Human Phenotype Ontology

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Hello! Guest! Please Login or Register! Clinician Mode

Examples Gene: MT-ND1, POLG, Region: M:1-1000 Variant: m.8993T>G, 1:g.10042757T>C rs3888511 MSCV_0000006, ClinVar: RCV000000015, Disease: Leigh syndrome, Phenotype: Retinopathy

Grandparent Node:
Abnormal paranasal sinus morphology (HP:0000245)

Grandparent Node:
Increased inflammatory response (HP:0012649)

Parent Node:
Sinusitis (HP:0000246)

..Starting node
..Chronic sinusitis (HP:0011109)

Term ID:

11109

Name:

Chronic sinusitis

Synonym:

Chronic sinus disease; Sinusitis, chronic

Definition:

A chronic form of sinusitis.

Comments:

Reference:

HP:0011109

Genes and Diseases:

Child Nodes:

Sister Nodes:

Acute sinusitis (HP:0000255)

Recurrent sinusitis (HP:0011108)

Input	HPO ID	HPO term	Distance	Gene	Gene id entrez	HGNC ID	DiseaseId	DiseaseName	Frequency	ClinVar variants
HPO disease - gene - phenotype typical associations:
HPO disease - gene - phenotype less frequent non-typical associations:
HP:0011109	HP:0011109	Chronic sinusitis	0	BLNK CL E G H	29760	14211	OMIM:613502	Agammaglobulinemia 4, autosomal recessive	.	4
HP:0011109	HP:0011109	Chronic sinusitis	0	CCDC103 CL E G H	388389	32700	OMIM:614679	Ciliary dyskinesia, primary, 17	.	36
HP:0011109	HP:0011109	Chronic sinusitis	0	CCDC103 CL E G H	388389	32700	ORPHA:244	Primary ciliary dyskinesia	HP:0040282 - Frequent	36
HP:0011109	HP:0011109	Chronic sinusitis	0	CCDC39 CL E G H	339829	25244	OMIM:613807	Ciliary dyskinesia, primary, 14		126
HP:0011109	HP:0011109	Chronic sinusitis	0	CCDC39 CL E G H	339829	25244	ORPHA:244	Primary ciliary dyskinesia	HP:0040282 - Frequent	126
HP:0011109	HP:0011109	Chronic sinusitis	0	CCDC40 CL E G H	55036	26090	OMIM:613808	CILIARY DYSKINESIA, PRIMARY, 15; CILD15		182
HP:0011109	HP:0011109	Chronic sinusitis	0	CCDC40 CL E G H	55036	26090	ORPHA:244	Primary ciliary dyskinesia	HP:0040282 - Frequent	182
HP:0011109	HP:0011109	Chronic sinusitis	0	CCDC65 CL E G H	85478	29937	OMIM:615504	Ciliary dyskinesia, primary, 27		23
HP:0011109	HP:0011109	Chronic sinusitis	0	CCDC65 CL E G H	85478	29937	ORPHA:244	Primary ciliary dyskinesia	HP:0040282 - Frequent	23
HP:0011109	HP:0011109	Chronic sinusitis	0	CCNO CL E G H	10309	18576	ORPHA:244	Primary ciliary dyskinesia	HP:0040282 - Frequent	23
HP:0011109	HP:0011109	Chronic sinusitis	0	CD79B CL E G H	974	1699	OMIM:612692	Agammaglobulinemia 6, autosomal recessive	.	6
HP:0011109	HP:0011109	Chronic sinusitis	0	CFAP221 CL E G H	200373	33720	ORPHA:244	Primary ciliary dyskinesia	HP:0040282 - Frequent
HP:0011109	HP:0011109	Chronic sinusitis	0	CFAP298 CL E G H	56683	1301	ORPHA:244	Primary ciliary dyskinesia	HP:0040282 - Frequent
HP:0011109	HP:0011109	Chronic sinusitis	0	CFAP300 CL E G H	85016	28188	OMIM:618063	Ciliary dyskinesia, primary, 38	.
HP:0011109	HP:0011109	Chronic sinusitis	0	CFAP300 CL E G H	85016	28188	ORPHA:244	Primary ciliary dyskinesia	HP:0040282 - Frequent
HP:0011109	HP:0011109	Chronic sinusitis	0	CFAP45 CL E G H	25790	17229	OMIM:619608	HETEROTAXY, VISCERAL, 11, AUTOSOMAL, WITH MALE INFERTILITY; HTX11
HP:0011109	HP:0011109	Chronic sinusitis	0	CFAP52 CL E G H	146845	16053	OMIM:619607	HETEROTAXY, VISCERAL, 10, AUTOSOMAL, WITH MALE INFERTILITY; HTX10
HP:0011109	HP:0011109	Chronic sinusitis	0	CFTR CL E G H	1080	1884	OMIM:219700	Cystic fibrosis		1371
HP:0011109	HP:0011109	Chronic sinusitis	0	DNAAF1 CL E G H	123872	30539	ORPHA:244	Primary ciliary dyskinesia	HP:0040282 - Frequent	116
HP:0011109	HP:0011109	Chronic sinusitis	0	DNAAF11 CL E G H	23639	16725	ORPHA:244	Primary ciliary dyskinesia	HP:0040282 - Frequent
HP:0011109	HP:0011109	Chronic sinusitis	0	DNAAF2 CL E G H	55172	20188	OMIM:612518	CILIARY DYSKINESIA, PRIMARY, 10; CILD10		78
