Human Phenotype Ontology

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Hello! Guest! Please Login or Register! Clinician Mode

Examples Gene: MT-ND1, POLG, Region: M:1-1000 Variant: m.8993T>G, 1:g.10042757T>C rs3888511 MSCV_0000006, ClinVar: RCV000000015, Disease: Leigh syndrome, Phenotype: Retinopathy

Grandparent Node:
Abnormality of the dentition (HP:0000164)

Parent Node:
Tooth malposition (HP:0000692)

..Starting node
..Increased overbite (HP:0011094)

Term ID:

11094

Name:

Increased overbite

Synonym:

Deep bite; Deep overbite; Increased overlap of upper and lower incisors; Overbite; Scissors bite; Supraocclusion

Definition:

Maxillary teeth cover the mandibular teeth when biting to an increased degree. The feature is defined as a vertical overlap of the maxillary incisors over the mandibular incisors that exceeds 2 mm.

Comments:

Reference:

HP:0011094

Genes and Diseases:

Child Nodes:

Sister Nodes:

Dental crowding (HP:0000678)

Dental malocclusion (HP:0000689)

Diastema (HP:0000699)

Irregularly spaced teeth (HP:0006316)

Misalignment of incisors (HP:0011062)

Open bite (HP:0010807)

Overjet (HP:0011095)

Widely spaced teeth (HP:0000687)

Input	HPO ID	HPO term	Distance	Gene	Gene id entrez	HGNC ID	DiseaseId	DiseaseName	Frequency	ClinVar variants
HPO disease - gene - phenotype typical associations:
HPO disease - gene - phenotype less frequent non-typical associations:
HP:0011094	HP:0011094	Increased overbite	0	ACP4 CL E G H	93650	14376	OMIM:617297	AMELOGENESIS IMPERFECTA, TYPE IJ; AI1J		7
HP:0011094	HP:0011094	Increased overbite	0	ALKBH8 CL E G H	91801	25189	OMIM:618504	Intellectual developmental disorder, autosomal recessive 71	.
HP:0011094	HP:0011094	Increased overbite	0	EP300 CL E G H	2033	3373	OMIM:613684	Rubinstein-Taybi syndrome 2	.	250
HP:0011094	HP:0011094	Increased overbite	0	EYA1 CL E G H	2138	3519	OMIM:113650	Branchiootorenal syndrome 1	.	135
HP:0011094	HP:0011094	Increased overbite	0	GRB10 CL E G H	2887	4564	ORPHA:96182	Silver-Russell syndrome due to maternal uniparental disomy of chromosome 7	HP:0040283 - Occasional
HP:0011094	HP:0011094	Increased overbite	0	HIVEP2 CL E G H	3097	4921	OMIM:616977	Mental retardation, autosomal dominant 43		13
HP:0011094	HP:0011094	Increased overbite	0	MYMX CL E G H	101929726	52391	OMIM:619941
HP:0011094	HP:0011094	Increased overbite	0	PRR12 CL E G H	57479	29217	OMIM:619539	NEUROOCULAR SYNDROME; NOC		1
HP:0011094	HP:0011094	Increased overbite	0	RIC1 CL E G H	57589	17686	OMIM:618761	CATIFA SYNDROME; CATIFA
HP:0011094	HP:0011094	Increased overbite	0	SIX1 CL E G H	6495	10887	OMIM:113650	Branchiootorenal syndrome 1	.	50
HP:0011094	HP:0011094	Increased overbite	0	SPART CL E G H	23111	18514	ORPHA:101000	Autosomal recessive spastic paraplegia type 20	HP:0040282 - Frequent	66

Genes (11) :ACP4 ALKBH8 EP300 EYA1 GRB10 HIVEP2 MYMX PRR12 RIC1 SIX1 SPART

Diseases (10) :OMIM:617297 OMIM:618504 OMIM:613684 OMIM:113650 ORPHA:96182 OMIM:616977 OMIM:619941 OMIM:619539 OMIM:618761 ORPHA:101000

Human Phenotype Ontology(HPO) is developed by the Human Phenotype Ontology Consortium. The version used here is December 15 2022 release.

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