Human Phenotype Ontology

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Examples Gene: MT-ND1, POLG, Region: M:1-1000 Variant: m.8993T>G, 1:g.10042757T>C rs3888511 MSCV_0000006, ClinVar: RCV000000015, Disease: Leigh syndrome, Phenotype: Retinopathy

Grandparent Node:
Abnormal paranasal sinus morphology (HP:0000245)

Grandparent Node:
Increased inflammatory response (HP:0012649)

Parent Node:
Recurrent upper respiratory tract infections (HP:0002788)

Parent Node:
Sinusitis (HP:0000246)

..Starting node
..Recurrent sinusitis (HP:0011108)

Term ID:

11108

Name:

Recurrent sinusitis

Synonym:

Recurrent sinus disease; Sinusitis, recurrent

Definition:

A recurrent form of sinusitis.

Comments:

Reference:

HP:0011108

Genes and Diseases:

Child Nodes:

Sister Nodes:

Acute sinusitis (HP:0000255)

Chronic sinusitis (HP:0011109)

Input	HPO ID	HPO term	Distance	Gene	Gene id entrez	HGNC ID	DiseaseId	DiseaseName	Frequency	ClinVar variants
HPO disease - gene - phenotype typical associations:
HPO disease - gene - phenotype less frequent non-typical associations:
HP:0011108	HP:0011108	Recurrent sinusitis	0	ACP5 CL E G H	54	124	OMIM:607944	Spondyloenchondrodysplasia with immune dysregulation	.	16
HP:0011108	HP:0011108	Recurrent sinusitis	0	ADA2 CL E G H	51816	1839	OMIM:615688	Vasculitis, autoinflammation, immunodeficiency, and hematologic defects syndrome		22
HP:0011108	HP:0011108	Recurrent sinusitis	0	ALMS1 CL E G H	7840	428	ORPHA:64	Alström syndrome	HP:0040282 - Frequent	404
HP:0011108	HP:0011108	Recurrent sinusitis	0	BTK CL E G H	695	1133	OMIM:300755	Agammaglobulinemia, X-linked		109
HP:0011108	HP:0011108	Recurrent sinusitis	0	C4B CL E G H	721	1324	OMIM:614379	Complement component 4B deficiency		1
HP:0011108	HP:0011108	Recurrent sinusitis	0	CCDC65 CL E G H	85478	29937	OMIM:615504	Ciliary dyskinesia, primary, 27	.	23
HP:0011108	HP:0011108	Recurrent sinusitis	0	CD19 CL E G H	930	1633	OMIM:240500	Immunodeficiency, common variable, 2		38
HP:0011108	HP:0011108	Recurrent sinusitis	0	CD19 CL E G H	930	1633	OMIM:613493	IMMUNODEFICIENCY, COMMON VARIABLE, 3; CVID3		38
HP:0011108	HP:0011108	Recurrent sinusitis	0	CFAP298 CL E G H	56683	1301	OMIM:615500	Ciliary dyskinesia, primary, 26
HP:0011108	HP:0011108	Recurrent sinusitis	0	CFI CL E G H	3426	5394	OMIM:610984	Complement factor I deficiency	.	57
HP:0011108	HP:0011108	Recurrent sinusitis	0	COL5A1 CL E G H	1289	2209	OMIM:130000	Ehlers-danlos syndrome, type I		660
HP:0011108	HP:0011108	Recurrent sinusitis	0	COL5A2 CL E G H	1290	2210	OMIM:130010	Ehlers-Danlos syndrome, classic type, 2		325
HP:0011108	HP:0011108	Recurrent sinusitis	0	CR2 CL E G H	1380	2336	OMIM:240500	Immunodeficiency, common variable, 2		10
HP:0011108	HP:0011108	Recurrent sinusitis	0	DNAAF1 CL E G H	123872	30539	OMIM:613193	Ciliary dyskinesia, primary, 13		116
HP:0011108	HP:0011108	Recurrent sinusitis	0	DNAAF11 CL E G H	23639	16725	OMIM:614935	Ciliary dyskinesia, primary, 19	.
HP:0011108	HP:0011108	Recurrent sinusitis	0	DNAAF2 CL E G H	55172	20188	OMIM:612518	CILIARY DYSKINESIA, PRIMARY, 10; CILD10		78
HP:0011108	HP:0011108	Recurrent sinusitis	0	DNAAF4 CL E G H	161582	21493	OMIM:615482	Ciliary dyskinesia, primary, 25	.	27
HP:0011108	HP:0011108	Recurrent sinusitis	0	DNAAF5 CL E G H	54919	26013	OMIM:614874	Ciliary dyskinesia, primary, 18	.	62
