Human Phenotype Ontology 
Grandparent Node:
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Abnormality of immune system physiology (HP:0010978)help
Parent Node:
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Abnormal inflammatory response (HP:0012647)help
..Starting node
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Increased inflammatory response (HP:0012649)help
Term ID: 12649
Name: Increased inflammatory response
Synonym:
Definition: A abnormal increase in the inflammatory response to injury or infection.
Comments:
Reference: HP:0012649
Genes and Diseases:
 
       Child Nodes:
........expandProstatitis (HP:0000024) help
........expandEpididymitis (HP:0000031) help
........expandNephritis (HP:0000123) help
................... HP:0000099 Glomerulonephritis
................... HP:0012330 Pyelonephritis
................... HP:0012784 Perinephritis
........expandSinusitis (HP:0000246) help
................... HP:0000255 Acute sinusitis
................... HP:0011108 Recurrent sinusitis
................... HP:0011109 Chronic sinusitis
........expandOtitis media (HP:0000388) help
................... HP:0000371 Acute otitis media
................... HP:0000389 Chronic otitis media
................... HP:0000403 Recurrent otitis media
................... HP:0031353 Otitis media with effusion
........expandPeriodontitis (HP:0000704) help
................... HP:0000166 Severe periodontitis
................... HP:0011058 Generalized periodontitis
................... HP:0011059 Localized periodontitis
........expandMeningitis (HP:0001287) help
................... HP:0007041 Chronic lymphocytic meningitis
........expandPancreatitis (HP:0001733) help
................... HP:0001735 Acute pancreatitis
................... HP:0005236 Chronic calcifying pancreatitis
................... HP:0006280 Chronic pancreatitis
................... HP:0100027 Recurrent pancreatitis
........expandPneumonia (HP:0002090) help
................... HP:0006532 Recurrent pneumonia
................... HP:0011951 Aspiration pneumonia
........expandOsteomyelitis (HP:0002754) help
................... HP:0001886 Foot osteomyelitis
................... HP:0005010 Osteomyelitis leading to amputation due to slow healing fractures
................... HP:0005661 Salmonella osteomyelitis
................... HP:0005901 Chronic recurrent multifocal osteomyelitis
................... HP:0007626 Mandibular osteomyelitis
........expandLymphadenitis (HP:0002840) help
........expandGastrointestinal inflammation (HP:0004386) help
................... HP:0002037 Inflammation of the large intestine
................... HP:0100280 Crohn's disease
................... HP:0100633 Esophagitis
........expandStomatitis (HP:0010280) help
................... HP:0011107 Recurrent aphthous stomatitis
........expandInflammatory abnormality of the skin (HP:0011123) help
................... HP:0000964 Eczema
................... HP:0000988 Skin rash
................... HP:0001019 Erythroderma
