276	Hypertonia	0	SLC6A5 CL E G H	9152	614618	Hyperekplexia 3	614618	C3553288	OMIM	1	532	11051	604159
HP:0001276	HP:0001276	Hypertonia	0	SLC6A8 CL E G H	6535	52503				ORPHA	1	903	11055	300036
HP:0001276	HP:0001276	Hypertonia	0	SLC6A9 CL E G H	6536	617301	Glycine encephalopathy with normal serum glycine	617301	C4310943	OMIM	1	168	11056	601019
HP:0001276	HP:0001276	Hypertonia	0	SMC1A CL E G H	8243	199	Cardiac hydatid cysts with intracavitary expansion			ORPHA	1	798	11111	300040
HP:0001276	HP:0001276	Hypertonia	0	SMC3 CL E G H	9126	199	Cardiac hydatid cysts with intracavitary expansion			ORPHA	1	358	2468	606062
HP:0001276	HP:0001276	Hypertonia	0	SORL1 CL E G H	6653	1020				ORPHA	1	320	11185	602005
HP:0001276	HP:0001276	Hypertonia	0	SOX10 CL E G H	6663	611584	Waardenburg syndrome type 2E	611584	C2700405	OMIM	1	302	11190	602229
HP:0001276	HP:0001276	Hypertonia	0	SUOX CL E G H	6821	272300	Sulfite oxidase deficiency	272300	C0268624	OMIM	1	275	11460	606887
HP:0001276	HP:0001276	Hypertonia	0	TERT CL E G H	7015	3322				ORPHA	1	2449	11730	187270
HP:0001276	HP:0001276	Hypertonia	0	TGFBR2 CL E G H	7048	144				ORPHA	1	842	11773	190182
HP:0001276	HP:0001276	Hypertonia	0	TINF2 CL E G H	26277	3322				ORPHA	1	330	11824	604319
HP:0001276	HP:0001276	Hypertonia	0	TINF2 CL E G H	26277	268130	Revesz syndrome	268130	C1327916	OMIM	1	330	11824	604319
HP:0001276	HP:0001276	Hypertonia	0	TMEM106B CL E G H	54664	617964	LEUKODYSTROPHY, HYPOMYELINATING, 16	617964	CN244907	OMIM	1	87	22407	613413
HP:0001276	HP:0001276	Hypertonia	0	TOMM40 CL E G H	10452	1020				ORPHA	1	14	18001	608061
HP:0001276	HP:0001276	Hypertonia	0	TOR1A CL E G H	1861	128100	Dystonia 1	128100	C1851945	OMIM	1	172	3098	605204
HP:0001276	HP:0001276	Hypertonia	0	TOR1A CL E G H	1861	256	Schrander-Stumpel Theunissen Hulsmans syndrome			ORPHA	1	172	3098	605204
HP:0001276	HP:0001276	Hypertonia	0	TRAF7 CL E G H	84231	618164	CARDIAC, FACIAL, AND DIGITAL ANOMALIES WITH DEVELOPMENTAL DELAY	618164		OMIM	1	101	20456	606692
HP:0001276	HP:0001276	Hypertonia	0	TREM2 CL E G H	54209	1020				ORPHA	1	110	17761	605086
HP:0001276	HP:0001276	Hypertonia	0	TUBGCP4 CL E G H	27229	2518				ORPHA	1	354	16691	609610
HP:0001276	HP:0001276	Hypertonia	0	TUBGCP6 CL E G H	85378	2518				ORPHA	1	1541	18127	610053
HP:0001276	HP:0001276	Hypertonia	0	VAC14 CL E G H	55697	617054	Striatonigral degeneration, childhood-onset	617054	C4310743	OMIM	1	220	25507	604632
HP:0001276	HP:0001276	Hypertonia	0	VPS37A CL E G H	137492	614898	Spastic paraplegia 53, autosomal recessive	614898	C3539494	OMIM	1	198	24928	609927
HP:0001276	HP:0001276	Hypertonia	0	ZSWIM6 CL E G H	57688	617865	NEURODEVELOPMENTAL DISORDER WITH MOVEMENT ABNORMALITIES, ABNORMAL GAIT, AND AUTISTIC FEATURES	617865	CN800196	OMIM	1	466	29316	615951
HP:0001276	HP:0002509	Limb hypertonia	1	ABCA7 CL E G H	10347	1020				ORPHA	1	148	37	605414
HP:0001276	HP:0031867	Neck hypertonia	1	ABCA7 CL E G H	10347	1020				ORPHA	1	148	37	605414
HP:0001276	HP:0002063	Rigidity	1	ABCA7 CL E G H	10347	1020				ORPHA	1	148	37	605414
HP:0001276	HP:0001257	Spasticity	1	ABCA7 CL E G H	10347	1020				ORPHA	1	148	37	605414
HP:0001276	HP:0002509	Limb hypertonia	1	ACD CL E G H	65057	3322				ORPHA	1	834	25070	609377
HP:0001276	HP:0031867	Neck hypertonia	1	ACD CL E G H	65057	3322				ORPHA	1	834	25070	609377
HP:0001276	HP:0002063	Rigidity	1	ACD CL E G H	65057	3322				ORPHA	1	834	25070	609377
HP:0001276	HP:0001257	Spasticity	1	ACD CL E G H	65057	3322				ORPHA	1	834	25070	609377
HP:0001276	HP:0002509	Limb hypertonia	1	ACOX1 CL E G H	51	264470	Pseudoneonatal adrenoleukodystrophy	264470	C1849678	OMIM	1	517	119	609751
HP:0001276	HP:0031867	Neck hypertonia	1	ACOX1 CL E G H	51	264470	Pseudoneonatal adrenoleukodystrophy	264470	C1849678	OMIM	1	517	119	609751
HP:0001276	HP:0002063	Rigidity	1	ACOX1 CL E G H	51	264470	Pseudoneonatal adrenoleukodystrophy	264470	C1849678	OMIM	1	517	119	609751
HP:0001276	HP:0001257	Spasticity	1	ACOX1 CL E G H	51	264470	Pseudoneonatal adrenoleukodystrophy	264470	C1849678	OMIM	1	517	119	609751
HP:0001276	HP:0002509	Limb hypertonia	1	AFG3L2 CL E G H	10939	610246	Spinocerebellar ataxia 28	610246	C1853249	OMIM	1	385	315	604581
HP:0001276	HP:0031867	Neck hypertonia	1	AFG3L2 CL E G H	10939	610246	Spinocerebellar ataxia 28	610246	C1853249	OMIM	1	385	315	604581
HP:0001276	HP:0002063	Rigidity	1	AFG3L2 CL E G H	10939	610246	Spinocerebellar ataxia 28	610246	C1853249	OMIM	1	385	315	604581
HP:0001276	HP:0001257	Spasticity	1	AFG3L2 CL E G H	10939	610246	Spinocerebellar ataxia 28	610246	C1853249	OMIM	1	385	315	604581
HP:0001276	HP:0002509	Limb hypertonia	1	ALG3 CL E G H	10195	601110	Congenital disorder of glycosylation type 1D	601110	C1832736	OMIM	1	179	23056	608750
HP:0001276	HP:0031867	Neck hypertonia	1	ALG3 CL E G H	10195	601110	Congenital disorder of glycosylation type 1D	601110	C1832736	OMIM	1	179	23056	608750
HP:0001276	HP:0002063	Rigidity	1	ALG3 CL E G H	10195	601110	Congenital disorder of glycosylation type 1D	601110	C1832736	OMIM	1	179	23056	608750
HP:0001276	HP:0001257	Spasticity	1	ALG3 CL E G H	10195	601110	Congenital disorder of glycosylation type 1D	601110	C1832736	OMIM	1	179	23056	608750
HP:0001276	HP:0002509	Limb hypertonia	1	APP CL E G H	351	1020				ORPHA	1	404	620	104760
HP:0001276	HP:0031867	Neck hypertonia	1	APP CL E G H	351	1020				ORPHA	1	404	620	104760
HP:0001276	HP:0002063	Rigidity	1	APP CL E G H	351	1020				ORPHA	1	404	620	104760
HP:0001276	HP:0001257	Spasticity	1	APP CL E G H	351	1020				ORPHA	1	404	620	104760
HP:0001276	HP:0002509	Limb hypertonia	1	ARHGEF9 CL E G H	23229	300607	Early infantile epileptic encephalopathy 8	300607	C1845102	OMIM	1	439	14561	300429
HP:0001276	HP:0031867	Neck hypertonia	1	ARHGEF9 CL E G H	23229	300607	Early infantile epileptic encephalopathy 8	300607	C1845102	OMIM	1	439	14561	300429
HP:0001276	HP:0002063	Rigidity	1	ARHGEF9 CL E G H	23229	300607	Early infantile epileptic encephalopathy 8	300607	C1845102	OMIM	1	439	14561	300429
HP:0001276	HP:0001257	Spasticity	1	ARHGEF9 CL E G H	23229	300607	Early infantile epileptic encephalopathy 8	300607	C1845102	OMIM	1	439	14561	300429
HP:0001276	HP:0002509	Limb hypertonia	1	ARV1 CL E G H	64801	617020	Epileptic encephalopathy, early infantile, 38	617020	C4310762	OMIM	1	71	29561	611647
HP:0001276	HP:0031867	Neck hypertonia	1	ARV1 CL E G H	64801	617020	Epileptic encephalopathy, early infantile, 38	617020	C4310762	OMIM	1	71	29561	611647
HP:0001276	HP:0002063	Rigidity	1	ARV1 CL E G H	64801	617020	Epileptic encephalopathy, early infantile, 38	617020	C4310762	OMIM	1	71	29561	611647
HP:0001276	HP:0001257	Spasticity	1	ARV1 CL E G H	64801	617020	Epileptic encephalopathy, early infantile, 38	617020	C4310762	OMIM	1	71	29561	611647
HP:0001276	HP:0002509	Limb hypertonia	1	ARX CL E G H	170302	308350	Epileptic encephalopathy, early infantile, 1	308350	C3463992	OMIM	1	679	18060	300382
HP:0001276	HP:0031867	Neck hypertonia	1	ARX CL E G H	170302	308350	Epileptic encephalopathy, early infantile, 1	308350	C3463992	OMIM	1	679	18060	300382
HP:0001276	HP:0002063	Rigidity	1	ARX CL E G H	170302	308350	Epileptic encephalopathy, early infantile, 1	308350	C3463992	OMIM	1	679	18060	300382
HP:0001276	HP:0001257	Spasticity	1	ARX CL E G H	170302	308350	Epileptic encephalopathy, early infantile, 1	308350	C3463992	OMIM	1	679	18060	300382
HP:0001276	HP:0002509	Limb hypertonia	1	ATAD1 CL E G H	84896	618011	HYPEREKPLEXIA 4	618011	CN248518	OMIM	1	116	25903	614452
HP:0001276	HP:0031867	Neck hypertonia	1	ATAD1 CL E G H	84896	618011	HYPEREKPLEXIA 4	618011	CN248518	OMIM	1	116	25903	614452
HP:0001276	HP:0002063	Rigidity	1	ATAD1 CL E G H	84896	618011	HYPEREKPLEXIA 4	618011	CN248518	OMIM	1	116	25903	614452
HP:0001276	HP:0001257	Spasticity	1	ATAD1 CL E G H	84896	618011	HYPEREKPLEXIA 4	618011	CN248518	OMIM	1	116	25903	614452
HP:0001276	HP:0002509	Limb hypertonia	1	ATP7A CL E G H	538	309400	Menkes kinky-hair syndrome	309400	C0022716	OMIM	1	1283	869	300011
HP:0001276	HP:0031867	Neck hypertonia	1	ATP7A CL E G H	538	309400	Menkes kinky-hair syndrome	309400	C0022716	OMIM	1	1283	869	300011
HP:0001276	HP:0002063	Rigidity	1	ATP7A CL E G H	538	309400	Menkes kinky-hair syndrome	309400	C0022716	OMIM	1	1283	869	300011
HP:0001276	HP:0001257	Spasticity	1	ATP7A CL E G H	538	309400	Menkes kinky-hair syndrome	309400	C0022716	OMIM	1	1283	869	300011
HP:0001276	HP:0002509	Limb hypertonia	1	B3GALNT2 CL E G H	148789	588				ORPHA	1	462	28596	610194
HP:0001276	HP:0031867	Neck hypertonia	1	B3GALNT2 CL E G H	148789	588				ORPHA	1	462	28596	610194
HP:0001276	HP:0002063	Rigidity	1	B3GALNT2 CL E G H	148789	588				ORPHA	1	462	28596	610194
HP:0001276	HP:0001257	Spasticity	1	B3GALNT2 CL E G H	148789	588				ORPHA	1	462	28596	610194
HP:0001276	HP:0002509	Limb hypertonia	1	BCKDHA CL E G H	593	248600	Maple syrup urine disease	248600	C0024776	OMIM	1	495	986	608348
