Human Phenotype Ontology 
Grandparent Node:
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Morphological central nervous system abnormality (HP:0002011)help
Parent Node:
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Atrophy/Degeneration affecting the central nervous system (HP:0007367)help
..Starting node
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Senile plaques (HP:0100256)help
Term ID: 100256
Name: Senile plaques
Synonym: Braindruse; Neuritic plaques; Senile druse
Definition: Senile plaques are extracellular deposits of amyloid in the gray matter of the brain.
Comments:
Reference: HP:0100256
Genes and Diseases:
 
       Child Nodes:
........expandCotton wool plaques (HP:0500028) help

 Sister Nodes: 
..expandAtrophy/Degeneration affecting the brainstem (HP:0007366) help
..expandAtrophy/Degeneration involving the corticospinal tracts (HP:0007372) help
..expandAtrophy/Degeneration involving the spinal cord (HP:0007344) help
..expandBrain atrophy (HP:0012444) help
..expandCentral nervous system degeneration (HP:0007009) help
..expandIncreased cerebral lipofuscin (HP:0011813) help
..expandMotor neuron atrophy (HP:0007373) help
..expandNeurodegeneration (HP:0002180) help
..expandNeuronal loss in central nervous system (HP:0002529) help
InputHPO IDHPO termDistanceGeneGene id entrezHGNC IDDiseaseIdDiseaseNameFrequencyOnsetHGMD variantsClinVar variants
 
HPO disease - gene - phenotype typical associations:
 
HPO disease - gene - phenotype less frequent non-typical associations:
HP:0100256HP:0100256Senile plaques0ABCA7 CL E G H1034737OMIM:608907Alzheimer disease 9, susceptibility to.3
HP:0100256HP:0100256Senile plaques0APOE CL E G H348613OMIM:606889Alzheimer disease 439
HP:0100256HP:0100256Senile plaques0C9ORF72 CL E G H20322828337ORPHA:100070Progressive non-fluent aphasiaHP:0040283 - Occasional56
HP:0100256HP:0100256Senile plaques0CHMP2B CL E G H2597824537ORPHA:100070Progressive non-fluent aphasiaHP:0040283 - Occasional42
HP:0100256HP:0100256Senile plaques0GRN CL E G H28964601ORPHA:100070Progressive non-fluent aphasiaHP:0040283 - Occasional126
HP:0100256HP:0100256Senile plaques0MAPT CL E G H41376893ORPHA:100070Progressive non-fluent aphasiaHP:0040283 - Occasional140
HP:0100256HP:0100256Senile plaques0MAPT CL E G H41376893OMIM:601104Supranuclear palsy, progressive, 1140
HP:0100256HP:0100256Senile plaques0PRNP CL E G H56219449ORPHA:282166Inherited Creutzfeldt-Jakob diseaseHP:0040282 - Frequent69
HP:0100256HP:0100256Senile plaques0PSEN1 CL E G H56639508ORPHA:100070Progressive non-fluent aphasiaHP:0040283 - Occasional241
HP:0100256HP:0100256Senile plaques0PSEN2 CL E G H56649509OMIM:606889Alzheimer disease 459
HP:0100256HP:0100256Senile plaques0TMEM106B CL E G H5466422407ORPHA:100070Progressive non-fluent aphasiaHP:0040283 - Occasional
HP:0100256HP:0100256Senile plaques0TREM2 CL E G H5420917761ORPHA:100070Progressive non-fluent aphasiaHP:0040283 - Occasional31
HP:0100256HP:0100256Senile plaques0VCP CL E G H741512666ORPHA:100070Progressive non-fluent aphasiaHP:0040283 - Occasional63
HP:0100256HP:0500028Cotton wool plaques1 CL E G H


Genes (12) :ABCA7 APOE C9ORF72 CHMP2B GRN MAPT PRNP PSEN1 PSEN2 TMEM106B TREM2 VCP

Diseases (5) :OMIM:608907 OMIM:606889 ORPHA:100070 OMIM:601104 ORPHA:282166
 

Human Phenotype Ontology(HPO) is developed by the Human Phenotype Ontology Consortium. The version used here is December 15 2022 release.