................... HP:0001047 Atopic dermatitis
................... HP:0001055 Erysipelas
................... HP:0001061 Acne
................... HP:0001581 Recurrent skin infections
................... HP:0003765 Psoriasiform dermatitis
................... HP:0007473 Crusting erythematous dermatitis
................... HP:0012219 Erythema nodosum
................... HP:0012322 Perifolliculitis
................... HP:0025084 Folliculitis
................... HP:0031190 Superficial dermal perivascular inflammatory infiltrate
................... HP:0031191 Deep dermal perivascular inflammatory infiltrate
................... HP:0031234 Neutrophilic infiltration of the skin
................... HP:0031292 Cutaneous abscess
................... HP:0200039 Pustule
........expandHepatitis (HP:0012115) help
................... HP:0004787 Fulminant hepatitis
................... HP:0006562 Viral hepatitis
................... HP:0200084 Giant cell hepatitis
................... HP:0200119 Acute hepatitis
................... HP:0200122 Atypical or prolonged hepatitis
................... HP:0200123 Chronic hepatitis
........expandMyelitis (HP:0012486) help
........expandPanniculitis (HP:0012490) help
........expandCholangitis (HP:0030151) help
................... HP:0030987 Suppurative cholangitis
................... HP:0030988 Granulomatous cholangitis
................... HP:0030989 Lymphoid cholangitis
................... HP:0030990 Pleomorphic cholangitis
................... HP:0030991 Sclerosing cholangitis
........expandVaginitis (HP:0030683) help
........expandSerositis (HP:0045073) help
................... HP:0001701 Pericarditis
................... HP:0002586 Peritonitis
........expandInflammatory abnormality of the eye (HP:0100533) help
................... HP:0000491 Keratitis
................... HP:0000498 Blepharitis
................... HP:0000509 Conjunctivitis
................... HP:0000554 Uveitis
................... HP:0100532 Scleritis
................... HP:0100534 Episcleritis
........expandFasciitis (HP:0100537) help
................... HP:0045029 Eosinophilic fasciitis
........expandUrinary bladder inflammation (HP:0100577) help
........expandEndocarditis (HP:0100584) help
................... HP:0006689 Bacterial endocarditis
................... HP:0011714 Libman-Sacks lesions
........expandMyositis (HP:0100614) help
........expandThyroiditis (HP:0100646) help
................... HP:0000872 Hashimoto thyroiditis
........expandOptic neuritis (HP:0100653) help
................... HP:0100654 Retrobulbar optic neuritis
........expandChondritis (HP:0100662) help

 Sister Nodes: 
..expandDecreased inflammatory response (HP:0012648) help
InputHPO IDHPO termDistanceGeneGene id entrezDiseaseIdDiseaseNameDiseaseMIMConceptIDSourceTypical associationHGMD variantsClinVar variantsHGNC IDGeneMIM
 
HPO disease - gene - phenotype typical associations:
 
HPO disease - gene - phenotype less frequent non-typical associations:
HP:0012649HP:0012649Increased inflammatory response0 CL E G H
HP:0012649HP:0012649Increased inflammatory response1 CL E G H
HP:0012649HP:0012649Increased inflammatory response2 CL E G H
HP:0012649HP:0012649Increased inflammatory response3 CL E G H
HP:0012649HP:0012649Increased inflammatory response4 CL E G H
HP:0012649HP:0012649Increased inflammatory response5 CL E G H


Genes (704) :ABCA12 ABCB4 ABCC6 ACP5 ACTA1 ACTG2 ADA ADA2 ADAM17 ADAMTS2 ADAMTS3 ADAR AFF4 AGA AGPAT2 AIP AIRE AK2 AKT1 ALDH3A2 ALMS1 ALOX12B ALOXE3 AMACR ANKRD11 ANKRD55 ANO5 AP2S1 AP3B1 APC APOA1 APOC2 APOE ARMC4 ARVCF ATAD1 ATL1 ATL3 ATM ATOH7 ATP7A ATP7B ATP8B1 AXIN1 B2M BAP1 BAZ1B BCKDHA BCKDHB BCL10 BCL11B BCOR BCS1L BIRC3 BLM BLNK BPTF BRAF BRCA1 BSCL2 BTD BTK BTNL2 C1QA C1QB C1QC C1R C1S C3 C4A C4B C5 CACNA1C CACNA1G CAPN3 CAPN5 CARD11 CARD14 CARD9 CARMIL2 CASP10 CASP8 CASR CAV1 CAVIN1 CBS CCBE1 CCDC103 CCDC114 CCDC151 CCDC39 CCDC40 CCDC47 CCDC65 CCR1 CCT5 CD151 CD19 CD247 CD28 CD3D CD3E CD3G CD40LG CD79A CD79B CD81 CDC73 CDH23 CDK10 CDKN1A CDKN1B CDKN2B CDKN2C CERS3 CFAP298 CFAP300 CFAP410 CFB CFHR5 CFI CFTR CHD7 CHST14 CIDEC CIITA CLCN7 CLDN1 CLEC7A CLIP2 COG6 COL11A2 COL1A1 COL2A1 COL3A1 COL4A3 COL4A4 COL4A5 COL5A1 COL5A2 COL7A1 COMT COX1 COX2 COX3 COX4I2 CPA1 CR2 CRLF1 CSPP1 CSTA CTC1 CTLA4 CTNNB1 CTRC CTSB CTSC CTSK CYBA CYBB CYBC1 CYP4F22 CYP7A1 CYP7B1 CYSLTR2 DBT DCDC2 DCLRE1C DDB2 DDR2 DEAF1 DGKE DHCR7 DKC1 DNAAF1 DNAAF2 DNAAF3 DNAAF4 DNAAF5 DNAI1 DNAI2 DNAJC21 DNAL1 DNASE1L3 DNMT1 DNMT3B DOCK8 DPF2 DRC1 DSG1 EBP ECM1 EDA EDAR EDARADD EFL1 EGFR ELANE ELN EMP2 ENPP1 EPG5 ERAP1 ERCC2 ERCC3 ERCC4 ERCC5 ERCC6 ERF ESR1 EXTL3 F5 FAM111B FAS FAT4 FCGR3A FECH FERMT1 FERMT3 FGA FGF3 FGFR2 FGFR3 FLG FLI1 FLII FLNA FLVCR1 FMO3 FMR1 FOS FOXC2 FOXE3 FOXP1 FOXP3 G6PC GAS8 GATA1 GATA2 GATA3 GBA GINS1 GJA1 GJB2 GJB3 GJB4 GJB6 GJC2 GLIS3 GLRA1 GLRB GLUL GNA11 GNAQ GNAS GNPTAB GORAB GP1BB GPHN GPIHBP1 GPR101 GPR35 GTF2H5 GTF2I GTF2IRD1 GUSB H6PD HBA1 HBA2 HBB HDAC4 HDAC8 HGD HIRA HLA-A HLA-B HLA-DPA1 HLA-DPB1 HLA-DQB1 HLA-DRB1 HLCS HNRNPA2B1 HOXA13 HPGD HPS1 HSD3B2 HSD3B7 HSPA9 HYAL1 HYDIN HYOU1 ICOS IDS IFIH1 IFNGR1 IFT172 IGF2R IGH IGHM IGLL1 IGSF3 IKBKG IKZF1 IL10 IL10RA IL10RB IL12A IL12A-AS1 IL12B IL12RB1 IL17F IL17RA IL17RC IL1RN IL21 IL21R IL23R IL2RA IL2RB IL2RG IL36RN IL6 IL7R IQSEC2 IRF5 IRF8 ITGA6 ITGB2 ITGB4 ITK JAGN1 JAK2 JAK3 JMJD1C KANSL1 KCNJ6 KCTD1 KDF1 KDM6A KDSR KIAA0586 KIF11 KIT KLRC4 KMT2A KMT2D KRT1 KRT10 KRT14 KRT16 KRT17 KRT18 KRT5 KRT9 KYNU LACC1 LAGE3 LAMA2 LAMA3 LAMB3 LAMC2 LBR LCK LEP LETM1 LHCGR LIG4 LIMK1 LIPN LMBRD1 LMF1 LMNA LMX1B LPIN2 LPL LRBA LRRC6 LRRC8A LTBP3 LYST LYZ MAF MAGI2 MALT1 MAP3K7 MASP2 MBTPS2 MCCC2 MEFV MEIS2 MEN1 MET MGP MIF MLX MLXIPL MMEL1 MMP1 MMUT MNX1 MPDU1 MPLKIP MPV17 MS4A1 MSMO1 MSN MST1 MTAP MVK MYD88 MYSM1 NAA10 NADK2 NBN NCF1 NCF2 NCF4 NCSTN ND1 ND4 ND5 ND6 NEK9 NELFA NFIX NFKB1 NFKB2 NGF NHP2 NIPAL4 NIPBL NLRC4 NLRP1 NLRP12 NLRP3 NME8 NOD2 NOP10 NOTCH2 NOTCH3 NR3C1 NSD1 NSD2 NSMCE2 NSMCE3 NSUN2 NTRK1 NUP107 NXN OCRL