HP:0001276	HP:0031867	Neck hypertonia	1	BCKDHA CL E G H	593	248600	Maple syrup urine disease	248600	C0024776	OMIM	1	495	986	608348
HP:0001276	HP:0002063	Rigidity	1	BCKDHA CL E G H	593	248600	Maple syrup urine disease	248600	C0024776	OMIM	1	495	986	608348
HP:0001276	HP:0001257	Spasticity	1	BCKDHA CL E G H	593	248600	Maple syrup urine disease	248600	C0024776	OMIM	1	495	986	608348
HP:0001276	HP:0002509	Limb hypertonia	1	BCKDHB CL E G H	594	248600	Maple syrup urine disease	248600	C0024776	OMIM	1	547	987	248611
HP:0001276	HP:0031867	Neck hypertonia	1	BCKDHB CL E G H	594	248600	Maple syrup urine disease	248600	C0024776	OMIM	1	547	987	248611
HP:0001276	HP:0002063	Rigidity	1	BCKDHB CL E G H	594	248600	Maple syrup urine disease	248600	C0024776	OMIM	1	547	987	248611
HP:0001276	HP:0001257	Spasticity	1	BCKDHB CL E G H	594	248600	Maple syrup urine disease	248600	C0024776	OMIM	1	547	987	248611
HP:0001276	HP:0002509	Limb hypertonia	1	BRAF CL E G H	673	115150	Cardiofaciocutaneous syndrome 1	115150	CN029449	OMIM	1	948	1097	164757
HP:0001276	HP:0031867	Neck hypertonia	1	BRAF CL E G H	673	115150	Cardiofaciocutaneous syndrome 1	115150	CN029449	OMIM	1	948	1097	164757
HP:0001276	HP:0002063	Rigidity	1	BRAF CL E G H	673	115150	Cardiofaciocutaneous syndrome 1	115150	CN029449	OMIM	1	948	1097	164757
HP:0001276	HP:0001257	Spasticity	1	BRAF CL E G H	673	115150	Cardiofaciocutaneous syndrome 1	115150	CN029449	OMIM	1	948	1097	164757
HP:0001276	HP:0002509	Limb hypertonia	1	BRAT1 CL E G H	221927	618056	NEURODEVELOPMENTAL DISORDER WITH CEREBELLAR ATROPHY AND WITH OR WITHOUT SEIZURES	618056	CN252657	OMIM	1	960	21701	614506
HP:0001276	HP:0031867	Neck hypertonia	1	BRAT1 CL E G H	221927	618056	NEURODEVELOPMENTAL DISORDER WITH CEREBELLAR ATROPHY AND WITH OR WITHOUT SEIZURES	618056	CN252657	OMIM	1	960	21701	614506
HP:0001276	HP:0002063	Rigidity	1	BRAT1 CL E G H	221927	618056	NEURODEVELOPMENTAL DISORDER WITH CEREBELLAR ATROPHY AND WITH OR WITHOUT SEIZURES	618056	CN252657	OMIM	1	960	21701	614506
HP:0001276	HP:0001257	Spasticity	1	BRAT1 CL E G H	221927	618056	NEURODEVELOPMENTAL DISORDER WITH CEREBELLAR ATROPHY AND WITH OR WITHOUT SEIZURES	618056	CN252657	OMIM	1	960	21701	614506
HP:0001276	HP:0002509	Limb hypertonia	1	BRAT1 CL E G H	221927	614498	Rigidity and multifocal seizure syndrome, lethal neonatal	614498	C3281029	OMIM	1	960	21701	614506
HP:0001276	HP:0031867	Neck hypertonia	1	BRAT1 CL E G H	221927	614498	Rigidity and multifocal seizure syndrome, lethal neonatal	614498	C3281029	OMIM	1	960	21701	614506
HP:0001276	HP:0002063	Rigidity	1	BRAT1 CL E G H	221927	614498	Rigidity and multifocal seizure syndrome, lethal neonatal	614498	C3281029	OMIM	1	960	21701	614506
HP:0001276	HP:0001257	Spasticity	1	BRAT1 CL E G H	221927	614498	Rigidity and multifocal seizure syndrome, lethal neonatal	614498	C3281029	OMIM	1	960	21701	614506
HP:0001276	HP:0002509	Limb hypertonia	1	CACNA1A CL E G H	773	617106	Epileptic encephalopathy, early infantile, 42	617106	C4310716	OMIM	1	2689	1388	601011
HP:0001276	HP:0031867	Neck hypertonia	1	CACNA1A CL E G H	773	617106	Epileptic encephalopathy, early infantile, 42	617106	C4310716	OMIM	1	2689	1388	601011
HP:0001276	HP:0002063	Rigidity	1	CACNA1A CL E G H	773	617106	Epileptic encephalopathy, early infantile, 42	617106	C4310716	OMIM	1	2689	1388	601011
HP:0001276	HP:0001257	Spasticity	1	CACNA1A CL E G H	773	617106	Epileptic encephalopathy, early infantile, 42	617106	C4310716	OMIM	1	2689	1388	601011
HP:0001276	HP:0002509	Limb hypertonia	1	CLCF1 CL E G H	23529	1545	Corsello Opitz syndrome			ORPHA	1	33	17412	607672
HP:0001276	HP:0031867	Neck hypertonia	1	CLCF1 CL E G H	23529	1545	Corsello Opitz syndrome			ORPHA	1	33	17412	607672
HP:0001276	HP:0002063	Rigidity	1	CLCF1 CL E G H	23529	1545	Corsello Opitz syndrome			ORPHA	1	33	17412	607672
HP:0001276	HP:0001257	Spasticity	1	CLCF1 CL E G H	23529	1545	Corsello Opitz syndrome			ORPHA	1	33	17412	607672
HP:0001276	HP:0002509	Limb hypertonia	1	COG4 CL E G H	25839	613489	Congenital disorder of glycosylation type 2J	613489	C3150736	OMIM	1	262	18620	606976
HP:0001276	HP:0031867	Neck hypertonia	1	COG4 CL E G H	25839	613489	Congenital disorder of glycosylation type 2J	613489	C3150736	OMIM	1	262	18620	606976
HP:0001276	HP:0002063	Rigidity	1	COG4 CL E G H	25839	613489	Congenital disorder of glycosylation type 2J	613489	C3150736	OMIM	1	262	18620	606976
HP:0001276	HP:0001257	Spasticity	1	COG4 CL E G H	25839	613489	Congenital disorder of glycosylation type 2J	613489	C3150736	OMIM	1	262	18620	606976
HP:0001276	HP:0002509	Limb hypertonia	1	COQ9 CL E G H	57017	614654	Coenzyme Q10 deficiency, primary, 5	614654	C3553374	OMIM	1	183	25302	612837
HP:0001276	HP:0031867	Neck hypertonia	1	COQ9 CL E G H	57017	614654	Coenzyme Q10 deficiency, primary, 5	614654	C3553374	OMIM	1	183	25302	612837
HP:0001276	HP:0002063	Rigidity	1	COQ9 CL E G H	57017	614654	Coenzyme Q10 deficiency, primary, 5	614654	C3553374	OMIM	1	183	25302	612837
HP:0001276	HP:0001257	Spasticity	1	COQ9 CL E G H	57017	614654	Coenzyme Q10 deficiency, primary, 5	614654	C3553374	OMIM	1	183	25302	612837
HP:0001276	HP:0002509	Limb hypertonia	1	CP CL E G H	1356	48818				ORPHA	1	655	2295	117700
HP:0001276	HP:0031867	Neck hypertonia	1	CP CL E G H	1356	48818				ORPHA	1	655	2295	117700
HP:0001276	HP:0002063	Rigidity	1	CP CL E G H	1356	48818				ORPHA	1	655	2295	117700
HP:0001276	HP:0001257	Spasticity	1	CP CL E G H	1356	48818				ORPHA	1	655	2295	117700
HP:0001276	HP:0002509	Limb hypertonia	1	CRLF1 CL E G H	9244	1545	Corsello Opitz syndrome			ORPHA	1	80	2364	604237
HP:0001276	HP:0031867	Neck hypertonia	1	CRLF1 CL E G H	9244	1545	Corsello Opitz syndrome			ORPHA	1	80	2364	604237
HP:0001276	HP:0002063	Rigidity	1	CRLF1 CL E G H	9244	1545	Corsello Opitz syndrome			ORPHA	1	80	2364	604237
HP:0001276	HP:0001257	Spasticity	1	CRLF1 CL E G H	9244	1545	Corsello Opitz syndrome			ORPHA	1	80	2364	604237
HP:0001276	HP:0002509	Limb hypertonia	1	CYB5R3 CL E G H	1727	250800	Deficiency of cytochrome-b5 reductase	250800	C0268193	OMIM	1	151	2873	613213
HP:0001276	HP:0031867	Neck hypertonia	1	CYB5R3 CL E G H	1727	250800	Deficiency of cytochrome-b5 reductase	250800	C0268193	OMIM	1	151	2873	613213
HP:0001276	HP:0002063	Rigidity	1	CYB5R3 CL E G H	1727	250800	Deficiency of cytochrome-b5 reductase	250800	C0268193	OMIM	1	151	2873	613213
HP:0001276	HP:0001257	Spasticity	1	CYB5R3 CL E G H	1727	250800	Deficiency of cytochrome-b5 reductase	250800	C0268193	OMIM	1	151	2873	613213
HP:0001276	HP:0002509	Limb hypertonia	1	DBT CL E G H	1629	248600	Maple syrup urine disease	248600	C0024776	OMIM	1	582	2698	248610
HP:0001276	HP:0031867	Neck hypertonia	1	DBT CL E G H	1629	248600	Maple syrup urine disease	248600	C0024776	OMIM	1	582	2698	248610
HP:0001276	HP:0002063	Rigidity	1	DBT CL E G H	1629	248600	Maple syrup urine disease	248600	C0024776	OMIM	1	582	2698	248610
HP:0001276	HP:0001257	Spasticity	1	DBT CL E G H	1629	248600	Maple syrup urine disease	248600	C0024776	OMIM	1	582	2698	248610
HP:0001276	HP:0002509	Limb hypertonia	1	DCX CL E G H	1641	2148				ORPHA	1	388	2714	300121
HP:0001276	HP:0031867	Neck hypertonia	1	DCX CL E G H	1641	2148				ORPHA	1	388	2714	300121
HP:0001276	HP:0002063	Rigidity	1	DCX CL E G H	1641	2148				ORPHA	1	388	2714	300121
HP:0001276	HP:0001257	Spasticity	1	DCX CL E G H	1641	2148				ORPHA	1	388	2714	300121
HP:0001276	HP:0002509	Limb hypertonia	1	DHCR7 CL E G H	1717	270400	Smith-Lemli-Opitz syndrome	270400	C0175694	OMIM	1	648	2860	602858
HP:0001276	HP:0031867	Neck hypertonia	1	DHCR7 CL E G H	1717	270400	Smith-Lemli-Opitz syndrome	270400	C0175694	OMIM	1	648	2860	602858
HP:0001276	HP:0002063	Rigidity	1	DHCR7 CL E G H	1717	270400	Smith-Lemli-Opitz syndrome	270400	C0175694	OMIM	1	648	2860	602858
HP:0001276	HP:0001257	Spasticity	1	DHCR7 CL E G H	1717	270400	Smith-Lemli-Opitz syndrome	270400	C0175694	OMIM	1	648	2860	602858
HP:0001276	HP:0002509	Limb hypertonia	1	DKC1 CL E G H	1736	3322				ORPHA	1	477	2890	300126
HP:0001276	HP:0031867	Neck hypertonia	1	DKC1 CL E G H	1736	3322				ORPHA	1	477	2890	300126
HP:0001276	HP:0002063	Rigidity	1	DKC1 CL E G H	1736	3322				ORPHA	1	477	2890	300126
HP:0001276	HP:0001257	Spasticity	1	DKC1 CL E G H	1736	3322				ORPHA	1	477	2890	300126
HP:0001276	HP:0002509	Limb hypertonia	1	DMPK CL E G H	1760	273				ORPHA	1	235	2933	605377
HP:0001276	HP:0031867	Neck hypertonia	1	DMPK CL E G H	1760	273				ORPHA	1	235	2933	605377
HP:0001276	HP:0002063	Rigidity	1	DMPK CL E G H	1760	273				ORPHA	1	235	2933	605377
HP:0001276	HP:0001257	Spasticity	1	DMPK CL E G H	1760	273				ORPHA	1	235	2933	605377
HP:0001276	HP:0002509	Limb hypertonia	1	DNAJC12 CL E G H	56521	617384	Hyperphenylalaninemia, mild, non-bh4-deficient	617384	C4479270	OMIM	1	93	28908	606060
HP:0001276	HP:0031867	Neck hypertonia	1	DNAJC12 CL E G H	56521	617384	Hyperphenylalaninemia, mild, non-bh4-deficient	617384	C4479270	OMIM	1	93	28908	606060