HP:0011108	HP:0011108	Recurrent sinusitis	0	DNAAF6 CL E G H	139212	28570	OMIM:300991	Ciliary dyskinesia, primary, 36, X-linked	.
HP:0011108	HP:0011108	Recurrent sinusitis	0	DNAH5 CL E G H	1767	2950	OMIM:608644	CILIARY DYSKINESIA, PRIMARY, 3; CILD3		527
HP:0011108	HP:0011108	Recurrent sinusitis	0	DNAI2 CL E G H	64446	18744	OMIM:612444	CILIARY DYSKINESIA, PRIMARY, 9; CILD9		104
HP:0011108	HP:0011108	Recurrent sinusitis	0	DNAJB13 CL E G H	374407	30718	OMIM:617091	CILIARY DYSKINESIA, PRIMARY, 34; CILD34		2
HP:0011108	HP:0011108	Recurrent sinusitis	0	DOCK8 CL E G H	81704	19191	ORPHA:217390	Combined immunodeficiency due to DOCK8 deficiency	HP:0040281 - Very frequent	217
HP:0011108	HP:0011108	Recurrent sinusitis	0	DOCK8 CL E G H	81704	19191	OMIM:243700	Hyper-Ige recurrent infection syndrome, autosomal recessive		217
HP:0011108	HP:0011108	Recurrent sinusitis	0	FCGR3A CL E G H	2214	3619	OMIM:615707	Immunodeficiency 20		4
HP:0011108	HP:0011108	Recurrent sinusitis	0	GAS2L2 CL E G H	246176	24846	OMIM:618449	Ciliary dyskinesia, primary, 41		1
HP:0011108	HP:0011108	Recurrent sinusitis	0	HYDIN CL E G H	54768	19368	OMIM:608647	Ciliary dyskinesia, primary, 5	.	21
HP:0011108	HP:0011108	Recurrent sinusitis	0	ICOS CL E G H	29851	5351	OMIM:607594	Immunodeficiency, common variable, 1	.	32
HP:0011108	HP:0011108	Recurrent sinusitis	0	ICOS CL E G H	29851	5351	OMIM:240500	Immunodeficiency, common variable, 2		32
HP:0011108	HP:0011108	Recurrent sinusitis	0	IGHM CL E G H	3507	5541	OMIM:601495	Agammaglobulinemia 1, autosomal recessive	.	7
HP:0011108	HP:0011108	Recurrent sinusitis	0	IKBKB CL E G H	3551	5960	OMIM:618204	IMMUNODEFICIENCY 15A; IMD15A		4
HP:0011108	HP:0011108	Recurrent sinusitis	0	IL17RA CL E G H	23765	5985	OMIM:613953	Immunodeficiency 51		196
HP:0011108	HP:0011108	Recurrent sinusitis	0	IL21R CL E G H	50615	6006	OMIM:615207	IMMUNODEFICIENCY 56; IMD56		7
HP:0011108	HP:0011108	Recurrent sinusitis	0	IRF2BP2 CL E G H	359948	21729	OMIM:617765	IMMUNODEFICIENCY, COMMON VARIABLE, 14; CVID14		4
HP:0011108	HP:0011108	Recurrent sinusitis	0	IVNS1ABP CL E G H	10625	16951	OMIM:618969	IMMUNODEFICIENCY 70; IMD70
HP:0011108	HP:0011108	Recurrent sinusitis	0	LRBA CL E G H	987	1742	OMIM:614700	IMMUNODEFICIENCY, COMMON VARIABLE, 8, WITH AUTOIMMUNITY; CVID8		45
HP:0011108	HP:0011108	Recurrent sinusitis	0	MAGT1 CL E G H	84061	28880	OMIM:300853	IMMUNODEFICIENCY, X-LINKED, WITH MAGNESIUM DEFECT, EPSTEIN-BARR VIRUS INFECTION, AND NEOPLASIA; XMEN		17
HP:0011108	HP:0011108	Recurrent sinusitis	0	MCIDAS CL E G H	345643	40050	OMIM:618695	CILIARY DYSKINESIA, PRIMARY, 42; CILD42		13
HP:0011108	HP:0011108	Recurrent sinusitis	0	MDM4 CL E G H	4194	6974	OMIM:618849	BONE MARROW FAILURE SYNDROME 6; BMFS6		1
HP:0011108	HP:0011108	Recurrent sinusitis	0	MGP CL E G H	4256	7060	ORPHA:85202	Keutel syndrome	HP:0040282 - Frequent	33
HP:0011108	HP:0011108	Recurrent sinusitis	0	NCF4 CL E G H	4689	7662	OMIM:613960	Chronic granulomatous disease 3, autosomal recessive	.	37
HP:0011108	HP:0011108	Recurrent sinusitis	0	NEK10 CL E G H	152110	18592	OMIM:618781	CILIARY DYSKINESIA, PRIMARY, 44; CILD44
HP:0011108	HP:0011108	Recurrent sinusitis	0	NFKB1 CL E G H	4790	7794	OMIM:616576	IMMUNODEFICIENCY, COMMON VARIABLE, 12; CVID12		7
HP:0011108	HP:0011108	Recurrent sinusitis	0	NFKB2 CL E G H	4791	7795	ORPHA:293978	Deficiency in anterior pituitary function-variable immunodeficiency syndrome	HP:0040281 - Very frequent	11
