Human Phenotype Ontology 
Grandparent Node:
Abnormality of the face (HP:0000271)help
Parent Node:
Abnormality of skin pigmentation (HP:0001000)help
Parent Node:
Abnormality of the periorbital region (HP:0000606)help
..Starting node
Periorbital hyperpigmentation (HP:0001106)help
Term ID: 1106
Name: Periorbital hyperpigmentation
Synonym: Dark circles around the eyes; Dark circles under the eyes; Darkening around the eyes; Idiopathic cutaneous hyperchromia at the orbital region; Infraorbital pigmentation; Periorbital melanosis; Pigmentation around the eyes
Definition: Increased pigmentation of the skin in the region surrounding the orbit of the eye.
Reference: HP:0001106
Genes and Diseases:
       Child Nodes:

 Sister Nodes: 
..expandAbnormal eyebrow morphology (HP:0000534) help
..expandAbnormal morphology of bony orbit of skull (HP:3000030) help
..expandAbnormality of the supraorbital ridges (HP:0100538) help
..expandBitemporal forceps marks (HP:0011336) help
..expandBitemporal hollowing (HP:0025386) help
..expandInfra-orbital crease (HP:0100876) help
..expandInfra-orbital fold (HP:0011232) help
..expandOrbital cyst (HP:0001144) help
..expandPeriorbital ecchymosis with tarsal plate sparing (HP:0025553) help
..expandPeriorbital edema (HP:0100539) help
..expandPeriorbital fullness (HP:0000629) help
..expandPeriorbital purpura (HP:0025552) help
..expandPeriorbital wrinkles (HP:0000607) help
InputHPO IDHPO termDistanceGeneGene id entrezHGNC IDDiseaseIdDiseaseNameFrequencyOnsetHGMD variantsClinVar variants
HPO disease - gene - phenotype typical associations:
HPO disease - gene - phenotype less frequent non-typical associations:
HP:0001106HP:0001106Periorbital hyperpigmentation0EDA CL E G H18963157OMIM:305100Ectodermal dysplasia 1, hypohidrotic, X-linked.115
HP:0001106HP:0001106Periorbital hyperpigmentation0EDAR CL E G H109132895OMIM:224900Ectodermal dysplasia 10B, hypohidrotic/hair/tooth type, autosomal recessive.86
HP:0001106HP:0001106Periorbital hyperpigmentation0EDARADD CL E G H12817814341OMIM:224900Ectodermal dysplasia 10B, hypohidrotic/hair/tooth type, autosomal recessive.56
HP:0001106HP:0001106Periorbital hyperpigmentation0KIF15 CL E G H5699217273ORPHA:26132321q22.11q22.12 microdeletion syndromeHP:0040283 - Occasional


Diseases (3) :OMIM:305100 OMIM:224900 ORPHA:261323

Human Phenotype Ontology(HPO) is developed by the Human Phenotype Ontology Consortium. The version used here is December 15 2022 release.