HP:0001276	HP:0002063	Rigidity	1	DNAJC12 CL E G H	56521	617384	Hyperphenylalaninemia, mild, non-bh4-deficient	617384	C4479270	OMIM	1	93	28908	606060
HP:0001276	HP:0001257	Spasticity	1	DNAJC12 CL E G H	56521	617384	Hyperphenylalaninemia, mild, non-bh4-deficient	617384	C4479270	OMIM	1	93	28908	606060
HP:0001276	HP:0002509	Limb hypertonia	1	DPAGT1 CL E G H	1798	608093	Congenital disorder of glycosylation type 1J	608093	C2931004	OMIM	1	258	2995	191350
HP:0001276	HP:0031867	Neck hypertonia	1	DPAGT1 CL E G H	1798	608093	Congenital disorder of glycosylation type 1J	608093	C2931004	OMIM	1	258	2995	191350
HP:0001276	HP:0002063	Rigidity	1	DPAGT1 CL E G H	1798	608093	Congenital disorder of glycosylation type 1J	608093	C2931004	OMIM	1	258	2995	191350
HP:0001276	HP:0001257	Spasticity	1	DPAGT1 CL E G H	1798	608093	Congenital disorder of glycosylation type 1J	608093	C2931004	OMIM	1	258	2995	191350
HP:0001276	HP:0002509	Limb hypertonia	1	DPYD CL E G H	1806	274270	Dihydropyrimidine dehydrogenase deficiency	274270	C2720286	OMIM	1	379	3012	612779
HP:0001276	HP:0031867	Neck hypertonia	1	DPYD CL E G H	1806	274270	Dihydropyrimidine dehydrogenase deficiency	274270	C2720286	OMIM	1	379	3012	612779
HP:0001276	HP:0002063	Rigidity	1	DPYD CL E G H	1806	274270	Dihydropyrimidine dehydrogenase deficiency	274270	C2720286	OMIM	1	379	3012	612779
HP:0001276	HP:0001257	Spasticity	1	DPYD CL E G H	1806	274270	Dihydropyrimidine dehydrogenase deficiency	274270	C2720286	OMIM	1	379	3012	612779
HP:0001276	HP:0002509	Limb hypertonia	1	EBP CL E G H	10682	300960	MEND syndrome	300960	C4085243	OMIM	1	291	3133	300205
HP:0001276	HP:0031867	Neck hypertonia	1	EBP CL E G H	10682	300960	MEND syndrome	300960	C4085243	OMIM	1	291	3133	300205
HP:0001276	HP:0002063	Rigidity	1	EBP CL E G H	10682	300960	MEND syndrome	300960	C4085243	OMIM	1	291	3133	300205
HP:0001276	HP:0001257	Spasticity	1	EBP CL E G H	10682	300960	MEND syndrome	300960	C4085243	OMIM	1	291	3133	300205
HP:0001276	HP:0002509	Limb hypertonia	1	EIF2AK3 CL E G H	9451	226980	Wolcott-Rallison dysplasia	226980	C0432217	OMIM	1	359	3255	604032
HP:0001276	HP:0031867	Neck hypertonia	1	EIF2AK3 CL E G H	9451	226980	Wolcott-Rallison dysplasia	226980	C0432217	OMIM	1	359	3255	604032
HP:0001276	HP:0002063	Rigidity	1	EIF2AK3 CL E G H	9451	226980	Wolcott-Rallison dysplasia	226980	C0432217	OMIM	1	359	3255	604032
HP:0001276	HP:0001257	Spasticity	1	EIF2AK3 CL E G H	9451	226980	Wolcott-Rallison dysplasia	226980	C0432217	OMIM	1	359	3255	604032
HP:0001276	HP:0002509	Limb hypertonia	1	EIF2S3 CL E G H	1968	85282				ORPHA	1	190	3267	300161
HP:0001276	HP:0031867	Neck hypertonia	1	EIF2S3 CL E G H	1968	85282				ORPHA	1	190	3267	300161
HP:0001276	HP:0002063	Rigidity	1	EIF2S3 CL E G H	1968	85282				ORPHA	1	190	3267	300161
HP:0001276	HP:0001257	Spasticity	1	EIF2S3 CL E G H	1968	85282				ORPHA	1	190	3267	300161
HP:0001276	HP:0002509	Limb hypertonia	1	EPCAM CL E G H	4072	144				ORPHA	1	613	11529	185535
HP:0001276	HP:0031867	Neck hypertonia	1	EPCAM CL E G H	4072	144				ORPHA	1	613	11529	185535
HP:0001276	HP:0002063	Rigidity	1	EPCAM CL E G H	4072	144				ORPHA	1	613	11529	185535
HP:0001276	HP:0001257	Spasticity	1	EPCAM CL E G H	4072	144				ORPHA	1	613	11529	185535
HP:0001276	HP:0002509	Limb hypertonia	1	ERCC1 CL E G H	2067	1466				ORPHA	1	113	3433	126380
HP:0001276	HP:0031867	Neck hypertonia	1	ERCC1 CL E G H	2067	1466				ORPHA	1	113	3433	126380
HP:0001276	HP:0002063	Rigidity	1	ERCC1 CL E G H	2067	1466				ORPHA	1	113	3433	126380
HP:0001276	HP:0001257	Spasticity	1	ERCC1 CL E G H	2067	1466				ORPHA	1	113	3433	126380
HP:0001276	HP:0002509	Limb hypertonia	1	ERCC1 CL E G H	2067	610758	Cerebrooculofacioskeletal syndrome 4	610758	C1853100	OMIM	1	113	3433	126380
HP:0001276	HP:0031867	Neck hypertonia	1	ERCC1 CL E G H	2067	610758	Cerebrooculofacioskeletal syndrome 4	610758	C1853100	OMIM	1	113	3433	126380
HP:0001276	HP:0002063	Rigidity	1	ERCC1 CL E G H	2067	610758	Cerebrooculofacioskeletal syndrome 4	610758	C1853100	OMIM	1	113	3433	126380
HP:0001276	HP:0001257	Spasticity	1	ERCC1 CL E G H	2067	610758	Cerebrooculofacioskeletal syndrome 4	610758	C1853100	OMIM	1	113	3433	126380
HP:0001276	HP:0002509	Limb hypertonia	1	ERCC2 CL E G H	2068	1466				ORPHA	1	1196	3434	126340
HP:0001276	HP:0031867	Neck hypertonia	1	ERCC2 CL E G H	2068	1466				ORPHA	1	1196	3434	126340
HP:0001276	HP:0002063	Rigidity	1	ERCC2 CL E G H	2068	1466				ORPHA	1	1196	3434	126340
HP:0001276	HP:0001257	Spasticity	1	ERCC2 CL E G H	2068	1466				ORPHA	1	1196	3434	126340
HP:0001276	HP:0002509	Limb hypertonia	1	ERCC5 CL E G H	2073	1466				ORPHA	1	425	3437	133530
HP:0001276	HP:0031867	Neck hypertonia	1	ERCC5 CL E G H	2073	1466				ORPHA	1	425	3437	133530
HP:0001276	HP:0002063	Rigidity	1	ERCC5 CL E G H	2073	1466				ORPHA	1	425	3437	133530
HP:0001276	HP:0001257	Spasticity	1	ERCC5 CL E G H	2073	1466				ORPHA	1	425	3437	133530
HP:0001276	HP:0002509	Limb hypertonia	1	ERCC6 CL E G H	2074	1466				ORPHA	1	1170	3438	609413
HP:0001276	HP:0031867	Neck hypertonia	1	ERCC6 CL E G H	2074	1466				ORPHA	1	1170	3438	609413
HP:0001276	HP:0002063	Rigidity	1	ERCC6 CL E G H	2074	1466				ORPHA	1	1170	3438	609413
HP:0001276	HP:0001257	Spasticity	1	ERCC6 CL E G H	2074	1466				ORPHA	1	1170	3438	609413
HP:0001276	HP:0002509	Limb hypertonia	1	EYA1 CL E G H	2138	2792	Hyperbilirubinemia type 1			ORPHA	1	434	3519	601653
HP:0001276	HP:0031867	Neck hypertonia	1	EYA1 CL E G H	2138	2792	Hyperbilirubinemia type 1			ORPHA	1	434	3519	601653
HP:0001276	HP:0002063	Rigidity	1	EYA1 CL E G H	2138	2792	Hyperbilirubinemia type 1			ORPHA	1	434	3519	601653
HP:0001276	HP:0001257	Spasticity	1	EYA1 CL E G H	2138	2792	Hyperbilirubinemia type 1			ORPHA	1	434	3519	601653
HP:0001276	HP:0002509	Limb hypertonia	1	EZH2 CL E G H	2146	277590	Weaver syndrome	277590	C0265210	OMIM	1	416	3527	601573
HP:0001276	HP:0031867	Neck hypertonia	1	EZH2 CL E G H	2146	277590	Weaver syndrome	277590	C0265210	OMIM	1	416	3527	601573
HP:0001276	HP:0002063	Rigidity	1	EZH2 CL E G H	2146	277590	Weaver syndrome	277590	C0265210	OMIM	1	416	3527	601573
HP:0001276	HP:0001257	Spasticity	1	EZH2 CL E G H	2146	277590	Weaver syndrome	277590	C0265210	OMIM	1	416	3527	601573
HP:0001276	HP:0002509	Limb hypertonia	1	FAN1 CL E G H	22909	144				ORPHA	1	360	29170	613534
HP:0001276	HP:0031867	Neck hypertonia	1	FAN1 CL E G H	22909	144				ORPHA	1	360	29170	613534
HP:0001276	HP:0002063	Rigidity	1	FAN1 CL E G H	22909	144				ORPHA	1	360	29170	613534
HP:0001276	HP:0001257	Spasticity	1	FAN1 CL E G H	22909	144				ORPHA	1	360	29170	613534
HP:0001276	HP:0002509	Limb hypertonia	1	FKRP CL E G H	79147	588				ORPHA	1	787	17997	606596
HP:0001276	HP:0031867	Neck hypertonia	1	FKRP CL E G H	79147	588				ORPHA	1	787	17997	606596
HP:0001276	HP:0002063	Rigidity	1	FKRP CL E G H	79147	588				ORPHA	1	787	17997	606596
HP:0001276	HP:0001257	Spasticity	1	FKRP CL E G H	79147	588				ORPHA	1	787	17997	606596
HP:0001276	HP:0002509	Limb hypertonia	1	FKTN CL E G H	2218	588				ORPHA	1	783	3622	607440
HP:0001276	HP:0031867	Neck hypertonia	1	FKTN CL E G H	2218	588				ORPHA	1	783	3622	607440
HP:0001276	HP:0002063	Rigidity	1	FKTN CL E G H	2218	588				ORPHA	1	783	3622	607440
HP:0001276	HP:0001257	Spasticity	1	FKTN CL E G H	2218	588				ORPHA	1	783	3622	607440
HP:0001276	HP:0002509	Limb hypertonia	1	FTO CL E G H	79068	612938	Growth retardation, developmental delay, coarse facies, and early death	612938	C2752001	OMIM	1	199	24678	610966
HP:0001276	HP:0031867	Neck hypertonia	1	FTO CL E G H	79068	612938	Growth retardation, developmental delay, coarse facies, and early death	612938	C2752001	OMIM	1	199	24678	610966
HP:0001276	HP:0002063	Rigidity	1	FTO CL E G H	79068	612938	Growth retardation, developmental delay, coarse facies, and early death	612938	C2752001	OMIM	1	199	24678	610966
HP:0001276	HP:0001257	Spasticity	1	FTO CL E G H	79068	612938	Growth retardation, developmental delay, coarse facies, and early death	612938	C2752001	OMIM	1	199	24678	610966
HP:0001276	HP:0002509	Limb hypertonia	1	GALC CL E G H	2581	245200	Galactosylceramide beta-galactosidase deficiency	245200	C0023521	OMIM	1	962	4115	606890
HP:0001276	HP:0031867	Neck hypertonia	1	GALC CL E G H	2581	245200	Galactosylceramide beta-galactosidase deficiency	245200	C0023521	OMIM	1	962	4115	606890
HP:0001276	HP:0002063	Rigidity	1	GALC CL E G H	2581	245200	Galactosylceramide beta-galactosidase deficiency	245200	C0023521	OMIM	1	962	4115	606890
HP:0001276	HP:0001257	Spasticity	1	GALC CL E G H	2581	245200	Galactosylceramide beta-galactosidase deficiency	245200	C0023521	OMIM	1	962	4115	606890
HP:0001276	HP:0002509	Limb hypertonia	1	GAMT CL E G H	2593	612736	Deficiency of guanidinoacetate methyltransferase	612736	C0574080	OMIM	1	487	4136	601240
HP:0001276	HP:0031867	Neck hypertonia	1	GAMT CL E G H	2593	612736	Deficiency of guanidinoacetate methyltransferase	612736	C0574080	OMIM	1	487	4136	601240
HP:0001276	HP:0002063	Rigidity	1	GAMT CL E G H	2593	612736	Deficiency of guanidinoacetate methyltransferase	612736	C0574080	OMIM	1	487	4136	601240
