Human Phenotype Ontology 
Grandparent Node:
expandPhenotypic abnormality (HP:0000118)help
Parent Node:
expandAbnormality of metabolism/homeostasis (HP:0001939)help
..Starting node
..expandFood intolerance (HP:0012537)help
Term ID: 12537
Name: Food intolerance
Synonym: Food intolerance; Non-allergic food hypersensitivity
Definition: A detrimental reaction to a food, beverage, food additive, or compound found in foods that produces symptoms in one or more body organs and systems that is not mediated by an immune reaction.
Comments:
Reference: HP:0012537
Genes and Diseases:
 
       Child Nodes:
........expandIntolerance to protein (HP:0001984) help
................... HP:0012538 Gluten intolerance

 Sister Nodes: 
..expandAbnormal blood ion concentration (HP:0003111) help
..expandAbnormal calcium-phosphate regulating hormone level (HP:0100530) help
..expandAbnormal cellular physiology (HP:0011017) help
..expandAbnormal circulating carbohydrate concentration (HP:0011013) help
..expandAbnormal circulating carboxylic acid concentration (HP:0004354) help
..expandAbnormal circulating lipid concentration (HP:0003119) help
..expandAbnormal circulating nitrogen compound concentration (HP:0004364) help
..expandAbnormal circulating nucleobase concentration (HP:0010932) help
..expandAbnormal circulating porphyrin concentration (HP:0010472) help
..expandAbnormal circulating protein concentration (HP:0010876) help
..expandAbnormal circulating selenium concentration (HP:0031903) help
..expandAbnormal enzyme/coenzyme activity (HP:0012379) help
..expandAbnormal erythrocyte sedimentation rate (HP:0025021) help
..expandAbnormal homeostasis (HP:0012337) help
..expandAbnormal sweat homeostasis (HP:0040127) help
..expandAbnormality of acid-base homeostasis (HP:0004360) help
..expandAbnormality of fluid regulation (HP:0011032) help
..expandAbnormality of Krebs cycle metabolism (HP:0000816) help
..expandAbnormality of superoxide metabolism (HP:0004358) help
..expandAbnormality of temperature regulation (HP:0004370) help
..expandAbnormality of urine homeostasis (HP:0003110) help
..expandAbnormality of vitamin metabolism (HP:0100508) help
..expandAmyloidosis (HP:0011034) help
..expandBloodstream infectious agent (HP:0031863) help
..expandGangrene (HP:0100758) help
..expandHyperbilirubinemia (HP:0002904) help
..expandIncreased level of propylene glycol in blood (HP:0410069) help
..expandKetosis (HP:0001946) help
..expandMolybdenum cofactor deficiency (HP:0003570) help
..expandobsolete Abnormality of glycoprotein metabolism (HP:0004367) help
..expandPresence of xenobiotic (HP:0031838) help
..expandReduced 5-oxoprolinase level (HP:0040142) help
..expandReduced acetaldehyde dehydrogenase level (HP:0003533) help
..expandReduced glutathione synthetase level (HP:0003343) help
InputHPO IDHPO termDistanceGeneGene id entrezHGNC IDDiseaseIdDiseaseNameFrequencyOnsetHGMD variantsClinVar variants
 
HPO disease - gene - phenotype typical associations:
 
HPO disease - gene - phenotype less frequent non-typical associations:
HP:0012537HP:0012537Food intolerance0ALG3 CL E G H1019523056OMIM:601110Congenital disorder of glycosylation, type Id.37
HP:0012537HP:0012537Food intolerance0ASXL1 CL E G H17102318318ORPHA:97297Bohring-Opitz syndromeHP:0040282 - Frequent145
HP:0012537HP:0012537Food intolerance0CLMP CL E G H7982724039OMIM:615237Congenital short bowel syndrome7
HP:0012537HP:0012537Food intolerance0COG8 CL E G H8434218623ORPHA:95428COG8-CDGHP:0040282 - Frequent39
HP:0012537HP:0012537Food intolerance0ELN CL E G H20063327OMIM:194050Williams-Beuren syndrome.172
HP:0012537HP:0012537Food intolerance0GALT CL E G H25924135ORPHA:79239Classic galactosemiaHP:0040282 - Frequent351
HP:0012537HP:0012537Food intolerance0MLXIPL CL E G H5108512744OMIM:194050Williams-Beuren syndrome.1
HP:0012537HP:0012537Food intolerance0SRCAP CL E G H1084716974ORPHA:2044Floating-Harbor syndrome138
HP:0012537HP:0012537Food intolerance0UNC45A CL E G H5589830594OMIM:619377OSTEOOTOHEPATOENTERIC SYNDROME; OOHE
HP:0012537HP:0001984Intolerance to protein1CLMP CL E G H7982724039OMIM:615237Congenital short bowel syndrome7
HP:0012537HP:0001984Intolerance to protein1SRCAP CL E G H1084716974ORPHA:2044Floating-Harbor syndrome138
HP:0012537HP:0012538Gluten intolerance2SRCAP CL E G H1084716974ORPHA:2044Floating-Harbor syndromeHP:0040284 - Very rare138


Genes (9) :ALG3 ASXL1 CLMP COG8 ELN GALT MLXIPL SRCAP UNC45A

Diseases (8) :OMIM:601110 ORPHA:97297 OMIM:615237 ORPHA:95428 OMIM:194050 ORPHA:79239 ORPHA:2044 OMIM:619377
 

Human Phenotype Ontology(HPO) is developed by the Human Phenotype Ontology Consortium. The version used here is December 15 2022 release.