HP:0011108	HP:0011108	Recurrent sinusitis	0	NFKB2 CL E G H	4791	7795	OMIM:615577	Immunodeficiency, common variable, 10		11
HP:0011108	HP:0011108	Recurrent sinusitis	0	NME5 CL E G H	8382	7853	OMIM:620032
HP:0011108	HP:0011108	Recurrent sinusitis	0	NME8 CL E G H	51314	16473	OMIM:610852	Ciliary dyskinesia, primary, 6	.	50
HP:0011108	HP:0011108	Recurrent sinusitis	0	ODAD1 CL E G H	93233	26560	OMIM:615067	Ciliary dyskinesia, primary, 20	.
HP:0011108	HP:0011108	Recurrent sinusitis	0	ODAD2 CL E G H	55130	25583	OMIM:615451	CILIARY DYSKINESIA, PRIMARY, 23; CILD23
HP:0011108	HP:0011108	Recurrent sinusitis	0	PIK3CD CL E G H	5293	8977	OMIM:619281	IMMUNODEFICIENCY 14B, AUTOSOMAL RECESSIVE; IMD14B		9
HP:0011108	HP:0011108	Recurrent sinusitis	0	PRKCD CL E G H	5580	9399	OMIM:615559	AUTOIMMUNE LYMPHOPROLIFERATIVE SYNDROME, TYPE III; ALPS3		10
HP:0011108	HP:0011108	Recurrent sinusitis	0	PSMB8 CL E G H	5696	9545	OMIM:256040	Proteasome-associated autoinflammatory syndrome 1 and digenic forms		20
HP:0011108	HP:0011108	Recurrent sinusitis	0	RAC2 CL E G H	5880	9802	OMIM:618986	IMMUNODEFICIENCY 73B WITH DEFECTIVE NEUTROPHIL CHEMOTAXIS AND LYMPHOPENIA; IMD73B		9
HP:0011108	HP:0011108	Recurrent sinusitis	0	RNF168 CL E G H	165918	26661	ORPHA:420741	RIDDLE syndrome	HP:0040282 - Frequent	7
HP:0011108	HP:0011108	Recurrent sinusitis	0	RSPH1 CL E G H	89765	12371	OMIM:615481	Ciliary dyskinesia, primary, 24	.	31
HP:0011108	HP:0011108	Recurrent sinusitis	0	RSPH4A CL E G H	345895	21558	OMIM:612649	Ciliary dyskinesia, primary, 11		58
HP:0011108	HP:0011108	Recurrent sinusitis	0	SASH3 CL E G H	54440	15975	OMIM:301082			1
HP:0011108	HP:0011108	Recurrent sinusitis	0	SH3KBP1 CL E G H	30011	13867	OMIM:300310	Immunodeficiency 61	.	2
HP:0011108	HP:0011108	Recurrent sinusitis	0	SPAG1 CL E G H	6674	11212	OMIM:615505	Ciliary dyskinesia, primary, 28	.	45
HP:0011108	HP:0011108	Recurrent sinusitis	0	SPI1 CL E G H	6688	11241	OMIM:619707	AGAMMAGLOBULINEMIA 10, AUTOSOMAL DOMINANT; AGM10
HP:0011108	HP:0011108	Recurrent sinusitis	0	STK36 CL E G H	27148	17209	OMIM:619436	CILIARY DYSKINESIA, PRIMARY, 46; CILD46		3
HP:0011108	HP:0011108	Recurrent sinusitis	0	STXBP2 CL E G H	6813	11445	OMIM:613101	HEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS, FAMILIAL, 5; FHL5		70
HP:0011108	HP:0011108	Recurrent sinusitis	0	TBX1 CL E G H	6899	11592	OMIM:188400	Digeorge syndrome		32
HP:0011108	HP:0011108	Recurrent sinusitis	0	TMCO1 CL E G H	54499	18188	OMIM:213980	Craniofacial dysmorphism, skeletal anomalies, and mental retardation syndrome		6
HP:0011108	HP:0011108	Recurrent sinusitis	0	TNFRSF13B CL E G H	23495	18153	OMIM:240500	Immunodeficiency, common variable, 2		32
HP:0011108	HP:0011108	Recurrent sinusitis	0	TNFRSF13C CL E G H	115650	17755	OMIM:240500	Immunodeficiency, common variable, 2		12
HP:0011108	HP:0011108	Recurrent sinusitis	0	TNFRSF13C CL E G H	115650	17755	OMIM:613494	Immunodeficiency, common variable, 4		12
HP:0011108	HP:0011108	Recurrent sinusitis	0	UNC119 CL E G H	9094	12565	OMIM:615518	IMMUNODEFICIENCY 13; IMD13		30
HP:0011108	HP:0011108	Recurrent sinusitis	0	USB1 CL E G H	79650	25792	OMIM:604173	Poikiloderma with neutropenia		8
HP:0011108	HP:0011108	Recurrent sinusitis	0	WAS CL E G H	7454	12731	OMIM:301000	Wiskott-Aldrich syndrome		65
HP:0011108	HP:0011108	Recurrent sinusitis	0	ZMYND10 CL E G H	51364	19412	OMIM:615444	Ciliary dyskinesia, primary, 22	.	20