HP:0001276	HP:0001257	Spasticity	1	GAMT CL E G H	2593	612736	Deficiency of guanidinoacetate methyltransferase	612736	C0574080	OMIM	1	487	4136	601240
HP:0001276	HP:0002509	Limb hypertonia	1	GBA CL E G H	2629	2072				ORPHA	1		4177	606463
HP:0001276	HP:0031867	Neck hypertonia	1	GBA CL E G H	2629	2072				ORPHA	1		4177	606463
HP:0001276	HP:0002063	Rigidity	1	GBA CL E G H	2629	2072				ORPHA	1		4177	606463
HP:0001276	HP:0001257	Spasticity	1	GBA CL E G H	2629	2072				ORPHA	1		4177	606463
HP:0001276	HP:0002509	Limb hypertonia	1	GBA CL E G H	2629	85212				ORPHA	1		4177	606463
HP:0001276	HP:0031867	Neck hypertonia	1	GBA CL E G H	2629	85212				ORPHA	1		4177	606463
HP:0001276	HP:0002063	Rigidity	1	GBA CL E G H	2629	85212				ORPHA	1		4177	606463
HP:0001276	HP:0001257	Spasticity	1	GBA CL E G H	2629	85212				ORPHA	1		4177	606463
HP:0001276	HP:0002509	Limb hypertonia	1	GLRA1 CL E G H	2741	149400	Hyperekplexia hereditary	149400	C1835614	OMIM	1	381	4326	138491
HP:0001276	HP:0031867	Neck hypertonia	1	GLRA1 CL E G H	2741	149400	Hyperekplexia hereditary	149400	C1835614	OMIM	1	381	4326	138491
HP:0001276	HP:0002063	Rigidity	1	GLRA1 CL E G H	2741	149400	Hyperekplexia hereditary	149400	C1835614	OMIM	1	381	4326	138491
HP:0001276	HP:0001257	Spasticity	1	GLRA1 CL E G H	2741	149400	Hyperekplexia hereditary	149400	C1835614	OMIM	1	381	4326	138491
HP:0001276	HP:0002509	Limb hypertonia	1	GLRB CL E G H	2743	614619	Hyperekplexia 2	614619	C3553291	OMIM	1	287	4329	138492
HP:0001276	HP:0031867	Neck hypertonia	1	GLRB CL E G H	2743	614619	Hyperekplexia 2	614619	C3553291	OMIM	1	287	4329	138492
HP:0001276	HP:0002063	Rigidity	1	GLRB CL E G H	2743	614619	Hyperekplexia 2	614619	C3553291	OMIM	1	287	4329	138492
HP:0001276	HP:0001257	Spasticity	1	GLRB CL E G H	2743	614619	Hyperekplexia 2	614619	C3553291	OMIM	1	287	4329	138492
HP:0001276	HP:0002509	Limb hypertonia	1	GM2A CL E G H	2760	272750	Tay-Sachs disease, variant AB	272750	C0268275	OMIM	1	166	4367	613109
HP:0001276	HP:0031867	Neck hypertonia	1	GM2A CL E G H	2760	272750	Tay-Sachs disease, variant AB	272750	C0268275	OMIM	1	166	4367	613109
HP:0001276	HP:0002063	Rigidity	1	GM2A CL E G H	2760	272750	Tay-Sachs disease, variant AB	272750	C0268275	OMIM	1	166	4367	613109
HP:0001276	HP:0001257	Spasticity	1	GM2A CL E G H	2760	272750	Tay-Sachs disease, variant AB	272750	C0268275	OMIM	1	166	4367	613109
HP:0001276	HP:0002509	Limb hypertonia	1	GMPPB CL E G H	29925	588				ORPHA	1	273	22932	615320
HP:0001276	HP:0031867	Neck hypertonia	1	GMPPB CL E G H	29925	588				ORPHA	1	273	22932	615320
HP:0001276	HP:0002063	Rigidity	1	GMPPB CL E G H	29925	588				ORPHA	1	273	22932	615320
HP:0001276	HP:0001257	Spasticity	1	GMPPB CL E G H	29925	588				ORPHA	1	273	22932	615320
HP:0001276	HP:0002509	Limb hypertonia	1	GMPPB CL E G H	29925	615351	Muscular dystrophy-dystroglycanopathy (congenital with mental retardation), type b, 14	615351	C3809221	OMIM	1	273	22932	615320
HP:0001276	HP:0031867	Neck hypertonia	1	GMPPB CL E G H	29925	615351	Muscular dystrophy-dystroglycanopathy (congenital with mental retardation), type b, 14	615351	C3809221	OMIM	1	273	22932	615320
HP:0001276	HP:0002063	Rigidity	1	GMPPB CL E G H	29925	615351	Muscular dystrophy-dystroglycanopathy (congenital with mental retardation), type b, 14	615351	C3809221	OMIM	1	273	22932	615320
HP:0001276	HP:0001257	Spasticity	1	GMPPB CL E G H	29925	615351	Muscular dystrophy-dystroglycanopathy (congenital with mental retardation), type b, 14	615351	C3809221	OMIM	1	273	22932	615320
HP:0001276	HP:0002509	Limb hypertonia	1	GPHN CL E G H	10243	149400	Hyperekplexia hereditary	149400	C1835614	OMIM	1	982	15465	603930
HP:0001276	HP:0031867	Neck hypertonia	1	GPHN CL E G H	10243	149400	Hyperekplexia hereditary	149400	C1835614	OMIM	1	982	15465	603930
HP:0001276	HP:0002063	Rigidity	1	GPHN CL E G H	10243	149400	Hyperekplexia hereditary	149400	C1835614	OMIM	1	982	15465	603930
HP:0001276	HP:0001257	Spasticity	1	GPHN CL E G H	10243	149400	Hyperekplexia hereditary	149400	C1835614	OMIM	1	982	15465	603930
HP:0001276	HP:0002509	Limb hypertonia	1	GRIN2D CL E G H	2906	617162	Epileptic encephalopathy, early infantile, 46	617162	C4310687	OMIM	1	519	4588	602717
HP:0001276	HP:0031867	Neck hypertonia	1	GRIN2D CL E G H	2906	617162	Epileptic encephalopathy, early infantile, 46	617162	C4310687	OMIM	1	519	4588	602717
HP:0001276	HP:0002063	Rigidity	1	GRIN2D CL E G H	2906	617162	Epileptic encephalopathy, early infantile, 46	617162	C4310687	OMIM	1	519	4588	602717
HP:0001276	HP:0001257	Spasticity	1	GRIN2D CL E G H	2906	617162	Epileptic encephalopathy, early infantile, 46	617162	C4310687	OMIM	1	519	4588	602717
HP:0001276	HP:0002509	Limb hypertonia	1	HDAC8 CL E G H	55869	199	Cardiac hydatid cysts with intracavitary expansion			ORPHA	1	322	13315	300269
HP:0001276	HP:0031867	Neck hypertonia	1	HDAC8 CL E G H	55869	199	Cardiac hydatid cysts with intracavitary expansion			ORPHA	1	322	13315	300269
HP:0001276	HP:0002063	Rigidity	1	HDAC8 CL E G H	55869	199	Cardiac hydatid cysts with intracavitary expansion			ORPHA	1	322	13315	300269
HP:0001276	HP:0001257	Spasticity	1	HDAC8 CL E G H	55869	199	Cardiac hydatid cysts with intracavitary expansion			ORPHA	1	322	13315	300269
HP:0001276	HP:0002509	Limb hypertonia	1	HEXA CL E G H	3073	272800	Tay-Sachs disease	272800	C0039373	OMIM	1	770	4878	606869
HP:0001276	HP:0031867	Neck hypertonia	1	HEXA CL E G H	3073	272800	Tay-Sachs disease	272800	C0039373	OMIM	1	770	4878	606869
HP:0001276	HP:0002063	Rigidity	1	HEXA CL E G H	3073	272800	Tay-Sachs disease	272800	C0039373	OMIM	1	770	4878	606869
HP:0001276	HP:0001257	Spasticity	1	HEXA CL E G H	3073	272800	Tay-Sachs disease	272800	C0039373	OMIM	1	770	4878	606869
HP:0001276	HP:0002509	Limb hypertonia	1	HIST1H1E CL E G H	3008	617537	RAHMAN SYNDROME	617537	C4479637	OMIM	1		4718	142220
HP:0001276	HP:0031867	Neck hypertonia	1	HIST1H1E CL E G H	3008	617537	RAHMAN SYNDROME	617537	C4479637	OMIM	1		4718	142220
HP:0001276	HP:0002063	Rigidity	1	HIST1H1E CL E G H	3008	617537	RAHMAN SYNDROME	617537	C4479637	OMIM	1		4718	142220
HP:0001276	HP:0001257	Spasticity	1	HIST1H1E CL E G H	3008	617537	RAHMAN SYNDROME	617537	C4479637	OMIM	1		4718	142220
HP:0001276	HP:0002509	Limb hypertonia	1	HLCS CL E G H	3141	253270	Holocarboxylase synthetase deficiency	253270	C0268581	OMIM	1	722	4976	609018
HP:0001276	HP:0031867	Neck hypertonia	1	HLCS CL E G H	3141	253270	Holocarboxylase synthetase deficiency	253270	C0268581	OMIM	1	722	4976	609018
HP:0001276	HP:0002063	Rigidity	1	HLCS CL E G H	3141	253270	Holocarboxylase synthetase deficiency	253270	C0268581	OMIM	1	722	4976	609018
HP:0001276	HP:0001257	Spasticity	1	HLCS CL E G H	3141	253270	Holocarboxylase synthetase deficiency	253270	C0268581	OMIM	1	722	4976	609018
HP:0001276	HP:0002509	Limb hypertonia	1	HNRNPH2 CL E G H	3188	300986	Mental retardation, X-linked, syndromic, Bain type	300986	C4310814	OMIM	1	186	5042	300610
HP:0001276	HP:0031867	Neck hypertonia	1	HNRNPH2 CL E G H	3188	300986	Mental retardation, X-linked, syndromic, Bain type	300986	C4310814	OMIM	1	186	5042	300610
HP:0001276	HP:0002063	Rigidity	1	HNRNPH2 CL E G H	3188	300986	Mental retardation, X-linked, syndromic, Bain type	300986	C4310814	OMIM	1	186	5042	300610
HP:0001276	HP:0001257	Spasticity	1	HNRNPH2 CL E G H	3188	300986	Mental retardation, X-linked, syndromic, Bain type	300986	C4310814	OMIM	1	186	5042	300610
HP:0001276	HP:0002509	Limb hypertonia	1	HSPG2 CL E G H	3339	800				ORPHA	1	1830	5273	142461
HP:0001276	HP:0031867	Neck hypertonia	1	HSPG2 CL E G H	3339	800				ORPHA	1	1830	5273	142461
HP:0001276	HP:0002063	Rigidity	1	HSPG2 CL E G H	3339	800				ORPHA	1	1830	5273	142461
HP:0001276	HP:0001257	Spasticity	1	HSPG2 CL E G H	3339	800				ORPHA	1	1830	5273	142461
HP:0001276	HP:0002509	Limb hypertonia	1	HTRA2 CL E G H	27429	617248	3-methylglutaconic aciduria, type VIII	617248	C4310650	OMIM	1	162	14348	606441
HP:0001276	HP:0031867	Neck hypertonia	1	HTRA2 CL E G H	27429	617248	3-methylglutaconic aciduria, type VIII	617248	C4310650	OMIM	1	162	14348	606441
HP:0001276	HP:0002063	Rigidity	1	HTRA2 CL E G H	27429	617248	3-methylglutaconic aciduria, type VIII	617248	C4310650	OMIM	1	162	14348	606441
HP:0001276	HP:0001257	Spasticity	1	HTRA2 CL E G H	27429	617248	3-methylglutaconic aciduria, type VIII	617248	C4310650	OMIM	1	162	14348	606441
HP:0001276	HP:0002509	Limb hypertonia	1	ITM2B CL E G H	9445	176500	Dementia familial British	176500	C1867773	OMIM	1	114	6174	603904
HP:0001276	HP:0031867	Neck hypertonia	1	ITM2B CL E G H	9445	176500	Dementia familial British	176500	C1867773	OMIM	1	114	6174	603904
HP:0001276	HP:0002063	Rigidity	1	ITM2B CL E G H	9445	176500	Dementia familial British	176500	C1867773	OMIM	1	114	6174	603904
HP:0001276	HP:0001257	Spasticity	1	ITM2B CL E G H	9445	176500	Dementia familial British	176500	C1867773	OMIM	1	114	6174	603904