HP:0011109	HP:0011109	Chronic sinusitis	0	DNAAF2 CL E G H	55172	20188	ORPHA:244	Primary ciliary dyskinesia	HP:0040282 - Frequent	78
HP:0011109	HP:0011109	Chronic sinusitis	0	DNAAF3 CL E G H	352909	30492	ORPHA:244	Primary ciliary dyskinesia	HP:0040282 - Frequent	63
HP:0011109	HP:0011109	Chronic sinusitis	0	DNAAF4 CL E G H	161582	21493	ORPHA:244	Primary ciliary dyskinesia	HP:0040282 - Frequent	27
HP:0011109	HP:0011109	Chronic sinusitis	0	DNAAF5 CL E G H	54919	26013	ORPHA:244	Primary ciliary dyskinesia	HP:0040282 - Frequent	62
HP:0011109	HP:0011109	Chronic sinusitis	0	DNAAF6 CL E G H	139212	28570	ORPHA:244	Primary ciliary dyskinesia	HP:0040282 - Frequent
HP:0011109	HP:0011109	Chronic sinusitis	0	DNAH1 CL E G H	25981	2940	ORPHA:244	Primary ciliary dyskinesia	HP:0040282 - Frequent	21
HP:0011109	HP:0011109	Chronic sinusitis	0	DNAH11 CL E G H	8701	2942	ORPHA:244	Primary ciliary dyskinesia	HP:0040282 - Frequent	542
HP:0011109	HP:0011109	Chronic sinusitis	0	DNAH5 CL E G H	1767	2950	ORPHA:244	Primary ciliary dyskinesia	HP:0040282 - Frequent	527
HP:0011109	HP:0011109	Chronic sinusitis	0	DNAH9 CL E G H	1770	2953	OMIM:618300	Ciliary dyskinesia, primary, 40		18
HP:0011109	HP:0011109	Chronic sinusitis	0	DNAH9 CL E G H	1770	2953	ORPHA:244	Primary ciliary dyskinesia	HP:0040282 - Frequent	18
HP:0011109	HP:0011109	Chronic sinusitis	0	DNAI1 CL E G H	27019	2954	OMIM:244400	Ciliary dyskinesia, primary, 1	.	73
HP:0011109	HP:0011109	Chronic sinusitis	0	DNAI1 CL E G H	27019	2954	ORPHA:244	Primary ciliary dyskinesia	HP:0040282 - Frequent	73
HP:0011109	HP:0011109	Chronic sinusitis	0	DNAI2 CL E G H	64446	18744	OMIM:612444	CILIARY DYSKINESIA, PRIMARY, 9; CILD9		104
HP:0011109	HP:0011109	Chronic sinusitis	0	DNAI2 CL E G H	64446	18744	ORPHA:244	Primary ciliary dyskinesia	HP:0040282 - Frequent	104
HP:0011109	HP:0011109	Chronic sinusitis	0	DNAJB13 CL E G H	374407	30718	ORPHA:244	Primary ciliary dyskinesia	HP:0040282 - Frequent	2
HP:0011109	HP:0011109	Chronic sinusitis	0	DNAL1 CL E G H	83544	23247	OMIM:614017	CILIARY DYSKINESIA, PRIMARY, 16; CILD16		167
HP:0011109	HP:0011109	Chronic sinusitis	0	DNAL1 CL E G H	83544	23247	ORPHA:244	Primary ciliary dyskinesia	HP:0040282 - Frequent	167
HP:0011109	HP:0011109	Chronic sinusitis	0	DRC1 CL E G H	92749	24245	OMIM:615294	CILIARY DYSKINESIA, PRIMARY, 21; CILD21		44
HP:0011109	HP:0011109	Chronic sinusitis	0	DRC1 CL E G H	92749	24245	ORPHA:244	Primary ciliary dyskinesia	HP:0040282 - Frequent	44
HP:0011109	HP:0011109	Chronic sinusitis	0	FCGR2A CL E G H	2212	3616	OMIM:219700	Cystic fibrosis		6
HP:0011109	HP:0011109	Chronic sinusitis	0	FOXJ1 CL E G H	2302	3816	OMIM:618699	CILIARY DYSKINESIA, PRIMARY, 43; CILD43
HP:0011109	HP:0011109	Chronic sinusitis	0	FOXJ1 CL E G H	2302	3816	ORPHA:244	Primary ciliary dyskinesia	HP:0040282 - Frequent
HP:0011109	HP:0011109	Chronic sinusitis	0	GAS2L2 CL E G H	246176	24846	ORPHA:244	Primary ciliary dyskinesia	HP:0040282 - Frequent	1
HP:0011109	HP:0011109	Chronic sinusitis	0	GAS8 CL E G H	2622	4166	ORPHA:244	Primary ciliary dyskinesia	HP:0040282 - Frequent	9
HP:0011109	HP:0011109	Chronic sinusitis	0	HYDIN CL E G H	54768	19368	ORPHA:244	Primary ciliary dyskinesia	HP:0040282 - Frequent	21
HP:0011109	HP:0011109	Chronic sinusitis	0	IGHG2 CL E G H	3501	5526	ORPHA:183675	Recurrent infections associated with rare immunoglobulin isotypes deficiency		1
HP:0011109	HP:0011109	Chronic sinusitis	0	IGKC CL E G H	3514	5716	ORPHA:183675	Recurrent infections associated with rare immunoglobulin isotypes deficiency		5
HP:0011109	HP:0011109	Chronic sinusitis	0	LRRC56 CL E G H	115399	25430	ORPHA:244	Primary ciliary dyskinesia	HP:0040282 - Frequent
HP:0011109	HP:0011109	Chronic sinusitis	0	MCIDAS CL E G H	345643	40050	ORPHA:244	Primary ciliary dyskinesia	HP:0040282 - Frequent	13
