Term ID: 1188
Name: Hand clenching
Synonym: Clenched hand; Clenched hands; Hand clenching
Definition: An abnormal hand posture in which the hands are clenched to fists. All digits held completely flexed at the metacarpophalangeal and interphalangeal joints. In prenatal sonography of the fetal clenched hand, the index finger overlaps a clenched fist formed by the other digits. The proximal interphalangeal articulation of the index finger is flexed and ulnarly deviated, and the thumb is adducted.
Comments:
Reference: HP:0001188
Genes and Diseases: Child Nodes: Sister Nodes: ..Curved fingers (HP:0004095) ..Large hands (HP:0001176) ..Mitten deformity (HP:0004057) ..Notched hand bones (HP:0004284) ..Overlapping fingers (HP:0010557) ..Overmodelled hand bones (HP:0004285) ..Pointed hand bones (HP:0004287) ..Short finger (HP:0009381) ..Undermodelled hand bones (HP:0004292) ..Valgus hand deformity (HP:0006228) Input HPO ID HPO term Distance Gene Gene id entrez HGNC ID DiseaseId DiseaseName Frequency Onset HGMD variants ClinVar variants HP:0001188 HP:0001188 Hand clenching 0 ASXL3 CL E G H 80816 29357 OMIM:615485 BAINBRIDGE-ROPERS SYNDROME; BRPS 49 HP:0001188 HP:0001188 Hand clenching 0 ATP6V1E1 CL E G H 529 857 OMIM:617402 Cutis laxa, autosomal recessive, type IIC . 2 HP:0001188 HP:0001188 Hand clenching 0 BCOR CL E G H 54880 20893 OMIM:300166 Microphthalmia, syndromic 2 HP:0040283 - Occasional 101 HP:0001188 HP:0001188 Hand clenching 0 BICD2 CL E G H 23299 17208 OMIM:618291 Spinal muscular atrophy, lower extremity-predominant, 2B, autosomal dominant . 46 HP:0001188 HP:0001188 Hand clenching 0 BLTP1 CL E G H 84162 26953 OMIM:617822 Alkuraya-Kucinskas syndrome . HP:0001188 HP:0001188 Hand clenching 0 CDK5 CL E G H 1020 1774 OMIM:616342 Lissencephaly 7 with cerebellar hypoplasia . 3 HP:0001188 HP:0001188 Hand clenching 0 CNTNAP1 CL E G H 8506 8011 OMIM:618186 Neuropathy, congenital hypomyelinating, 3 . 9 HP:0001188 HP:0001188 Hand clenching 0 DST CL E G H 667 1090 OMIM:614653 Neuropathy, hereditary sensory and autonomic, type VI . 108 HP:0001188 HP:0001188 Hand clenching 0 FLNB CL E G H 2317 3755 ORPHA:56305 Atelosteogenesis type III HP:0040283 - Occasional 233 HP:0001188 HP:0001188 Hand clenching 0 GLE1 CL E G H 2733 4315 OMIM:611890 Congenital arthrogryposis with anterior horn cell disease . 45 HP:0001188 HP:0001188 Hand clenching 0 GNB1 CL E G H 2782 4396 OMIM:616973 Mental retardation, autosomal dominant 42 12 HP:0001188 HP:0001188 Hand clenching 0 GRIK2 CL E G H 2898 4580 OMIM:619580 NEURODEVELOPMENTAL DISORDER WITH IMPAIRED LANGUAGE AND ATAXIA AND WITH OR WITHOUT SEIZURES; NEDLAS 32 HP:0001188 HP:0001188 Hand clenching 0 GTPBP2 CL E G H 54676 4670 OMIM:617988 Jaberi-Elahi syndrome . HP:0001188 HP:0001188 Hand clenching 0 HNRNPH1 CL E G H 3187 5041 OMIM:620083 HP:0001188 HP:0001188 Hand clenching 0 KCNA1 CL E G H 3736 6218 ORPHA:37612 Episodic ataxia type 1 HP:0040283 - Occasional 145 HP:0001188 HP:0001188 Hand clenching 0 KIDINS220 CL E G H 57498 29508 OMIM:619501 VENTRICULOMEGALY AND ARTHROGRYPOSIS; VENARG 4 HP:0001188 HP:0001188 Hand clenching 0 L1CAM CL E G H 3897 6470 ORPHA:2466 MASA syndrome HP:0040281 - Very frequent 134 HP:0001188 HP:0001188 Hand clenching 0 MAPT CL E G H 4137 6893 ORPHA:240103 Progressive supranuclear palsy-corticobasal syndrome HP:0040282 - Frequent 140 HP:0001188 HP:0001188 Hand clenching 0 MOGS CL E G H 7841 24862 OMIM:606056 Congenital disorder of glycosylation, type IIB . 37 HP:0001188 HP:0001188 Hand clenching 0 MYOD1 CL E G H 4654 7611 OMIM:618975 MYOPATHY, CONGENITAL, WITH DIAPHRAGMATIC DEFECTS, RESPIRATORY INSUFFICIENCY, AND DYSMORPHIC FACIES; MYODRIF HP:0001188 HP:0001188 Hand clenching 0 NEB CL E G H 4703 7720 OMIM:256030 Nemaline myopathy 2, autosomal recessive . 745 HP:0001188 HP:0001188 Hand clenching 0 SCYL2 CL E G H 55681 19286 OMIM:618766 ARTHROGRYPOSIS MULTIPLEX CONGENITA 4, NEUROGENIC, WITH AGENESIS OF THE CORPUS CALLOSUM; AMC4 HP:0001188 HP:0001188 Hand clenching 0 SLC6A9 CL E G H 6536 11056 OMIM:617301 Glycine encephalopathy with normal serum glycine 4 HP:0001188 HP:0001188 Hand clenching 0 SMG9 CL E G H 56006 25763 OMIM:616920 Heart and brain malformation syndrome 2 HP:0001188 HP:0001188 Hand clenching 0 SYNE1 CL E G H 23345 17089 ORPHA:319332 Autosomal recessive myogenic arthrogryposis multiplex congenita 1129 HP:0001188 HP:0001188 Hand clenching 0 TBR1 CL E G H 10716 11590 ORPHA:1617 2q24 microdeletion syndrome HP:0040281 - Very frequent 1 HP:0001188 HP:0001188 Hand clenching 0 TOR1A CL E G H 1861 3098 OMIM:618947 ARTHROGRYPOSIS MULTIPLEX CONGENITA 5; AMC5 47 HP:0001188 HP:0001188 Hand clenching 0 TPM2 CL E G H 7169 12011 OMIM:108120 Arthrogryposis, distal, type 1A . 54 HP:0001188 HP:0001188 Hand clenching 0 WDR73 CL E G H 84942 25928 OMIM:251300 Galloway-mowat syndrome 1 . 14
Human Phenotype Ontology(HPO) is developed by the Human Phenotype Ontology Consortium. The version used here is December 15 2022 release.