HP:0001276	HP:0002509	Limb hypertonia	1	KCNQ2 CL E G H	3785	306				ORPHA	1	1689	6296	602235
HP:0001276	HP:0031867	Neck hypertonia	1	KCNQ2 CL E G H	3785	306				ORPHA	1	1689	6296	602235
HP:0001276	HP:0002063	Rigidity	1	KCNQ2 CL E G H	3785	306				ORPHA	1	1689	6296	602235
HP:0001276	HP:0001257	Spasticity	1	KCNQ2 CL E G H	3785	306				ORPHA	1	1689	6296	602235
HP:0001276	HP:0002509	Limb hypertonia	1	KCNQ2 CL E G H	3785	1949	Benign familial neonatal seizures		CN200689	ORPHA	1	1689	6296	602235
HP:0001276	HP:0031867	Neck hypertonia	1	KCNQ2 CL E G H	3785	1949	Benign familial neonatal seizures		CN200689	ORPHA	1	1689	6296	602235
HP:0001276	HP:0002063	Rigidity	1	KCNQ2 CL E G H	3785	1949	Benign familial neonatal seizures		CN200689	ORPHA	1	1689	6296	602235
HP:0001276	HP:0001257	Spasticity	1	KCNQ2 CL E G H	3785	1949	Benign familial neonatal seizures		CN200689	ORPHA	1	1689	6296	602235
HP:0001276	HP:0002509	Limb hypertonia	1	KCNQ3 CL E G H	3786	306				ORPHA	1	1082	6297	602232
HP:0001276	HP:0031867	Neck hypertonia	1	KCNQ3 CL E G H	3786	306				ORPHA	1	1082	6297	602232
HP:0001276	HP:0002063	Rigidity	1	KCNQ3 CL E G H	3786	306				ORPHA	1	1082	6297	602232
HP:0001276	HP:0001257	Spasticity	1	KCNQ3 CL E G H	3786	306				ORPHA	1	1082	6297	602232
HP:0001276	HP:0002509	Limb hypertonia	1	KCNQ3 CL E G H	3786	1949	Benign familial neonatal seizures		CN200689	ORPHA	1	1082	6297	602232
HP:0001276	HP:0031867	Neck hypertonia	1	KCNQ3 CL E G H	3786	1949	Benign familial neonatal seizures		CN200689	ORPHA	1	1082	6297	602232
HP:0001276	HP:0002063	Rigidity	1	KCNQ3 CL E G H	3786	1949	Benign familial neonatal seizures		CN200689	ORPHA	1	1082	6297	602232
HP:0001276	HP:0001257	Spasticity	1	KCNQ3 CL E G H	3786	1949	Benign familial neonatal seizures		CN200689	ORPHA	1	1082	6297	602232
HP:0001276	HP:0002509	Limb hypertonia	1	KMT2A CL E G H	4297	199	Cardiac hydatid cysts with intracavitary expansion			ORPHA	1	1317	7132	159555
HP:0001276	HP:0031867	Neck hypertonia	1	KMT2A CL E G H	4297	199	Cardiac hydatid cysts with intracavitary expansion			ORPHA	1	1317	7132	159555
HP:0001276	HP:0002063	Rigidity	1	KMT2A CL E G H	4297	199	Cardiac hydatid cysts with intracavitary expansion			ORPHA	1	1317	7132	159555
HP:0001276	HP:0001257	Spasticity	1	KMT2A CL E G H	4297	199	Cardiac hydatid cysts with intracavitary expansion			ORPHA	1	1317	7132	159555
HP:0001276	HP:0002509	Limb hypertonia	1	KRAS CL E G H	3845	144				ORPHA	1	440	6407	190070
HP:0001276	HP:0031867	Neck hypertonia	1	KRAS CL E G H	3845	144				ORPHA	1	440	6407	190070
HP:0001276	HP:0002063	Rigidity	1	KRAS CL E G H	3845	144				ORPHA	1	440	6407	190070
HP:0001276	HP:0001257	Spasticity	1	KRAS CL E G H	3845	144				ORPHA	1	440	6407	190070
HP:0001276	HP:0002509	Limb hypertonia	1	KYNU CL E G H	8942	79155				ORPHA	1	62	6469	605197
HP:0001276	HP:0031867	Neck hypertonia	1	KYNU CL E G H	8942	79155				ORPHA	1	62	6469	605197
HP:0001276	HP:0002063	Rigidity	1	KYNU CL E G H	8942	79155				ORPHA	1	62	6469	605197
HP:0001276	HP:0001257	Spasticity	1	KYNU CL E G H	8942	79155				ORPHA	1	62	6469	605197
HP:0001276	HP:0002509	Limb hypertonia	1	KYNU CL E G H	8942	236800	Hydroxykynureninuria	236800	C0268474	OMIM	1	62	6469	605197
HP:0001276	HP:0031867	Neck hypertonia	1	KYNU CL E G H	8942	236800	Hydroxykynureninuria	236800	C0268474	OMIM	1	62	6469	605197
HP:0001276	HP:0002063	Rigidity	1	KYNU CL E G H	8942	236800	Hydroxykynureninuria	236800	C0268474	OMIM	1	62	6469	605197
HP:0001276	HP:0001257	Spasticity	1	KYNU CL E G H	8942	236800	Hydroxykynureninuria	236800	C0268474	OMIM	1	62	6469	605197
HP:0001276	HP:0002509	Limb hypertonia	1	LARGE1 CL E G H	9215	588				ORPHA	1	658	6511	603590
HP:0001276	HP:0031867	Neck hypertonia	1	LARGE1 CL E G H	9215	588				ORPHA	1	658	6511	603590
HP:0001276	HP:0002063	Rigidity	1	LARGE1 CL E G H	9215	588				ORPHA	1	658	6511	603590
HP:0001276	HP:0001257	Spasticity	1	LARGE1 CL E G H	9215	588				ORPHA	1	658	6511	603590
HP:0001276	HP:0002509	Limb hypertonia	1	MBOAT7 CL E G H	79143	617188	Mental retardation, autosomal recessive 57	617188	C4310673	OMIM	1	71	15505	606048
HP:0001276	HP:0031867	Neck hypertonia	1	MBOAT7 CL E G H	79143	617188	Mental retardation, autosomal recessive 57	617188	C4310673	OMIM	1	71	15505	606048
HP:0001276	HP:0002063	Rigidity	1	MBOAT7 CL E G H	79143	617188	Mental retardation, autosomal recessive 57	617188	C4310673	OMIM	1	71	15505	606048
HP:0001276	HP:0001257	Spasticity	1	MBOAT7 CL E G H	79143	617188	Mental retardation, autosomal recessive 57	617188	C4310673	OMIM	1	71	15505	606048
HP:0001276	HP:0002509	Limb hypertonia	1	MFN2 CL E G H	9927	609260	Charcot-Marie-Tooth disease, type 2A2A	609260	C1836485	OMIM	1	1063	16877	608507
HP:0001276	HP:0031867	Neck hypertonia	1	MFN2 CL E G H	9927	609260	Charcot-Marie-Tooth disease, type 2A2A	609260	C1836485	OMIM	1	1063	16877	608507
HP:0001276	HP:0002063	Rigidity	1	MFN2 CL E G H	9927	609260	Charcot-Marie-Tooth disease, type 2A2A	609260	C1836485	OMIM	1	1063	16877	608507
HP:0001276	HP:0001257	Spasticity	1	MFN2 CL E G H	9927	609260	Charcot-Marie-Tooth disease, type 2A2A	609260	C1836485	OMIM	1	1063	16877	608507
HP:0001276	HP:0002509	Limb hypertonia	1	MGAT2 CL E G H	4247	212066	Carbohydrate-deficient glycoprotein syndrome type II	212066	C2931008	OMIM	1	123	7045	602616
HP:0001276	HP:0031867	Neck hypertonia	1	MGAT2 CL E G H	4247	212066	Carbohydrate-deficient glycoprotein syndrome type II	212066	C2931008	OMIM	1	123	7045	602616
HP:0001276	HP:0002063	Rigidity	1	MGAT2 CL E G H	4247	212066	Carbohydrate-deficient glycoprotein syndrome type II	212066	C2931008	OMIM	1	123	7045	602616
HP:0001276	HP:0001257	Spasticity	1	MGAT2 CL E G H	4247	212066	Carbohydrate-deficient glycoprotein syndrome type II	212066	C2931008	OMIM	1	123	7045	602616
HP:0001276	HP:0002509	Limb hypertonia	1	MIPEP CL E G H	4285	617228	Combined oxidative phosphorylation deficiency 31	617228	C4310661	OMIM	1	185	7104	602241
HP:0001276	HP:0031867	Neck hypertonia	1	MIPEP CL E G H	4285	617228	Combined oxidative phosphorylation deficiency 31	617228	C4310661	OMIM	1	185	7104	602241
HP:0001276	HP:0002063	Rigidity	1	MIPEP CL E G H	4285	617228	Combined oxidative phosphorylation deficiency 31	617228	C4310661	OMIM	1	185	7104	602241
HP:0001276	HP:0001257	Spasticity	1	MIPEP CL E G H	4285	617228	Combined oxidative phosphorylation deficiency 31	617228	C4310661	OMIM	1	185	7104	602241
HP:0001276	HP:0002509	Limb hypertonia	1	MLH1 CL E G H	4292	144				ORPHA	1	4826	7127	120436
HP:0001276	HP:0031867	Neck hypertonia	1	MLH1 CL E G H	4292	144				ORPHA	1	4826	7127	120436
HP:0001276	HP:0002063	Rigidity	1	MLH1 CL E G H	4292	144				ORPHA	1	4826	7127	120436
HP:0001276	HP:0001257	Spasticity	1	MLH1 CL E G H	4292	144				ORPHA	1	4826	7127	120436
HP:0001276	HP:0002509	Limb hypertonia	1	MLH3 CL E G H	27030	144				ORPHA	1	1824	7128	604395
HP:0001276	HP:0031867	Neck hypertonia	1	MLH3 CL E G H	27030	144				ORPHA	1	1824	7128	604395
HP:0001276	HP:0002063	Rigidity	1	MLH3 CL E G H	27030	144				ORPHA	1	1824	7128	604395
HP:0001276	HP:0001257	Spasticity	1	MLH3 CL E G H	27030	144				ORPHA	1	1824	7128	604395
HP:0001276	HP:0002509	Limb hypertonia	1	MSH2 CL E G H	4436	144				ORPHA	1	6374	7325	609309
HP:0001276	HP:0031867	Neck hypertonia	1	MSH2 CL E G H	4436	144				ORPHA	1	6374	7325	609309
HP:0001276	HP:0002063	Rigidity	1	MSH2 CL E G H	4436	144				ORPHA	1	6374	7325	609309
HP:0001276	HP:0001257	Spasticity	1	MSH2 CL E G H	4436	144				ORPHA	1	6374	7325	609309
HP:0001276	HP:0002509	Limb hypertonia	1	MSH6 CL E G H	2956	144				ORPHA	1	7706	7329	600678
HP:0001276	HP:0031867	Neck hypertonia	1	MSH6 CL E G H	2956	144				ORPHA	1	7706	7329	600678
HP:0001276	HP:0002063	Rigidity	1	MSH6 CL E G H	2956	144				ORPHA	1	7706	7329	600678
HP:0001276	HP:0001257	Spasticity	1	MSH6 CL E G H	2956	144				ORPHA	1	7706	7329	600678
HP:0001276	HP:0002509	Limb hypertonia	1	MYO5A CL E G H	4644	79476				ORPHA	1	249	7602	160777
HP:0001276	HP:0031867	Neck hypertonia	1	MYO5A CL E G H	4644	79476				ORPHA	1	249	7602	160777
HP:0001276	HP:0002063	Rigidity	1	MYO5A CL E G H	4644	79476				ORPHA	1	249	7602	160777
HP:0001276	HP:0001257	Spasticity	1	MYO5A CL E G H	4644	79476				ORPHA	1	249	7602	160777
HP:0001276	HP:0002509	Limb hypertonia	1	NAA10 CL E G H	8260	300855	N-terminal acetyltransferase deficiency	300855	C3275447	OMIM	1	361	18704	300013
HP:0001276	HP:0031867	Neck hypertonia	1	NAA10 CL E G H	8260	300855	N-terminal acetyltransferase deficiency	300855	C3275447	OMIM	1	361	18704	300013
HP:0001276	HP:0002063	Rigidity	1	NAA10 CL E G H	8260	300855	N-terminal acetyltransferase deficiency	300855	C3275447	OMIM	1	361	18704	300013
HP:0001276	HP:0001257	Spasticity	1	NAA10 CL E G H	8260	300855	N-terminal acetyltransferase deficiency	300855	C3275447	OMIM	1	361	18704	300013
HP:0001276	HP:0002509	Limb hypertonia	1	NECAP1 CL E G H	25977	615833	Early infantile epileptic encephalopathy 21	615833	C4014430	OMIM	1	167	24539	611623