HP:0011109	HP:0011109	Chronic sinusitis	0	MGP CL E G H	4256	7060	OMIM:245150	Keutel syndrome	.	33
HP:0011109	HP:0011109	Chronic sinusitis	0	NEK10 CL E G H	152110	18592	ORPHA:244	Primary ciliary dyskinesia	HP:0040282 - Frequent
HP:0011109	HP:0011109	Chronic sinusitis	0	NME8 CL E G H	51314	16473	ORPHA:244	Primary ciliary dyskinesia	HP:0040282 - Frequent	50
HP:0011109	HP:0011109	Chronic sinusitis	0	ODAD1 CL E G H	93233	26560	ORPHA:244	Primary ciliary dyskinesia	HP:0040282 - Frequent
HP:0011109	HP:0011109	Chronic sinusitis	0	ODAD2 CL E G H	55130	25583	ORPHA:244	Primary ciliary dyskinesia	HP:0040282 - Frequent
HP:0011109	HP:0011109	Chronic sinusitis	0	ODAD3 CL E G H	115948	28303	OMIM:616037	Ciliary dyskinesia, primary, 30
HP:0011109	HP:0011109	Chronic sinusitis	0	ODAD3 CL E G H	115948	28303	ORPHA:244	Primary ciliary dyskinesia	HP:0040282 - Frequent
HP:0011109	HP:0011109	Chronic sinusitis	0	ODAD4 CL E G H	83538	25280	OMIM:617092	Ciliary dyskinesia, primary, 35	.
HP:0011109	HP:0011109	Chronic sinusitis	0	ODAD4 CL E G H	83538	25280	ORPHA:244	Primary ciliary dyskinesia	HP:0040282 - Frequent
HP:0011109	HP:0011109	Chronic sinusitis	0	OFD1 CL E G H	8481	2567	ORPHA:244	Primary ciliary dyskinesia	HP:0040282 - Frequent	201
HP:0011109	HP:0011109	Chronic sinusitis	0	PGM3 CL E G H	5238	8907	ORPHA:443811	PGM3-CDG	HP:0040283 - Occasional	15
HP:0011109	HP:0011109	Chronic sinusitis	0	RNF168 CL E G H	165918	26661	ORPHA:420741	RIDDLE syndrome	HP:0040282 - Frequent	7
HP:0011109	HP:0011109	Chronic sinusitis	0	RPGR CL E G H	6103	10295	ORPHA:244	Primary ciliary dyskinesia	HP:0040282 - Frequent	200
HP:0011109	HP:0011109	Chronic sinusitis	0	RPGR CL E G H	6103	10295	OMIM:300455	RETINITIS PIGMENTOSA, X-LINKED, AND SINORESPIRATORY INFECTIONS, WITH OR WITHOUT DEAFNESS		200
HP:0011109	HP:0011109	Chronic sinusitis	0	RSPH1 CL E G H	89765	12371	ORPHA:244	Primary ciliary dyskinesia	HP:0040282 - Frequent	31
HP:0011109	HP:0011109	Chronic sinusitis	0	RSPH3 CL E G H	83861	21054	OMIM:616481	Ciliary dyskinesia, primary, 32		5
HP:0011109	HP:0011109	Chronic sinusitis	0	RSPH3 CL E G H	83861	21054	ORPHA:244	Primary ciliary dyskinesia	HP:0040282 - Frequent	5
HP:0011109	HP:0011109	Chronic sinusitis	0	RSPH4A CL E G H	345895	21558	ORPHA:244	Primary ciliary dyskinesia	HP:0040282 - Frequent	58
HP:0011109	HP:0011109	Chronic sinusitis	0	RSPH9 CL E G H	221421	21057	OMIM:612650	CILIARY DYSKINESIA, PRIMARY, 12; CILD12		20
HP:0011109	HP:0011109	Chronic sinusitis	0	RSPH9 CL E G H	221421	21057	ORPHA:244	Primary ciliary dyskinesia	HP:0040282 - Frequent	20
HP:0011109	HP:0011109	Chronic sinusitis	0	SASH3 CL E G H	54440	15975	OMIM:301082			1
HP:0011109	HP:0011109	Chronic sinusitis	0	SPAG1 CL E G H	6674	11212	ORPHA:244	Primary ciliary dyskinesia	HP:0040282 - Frequent	45
HP:0011109	HP:0011109	Chronic sinusitis	0	SPEF2 CL E G H	79925	26293	ORPHA:244	Primary ciliary dyskinesia	HP:0040282 - Frequent	15
HP:0011109	HP:0011109	Chronic sinusitis	0	STK36 CL E G H	27148	17209	ORPHA:244	Primary ciliary dyskinesia	HP:0040282 - Frequent	3
HP:0011109	HP:0011109	Chronic sinusitis	0	TAP1 CL E G H	6890	43	OMIM:604571	Bare lymphocyte syndrome, type I	.	5
HP:0011109	HP:0011109	Chronic sinusitis	0	TAP2 CL E G H	6891	44	OMIM:604571	Bare lymphocyte syndrome, type I	.	17
HP:0011109	HP:0011109	Chronic sinusitis	0	TAPBP CL E G H	6892	11566	OMIM:604571	Bare lymphocyte syndrome, type I	.	3
HP:0011109	HP:0011109	Chronic sinusitis	0	TGFB1 CL E G H	7040	11766	OMIM:219700	Cystic fibrosis		13
HP:0011109	HP:0011109	Chronic sinusitis	0	TTC12 CL E G H	54970	23700	ORPHA:244	Primary ciliary dyskinesia	HP:0040282 - Frequent
HP:0011109	HP:0011109	Chronic sinusitis	0	ZMYND10 CL E G H	51364	19412	ORPHA:244	Primary ciliary dyskinesia	HP:0040282 - Frequent	20

