Human Phenotype Ontology

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Examples Gene: MT-ND1, POLG, Region: M:1-1000 Variant: m.8993T>G, 1:g.10042757T>C rs3888511 MSCV_0000006, ClinVar: RCV000000015, Disease: Leigh syndrome, Phenotype: Retinopathy

Grandparent Node:
Hearing abnormality (HP:0000364)

Parent Node:
Hearing impairment (HP:0000365)

..Starting node
..Aminoglycoside-induced hearing loss (HP:0011975)

Term ID:

11975

Name:

Aminoglycoside-induced hearing loss

Synonym:

Definition:

Partial or complete loss of hearing following ingestion of aminoglycoside antibiotics.

Comments:

Reference:

HP:0011975

Genes and Diseases:

Child Nodes:

Sister Nodes:

Conductive hearing impairment (HP:0000405)

High-frequency hearing impairment (HP:0005101)

Low-frequency hearing loss (HP:0008542)

Mid-frequency hearing loss (HP:0012781)

Mild hearing impairment (HP:0012712)

Moderate hearing impairment (HP:0012713)

Profound hearing impairment (HP:0012715)

Progressive hearing impairment (HP:0001730)

Sensorineural hearing impairment (HP:0000407)

Severe hearing impairment (HP:0012714)

Transient hearing impairment (HP:0012779)

Unilateral deafness (HP:0009900)

Input	HPO ID	HPO term	Distance	Gene	Gene id entrez	HGNC ID	DiseaseId	DiseaseName	Frequency	ClinVar variants
HPO disease - gene - phenotype typical associations:
HPO disease - gene - phenotype less frequent non-typical associations:
HP:0011975	HP:0011975	Aminoglycoside-induced hearing loss	0	TRMU CL E G H	55687	25481	OMIM:580000	Deafness, aminoglycoside-induced	.	101
HP:0011975	HP:0011975	Aminoglycoside-induced hearing loss	0	TRNS1 CL E G H	4574	7497	OMIM:580000	Deafness, aminoglycoside-induced	.

Genes (2) :TRMU TRNS1

Diseases (1) :OMIM:580000

Human Phenotype Ontology(HPO) is developed by the Human Phenotype Ontology Consortium. The version used here is December 15 2022 release.