HP:0001276	HP:0031867	Neck hypertonia	1	NECAP1 CL E G H	25977	615833	Early infantile epileptic encephalopathy 21	615833	C4014430	OMIM	1	167	24539	611623
HP:0001276	HP:0002063	Rigidity	1	NECAP1 CL E G H	25977	615833	Early infantile epileptic encephalopathy 21	615833	C4014430	OMIM	1	167	24539	611623
HP:0001276	HP:0001257	Spasticity	1	NECAP1 CL E G H	25977	615833	Early infantile epileptic encephalopathy 21	615833	C4014430	OMIM	1	167	24539	611623
HP:0001276	HP:0002509	Limb hypertonia	1	NIPBL CL E G H	25836	199	Cardiac hydatid cysts with intracavitary expansion			ORPHA	1	1201	28862	608667
HP:0001276	HP:0031867	Neck hypertonia	1	NIPBL CL E G H	25836	199	Cardiac hydatid cysts with intracavitary expansion			ORPHA	1	1201	28862	608667
HP:0001276	HP:0002063	Rigidity	1	NIPBL CL E G H	25836	199	Cardiac hydatid cysts with intracavitary expansion			ORPHA	1	1201	28862	608667
HP:0001276	HP:0001257	Spasticity	1	NIPBL CL E G H	25836	199	Cardiac hydatid cysts with intracavitary expansion			ORPHA	1	1201	28862	608667
HP:0001276	HP:0002509	Limb hypertonia	1	NIPBL CL E G H	25836	122470	Cornelia de Lange syndrome 1	122470	CN029798	OMIM	1	1201	28862	608667
HP:0001276	HP:0031867	Neck hypertonia	1	NIPBL CL E G H	25836	122470	Cornelia de Lange syndrome 1	122470	CN029798	OMIM	1	1201	28862	608667
HP:0001276	HP:0002063	Rigidity	1	NIPBL CL E G H	25836	122470	Cornelia de Lange syndrome 1	122470	CN029798	OMIM	1	1201	28862	608667
HP:0001276	HP:0001257	Spasticity	1	NIPBL CL E G H	25836	122470	Cornelia de Lange syndrome 1	122470	CN029798	OMIM	1	1201	28862	608667
HP:0001276	HP:0002509	Limb hypertonia	1	OGDH CL E G H	4967	31	Serpiginous choroiditis			ORPHA	1	105	8124	613022
HP:0001276	HP:0031867	Neck hypertonia	1	OGDH CL E G H	4967	31	Serpiginous choroiditis			ORPHA	1	105	8124	613022
HP:0001276	HP:0002063	Rigidity	1	OGDH CL E G H	4967	31	Serpiginous choroiditis			ORPHA	1	105	8124	613022
HP:0001276	HP:0001257	Spasticity	1	OGDH CL E G H	4967	31	Serpiginous choroiditis			ORPHA	1	105	8124	613022
HP:0001276	HP:0002509	Limb hypertonia	1	PAH CL E G H	5053	79254				ORPHA	1	1316	8582	612349
HP:0001276	HP:0031867	Neck hypertonia	1	PAH CL E G H	5053	79254				ORPHA	1	1316	8582	612349
HP:0001276	HP:0002063	Rigidity	1	PAH CL E G H	5053	79254				ORPHA	1	1316	8582	612349
HP:0001276	HP:0001257	Spasticity	1	PAH CL E G H	5053	79254				ORPHA	1	1316	8582	612349
HP:0001276	HP:0002509	Limb hypertonia	1	PARN CL E G H	5073	3322				ORPHA	1	443	8609	604212
HP:0001276	HP:0031867	Neck hypertonia	1	PARN CL E G H	5073	3322				ORPHA	1	443	8609	604212
HP:0001276	HP:0002063	Rigidity	1	PARN CL E G H	5073	3322				ORPHA	1	443	8609	604212
HP:0001276	HP:0001257	Spasticity	1	PARN CL E G H	5073	3322				ORPHA	1	443	8609	604212
HP:0001276	HP:0002509	Limb hypertonia	1	PAX1 CL E G H	5075	2792	Hyperbilirubinemia type 1			ORPHA	1	208	8615	167411
HP:0001276	HP:0031867	Neck hypertonia	1	PAX1 CL E G H	5075	2792	Hyperbilirubinemia type 1			ORPHA	1	208	8615	167411
HP:0001276	HP:0002063	Rigidity	1	PAX1 CL E G H	5075	2792	Hyperbilirubinemia type 1			ORPHA	1	208	8615	167411
HP:0001276	HP:0001257	Spasticity	1	PAX1 CL E G H	5075	2792	Hyperbilirubinemia type 1			ORPHA	1	208	8615	167411
HP:0001276	HP:0002509	Limb hypertonia	1	PCBD1 CL E G H	5092	264070	Hyperphenylalaninemia, BH4-deficient, D	264070	C1849700	OMIM	1	67	8646	126090
HP:0001276	HP:0031867	Neck hypertonia	1	PCBD1 CL E G H	5092	264070	Hyperphenylalaninemia, BH4-deficient, D	264070	C1849700	OMIM	1	67	8646	126090
HP:0001276	HP:0002063	Rigidity	1	PCBD1 CL E G H	5092	264070	Hyperphenylalaninemia, BH4-deficient, D	264070	C1849700	OMIM	1	67	8646	126090
HP:0001276	HP:0001257	Spasticity	1	PCBD1 CL E G H	5092	264070	Hyperphenylalaninemia, BH4-deficient, D	264070	C1849700	OMIM	1	67	8646	126090
HP:0001276	HP:0002509	Limb hypertonia	1	PIK3CA CL E G H	5290	144				ORPHA	1	975	8975	171834
HP:0001276	HP:0031867	Neck hypertonia	1	PIK3CA CL E G H	5290	144				ORPHA	1	975	8975	171834
HP:0001276	HP:0002063	Rigidity	1	PIK3CA CL E G H	5290	144				ORPHA	1	975	8975	171834
HP:0001276	HP:0001257	Spasticity	1	PIK3CA CL E G H	5290	144				ORPHA	1	975	8975	171834
HP:0001276	HP:0002509	Limb hypertonia	1	PITX3 CL E G H	5309	610623	Cataract 11	610623	C1864567	OMIM	1	39	9006	602669
HP:0001276	HP:0031867	Neck hypertonia	1	PITX3 CL E G H	5309	610623	Cataract 11	610623	C1864567	OMIM	1	39	9006	602669
HP:0001276	HP:0002063	Rigidity	1	PITX3 CL E G H	5309	610623	Cataract 11	610623	C1864567	OMIM	1	39	9006	602669
HP:0001276	HP:0001257	Spasticity	1	PITX3 CL E G H	5309	610623	Cataract 11	610623	C1864567	OMIM	1	39	9006	602669
HP:0001276	HP:0002509	Limb hypertonia	1	PLA2G6 CL E G H	8398	610217	Neurodegeneration with brain iron accumulation 2b	610217	C1857747	OMIM	1	598	9039	603604
HP:0001276	HP:0031867	Neck hypertonia	1	PLA2G6 CL E G H	8398	610217	Neurodegeneration with brain iron accumulation 2b	610217	C1857747	OMIM	1	598	9039	603604
HP:0001276	HP:0002063	Rigidity	1	PLA2G6 CL E G H	8398	610217	Neurodegeneration with brain iron accumulation 2b	610217	C1857747	OMIM	1	598	9039	603604
HP:0001276	HP:0001257	Spasticity	1	PLA2G6 CL E G H	8398	610217	Neurodegeneration with brain iron accumulation 2b	610217	C1857747	OMIM	1	598	9039	603604
HP:0001276	HP:0002509	Limb hypertonia	1	PLAA CL E G H	9373	617527	NEURODEVELOPMENTAL DISORDER WITH PROGRESSIVE MICROCEPHALY, SPASTICITY, AND BRAIN ANOMALIES	617527	C4479631	OMIM	1	338	9043	603873
HP:0001276	HP:0031867	Neck hypertonia	1	PLAA CL E G H	9373	617527	NEURODEVELOPMENTAL DISORDER WITH PROGRESSIVE MICROCEPHALY, SPASTICITY, AND BRAIN ANOMALIES	617527	C4479631	OMIM	1	338	9043	603873
HP:0001276	HP:0002063	Rigidity	1	PLAA CL E G H	9373	617527	NEURODEVELOPMENTAL DISORDER WITH PROGRESSIVE MICROCEPHALY, SPASTICITY, AND BRAIN ANOMALIES	617527	C4479631	OMIM	1	338	9043	603873
HP:0001276	HP:0001257	Spasticity	1	PLAA CL E G H	9373	617527	NEURODEVELOPMENTAL DISORDER WITH PROGRESSIVE MICROCEPHALY, SPASTICITY, AND BRAIN ANOMALIES	617527	C4479631	OMIM	1	338	9043	603873
HP:0001276	HP:0002509	Limb hypertonia	1	PLK4 CL E G H	10733	2518				ORPHA	1	407	11397	605031
HP:0001276	HP:0031867	Neck hypertonia	1	PLK4 CL E G H	10733	2518				ORPHA	1	407	11397	605031
HP:0001276	HP:0002063	Rigidity	1	PLK4 CL E G H	10733	2518				ORPHA	1	407	11397	605031
HP:0001276	HP:0001257	Spasticity	1	PLK4 CL E G H	10733	2518				ORPHA	1	407	11397	605031
HP:0001276	HP:0002509	Limb hypertonia	1	PLPBP CL E G H	11212	617290	Epilepsy, early-onset, vitamin b6-dependent	617290	C4310632	OMIM	1	90	9457	604436
HP:0001276	HP:0031867	Neck hypertonia	1	PLPBP CL E G H	11212	617290	Epilepsy, early-onset, vitamin b6-dependent	617290	C4310632	OMIM	1	90	9457	604436
HP:0001276	HP:0002063	Rigidity	1	PLPBP CL E G H	11212	617290	Epilepsy, early-onset, vitamin b6-dependent	617290	C4310632	OMIM	1	90	9457	604436
HP:0001276	HP:0001257	Spasticity	1	PLPBP CL E G H	11212	617290	Epilepsy, early-onset, vitamin b6-dependent	617290	C4310632	OMIM	1	90	9457	604436
HP:0001276	HP:0002509	Limb hypertonia	1	PMS1 CL E G H	5378	144				ORPHA	1	96	9121	600258
HP:0001276	HP:0031867	Neck hypertonia	1	PMS1 CL E G H	5378	144				ORPHA	1	96	9121	600258
HP:0001276	HP:0002063	Rigidity	1	PMS1 CL E G H	5378	144				ORPHA	1	96	9121	600258
HP:0001276	HP:0001257	Spasticity	1	PMS1 CL E G H	5378	144				ORPHA	1	96	9121	600258
HP:0001276	HP:0002509	Limb hypertonia	1	PMS2 CL E G H	5395	144				ORPHA	1	4346	9122	600259
HP:0001276	HP:0031867	Neck hypertonia	1	PMS2 CL E G H	5395	144				ORPHA	1	4346	9122	600259
HP:0001276	HP:0002063	Rigidity	1	PMS2 CL E G H	5395	144				ORPHA	1	4346	9122	600259
HP:0001276	HP:0001257	Spasticity	1	PMS2 CL E G H	5395	144				ORPHA	1	4346	9122	600259
HP:0001276	HP:0002509	Limb hypertonia	1	PNPO CL E G H	55163	79096				ORPHA	1	281	30260	603287
HP:0001276	HP:0031867	Neck hypertonia	1	PNPO CL E G H	55163	79096				ORPHA	1	281	30260	603287
HP:0001276	HP:0002063	Rigidity	1	PNPO CL E G H	55163	79096				ORPHA	1	281	30260	603287
HP:0001276	HP:0001257	Spasticity	1	PNPO CL E G H	55163	79096				ORPHA	1	281	30260	603287
HP:0001276	HP:0002509	Limb hypertonia	1	PNPO CL E G H	55163	610090	Pyridoxal 5'-phosphate-dependent epilepsy	610090	C1864723	OMIM	1	281	30260	603287
HP:0001276	HP:0031867	Neck hypertonia	1	PNPO CL E G H	55163	610090	Pyridoxal 5'-phosphate-dependent epilepsy	610090	C1864723	OMIM	1	281	30260	603287
HP:0001276	HP:0002063	Rigidity	1	PNPO CL E G H	55163	610090	Pyridoxal 5'-phosphate-dependent epilepsy	610090	C1864723	OMIM	1	281	30260	603287
HP:0001276	HP:0001257	Spasticity	1	PNPO CL E G H	55163	610090	Pyridoxal 5'-phosphate-dependent epilepsy	610090	C1864723	OMIM	1	281	30260	603287
HP:0001276	HP:0002509	Limb hypertonia	1	POLG CL E G H	5428	203700	Progressive sclerosing poliodystrophy	203700	C0205710	OMIM	1	1917	9179	174763
HP:0001276	HP:0031867	Neck hypertonia	1	POLG CL E G H	5428	203700	Progressive sclerosing poliodystrophy	203700	C0205710	OMIM	1	1917	9179	174763