Genes (63) :BLNK CCDC103 CCDC39 CCDC40 CCDC65 CCNO CD79B CFAP221 CFAP298 CFAP300 CFAP45 CFAP52 CFTR DNAAF1 DNAAF11 DNAAF2 DNAAF3 DNAAF4 DNAAF5 DNAAF6 DNAH1 DNAH11 DNAH5 DNAH9 DNAI1 DNAI2 DNAJB13 DNAL1 DRC1 FCGR2A FOXJ1 GAS2L2 GAS8 HYDIN IGHG2 IGKC LRRC56 MCIDAS MGP NEK10 NME8 ODAD1 ODAD2 ODAD3 ODAD4 OFD1 PGM3 RNF168 RPGR RSPH1 RSPH3 RSPH4A RSPH9 SASH3 SPAG1 SPEF2 STK36 TAP1 TAP2 TAPBP TGFB1 TTC12 ZMYND10

Diseases (29) :OMIM:613502 OMIM:614679 ORPHA:244 OMIM:613807 OMIM:613808 OMIM:615504 OMIM:612692 OMIM:618063 OMIM:619608 OMIM:619607 OMIM:219700 OMIM:612518 OMIM:618300 OMIM:244400 OMIM:612444 OMIM:614017 OMIM:615294 OMIM:618699 ORPHA:183675 OMIM:245150 OMIM:616037 OMIM:617092 ORPHA:443811 ORPHA:420741 OMIM:300455 OMIM:616481 OMIM:612650 OMIM:301082 OMIM:604571

Human Phenotype Ontology(HPO) is developed by the Human Phenotype Ontology Consortium. The version used here is December 15 2022 release.

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