Human Phenotype Ontology 
Grandparent Node:
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Phenotypic abnormality (HP:0000118)help
Parent Node:
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Abnormality of metabolism/homeostasis (HP:0001939)help
..Starting node
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Gangrene (HP:0100758)help
Term ID: 100758
Name: Gangrene
Synonym: Death of body tissue due to lack of blood flow or infection
Definition: A serious and potentially life-threatening condition that arises when a considerable mass of body tissue dies (necrosis).
Comments:
Reference: HP:0100758
Genes and Diseases:
 
       Child Nodes:

 Sister Nodes: 
..expandAbnormal blood ion concentration (HP:0003111) help
..expandAbnormal calcium-phosphate regulating hormone level (HP:0100530) help
..expandAbnormal cellular physiology (HP:0011017) help
..expandAbnormal circulating carbohydrate concentration (HP:0011013) help
..expandAbnormal circulating carboxylic acid concentration (HP:0004354) help
..expandAbnormal circulating lipid concentration (HP:0003119) help
..expandAbnormal circulating nitrogen compound concentration (HP:0004364) help
..expandAbnormal circulating nucleobase concentration (HP:0010932) help
..expandAbnormal circulating porphyrin concentration (HP:0010472) help
..expandAbnormal circulating protein concentration (HP:0010876) help
..expandAbnormal circulating selenium concentration (HP:0031903) help
..expandAbnormal enzyme/coenzyme activity (HP:0012379) help
..expandAbnormal erythrocyte sedimentation rate (HP:0025021) help
..expandAbnormal homeostasis (HP:0012337) help
..expandAbnormal sweat homeostasis (HP:0040127) help
..expandAbnormality of acid-base homeostasis (HP:0004360) help
..expandAbnormality of fluid regulation (HP:0011032) help
..expandAbnormality of Krebs cycle metabolism (HP:0000816) help
..expandAbnormality of superoxide metabolism (HP:0004358) help
..expandAbnormality of temperature regulation (HP:0004370) help
..expandAbnormality of urine homeostasis (HP:0003110) help
..expandAbnormality of vitamin metabolism (HP:0100508) help
..expandAmyloidosis (HP:0011034) help
..expandBloodstream infectious agent (HP:0031863) help
..expandFood intolerance (HP:0012537) help
..expandHyperbilirubinemia (HP:0002904) help
..expandIncreased level of propylene glycol in blood (HP:0410069) help
..expandKetosis (HP:0001946) help
..expandMolybdenum cofactor deficiency (HP:0003570) help
..expandobsolete Abnormality of glycoprotein metabolism (HP:0004367) help
..expandPresence of xenobiotic (HP:0031838) help
..expandReduced 5-oxoprolinase level (HP:0040142) help
..expandReduced acetaldehyde dehydrogenase level (HP:0003533) help
..expandReduced glutathione synthetase level (HP:0003343) help
InputHPO IDHPO termDistanceGeneGene id entrezHGNC IDDiseaseIdDiseaseNameFrequencyOnsetHGMD variantsClinVar variants
 
HPO disease - gene - phenotype typical associations:
 
