Human Phenotype Ontology 
Grandparent Node:
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Abnormality of the tongue (HP:0000157)help
Parent Node:
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Abnormal tongue morphology (HP:0030809)help
..Starting node
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Bifid tongue (HP:0010297)help
Term ID: 10297
Name: Bifid tongue
Synonym: Bifurcated tongue; Bilobed tongue; Cleft tongue; Forked tongue; Snake tongue; Split tongue
Definition: Tongue with a median apical indentation or fork.
Comments:
Reference: HP:0010297
Genes and Diseases:
 
       Child Nodes:

 Sister Nodes: 
..expandAbnormal hyoglossus muscle morphology (HP:3000051) help
..expandAbnormal lingual artery morphology (HP:3000074) help
..expandAbnormality of lingual tonsil (HP:3000076) help
..expandAbnormality of the tongue muscle (HP:0040173) help
..expandAnkyloglossia (HP:0010296) help
..expandAplasia/Hypoplasia of the tongue (HP:0010295) help
..expandDuplicated tongue (HP:0040294) help
..expandFurrowed tongue (HP:0000221) help
..expandGeographic tongue (HP:0025252) help
..expandGlossitis (HP:0000206) help
..expandGlossoptosis (HP:0000162) help
..expandLobulated tongue (HP:0000180) help
..expandMacroglossia (HP:0000158) help
..expandPosteriorly placed tongue (HP:0009087) help
..expandProtruding tongue (HP:0010808) help
..expandSmooth tongue (HP:0010298) help
..expandStiff tongue (HP:0031373) help
..expandStrawberry tongue (HP:0031042) help
..expandTongue atrophy (HP:0012473) help
..expandTongue nodules (HP:0000199) help
..expandTongue telangiectasia (HP:0000227) help
InputHPO IDHPO termDistanceGeneGene id entrezHGNC IDDiseaseIdDiseaseNameFrequencyOnsetHGMD variantsClinVar variants
 
HPO disease - gene - phenotype typical associations:
 
