Human Phenotype Ontology

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Hello! Guest! Please Login or Register! Clinician Mode

Examples Gene: MT-ND1, POLG, Region: M:1-1000 Variant: m.8993T>G, 1:g.10042757T>C rs3888511 MSCV_0000006, ClinVar: RCV000000015, Disease: Leigh syndrome, Phenotype: Retinopathy

Grandparent Node:
Abnormality of movement (HP:0100022)

Parent Node:
Gait disturbance (HP:0001288)

..Starting node
..Scissor gait (HP:0012407)

Term ID:

12407

Name:

Scissor gait

Synonym:

Scissor gait; Scissor walk; Scissors gait

Definition:

A type of spastic paraparetic gait in which the muscle tone in the adductors is marked. It is characterized by hypertonia and flexion in the legs, hips and pelvis accompanied by extreme adduction leading to the knees and thighs hitting, or sometimes even crossing, in a scissors-like movement. The opposing muscles (abductors) become comparatively weak from lack of use.

Comments:

Reference:

HP:0012407

Genes and Diseases:

Child Nodes:

Sister Nodes:

Broad-based gait (HP:0002136)

Cerebellar ataxia associated with quadrupedal gait (HP:0009878)

Cock-walk gait (HP:0031848)

Difficulty walking (HP:0002355)

Difficulty walking backward (HP:0031847)

Falls (HP:0002527)

Freezing of gait (HP:0031825)

Gait apraxia (HP:0010521)

Gait ataxia (HP:0002066)

Gait imbalance (HP:0002141)

Hobby horse gait (HP:0031856)

Impaired tandem gait (HP:0031629)

Inability to walk (HP:0002540)

obsolete Toe walking (HP:0040083)

Shuffling gait (HP:0002362)

Steppage gait (HP:0003376)

Tip-toe gait (HP:0030051)

Unsteady gait (HP:0002317)

Waddling gait (HP:0002515)

Input	HPO ID	HPO term	Distance	Gene	Gene id entrez	HGNC ID	DiseaseId	DiseaseName	Frequency	ClinVar variants
HPO disease - gene - phenotype typical associations:
HPO disease - gene - phenotype less frequent non-typical associations:
HP:0012407	HP:0012407	Scissor gait	0	AMPD2 CL E G H	271	469	ORPHA:401805	Autosomal recessive spastic paraplegia type 63	HP:0040282 - Frequent	21
HP:0012407	HP:0012407	Scissor gait	0	AMPD2 CL E G H	271	469	OMIM:615686	Spastic paraplegia 63, autosomal recessive	.	21
HP:0012407	HP:0012407	Scissor gait	0	ARL6IP1 CL E G H	23204	697	ORPHA:401780	Autosomal recessive spastic paraplegia type 61	HP:0040282 - Frequent	1
HP:0012407	HP:0012407	Scissor gait	0	ARL6IP1 CL E G H	23204	697	OMIM:615685	Spastic paraplegia 61, autosomal recessive	.	1
HP:0012407	HP:0012407	Scissor gait	0	ATP6AP2 CL E G H	10159	18305	ORPHA:363654	X-linked parkinsonism-spasticity syndrome	HP:0040283 - Occasional	36
HP:0012407	HP:0012407	Scissor gait	0	ERCC6 CL E G H	2074	3438	OMIM:278800	De Sanctis-Cacchione syndrome		199
HP:0012407	HP:0012407	Scissor gait	0	FARS2 CL E G H	10667	21062	ORPHA:466722	Autosomal recessive spastic paraplegia type 77	HP:0040282 - Frequent	36
HP:0012407	HP:0012407	Scissor gait	0	FBXO7 CL E G H	25793	13586	OMIM:260300	Parkinson disease 15, autosomal recessive early-onset	.	36
HP:0012407	HP:0012407	Scissor gait	0	KIF1A CL E G H	547	888	ORPHA:101010	Autosomal spastic paraplegia type 30	HP:0040282 - Frequent	276
HP:0012407	HP:0012407	Scissor gait	0	SHMT2 CL E G H	6472	10852	OMIM:619121	NEURODEVELOPMENTAL DISORDER WITH CARDIOMYOPATHY, SPASTICITY, AND BRAIN ABNORMALITIES; NEDCASB
HP:0012407	HP:0012407	Scissor gait	0	SLC39A14 CL E G H	23516	20858	ORPHA:521406	Dystonia-parkinsonism-hypermanganesemia syndrome	HP:0040282 - Frequent	5
HP:0012407	HP:0012407	Scissor gait	0	SLC39A14 CL E G H	23516	20858	OMIM:617013	Hypermanganesemia with dystonia 2		5

Genes (9) :AMPD2 ARL6IP1 ATP6AP2 ERCC6 FARS2 FBXO7 KIF1A SHMT2 SLC39A14

Diseases (12) :ORPHA:401805 OMIM:615686 ORPHA:401780 OMIM:615685 ORPHA:363654 OMIM:278800 ORPHA:466722 OMIM:260300 ORPHA:101010 OMIM:619121 ORPHA:521406 OMIM:617013

Human Phenotype Ontology(HPO) is developed by the Human Phenotype Ontology Consortium. The version used here is December 15 2022 release.

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