Human Phenotype Ontology 
Grandparent Node:
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Abnormal digit morphology (HP:0011297)help
Parent Node:
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Abnormal fingertip morphology (HP:0001211)help
Parent Node:
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Clubbing (HP:0001217)help
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Clubbing of fingers (HP:0100759)help
Term ID: 100759
Name: Clubbing of fingers
Synonym: Clubbed fingers; Clubbing (hands); Clubbing of fingers; Finger clubbing
Definition: Terminal broadening of the fingers (distal phalanges of the fingers).
Comments:
Reference: HP:0100759
Genes and Diseases:
 
       Child Nodes:

 Sister Nodes: 
..expandClubbing of toes (HP:0100760) help
InputHPO IDHPO termDistanceGeneGene id entrezHGNC IDDiseaseIdDiseaseNameFrequencyOnsetHGMD variantsClinVar variants
 
HPO disease - gene - phenotype typical associations:
 
HPO disease - gene - phenotype less frequent non-typical associations:
HP:0100759HP:0100759Clubbing of fingers0ABCA3 CL E G H2133ORPHA:2032Idiopathic pulmonary fibrosisHP:0040282 - Frequent147
HP:0100759HP:0100759Clubbing of fingers0ATP11A CL E G H2325013552ORPHA:2032Idiopathic pulmonary fibrosisHP:0040282 - Frequent
HP:0100759HP:0100759Clubbing of fingers0BMPR1A CL E G H6571076ORPHA:79076Juvenile polyposis of infancyHP:0040283 - Occasional385
HP:0100759HP:0100759Clubbing of fingers0CD55 CL E G H16042665OMIM:226300Complement hyperactivation, angiopathic thrombosis, and protein-losing enteropathy.9
HP:0100759HP:0100759Clubbing of fingers0CFTR CL E G H10801884OMIM:219700Cystic fibrosis1371
HP:0100759HP:0100759Clubbing of fingers0DPP9 CL E G H9103918648ORPHA:2032Idiopathic pulmonary fibrosisHP:0040282 - Frequent
HP:0100759HP:0100759Clubbing of fingers0DSP CL E G H18323052OMIM:605676Cardiomyopathy, dilated, with woolly hair and keratoderma747
HP:0100759HP:0100759Clubbing of fingers0DSP CL E G H18323052ORPHA:2032Idiopathic pulmonary fibrosisHP:0040282 - Frequent747
HP:0100759HP:0100759Clubbing of fingers0EIF2AK4 CL E G H44027519687ORPHA:199241Pulmonary capillary hemangiomatosisHP:0040282 - Frequent40
HP:0100759HP:0100759Clubbing of fingers0FAM13A CL E G H1014419367ORPHA:2032Idiopathic pulmonary fibrosisHP:0040282 - Frequent
HP:0100759HP:0100759Clubbing of fingers0FCGR2A CL E G H22123616OMIM:219700Cystic fibrosis6
HP:0100759HP:0100759Clubbing of fingers0GJB6 CL E G H108044288ORPHA:189Hidrotic ectodermal dysplasia56
HP:0100759HP:0100759Clubbing of fingers0HNRNPH1 CL E G H31875041OMIM:620083
HP:0100759HP:0100759Clubbing of fingers0HPGD CL E G H32485154ORPHA:217059Isolated congenital digital clubbing55
HP:0100759HP:0100759Clubbing of fingers0HSPG2 CL E G H33395273ORPHA:1865Dyssegmental dysplasia, Silverman-Handmaker typeHP:0040283 - Occasional345
HP:0100759HP:0100759Clubbing of fingers0IL21 CL E G H590676005OMIM:615767IMMUNODEFICIENCY, COMMON VARIABLE, 11; CVID113
HP:0100759HP:0100759Clubbing of fingers0INTU CL E G H2715229239OMIM:617926OROFACIODIGITAL SYNDROME XVII; OFD17
HP:0100759HP:0100759Clubbing of fingers0JAG1 CL E G H1826188OMIM:619574CHARCOT-MARIE-TOOTH DISEASE, AXONAL, TYPE 2HH; CMT2HH257
HP:0100759HP:0100759Clubbing of fingers0LRBA CL E G H9871742OMIM:614700IMMUNODEFICIENCY, COMMON VARIABLE, 8, WITH AUTOIMMUNITY; CVID845
HP:0100759HP:0100759Clubbing of fingers0MUC5B CL E G H7278977516ORPHA:2032Idiopathic pulmonary fibrosisHP:0040282 - Frequent133
HP:0100759HP:0100759Clubbing of fingers0MUC5B CL E G H7278977516OMIM:178500Pulmonary fibrosis, idiopathic133