HPO disease - gene - phenotype less frequent non-typical associations:
HP:0010297HP:0010297Bifid tongue0ALX3 CL E G H257449ORPHA:391474FrontorhinyHP:0040282 - Frequent9
HP:0010297HP:0010297Bifid tongue0C2CD3 CL E G H2600524564ORPHA:434179Orofaciodigital syndrome type 14HP:0040282 - Frequent27
HP:0010297HP:0010297Bifid tongue0C2CD3 CL E G H2600524564OMIM:615948Orofaciodigital syndrome XIV.27
HP:0010297HP:0010297Bifid tongue0CEP120 CL E G H15324126690OMIM:616300Short-Rib thoracic dysplasia 13 with or without polydactyly.7
HP:0010297HP:0010297Bifid tongue0DDX59 CL E G H8347925360ORPHA:2919Orofaciodigital syndrome type 5HP:0040282 - Frequent2
HP:0010297HP:0010297Bifid tongue0DDX59 CL E G H8347925360OMIM:174300Orofaciodigital syndrome V2
HP:0010297HP:0010297Bifid tongue0DHCR7 CL E G H17172860ORPHA:818Smith-Lemli-Opitz syndromeHP:0040283 - Occasional159
HP:0010297HP:0010297Bifid tongue0DVL1 CL E G H18553084ORPHA:3107Autosomal dominant Robinow syndromeHP:0040282 - Frequent14
HP:0010297HP:0010297Bifid tongue0DVL1 CL E G H18553084OMIM:180700Robinow syndrome, autosomal dominant 114
HP:0010297HP:0010297Bifid tongue0DVL3 CL E G H18573087ORPHA:3107Autosomal dominant Robinow syndromeHP:0040282 - Frequent5
HP:0010297HP:0010297Bifid tongue0DVL3 CL E G H18573087OMIM:616894ROBINOW SYNDROME, AUTOSOMAL DOMINANT 3; DRS35
HP:0010297HP:0010297Bifid tongue0DYNC2H1 CL E G H796592962OMIM:613091Asphyxiating thoracic dystrophy 3HP:0040283 - Occasional304
HP:0010297HP:0010297Bifid tongue0DYNC2H1 CL E G H796592962ORPHA:93271Short rib-polydactyly syndrome, Verma-Naumoff typeHP:0040283 - Occasional304
HP:0010297HP:0010297Bifid tongue0DYNC2I1 CL E G H5511221862ORPHA:93271Short rib-polydactyly syndrome, Verma-Naumoff typeHP:0040283 - Occasional
HP:0010297HP:0010297Bifid tongue0DYNC2I2 CL E G H8989128296ORPHA:93271Short rib-polydactyly syndrome, Verma-Naumoff typeHP:0040283 - Occasional
HP:0010297HP:0010297Bifid tongue0FRAS1 CL E G H8014419185ORPHA:2052Fraser syndromeHP:0040282 - Frequent353
HP:0010297HP:0010297Bifid tongue0FREM2 CL E G H34164025396ORPHA:2052Fraser syndromeHP:0040282 - Frequent263
HP:0010297HP:0010297Bifid tongue0FZD2 CL E G H25354040ORPHA:3107Autosomal dominant Robinow syndromeHP:0040282 - Frequent
HP:0010297HP:0010297Bifid tongue0GRIP1 CL E G H2342618708ORPHA:2052Fraser syndromeHP:0040282 - Frequent80
HP:0010297HP:0010297Bifid tongue0HNRNPK CL E G H31905044ORPHA:352665Neurodevelopmental disorder-craniofacial dysmorphism-cardiac defect-skeletal anomalies syndrome due to 9q21.3 microdeletionHP:0040283 - Occasional8
HP:0010297HP:0010297Bifid tongue0HNRNPK CL E G H31905044ORPHA:453504Neurodevelopmental disorder-craniofacial dysmorphism-cardiac defect-skeletal anomalies syndrome due to a point mutationHP:0040283 - Occasional8
HP:0010297HP:0010297Bifid tongue0IFT80 CL E G H5756029262ORPHA:93271Short rib-polydactyly syndrome, Verma-Naumoff typeHP:0040283 - Occasional65
HP:0010297HP:0010297Bifid tongue0IPO8 CL E G H105269853OMIM:619472VISS syndrome
HP:0010297HP:0010297Bifid tongue0MCTP2 CL E G H5578425636ORPHA:1596Distal monosomy 15qHP:0040282 - Frequent3
HP:0010297HP:0010297Bifid tongue0NEK1 CL E G H47507744ORPHA:2751Orofaciodigital syndrome type 2HP:0040282 - Frequent101
HP:0010297HP:0010297Bifid tongue0NXN CL E G H6435918008ORPHA:1507Autosomal recessive Robinow syndromeHP:0040282 - Frequent2
HP:0010297HP:0010297Bifid tongue0OFD1 CL E G H84812567OMIM:311200Orofaciodigital syndrome IHP:0040282 - Frequent201
HP:0010297HP:0010297Bifid tongue0RIPK4 CL E G H54101496ORPHA:1401CHAND syndromeHP:0040282 - Frequent69
HP:0010297HP:0010297Bifid tongue0ROR2 CL E G H492010257ORPHA:1507Autosomal recessive Robinow syndromeHP:0040282 - Frequent120
HP:0010297HP:0010297Bifid tongue0ROR2 CL E G H492010257OMIM:268310Robinow syndrome, autosomal recessive120
HP:0010297HP:0010297Bifid tongue0WDR35 CL E G H5753929250ORPHA:93271Short rib-polydactyly syndrome, Verma-Naumoff typeHP:0040283 - Occasional136
HP:0010297HP:0010297Bifid tongue0WNT5A CL E G H747412784ORPHA:3107Autosomal dominant Robinow syndromeHP:0040282 - Frequent98
HP:0010297HP:0010297Bifid tongue0WNT5A CL E G H747412784OMIM:180700Robinow syndrome, autosomal dominant 198


Genes (25) :ALX3 C2CD3 CEP120 DDX59 DHCR7 DVL1 DVL3 DYNC2H1 DYNC2I1 DYNC2I2 FRAS1 FREM2 FZD2 GRIP1 HNRNPK IFT80 IPO8 MCTP2 NEK1 NXN OFD1 RIPK4 ROR2 WDR35 WNT5A

Diseases (22) :ORPHA:391474 ORPHA:434179 OMIM:615948 OMIM:616300 ORPHA:2919 OMIM:174300 ORPHA:818 ORPHA:3107 OMIM:180700 OMIM:616894 OMIM:613091 ORPHA:93271 ORPHA:2052 ORPHA:352665 ORPHA:453504 OMIM:619472 ORPHA:1596 ORPHA:2751 ORPHA:1507 OMIM:311200 ORPHA:1401 OMIM:268310
 

Human Phenotype Ontology(HPO) is developed by the Human Phenotype Ontology Consortium. The version used here is December 15 2022 release.