HPO disease - gene - phenotype less frequent non-typical associations:
HP:0100758HP:0100758Gangrene0ABCA12 CL E G H2615414637ORPHA:313Lamellar ichthyosisHP:0040283 - Occasional130
HP:0100758HP:0100758Gangrene0ABCC6 CL E G H36857ORPHA:51608Generalized arterial calcification of infancyHP:0040284 - Very rare415
HP:0100758HP:0100758Gangrene0AGXT CL E G H189341OMIM:259900Hyperoxaluria, primary, type I.260
HP:0100758HP:0100758Gangrene0ALOX12B CL E G H242430ORPHA:313Lamellar ichthyosisHP:0040283 - Occasional75
HP:0100758HP:0100758Gangrene0ALOXE3 CL E G H5934413743ORPHA:313Lamellar ichthyosisHP:0040283 - Occasional63
HP:0100758HP:0100758Gangrene0ASPRV1 CL E G H15151626321ORPHA:313Lamellar ichthyosisHP:0040283 - Occasional1
HP:0100758HP:0100758Gangrene0BCOR CL E G H5488020893ORPHA:520Acute promyelocytic leukemiaHP:0040284 - Very rare101
HP:0100758HP:0100758Gangrene0C4A CL E G H7201323ORPHA:117Behçet diseaseHP:0040283 - Occasional1
HP:0100758HP:0100758Gangrene0CAT CL E G H8471516ORPHA:926AcatalasemiaHP:0040283 - Occasional5
HP:0100758HP:0100758Gangrene0CCR1 CL E G H12301602ORPHA:117Behçet diseaseHP:0040283 - Occasional
HP:0100758HP:0100758Gangrene0CD28 CL E G H9401653ORPHA:3162Sézary syndromeHP:0040283 - Occasional
HP:0100758HP:0100758Gangrene0CTLA4 CL E G H14932505ORPHA:900Granulomatosis with polyangiitisHP:0040283 - Occasional10
HP:0100758HP:0100758Gangrene0CTLA4 CL E G H14932505ORPHA:3162Sézary syndromeHP:0040283 - Occasional10
HP:0100758HP:0100758Gangrene0CYP4F22 CL E G H12641026820ORPHA:313Lamellar ichthyosisHP:0040283 - Occasional54
HP:0100758HP:0100758Gangrene0ENPP1 CL E G H51673356ORPHA:51608Generalized arterial calcification of infancyHP:0040284 - Very rare151
HP:0100758HP:0100758Gangrene0ERAP1 CL E G H5175218173ORPHA:117Behçet diseaseHP:0040283 - Occasional1
HP:0100758HP:0100758Gangrene0FAS CL E G H35511920ORPHA:117Behçet diseaseHP:0040283 - Occasional59
HP:0100758HP:0100758Gangrene0FIP1L1 CL E G H8160819124ORPHA:520Acute promyelocytic leukemiaHP:0040284 - Very rare4
HP:0100758HP:0100758Gangrene0HLA-B CL E G H31064932ORPHA:117Behçet diseaseHP:0040283 - Occasional4
HP:0100758HP:0100758Gangrene0HLA-B CL E G H31064932ORPHA:397Giant cell arteritisHP:0040283 - Occasional4
HP:0100758HP:0100758Gangrene0HLA-B CL E G H31064932ORPHA:3287Takayasu arteritisHP:0040282 - Frequent4
HP:0100758HP:0100758Gangrene0HLA-DPA1 CL E G H31134938ORPHA:900Granulomatosis with polyangiitisHP:0040283 - Occasional
HP:0100758HP:0100758Gangrene0HLA-DPB1 CL E G H31154940ORPHA:900Granulomatosis with polyangiitisHP:0040283 - Occasional1
HP:0100758HP:0100758Gangrene0HLA-DRB1 CL E G H31234948ORPHA:397Giant cell arteritisHP:0040283 - Occasional2
HP:0100758HP:0100758Gangrene0IFNGR1 CL E G H34595439ORPHA:117Behçet diseaseHP:0040283 - Occasional60
HP:0100758HP:0100758Gangrene0IL10 CL E G H35865962ORPHA:117Behçet diseaseHP:0040283 - Occasional2
HP:0100758HP:0100758Gangrene0IL12A CL E G H35925969ORPHA:117Behçet diseaseHP:0040283 - Occasional
HP:0100758HP:0100758Gangrene0IL12A-AS1 CL E G H10192837649094ORPHA:117Behçet diseaseHP:0040283 - Occasional
HP:0100758HP:0100758Gangrene0IL12B CL E G H35935970ORPHA:3287Takayasu arteritisHP:0040282 - Frequent31
HP:0100758HP:0100758Gangrene0IL23R CL E G H14923319100ORPHA:117Behçet diseaseHP:0040283 - Occasional1
HP:0100758HP:0100758Gangrene0IRF2BP2 CL E G H35994821729ORPHA:520Acute promyelocytic leukemiaHP:0040284 - Very rare4
HP:0100758HP:0100758Gangrene0KIF11 CL E G H38326388ORPHA:2526Microcephaly-lymphedema-chorioretinopathy syndromeHP:0040283 - Occasional46
HP:0100758HP:0100758Gangrene0KLRC4 CL E G H83026377ORPHA:117Behçet diseaseHP:0040283 - Occasional