HP:0100759HP:0100759Clubbing of fingers0NCKAP1L CL E G H30714862OMIM:618982IMMUNODEFICIENCY 72 WITH AUTOINFLAMMATION; IMD72
HP:0100759HP:0100759Clubbing of fingers0NLRP3 CL E G H11454816400OMIM:191900Muckle-Wells syndrome217
HP:0100759HP:0100759Clubbing of fingers0PARN CL E G H50738609ORPHA:2032Idiopathic pulmonary fibrosisHP:0040282 - Frequent26
HP:0100759HP:0100759Clubbing of fingers0PSMB8 CL E G H56969545OMIM:256040Proteasome-associated autoinflammatory syndrome 1 and digenic forms.20
HP:0100759HP:0100759Clubbing of fingers0PTEN CL E G H57289588ORPHA:79076Juvenile polyposis of infancyHP:0040283 - Occasional948
HP:0100759HP:0100759Clubbing of fingers0PTH1R CL E G H57459608OMIM:156400Metaphyseal chondrodysplasia, Jansen type.58
HP:0100759HP:0100759Clubbing of fingers0RASGRP1 CL E G H101259878OMIM:618534IMMUNODEFICIENCY 64; IMD64
HP:0100759HP:0100759Clubbing of fingers0RTEL1 CL E G H5175015888ORPHA:2032Idiopathic pulmonary fibrosisHP:0040282 - Frequent77
HP:0100759HP:0100759Clubbing of fingers0SFTPA1 CL E G H65350910798ORPHA:2032Idiopathic pulmonary fibrosisHP:0040282 - Frequent19
HP:0100759HP:0100759Clubbing of fingers0SFTPA2 CL E G H72923810799ORPHA:2032Idiopathic pulmonary fibrosisHP:0040282 - Frequent10
HP:0100759HP:0100759Clubbing of fingers0SFTPA2 CL E G H72923810799OMIM:178500Pulmonary fibrosis, idiopathic10
HP:0100759HP:0100759Clubbing of fingers0SFTPC CL E G H644010802ORPHA:2032Idiopathic pulmonary fibrosisHP:0040282 - Frequent33
HP:0100759HP:0100759Clubbing of fingers0SFTPC CL E G H644010802OMIM:178500Pulmonary fibrosis, idiopathic33
HP:0100759HP:0100759Clubbing of fingers0SLC34A2 CL E G H1056811020ORPHA:60025Pulmonary alveolar microlithiasisHP:0040283 - Occasional7
HP:0100759HP:0100759Clubbing of fingers0SLC5A6 CL E G H888411041OMIM:618973NEURODEGENERATION, INFANTILE-ONSET, BIOTIN-RESPONSIVE; NERIB
HP:0100759HP:0100759Clubbing of fingers0SLCO2A1 CL E G H657810955OMIM:167100Hypertrophic osteoarthropathy, primary, autosomal dominant13
HP:0100759HP:0100759Clubbing of fingers0STK11 CL E G H679411389OMIM:175200Peutz-Jeghers syndrome.740
HP:0100759HP:0100759Clubbing of fingers0STN1 CL E G H7999126200ORPHA:2032Idiopathic pulmonary fibrosisHP:0040282 - Frequent2
HP:0100759HP:0100759Clubbing of fingers0TERC CL E G H701211727ORPHA:2032Idiopathic pulmonary fibrosisHP:0040282 - Frequent48
HP:0100759HP:0100759Clubbing of fingers0TERT CL E G H701511730ORPHA:2032Idiopathic pulmonary fibrosisHP:0040282 - Frequent238
HP:0100759HP:0100759Clubbing of fingers0TERT CL E G H701511730OMIM:614742PULMONARY FIBROSIS AND/OR BONE MARROW FAILURE, TELOMERE-RELATED, 1; PFBMFT1238
HP:0100759HP:0100759Clubbing of fingers0TERT CL E G H701511730OMIM:178500Pulmonary fibrosis, idiopathic238
HP:0100759HP:0100759Clubbing of fingers0TGFB1 CL E G H704011766OMIM:219700Cystic fibrosis13
HP:0100759HP:0100759Clubbing of fingers0TLL1 CL E G H709211843ORPHA:99106Atrial septal defect, ostium primum typeHP:0040283 - Occasional6


Genes (39) :ABCA3 ATP11A BMPR1A CD55 CFTR DPP9 DSP EIF2AK4 FAM13A FCGR2A GJB6 HNRNPH1 HPGD HSPG2 IL21 INTU JAG1 LRBA MUC5B NCKAP1L NLRP3 PARN PSMB8 PTEN PTH1R RASGRP1 RTEL1 SFTPA1 SFTPA2 SFTPC SLC34A2 SLC5A6 SLCO2A1 STK11 STN1 TERC TERT TGFB1 TLL1

Diseases (26) :ORPHA:2032 ORPHA:79076 OMIM:226300 OMIM:219700 OMIM:605676 ORPHA:199241 ORPHA:189 OMIM:620083 ORPHA:217059 ORPHA:1865 OMIM:615767 OMIM:617926 OMIM:619574 OMIM:614700 OMIM:178500 OMIM:618982 OMIM:191900 OMIM:256040 OMIM:156400 OMIM:618534 ORPHA:60025 OMIM:618973 OMIM:167100 OMIM:175200 OMIM:614742 ORPHA:99106
 

Human Phenotype Ontology(HPO) is developed by the Human Phenotype Ontology Consortium. The version used here is December 15 2022 release.