Human Phenotype Ontology 
Grandparent Node:
expand
Abnormality of the skin (HP:0000951)help
Parent Node:
expand
Abnormality of skin morphology (HP:0011121)help
..Starting node
..expand
Lichenification (HP:0100725)help
Term ID: 100725
Name: Lichenification
Synonym:
Definition: Thickening and hardening of the epidermis seen with exaggeration of normal skin lines.
Comments:
Reference: HP:0100725
Genes and Diseases:
 
       Child Nodes:
........expandFlexural lichenification (HP:0007453) help

 Sister Nodes: 
..expandAbnormal blistering of the skin (HP:0008066) help
..expandAbnormal cutaneous collagen fibril morphology (HP:0031512) help
..expandAbnormal cutaneous elastic fiber morphology (HP:0025082) help
..expandAbnormal dermoepidermal junction morphology (HP:0031538) help
..expandAbnormal elasticity of skin (HP:0010647) help
..expandAbnormal epidermal morphology (HP:0011124) help
..expandAbnormality of skin pigmentation (HP:0001000) help
..expandDermal translucency (HP:0010648) help
..expandDry skin (HP:0000958) help
..expandElevated dermal desmosine content (HP:0025083) help
..expandGeneralized abnormality of skin (HP:0011354) help
..expandLocalized skin lesion (HP:0011355) help
..expandOchronosis (HP:0030764) help
..expandPallor (HP:0000980) help
..expandPoikiloderma (HP:0001029) help
..expandRegional abnormality of skin (HP:0011356) help
..expandStiff skin (HP:0030053) help
..expandThickened skin (HP:0001072) help
InputHPO IDHPO termDistanceGeneGene id entrezHGNC IDDiseaseIdDiseaseNameFrequencyOnsetHGMD variantsClinVar variants
 
HPO disease - gene - phenotype typical associations:
 
HPO disease - gene - phenotype less frequent non-typical associations:
HP:0100725HP:0100725Lichenification0CARD14 CL E G H7909216446ORPHA:2897Pityriasis rubra pilarisHP:0040283 - Occasional33
HP:0100725HP:0100725Lichenification0CD28 CL E G H9401653ORPHA:3162Sézary syndromeHP:0040281 - Very frequent
HP:0100725HP:0100725Lichenification0COL7A1 CL E G H12942214ORPHA:89843Dystrophic epidermolysis bullosa pruriginosaHP:0040282 - Frequent263
HP:0100725HP:0100725Lichenification0CSTA CL E G H14752481OMIM:607936Peeling skin syndrome 4.4
HP:0100725HP:0100725Lichenification0CTLA4 CL E G H14932505ORPHA:3162Sézary syndromeHP:0040281 - Very frequent10
HP:0100725HP:0100725Lichenification0FLT4 CL E G H23243767ORPHA:79452Milroy diseaseHP:0040283 - Occasional90
HP:0100725HP:0100725Lichenification0GJC2 CL E G H5716517494ORPHA:79452Milroy diseaseHP:0040283 - Occasional37
HP:0100725HP:0100725Lichenification0HLA-DRA CL E G H31224947ORPHA:505Graham Little-Piccardi-Lassueur syndromeHP:0040282 - Frequent
HP:0100725HP:0100725Lichenification0LBR CL E G H39306518ORPHA:779Reynolds syndromeHP:0040283 - Occasional70
HP:0100725HP:0100725Lichenification0NTRK1 CL E G H49148031ORPHA:642Hereditary sensory and autonomic neuropathy type 4HP:0040282 - Frequent97
HP:0100725HP:0100725Lichenification0NTRK1 CL E G H49148031OMIM:256800Insensitivity to pain, congenital, with anhidrosis.97
HP:0100725HP:0100725Lichenification0OSMR CL E G H91808507OMIM:105250Amyloidosis, primary localized cutaneous, 1.5
HP:0100725HP:0100725Lichenification0TNFRSF1B CL E G H713311917ORPHA:3162Sézary syndromeHP:0040281 - Very frequent
HP:0100725HP:0007453Flexural lichenification1 CL E G H


Genes (12) :CARD14 CD28 COL7A1 CSTA CTLA4 FLT4 GJC2 HLA-DRA LBR NTRK1 OSMR TNFRSF1B

Diseases (10) :ORPHA:2897 ORPHA:3162 ORPHA:89843 OMIM:607936 ORPHA:79452 ORPHA:505 ORPHA:779 ORPHA:642 OMIM:256800 OMIM:105250
 

Human Phenotype Ontology(HPO) is developed by the Human Phenotype Ontology Consortium. The version used here is December 15 2022 release.