HP:0001276	HP:0002063	Rigidity	1	POLG CL E G H	5428	203700	Progressive sclerosing poliodystrophy	203700	C0205710	OMIM	1	1917	9179	174763
HP:0001276	HP:0001257	Spasticity	1	POLG CL E G H	5428	203700	Progressive sclerosing poliodystrophy	203700	C0205710	OMIM	1	1917	9179	174763
HP:0001276	HP:0002509	Limb hypertonia	1	POMGNT1 CL E G H	55624	588				ORPHA	1	943	19139	606822
HP:0001276	HP:0031867	Neck hypertonia	1	POMGNT1 CL E G H	55624	588				ORPHA	1	943	19139	606822
HP:0001276	HP:0002063	Rigidity	1	POMGNT1 CL E G H	55624	588				ORPHA	1	943	19139	606822
HP:0001276	HP:0001257	Spasticity	1	POMGNT1 CL E G H	55624	588				ORPHA	1	943	19139	606822
HP:0001276	HP:0002509	Limb hypertonia	1	POMT1 CL E G H	10585	588				ORPHA	1	737	9202	607423
HP:0001276	HP:0031867	Neck hypertonia	1	POMT1 CL E G H	10585	588				ORPHA	1	737	9202	607423
HP:0001276	HP:0002063	Rigidity	1	POMT1 CL E G H	10585	588				ORPHA	1	737	9202	607423
HP:0001276	HP:0001257	Spasticity	1	POMT1 CL E G H	10585	588				ORPHA	1	737	9202	607423
HP:0001276	HP:0002509	Limb hypertonia	1	POMT2 CL E G H	29954	588				ORPHA	1	766	19743	607439
HP:0001276	HP:0031867	Neck hypertonia	1	POMT2 CL E G H	29954	588				ORPHA	1	766	19743	607439
HP:0001276	HP:0002063	Rigidity	1	POMT2 CL E G H	29954	588				ORPHA	1	766	19743	607439
HP:0001276	HP:0001257	Spasticity	1	POMT2 CL E G H	29954	588				ORPHA	1	766	19743	607439
HP:0001276	HP:0002509	Limb hypertonia	1	PRF1 CL E G H	5551	603553	Hemophagocytic lymphohistiocytosis, familial, 2	603553	C1863727	OMIM	1	404	9360	170280
HP:0001276	HP:0031867	Neck hypertonia	1	PRF1 CL E G H	5551	603553	Hemophagocytic lymphohistiocytosis, familial, 2	603553	C1863727	OMIM	1	404	9360	170280
HP:0001276	HP:0002063	Rigidity	1	PRF1 CL E G H	5551	603553	Hemophagocytic lymphohistiocytosis, familial, 2	603553	C1863727	OMIM	1	404	9360	170280
HP:0001276	HP:0001257	Spasticity	1	PRF1 CL E G H	5551	603553	Hemophagocytic lymphohistiocytosis, familial, 2	603553	C1863727	OMIM	1	404	9360	170280
HP:0001276	HP:0002509	Limb hypertonia	1	PRRT2 CL E G H	112476	306				ORPHA	1	702	30500	614386
HP:0001276	HP:0031867	Neck hypertonia	1	PRRT2 CL E G H	112476	306				ORPHA	1	702	30500	614386
HP:0001276	HP:0002063	Rigidity	1	PRRT2 CL E G H	112476	306				ORPHA	1	702	30500	614386
HP:0001276	HP:0001257	Spasticity	1	PRRT2 CL E G H	112476	306				ORPHA	1	702	30500	614386
HP:0001276	HP:0002509	Limb hypertonia	1	PSAP CL E G H	5660	611722	Krabbe disease atypical due to Saposin A deficiency	611722	C2673266	OMIM	1	598	9498	176801
HP:0001276	HP:0031867	Neck hypertonia	1	PSAP CL E G H	5660	611722	Krabbe disease atypical due to Saposin A deficiency	611722	C2673266	OMIM	1	598	9498	176801
HP:0001276	HP:0002063	Rigidity	1	PSAP CL E G H	5660	611722	Krabbe disease atypical due to Saposin A deficiency	611722	C2673266	OMIM	1	598	9498	176801
HP:0001276	HP:0001257	Spasticity	1	PSAP CL E G H	5660	611722	Krabbe disease atypical due to Saposin A deficiency	611722	C2673266	OMIM	1	598	9498	176801
HP:0001276	HP:0002509	Limb hypertonia	1	PSAT1 CL E G H	29968	610992	Phosphoserine aminotransferase deficiency	610992	C1970253	OMIM	1	443	19129	610936
HP:0001276	HP:0031867	Neck hypertonia	1	PSAT1 CL E G H	29968	610992	Phosphoserine aminotransferase deficiency	610992	C1970253	OMIM	1	443	19129	610936
HP:0001276	HP:0002063	Rigidity	1	PSAT1 CL E G H	29968	610992	Phosphoserine aminotransferase deficiency	610992	C1970253	OMIM	1	443	19129	610936
HP:0001276	HP:0001257	Spasticity	1	PSAT1 CL E G H	29968	610992	Phosphoserine aminotransferase deficiency	610992	C1970253	OMIM	1	443	19129	610936
HP:0001276	HP:0002509	Limb hypertonia	1	PSEN1 CL E G H	5663	1020				ORPHA	1	452	9508	104311
HP:0001276	HP:0031867	Neck hypertonia	1	PSEN1 CL E G H	5663	1020				ORPHA	1	452	9508	104311
HP:0001276	HP:0002063	Rigidity	1	PSEN1 CL E G H	5663	1020				ORPHA	1	452	9508	104311
HP:0001276	HP:0001257	Spasticity	1	PSEN1 CL E G H	5663	1020				ORPHA	1	452	9508	104311
HP:0001276	HP:0002509	Limb hypertonia	1	PSEN2 CL E G H	5664	1020				ORPHA	1	237	9509	600759
HP:0001276	HP:0031867	Neck hypertonia	1	PSEN2 CL E G H	5664	1020				ORPHA	1	237	9509	600759
HP:0001276	HP:0002063	Rigidity	1	PSEN2 CL E G H	5664	1020				ORPHA	1	237	9509	600759
HP:0001276	HP:0001257	Spasticity	1	PSEN2 CL E G H	5664	1020				ORPHA	1	237	9509	600759
HP:0001276	HP:0002509	Limb hypertonia	1	PSPH CL E G H	5723	614023	Deficiency of phosphoserine phosphatase	614023	C1291463	OMIM	1	160	9577	172480
HP:0001276	HP:0031867	Neck hypertonia	1	PSPH CL E G H	5723	614023	Deficiency of phosphoserine phosphatase	614023	C1291463	OMIM	1	160	9577	172480
HP:0001276	HP:0002063	Rigidity	1	PSPH CL E G H	5723	614023	Deficiency of phosphoserine phosphatase	614023	C1291463	OMIM	1	160	9577	172480
HP:0001276	HP:0001257	Spasticity	1	PSPH CL E G H	5723	614023	Deficiency of phosphoserine phosphatase	614023	C1291463	OMIM	1	160	9577	172480
HP:0001276	HP:0002509	Limb hypertonia	1	PTS CL E G H	5805	261640	6-pyruvoyl-tetrahydropterin synthase deficiency	261640	C0878676	OMIM	1	214	9689	612719
HP:0001276	HP:0031867	Neck hypertonia	1	PTS CL E G H	5805	261640	6-pyruvoyl-tetrahydropterin synthase deficiency	261640	C0878676	OMIM	1	214	9689	612719
HP:0001276	HP:0002063	Rigidity	1	PTS CL E G H	5805	261640	6-pyruvoyl-tetrahydropterin synthase deficiency	261640	C0878676	OMIM	1	214	9689	612719
HP:0001276	HP:0001257	Spasticity	1	PTS CL E G H	5805	261640	6-pyruvoyl-tetrahydropterin synthase deficiency	261640	C0878676	OMIM	1	214	9689	612719
HP:0001276	HP:0002509	Limb hypertonia	1	QDPR CL E G H	5860	261630	Dihydropteridine reductase deficiency	261630	C0268465	OMIM	1	259	9752	612676
HP:0001276	HP:0031867	Neck hypertonia	1	QDPR CL E G H	5860	261630	Dihydropteridine reductase deficiency	261630	C0268465	OMIM	1	259	9752	612676
HP:0001276	HP:0002063	Rigidity	1	QDPR CL E G H	5860	261630	Dihydropteridine reductase deficiency	261630	C0268465	OMIM	1	259	9752	612676
HP:0001276	HP:0001257	Spasticity	1	QDPR CL E G H	5860	261630	Dihydropteridine reductase deficiency	261630	C0268465	OMIM	1	259	9752	612676
HP:0001276	HP:0002509	Limb hypertonia	1	RAD21 CL E G H	5885	199	Cardiac hydatid cysts with intracavitary expansion			ORPHA	1	293	9811	606462
HP:0001276	HP:0031867	Neck hypertonia	1	RAD21 CL E G H	5885	199	Cardiac hydatid cysts with intracavitary expansion			ORPHA	1	293	9811	606462
HP:0001276	HP:0002063	Rigidity	1	RAD21 CL E G H	5885	199	Cardiac hydatid cysts with intracavitary expansion			ORPHA	1	293	9811	606462
HP:0001276	HP:0001257	Spasticity	1	RAD21 CL E G H	5885	199	Cardiac hydatid cysts with intracavitary expansion			ORPHA	1	293	9811	606462
HP:0001276	HP:0002509	Limb hypertonia	1	RTEL1 CL E G H	51750	3322				ORPHA	1	2005	15888	608833
HP:0001276	HP:0031867	Neck hypertonia	1	RTEL1 CL E G H	51750	3322				ORPHA	1	2005	15888	608833
HP:0001276	HP:0002063	Rigidity	1	RTEL1 CL E G H	51750	3322				ORPHA	1	2005	15888	608833
HP:0001276	HP:0001257	Spasticity	1	RTEL1 CL E G H	51750	3322				ORPHA	1	2005	15888	608833
HP:0001276	HP:0002509	Limb hypertonia	1	SCN2A CL E G H	6326	306				ORPHA	1	1914	10588	182390
HP:0001276	HP:0031867	Neck hypertonia	1	SCN2A CL E G H	6326	306				ORPHA	1	1914	10588	182390
HP:0001276	HP:0002063	Rigidity	1	SCN2A CL E G H	6326	306				ORPHA	1	1914	10588	182390
HP:0001276	HP:0001257	Spasticity	1	SCN2A CL E G H	6326	306				ORPHA	1	1914	10588	182390
HP:0001276	HP:0002509	Limb hypertonia	1	SCN4A CL E G H	6329	99734				ORPHA	1	1391	10591	603967
HP:0001276	HP:0031867	Neck hypertonia	1	SCN4A CL E G H	6329	99734				ORPHA	1	1391	10591	603967
HP:0001276	HP:0002063	Rigidity	1	SCN4A CL E G H	6329	99734				ORPHA	1	1391	10591	603967
HP:0001276	HP:0001257	Spasticity	1	SCN4A CL E G H	6329	99734				ORPHA	1	1391	10591	603967
HP:0001276	HP:0002509	Limb hypertonia	1	SCN4A CL E G H	6329	99735				ORPHA	1	1391	10591	603967
HP:0001276	HP:0031867	Neck hypertonia	1	SCN4A CL E G H	6329	99735				ORPHA	1	1391	10591	603967
HP:0001276	HP:0002063	Rigidity	1	SCN4A CL E G H	6329	99735				ORPHA	1	1391	10591	603967
HP:0001276	HP:0001257	Spasticity	1	SCN4A CL E G H	6329	99735				ORPHA	1	1391	10591	603967
HP:0001276	HP:0002509	Limb hypertonia	1	SCN4A CL E G H	6329	99736				ORPHA	1	1391	10591	603967
HP:0001276	HP:0031867	Neck hypertonia	1	SCN4A CL E G H	6329	99736				ORPHA	1	1391	10591	603967
HP:0001276	HP:0002063	Rigidity	1	SCN4A CL E G H	6329	99736				ORPHA	1	1391	10591	603967
HP:0001276	HP:0001257	Spasticity	1	SCN4A CL E G H	6329	99736				ORPHA	1	1391	10591	603967
HP:0001276	HP:0002509	Limb hypertonia	1	SCN8A CL E G H	6334	306				ORPHA	1	1494	10596	600702
HP:0001276	HP:0031867	Neck hypertonia	1	SCN8A CL E G H	6334	306				ORPHA	1	1494	10596	600702
HP:0001276	HP:0002063	Rigidity	1	SCN8A CL E G H	6334	306				ORPHA	1	1494	10596	600702
HP:0001276	HP:0001257	Spasticity	1	SCN8A CL E G H	6334	306				ORPHA	1	1494	10596	600702
HP:0001276	HP:0002509	Limb hypertonia	1	SETD5 CL E G H	55209	199	Cardiac hydatid cysts with intracavitary expansion			ORPHA	1	617	25566	615743