OFD1 OPLAH ORAI1 ORC6 OTULIN PAH PANK2 PAPSS2 PARN PAX6 PCCA PCCB PCYT1A PDGFRA PDGFRL PEPD PGM1 PGM3 PHGDH PIEZO1 PIGA PIGN PIH1D3 PIK3CA PIK3R1 PITX3 PKP1 PLCD1 PLCG2 PLEC PLG PLOD1 PLXND1 PNP PNPLA1 PNPLA2 POLA1 POLG POLH POMP POR POU2AF1 PPARG PRG4 PRKACA PRKAR1A PRKCD PRKDC PRSS1 PRSS2 PRTN3 PSEN1 PSENEN PSMB4 PSMB8 PSMB9 PSMD12 PSPH PSTPIP1 PTEN PTPN2 PTPN22 PTPRC RAB7A RAD21 RAG1 RAG2 RAI1 RBCK1 RBM8A RBP4 RETREG1 REV3L RFC2 RFX5 RFXANK RFXAP RIPK1 RMRP RNASEH2A RNASEH2B RNASEH2C RNF125 RNF168 RNU4ATAC ROR2 RPGR RPL11 RREB1 RSPH1 RSPH4A RSPH9 RTEL1 RUNX2 RYR1 SAMD9 SAMHD1 SBDS SCN9A SDCCAG8 SDHA SDHB SDHC SDR9C7 SEC23B SEC24C SELENON SERPINA1 SETBP1 SETD2 SETD5 SF3B1 SFTPA2 SFTPC SGCG SH2D1A SH3PXD2B SHANK3 SHOC2 SHPK SIK3 SKIV2L SLC25A13 SLC25A15 SLC25A24 SLC29A3 SLC2A10 SLC30A2 SLC35A1 SLC35C1 SLC37A4 SLC39A4 SLC6A19 SLC6A5 SLC7A7 SLC9A3 SLCO2A1 SMAD3 SMARCA2 SMARCAD1 SMARCD2 SMC1A SMC3 SNX10 SOX18 SP110 SPAG1 SPIB SPINK1 SPINK5 SPTLC1 SPTLC2 SRCAP SRD5A3 SRP54 SRY ST14 STAT1 STAT3 STAT4 STUB1 STX16 SULT2B1 SUOX TAF1 TAP1 TAP2 TAPBP TBC1D24 TBL2 TBX1 TBX19 TBX2 TBX4 TCF3 TCF4 TCIRG1 TEK TERC TERT TFRC TGDS TGFB1 TGFB2 TGFB3 TGFBR1 TGFBR2 TGM1 TGM5 TINF2 TK2 TKT TLK2 TLR4 TMC6 TMC8 TMEM173 TNFAIP3 TNFRSF11A TNFRSF13B TNFRSF13C TNFRSF1A TNFRSF1B TNFSF11 TNFSF12 TNFSF15 TNPO3 TNXB TP53 TP63 TPP2 TRAF3IP2 TRAF6 TRAPPC11 TREX1 TRNF TRNH TRNL1 TRNQ TRNS1 TRNS2 TRNW TRPM1 TTC25 TTC7A UBAC2 UFD1 UMOD UNC119 UNG UROS USB1 USP8 VIPAS39 VPS33B WAS WDR19 WDR35 WIPF1 WNT4 WRAP53 XDH XIAP XPA XPC XPNPEP3 ZAP70 ZBTB24 ZEB1 ZEB2 ZMPSTE24 ZMYND10 ZNF341 ZNF750

Diseases (663) :600803 607944 97244 155310 277 39041 102700 615688 51 528 615109 816 203800 600740 608233 207750 613708 615632 208900 198 565 243300 39044 248600 617237 124000 125 33110 47 300755 307200 75392 130080 613783 617174 117 601005 253600 615206 617638 603909 607271 145980 606721 236200 613807 613808 618268 609057 1572 308230 143 99880 615561 610984 435651 209920 667 607626 1334 130050 286 203780 301050 550 1775 900 763 379 233690 306400 209902 613812 603554 602450 613193 606763 244400 614420 614116 242860 217390 2686 2908 173650 2791 93262 616482 370348 88628 908 232200 610199 145981 231070 171 584 232 56 179 3287 36426 615422 2796 607594 209950 615978 616394 149700 186 612852 615207 312863 300400 614204 608971 226990 79403 116920 613011 600802 2526 79155 258 615758 79284 277380 2348 79084 280365 77297 609628 238600 614700 617809 167 342 245150 79312 289916 251000 431361 251260 233700 233710 608654 122470 617388 610852 955 117550 617241 642 256800 534 300209 612782 617099 606054 614921 194380 615108 97231 722 217090 613179 254886 79083 167800 617591 256040 69126 158350 601457 613115 616260 420741 300455 1452 98905 60 178500 253700 440713 614602 603471 238459 266265 232220 222700 613640 391487 2314 412057 199296 259700 618050 615934 32960 444463 436252 162000 615518 608106 906 301000 613610 300635 269840 614069 79394 313 457 758 614328 1901 2136 616368 93 208400 608594 