Human Phenotype Ontology 
Grandparent Node:
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Abnormal leukocyte morphology (HP:0001881)help
Grandparent Node:
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Hematological neoplasm (HP:0004377)help
Parent Node:
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Leukemia (HP:0001909)help
..Starting node
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Myeloid leukemia (HP:0012324)help
Term ID: 12324
Name: Myeloid leukemia
Synonym: Myeloid leukaemia
Definition: A leukemia that originates from a myeloid cell, that is the blood forming cells of the bone marrow.
Comments:
Reference: HP:0012324
Genes and Diseases:
 
       Child Nodes:
........expandAcute myelomonocytic leukemia (HP:0004820) help
........expandJuvenile myelomonocytic leukemia (HP:0012209) help
........expandChronic myelomonocytic leukemia (HP:0012325) help

 Sister Nodes: 
..expandAcute leukemia (HP:0002488) help
..expandChronic leukemia (HP:0005558) help
..expandLymphoid leukemia (HP:0005526) help
..expandMyeloproliferative disorder (HP:0005547) help
InputHPO IDHPO termDistanceGeneGene id entrezHGNC IDDiseaseIdDiseaseNameFrequencyOnsetHGMD variantsClinVar variants
 
HPO disease - gene - phenotype typical associations:
 
HPO disease - gene - phenotype less frequent non-typical associations:
HP:0012324HP:0012324Myeloid leukemia0ARHGAP26 CL E G H2309217073OMIM:607785Juvenile myelomonocytic leukemia12
HP:0012324HP:0012324Myeloid leukemia0ASXL1 CL E G H17102318318ORPHA:98849Systemic mastocytosis with associated hematologic neoplasmHP:0040281 - Very frequent145
HP:0012324HP:0012324Myeloid leukemia0BRAF CL E G H6731097OMIM:163950Noonan syndrome 1276
HP:0012324HP:0012324Myeloid leukemia0CBL CL E G H8671541OMIM:607785Juvenile myelomonocytic leukemia317
HP:0012324HP:0012324Myeloid leukemia0CBL CL E G H8671541OMIM:613563Noonan syndrome-like disorder with or without juvenile myelomonocytic leukemia317
HP:0012324HP:0012324Myeloid leukemia0DNMT3A CL E G H17882978ORPHA:404443Tatton-Brown-Rahman syndromeHP:0040284 - Very rare44
HP:0012324HP:0012324Myeloid leukemia0F13A1 CL E G H21623531ORPHA:331Congenital factor XIII deficiencyHP:0040284 - Very rare60
HP:0012324HP:0012324Myeloid leukemia0F13B CL E G H21653534ORPHA:331Congenital factor XIII deficiencyHP:0040284 - Very rare32
HP:0012324HP:0012324Myeloid leukemia0GATA2 CL E G H26244171OMIM:614172Immunodeficiency 21.137
HP:0012324HP:0012324Myeloid leukemia0IDH1 CL E G H34175382ORPHA:99646Metaphyseal chondromatosis with D-2-hydroxyglutaric aciduria15
HP:0012324HP:0012324Myeloid leukemia0KIT CL E G H38156342ORPHA:98849Systemic mastocytosis with associated hematologic neoplasmHP:0040281 - Very frequent327
HP:0012324HP:0012324Myeloid leukemia0KRAS CL E G H38456407OMIM:609942Noonan syndrome 3196
HP:0012324HP:0012324Myeloid leukemia0MAP2K1 CL E G H56046840OMIM:163950Noonan syndrome 1134
HP:0012324HP:0012324Myeloid leukemia0NF1 CL E G H47637765OMIM:607785Juvenile myelomonocytic leukemia1952
HP:0012324HP:0012324Myeloid leukemia0NRAS CL E G H48937989OMIM:613224Noonan syndrome 6102
HP:0012324HP:0012324Myeloid leukemia0PTPN11 CL E G H57819644OMIM:607785Juvenile myelomonocytic leukemia291
HP:0012324HP:0012324Myeloid leukemia0PTPN11 CL E G H57819644OMIM:163950Noonan syndrome 1291
HP:0012324HP:0012324Myeloid leukemia0SAMD9L CL E G H2192851349ORPHA:2585Ataxia-pancytopenia syndrome4
HP:0012324HP:0012324Myeloid leukemia0SAMD9L CL E G H2192851349OMIM:159550Ataxia-Pancytopenia syndrome4