HP:0100758HP:0100758Gangrene0LIPN CL E G H64341823452ORPHA:313Lamellar ichthyosisHP:0040283 - Occasional1
HP:0100758HP:0100758Gangrene0MEFV CL E G H42106998ORPHA:117Behçet diseaseHP:0040283 - Occasional281
HP:0100758HP:0100758Gangrene0MLX CL E G H694511645ORPHA:3287Takayasu arteritisHP:0040282 - Frequent
HP:0100758HP:0100758Gangrene0NABP1 CL E G H6485926232ORPHA:520Acute promyelocytic leukemiaHP:0040284 - Very rare
HP:0100758HP:0100758Gangrene0NIPAL4 CL E G H34893828018ORPHA:313Lamellar ichthyosisHP:0040283 - Occasional60
HP:0100758HP:0100758Gangrene0NPM1 CL E G H48697910ORPHA:520Acute promyelocytic leukemiaHP:0040284 - Very rare12
HP:0100758HP:0100758Gangrene0NUMA1 CL E G H49268059ORPHA:520Acute promyelocytic leukemiaHP:0040284 - Very rare
HP:0100758HP:0100758Gangrene0P4HA2 CL E G H89748547ORPHA:397Giant cell arteritisHP:0040283 - Occasional3
HP:0100758HP:0100758Gangrene0PML CL E G H53719113ORPHA:520Acute promyelocytic leukemiaHP:0040284 - Very rare3
HP:0100758HP:0100758Gangrene0PRKAR1A CL E G H55739388ORPHA:520Acute promyelocytic leukemiaHP:0040284 - Very rare134
HP:0100758HP:0100758Gangrene0PROC CL E G H56249451ORPHA:745Severe hereditary thrombophilia due to congenital protein C deficiencyHP:0040283 - Occasional65
HP:0100758HP:0100758Gangrene0PROS1 CL E G H56279456ORPHA:743Severe hereditary thrombophilia due to congenital protein S deficiencyHP:0040283 - Occasional75
HP:0100758HP:0100758Gangrene0PRTN3 CL E G H56579495ORPHA:900Granulomatosis with polyangiitisHP:0040283 - Occasional
HP:0100758HP:0100758Gangrene0PTPN22 CL E G H261919652ORPHA:397Giant cell arteritisHP:0040283 - Occasional3
HP:0100758HP:0100758Gangrene0PTPN22 CL E G H261919652ORPHA:900Granulomatosis with polyangiitisHP:0040283 - Occasional3
HP:0100758HP:0100758Gangrene0RARA CL E G H59149864ORPHA:520Acute promyelocytic leukemiaHP:0040284 - Very rare2
HP:0100758HP:0100758Gangrene0SDR9C7 CL E G H12121429958ORPHA:313Lamellar ichthyosisHP:0040283 - Occasional2
HP:0100758HP:0100758Gangrene0STAT3 CL E G H677411364ORPHA:520Acute promyelocytic leukemiaHP:0040284 - Very rare110
HP:0100758HP:0100758Gangrene0STAT4 CL E G H677511365ORPHA:117Behçet diseaseHP:0040283 - Occasional2
HP:0100758HP:0100758Gangrene0STAT5B CL E G H677711367ORPHA:520Acute promyelocytic leukemiaHP:0040284 - Very rare12
HP:0100758HP:0100758Gangrene0SULT2B1 CL E G H682011459ORPHA:313Lamellar ichthyosisHP:0040283 - Occasional4
HP:0100758HP:0100758Gangrene0TBL1XR1 CL E G H7971829529ORPHA:520Acute promyelocytic leukemiaHP:0040284 - Very rare22
HP:0100758HP:0100758Gangrene0TGM1 CL E G H705111777ORPHA:313Lamellar ichthyosisHP:0040283 - Occasional98
HP:0100758HP:0100758Gangrene0TLR4 CL E G H709911850ORPHA:117Behçet diseaseHP:0040283 - Occasional3
HP:0100758HP:0100758Gangrene0TNFRSF1B CL E G H713311917ORPHA:3162Sézary syndromeHP:0040283 - Occasional
HP:0100758HP:0100758Gangrene0UBAC2 CL E G H33786720486ORPHA:117Behçet diseaseHP:0040283 - Occasional
HP:0100758HP:0100758Gangrene0ZBTB16 CL E G H770412930ORPHA:520Acute promyelocytic leukemiaHP:0040284 - Very rare1


Genes (56) :ABCA12 ABCC6 AGXT ALOX12B ALOXE3 ASPRV1 BCOR C4A CAT CCR1 CD28 CTLA4 CYP4F22 ENPP1 ERAP1 FAS FIP1L1 HLA-B HLA-DPA1 HLA-DPB1 HLA-DRB1 IFNGR1 IL10 IL12A IL12A-AS1 IL12B IL23R IRF2BP2 KIF11 KLRC4 LIPN MEFV MLX NABP1 NIPAL4 NPM1 NUMA1 P4HA2 PML PRKAR1A PROC PROS1 PRTN3 PTPN22 RARA SDR9C7 STAT3 STAT4 STAT5B SULT2B1 TBL1XR1 TGM1 TLR4 TNFRSF1B UBAC2 ZBTB16

Diseases (13) :ORPHA:313 ORPHA:51608 OMIM:259900 ORPHA:520 ORPHA:117 ORPHA:926 ORPHA:3162 ORPHA:900 ORPHA:397 ORPHA:3287 ORPHA:2526 ORPHA:745 ORPHA:743
 

Human Phenotype Ontology(HPO) is developed by the Human Phenotype Ontology Consortium. The version used here is December 15 2022 release.