963 33355 64 214950 261250 53697 105200 158029 412 615451 567 3197 221900 905 277900 904 309800 613502 529962 168829 269700 253260 797 614380 458803 193235 2897 602723 618131 676 428 235510 614679 615067 616037 615504 139578 240500 613493 2584 3162 615617 615615 615607 613501 612692 145001 96253 652 276152 615500 618063 602271 614809 219700 601776 53 166600 614576 1427 215150 287 156550 104200 79409 79408 226600 612714 272430 263534 616100 50943 678 245010 245000 170650 604777 617394 910 278740 271665 819 615008 270400 305000 612518 615482 614874 612444 811 617052 614017 36412 243700 618027 615294 615508 302960 530 305100 1810 616069 194050 220295 601675 278730 278800 207 785 615363 617425 131 615704 615707 79278 177000 612840 101200 123500 100800 15 617443 2308 309350 602079 33001 153400 304790 616726 79277 3226 2237 617827 317 477 602540 129500 613480 610015 79444 79443 94089 252500 444490 616395 604931 163596 1001 199 703 85414 253270 140000 1525 90791 607765 601492 608647 233600 309900 601495 613500 464 308300 612567 613953 616445 615767 606367 616022 610443 435628 2036 181270 147920 300867 280785 44890 79503 312 113800 2199 609165 79396 167210 158681 79404 779 169400 614962 280 3000 235 606593 151660 161200 614935 601088 157800 613791 2273 308205 308800 249100 134610 261190 131100 85202 609180 256810 616834 300988 112250 343 260920 618116 647 613960 616576 293978 615577 612281 1451 47045 616050 611762 575 191900 120100 148200 90340 186580 136 786 617253 611091 1507 2750 613803 79254 261600 216866 612847 148190 608940 742 170100 615816 79351 280633 300991 158668 2387 614468 226670 225400 570 615024 98908 301220 94125 90342 278750 618048 95699 615830 615 255960 615966 613737 613736 2615 79350 604416 109 397 600882 615895 618108 616651 612562 615481 612649 612650 617053 610455 615993 616858 798 616831 308240 137834 249420 48652 607721 618162 238970 168569 602782 3342 608118 232240 37 2116 616868 3051 601358 1658 617475 615505 608189 634 256500 162400 2044 136140 612379 1772 602400 614162 615952 147060 272300 53351 300966 604571 79500 188400 618223 261279 616941 2896 1059 616740 1388 242300 254875 617044 302 616744 612301 613494 142680 259710 69085 103285 1896 604292 106260 129400 615527 615356 613216 617092 243150 263700 604173 613404 208085 313900 614376 614378 614493 247768 158330 278300 278700 278720 613159 613270 235730 615444 240300 114550 52417 115150 79241 613652 613779 614379 617694 397715 615861 146700 230900 148210 615947 79242 259100 203300 616854 615846 613148 617337 118900 301006 214500 617609 300918 210210 176450 610377 183713 142690 614262 602535 616730 300868 276280 208250 615559 274000 615147 615190 612289 613795 137940 79124 618213 614816 615582 609192 610168 617006 618282 610227 3453 85410 314652 609536 242840 88632 613956 740 234050 133020 285 212050 613108 617137 260005 614878
 

Human Phenotype Ontology(HPO) is developed by the Human Phenotype Ontology Consortium. The version used here is June 2019 release.