HP:0001276	HP:0031867	Neck hypertonia	1	SETD5 CL E G H	55209	199	Cardiac hydatid cysts with intracavitary expansion			ORPHA	1	617	25566	615743
HP:0001276	HP:0002063	Rigidity	1	SETD5 CL E G H	55209	199	Cardiac hydatid cysts with intracavitary expansion			ORPHA	1	617	25566	615743
HP:0001276	HP:0001257	Spasticity	1	SETD5 CL E G H	55209	199	Cardiac hydatid cysts with intracavitary expansion			ORPHA	1	617	25566	615743
HP:0001276	HP:0002509	Limb hypertonia	1	SLC19A3 CL E G H	80704	607483	Basal ganglia disease, biotin-responsive	607483	C1843807	OMIM	1	482	16266	606152
HP:0001276	HP:0031867	Neck hypertonia	1	SLC19A3 CL E G H	80704	607483	Basal ganglia disease, biotin-responsive	607483	C1843807	OMIM	1	482	16266	606152
HP:0001276	HP:0002063	Rigidity	1	SLC19A3 CL E G H	80704	607483	Basal ganglia disease, biotin-responsive	607483	C1843807	OMIM	1	482	16266	606152
HP:0001276	HP:0001257	Spasticity	1	SLC19A3 CL E G H	80704	607483	Basal ganglia disease, biotin-responsive	607483	C1843807	OMIM	1	482	16266	606152
HP:0001276	HP:0002509	Limb hypertonia	1	SLC6A19 CL E G H	340024	234500	Neutral 1 amino acid transport defect	234500	C0018609	OMIM	1	371	27960	608893
HP:0001276	HP:0031867	Neck hypertonia	1	SLC6A19 CL E G H	340024	234500	Neutral 1 amino acid transport defect	234500	C0018609	OMIM	1	371	27960	608893
HP:0001276	HP:0002063	Rigidity	1	SLC6A19 CL E G H	340024	234500	Neutral 1 amino acid transport defect	234500	C0018609	OMIM	1	371	27960	608893
HP:0001276	HP:0001257	Spasticity	1	SLC6A19 CL E G H	340024	234500	Neutral 1 amino acid transport defect	234500	C0018609	OMIM	1	371	27960	608893
HP:0001276	HP:0002509	Limb hypertonia	1	SLC6A3 CL E G H	6531	613135	Infantile Parkinsonism-dystonia	613135	C2751067	OMIM	1	479	11049	126455
HP:0001276	HP:0031867	Neck hypertonia	1	SLC6A3 CL E G H	6531	613135	Infantile Parkinsonism-dystonia	613135	C2751067	OMIM	1	479	11049	126455
HP:0001276	HP:0002063	Rigidity	1	SLC6A3 CL E G H	6531	613135	Infantile Parkinsonism-dystonia	613135	C2751067	OMIM	1	479	11049	126455
HP:0001276	HP:0001257	Spasticity	1	SLC6A3 CL E G H	6531	613135	Infantile Parkinsonism-dystonia	613135	C2751067	OMIM	1	479	11049	126455
HP:0001276	HP:0002509	Limb hypertonia	1	SLC6A5 CL E G H	9152	614618	Hyperekplexia 3	614618	C3553288	OMIM	1	532	11051	604159
HP:0001276	HP:0031867	Neck hypertonia	1	SLC6A5 CL E G H	9152	614618	Hyperekplexia 3	614618	C3553288	OMIM	1	532	11051	604159
HP:0001276	HP:0002063	Rigidity	1	SLC6A5 CL E G H	9152	614618	Hyperekplexia 3	614618	C3553288	OMIM	1	532	11051	604159
HP:0001276	HP:0001257	Spasticity	1	SLC6A5 CL E G H	9152	614618	Hyperekplexia 3	614618	C3553288	OMIM	1	532	11051	604159
HP:0001276	HP:0002509	Limb hypertonia	1	SLC6A8 CL E G H	6535	52503				ORPHA	1	903	11055	300036
HP:0001276	HP:0031867	Neck hypertonia	1	SLC6A8 CL E G H	6535	52503				ORPHA	1	903	11055	300036
HP:0001276	HP:0002063	Rigidity	1	SLC6A8 CL E G H	6535	52503				ORPHA	1	903	11055	300036
HP:0001276	HP:0001257	Spasticity	1	SLC6A8 CL E G H	6535	52503				ORPHA	1	903	11055	300036
HP:0001276	HP:0002509	Limb hypertonia	1	SLC6A9 CL E G H	6536	617301	Glycine encephalopathy with normal serum glycine	617301	C4310943	OMIM	1	168	11056	601019
HP:0001276	HP:0031867	Neck hypertonia	1	SLC6A9 CL E G H	6536	617301	Glycine encephalopathy with normal serum glycine	617301	C4310943	OMIM	1	168	11056	601019
HP:0001276	HP:0002063	Rigidity	1	SLC6A9 CL E G H	6536	617301	Glycine encephalopathy with normal serum glycine	617301	C4310943	OMIM	1	168	11056	601019
HP:0001276	HP:0001257	Spasticity	1	SLC6A9 CL E G H	6536	617301	Glycine encephalopathy with normal serum glycine	617301	C4310943	OMIM	1	168	11056	601019
HP:0001276	HP:0002509	Limb hypertonia	1	SMC1A CL E G H	8243	199	Cardiac hydatid cysts with intracavitary expansion			ORPHA	1	798	11111	300040
HP:0001276	HP:0031867	Neck hypertonia	1	SMC1A CL E G H	8243	199	Cardiac hydatid cysts with intracavitary expansion			ORPHA	1	798	11111	300040
HP:0001276	HP:0002063	Rigidity	1	SMC1A CL E G H	8243	199	Cardiac hydatid cysts with intracavitary expansion			ORPHA	1	798	11111	300040
HP:0001276	HP:0001257	Spasticity	1	SMC1A CL E G H	8243	199	Cardiac hydatid cysts with intracavitary expansion			ORPHA	1	798	11111	300040
HP:0001276	HP:0002509	Limb hypertonia	1	SMC3 CL E G H	9126	199	Cardiac hydatid cysts with intracavitary expansion			ORPHA	1	358	2468	606062
HP:0001276	HP:0031867	Neck hypertonia	1	SMC3 CL E G H	9126	199	Cardiac hydatid cysts with intracavitary expansion			ORPHA	1	358	2468	606062
HP:0001276	HP:0002063	Rigidity	1	SMC3 CL E G H	9126	199	Cardiac hydatid cysts with intracavitary expansion			ORPHA	1	358	2468	606062
HP:0001276	HP:0001257	Spasticity	1	SMC3 CL E G H	9126	199	Cardiac hydatid cysts with intracavitary expansion			ORPHA	1	358	2468	606062
HP:0001276	HP:0002509	Limb hypertonia	1	SORL1 CL E G H	6653	1020				ORPHA	1	320	11185	602005
HP:0001276	HP:0031867	Neck hypertonia	1	SORL1 CL E G H	6653	1020				ORPHA	1	320	11185	602005
HP:0001276	HP:0002063	Rigidity	1	SORL1 CL E G H	6653	1020				ORPHA	1	320	11185	602005
HP:0001276	HP:0001257	Spasticity	1	SORL1 CL E G H	6653	1020				ORPHA	1	320	11185	602005
HP:0001276	HP:0002509	Limb hypertonia	1	SOX10 CL E G H	6663	611584	Waardenburg syndrome type 2E	611584	C2700405	OMIM	1	302	11190	602229
HP:0001276	HP:0031867	Neck hypertonia	1	SOX10 CL E G H	6663	611584	Waardenburg syndrome type 2E	611584	C2700405	OMIM	1	302	11190	602229
HP:0001276	HP:0002063	Rigidity	1	SOX10 CL E G H	6663	611584	Waardenburg syndrome type 2E	611584	C2700405	OMIM	1	302	11190	602229
HP:0001276	HP:0001257	Spasticity	1	SOX10 CL E G H	6663	611584	Waardenburg syndrome type 2E	611584	C2700405	OMIM	1	302	11190	602229
HP:0001276	HP:0002509	Limb hypertonia	1	SUOX CL E G H	6821	272300	Sulfite oxidase deficiency	272300	C0268624	OMIM	1	275	11460	606887
HP:0001276	HP:0031867	Neck hypertonia	1	SUOX CL E G H	6821	272300	Sulfite oxidase deficiency	272300	C0268624	OMIM	1	275	11460	606887
HP:0001276	HP:0002063	Rigidity	1	SUOX CL E G H	6821	272300	Sulfite oxidase deficiency	272300	C0268624	OMIM	1	275	11460	606887
HP:0001276	HP:0001257	Spasticity	1	SUOX CL E G H	6821	272300	Sulfite oxidase deficiency	272300	C0268624	OMIM	1	275	11460	606887
HP:0001276	HP:0002509	Limb hypertonia	1	TERT CL E G H	7015	3322				ORPHA	1	2449	11730	187270
HP:0001276	HP:0031867	Neck hypertonia	1	TERT CL E G H	7015	3322				ORPHA	1	2449	11730	187270
HP:0001276	HP:0002063	Rigidity	1	TERT CL E G H	7015	3322				ORPHA	1	2449	11730	187270
HP:0001276	HP:0001257	Spasticity	1	TERT CL E G H	7015	3322				ORPHA	1	2449	11730	187270
HP:0001276	HP:0002509	Limb hypertonia	1	TGFBR2 CL E G H	7048	144				ORPHA	1	842	11773	190182
HP:0001276	HP:0031867	Neck hypertonia	1	TGFBR2 CL E G H	7048	144				ORPHA	1	842	11773	190182
HP:0001276	HP:0002063	Rigidity	1	TGFBR2 CL E G H	7048	144				ORPHA	1	842	11773	190182
HP:0001276	HP:0001257	Spasticity	1	TGFBR2 CL E G H	7048	144				ORPHA	1	842	11773	190182
HP:0001276	HP:0002509	Limb hypertonia	1	TINF2 CL E G H	26277	3322				ORPHA	1	330	11824	604319
HP:0001276	HP:0031867	Neck hypertonia	1	TINF2 CL E G H	26277	3322				ORPHA	1	330	11824	604319
HP:0001276	HP:0002063	Rigidity	1	TINF2 CL E G H	26277	3322				ORPHA	1	330	11824	604319
HP:0001276	HP:0001257	Spasticity	1	TINF2 CL E G H	26277	3322				ORPHA	1	330	11824	604319
HP:0001276	HP:0002509	Limb hypertonia	1	TINF2 CL E G H	26277	268130	Revesz syndrome	268130	C1327916	OMIM	1	330	11824	604319
HP:0001276	HP:0031867	Neck hypertonia	1	TINF2 CL E G H	26277	268130	Revesz syndrome	268130	C1327916	OMIM	1	330	11824	604319
HP:0001276	HP:0002063	Rigidity	1	TINF2 CL E G H	26277	268130	Revesz syndrome	268130	C1327916	OMIM	1	330	11824	604319
HP:0001276	HP:0001257	Spasticity	1	TINF2 CL E G H	26277	268130	Revesz syndrome	268130	C1327916	OMIM	1	330	11824	604319
HP:0001276	HP:0002509	Limb hypertonia	1	TMEM106B CL E G H	54664	617964	LEUKODYSTROPHY, HYPOMYELINATING, 16	617964	CN244907	OMIM	1	87	22407	613413
HP:0001276	HP:0031867	Neck hypertonia	1	TMEM106B CL E G H	54664	617964	LEUKODYSTROPHY, HYPOMYELINATING, 16	617964	CN244907	OMIM	1	87	22407	613413
HP:0001276	HP:0002063	Rigidity	1	TMEM106B CL E G H	54664	617964	LEUKODYSTROPHY, HYPOMYELINATING, 16	617964	CN244907	OMIM	1	87	22407	613413
HP:0001276	HP:0001257	Spasticity	1	TMEM106B CL E G H	54664	617964	LEUKODYSTROPHY, HYPOMYELINATING, 16	617964	CN244907	OMIM	1	87	22407	613413
HP:0001276	HP:0002509	Limb hypertonia	1	TOMM40 CL E G H	10452	1020				ORPHA	1	14	18001	608061
HP:0001276	HP:0031867	Neck hypertonia	1	TOMM40 CL E G H	10452	1020				ORPHA	1	14	18001	608061
HP:0001276	HP:0002063	Rigidity	1	TOMM40 CL E G H	10452	1020				ORPHA	1	14	18001	608061
HP:0001276	HP:0001257	Spasticity	1	TOMM40 CL E G H	10452	1020				ORPHA	1	14	18001	608061
HP:0001276	HP:0002509	Limb hypertonia	1	TOR1A CL E G H	1861	128100	Dystonia 1	128100	C1851945	OMIM	1	172	3098	605204
HP:0001276	HP:0031867	Neck hypertonia	1	TOR1A<