HP:0012324HP:0012324Myeloid leukemia0SETBP1 CL E G H2604015573ORPHA:798Schinzel-Giedion syndromeHP:0040284 - Very rare143
HP:0012324HP:0012324Myeloid leukemia0SRSF2 CL E G H642710783ORPHA:98849Systemic mastocytosis with associated hematologic neoplasmHP:0040281 - Very frequent1
HP:0012324HP:0012324Myeloid leukemia0TERC CL E G H701211727OMIM:614743Pulmonary fibrosis and/or bone marrow failure, telomere-related, 2.48
HP:0012324HP:0012324Myeloid leukemia0TERT CL E G H701511730OMIM:614742PULMONARY FIBROSIS AND/OR BONE MARROW FAILURE, TELOMERE-RELATED, 1; PFBMFT1238
HP:0012324HP:0012324Myeloid leukemia0TET2 CL E G H5479025941ORPHA:98849Systemic mastocytosis with associated hematologic neoplasmHP:0040281 - Very frequent3
HP:0012324HP:0012209Juvenile myelomonocytic leukemia1ARHGAP26 CL E G H2309217073OMIM:607785Juvenile myelomonocytic leukemia.12
HP:0012324HP:0012325Chronic myelomonocytic leukemia1ASXL1 CL E G H17102318318ORPHA:98849Systemic mastocytosis with associated hematologic neoplasmHP:0040283 - Occasional145
HP:0012324HP:0012209Juvenile myelomonocytic leukemia1BRAF CL E G H6731097OMIM:163950Noonan syndrome 1276
HP:0012324HP:0012209Juvenile myelomonocytic leukemia1CBL CL E G H8671541OMIM:607785Juvenile myelomonocytic leukemia.317
HP:0012324HP:0012209Juvenile myelomonocytic leukemia1CBL CL E G H8671541OMIM:613563Noonan syndrome-like disorder with or without juvenile myelomonocytic leukemia.317
HP:0012324HP:0004820Acute myelomonocytic leukemia1IDH1 CL E G H34175382ORPHA:99646Metaphyseal chondromatosis with D-2-hydroxyglutaric aciduria15
HP:0012324HP:0012325Chronic myelomonocytic leukemia1KIT CL E G H38156342ORPHA:98849Systemic mastocytosis with associated hematologic neoplasmHP:0040283 - Occasional327
HP:0012324HP:0012209Juvenile myelomonocytic leukemia1KRAS CL E G H38456407OMIM:609942Noonan syndrome 3196
HP:0012324HP:0012209Juvenile myelomonocytic leukemia1MAP2K1 CL E G H56046840OMIM:163950Noonan syndrome 1134
HP:0012324HP:0012209Juvenile myelomonocytic leukemia1NF1 CL E G H47637765OMIM:607785Juvenile myelomonocytic leukemia.1952
HP:0012324HP:0012209Juvenile myelomonocytic leukemia1NRAS CL E G H48937989OMIM:613224Noonan syndrome 6.102
HP:0012324HP:0012209Juvenile myelomonocytic leukemia1PTPN11 CL E G H57819644OMIM:607785Juvenile myelomonocytic leukemia.291
HP:0012324HP:0012209Juvenile myelomonocytic leukemia1PTPN11 CL E G H57819644OMIM:163950Noonan syndrome 1291
HP:0012324HP:0004820Acute myelomonocytic leukemia1SAMD9L CL E G H2192851349OMIM:159550Ataxia-Pancytopenia syndrome.4
HP:0012324HP:0004820Acute myelomonocytic leukemia1SAMD9L CL E G H2192851349ORPHA:2585Ataxia-pancytopenia syndromeHP:0040282 - Frequent4
HP:0012324HP:0012325Chronic myelomonocytic leukemia1SRSF2 CL E G H642710783ORPHA:98849Systemic mastocytosis with associated hematologic neoplasmHP:0040283 - Occasional1
HP:0012324HP:0012325Chronic myelomonocytic leukemia1TET2 CL E G H5479025941ORPHA:98849Systemic mastocytosis with associated hematologic neoplasmHP:0040283 - Occasional3


Genes (21) :ARHGAP26 ASXL1 BRAF CBL DNMT3A F13A1 F13B GATA2 IDH1 KIT KRAS MAP2K1 NF1 NRAS PTPN11 SAMD9L SETBP1 SRSF2 TERC TERT TET2

Diseases (15) :OMIM:607785 ORPHA:98849 OMIM:163950 OMIM:613563 ORPHA:404443 ORPHA:331 OMIM:614172 ORPHA:99646 OMIM:609942 OMIM:613224 ORPHA:2585 OMIM:159550 ORPHA:798 OMIM:614743 OMIM:614742
 

Human Phenotype Ontology(HPO) is developed by the Human Phenotype Ontology Consortium. The version used here is December 15 2022 release.