Genes (66) :ACP5 ADA2 ALMS1 BTK C4B CCDC65 CD19 CFAP298 CFI COL5A1 COL5A2 CR2 DNAAF1 DNAAF11 DNAAF2 DNAAF4 DNAAF5 DNAAF6 DNAH5 DNAI2 DNAJB13 DOCK8 FCGR3A GAS2L2 HYDIN ICOS IGHM IKBKB IL17RA IL21R IRF2BP2 IVNS1ABP LRBA MAGT1 MCIDAS MDM4 MGP NCF4 NEK10 NFKB1 NFKB2 NME5 NME8 ODAD1 ODAD2 PIK3CD PRKCD PSMB8 RAC2 RNF168 RSPH1 RSPH4A SASH3 SH3KBP1 SPAG1 SPI1 STK36 STXBP2 TBX1 TMCO1 TNFRSF13B TNFRSF13C UNC119 USB1 WAS ZMYND10

Diseases (67) :OMIM:607944 OMIM:615688 ORPHA:64 OMIM:300755 OMIM:614379 OMIM:615504 OMIM:240500 OMIM:613493 OMIM:615500 OMIM:610984 OMIM:130000 OMIM:130010 OMIM:613193 OMIM:614935 OMIM:612518 OMIM:615482 OMIM:614874 OMIM:300991 OMIM:608644 OMIM:612444 OMIM:617091 ORPHA:217390 OMIM:243700 OMIM:615707 OMIM:618449 OMIM:608647 OMIM:607594 OMIM:601495 OMIM:618204 OMIM:613953 OMIM:615207 OMIM:617765 OMIM:618969 OMIM:614700 OMIM:300853 OMIM:618695 OMIM:618849 ORPHA:85202 OMIM:613960 OMIM:618781 OMIM:616576 ORPHA:293978 OMIM:615577 OMIM:620032 OMIM:610852 OMIM:615067 OMIM:615451 OMIM:619281 OMIM:615559 OMIM:256040 OMIM:618986 ORPHA:420741 OMIM:615481 OMIM:612649 OMIM:301082 OMIM:300310 OMIM:615505 OMIM:619707 OMIM:619436 OMIM:613101 OMIM:188400 OMIM:213980 OMIM:613494 OMIM:615518 OMIM:604173 OMIM:301000 OMIM:615444

Human Phenotype Ontology(HPO) is developed by the Human Phenotype Ontology Consortium. The version used here is December 15 2022 release.

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